A woman heads home after church, but never makes it there alive, triggering a homicide investigation.

Volunteers and police spend weeks searching for a missing girl. A psychic later leads them to a field where the body was found.

Forensic investigators try to stop a killer who is apparently responsible for two slayings in a community in South Carolina.

When DNA proves that a man who practically admits to a brutal attack is innocent, police wonder why he is willing to take the blame.

When a businessman is murdered, motives and suspects are plentiful. Was it simply a disgruntled employee or client? Or do some racy photos hold the clue to the crime?

A family break turns into a nightmare when the wife is found face-down in a lake; with no idea whether it was murder, an accident or suicide, police turn to a new forensic technique.

When friends see a woman in the back of a car flailing her arms and screaming, they assume she is having fun, but when they later come upon a jacket and a pool of blood, they realize they witnessed an abduction in progress.

An attack on a couple's home leaves the husband dead, the wife gravely injured and their son as a prime suspect; hundreds of miles away, a DNA sample may lead to the killer.

Detectives think they've solved a murder when they find the weapon and victim's blood in a man's flat, but the evidence may have been planted.

Stories from across the world and refreshing conversations with Audie Cornish.

Stories from across the world and refreshing conversations with Audie Cornish.

Melanie Zanona; Catherine Lucey; Isaac Arnsdorf.

San Diego police investigate the murder of a missing person whose hands turn up in a dumpster; an anonymous letter, containing details only the killer would know, offers clues to solving the case.

One year after her father's death, a teen's role in a high school production of "Hamlet" causes her to reveal the chilling truth behind her family's tragedy.

A mother puts her hope in the internet and an independent investigation to clear her name after authorities charge her with murdering her 17-month-old son in a fire considered to be intentionally set.

When a man dies unexpectedly in the office of a noted California doctor, police begin what they think will be a routine investigation, but discoveries of false identities and insurance fraud raise questions about the doctor's role.

A forensic scientist uses his skills to preserve a footprint left in snow to help authorities nab two men suspected of robbing an Ontario couple and shooting the husband in the head.

Fingerprints taken from a piece of cloth help solve the rape and murder of a 22-year-old woman in Henrico County, Va.

The FBI profiles a suspect in the kidnapping and murder of a 6-year-old girl during an evening church service; a witness leads authorities to the likely killer, but then becomes a victim herself.

Photographs found in a dumpster lead to the killer of Los Angeles model Linda Sobek; the man claims he did not intentionally kill her despite evidence to the contrary.

A murder mystery theater performance in Easton, Md., turns into a real-life mystery when a body is found after the performance ends.

When a woman dies in a horseback riding accident, police uncover a web of lies in her husband's background after his suspicious behavior prompts a closer look.

A serial killer in Tampa, Fla., taunts police by strangling prostitutes and leaving their bodies in plain sight, but tire marks and fibers lead to the culprit.

Missouri police are thrust into a bizarre web of homeless drifters and cattle auctions when they are called to retrieve a dead body.

A killer wants to outwit the police and keep the identity of his victim secret so he removes the teeth; however, lab tests on the skull reveal not just the horrific nature of the murder, but the identity of the victim too.

When a fundamentalist group is accused of robbing banks, authorities know they are dealing with experienced criminals and overwhelming evidence, but the defense is very well-funded.

A wife is missing in Key West; investigators wonder if they should be searching for a missing person or a killer.

Suicide notes and a pistol in hand lead police to suspect that a mother of two young children appeared to had killed herself, but when investigators learned of a house fire she was in three years earlier, they reinvestigate.

The violent death of an Air Force officer's wife outside a Philippines air base is examined, amid accusations of a love triangle involving the murdered woman's husband; investigators use groundbreaking computer forensics to make their case.

Pieces of plastic the size of sand hold clues to a bombing.

At first glance it appears a young woman suffocated, but further investigation shows the scene was staged.

A killer is careless when a home is destroyed by fire and a young boy is missing.

A patrol officer is shocked by the amount of blood at a traffic accident and is shocked by the coroner's ruling until an anonymous phone call re-ignites the case.

An irrigation canal murder remains unsolved until a similar murder occurs.

The light of day and DNA picture painted by molecular biologist reveals new clues about a nighttime traffic accident.

On Valentine's Day, an obstetrician finds his wife dead and calls 911; police discover inconsistencies between the blood spatter evidence and his version of events.

Weed analysis and photogrammetry are used to help solve the 1995 murder of a California teenager is found dead after disappearing from her home.

When police recover the submerged car of missing man, they find no body; the investigation that follows uncovers a deadly obsession and the motive for murder.

Emergency dispatch recieved a call from a man who said his girlfriend shot and killed herself. But the wound was not self-inflicted.

Investigators piece together evidence found at the scene of a Native American woman's murder; the tyre tracks and shoe impressions could lead them to the killer.

Detectives search for the bombers of two churches in Illinois, hoping that the materials used in the remnants of the handmade bombs will offer the clues to catch the culprits.

There was no apparent reason for the young, healthy college student to be dead; but when the medical examiner found the tiniest of clues during the autopsy, investigators were able to unravel the mystery of betrayal and revenge.

A woman is stabbed a hundred times and her body positioned in a suggestive manner. This could be a hate crime against women.

Police are able to create a composite sketch of a man burnt beyond recognition. But tracking the killer is more challenging.

By cutting a strand of a murdered man's hair into sections, forensics reveal a record of his last six months alive, and find he was frequently ingesting huge amounts of arsenic.

A bullet-riddled car, a missing driver, and no witnesses, an ambush or a random attack; the clue was something so tiny, it was measured in millionths of a meter.

Teenager is found half-naked with her throat slit; a single foreign hair found on her thumb may finger the killer.

Two women who lived in the same apartment complex were brutally murdered; the similarities of the crime scenes led police to believe they were dealing with a serial killer who hated women, and they had to find him before he struck again.

Weeks after a student vanishes, the body of an unknown female is found in the ashes of a fire 700 miles away; an alert policeman realizes the crimes could be connected.

Investigators face a growing list of suspects after a beautiful flight attendant is brutally murdered in her own home.

The assistant manager of the restaurant had been stabbed to death; police knew why he'd been killed: $8,000 was missing from the safe. As to who was responsible, his family and friends couldn't even imagine who'd want to hurt him.

Florida authorities rely on DNA evidence to try to nail the killer of a woman who was abducted from her late-night job at a convenience store, raped and strangled.

A wild fire in a secluded parking lot leads police to discover a dreadful homicide, with the suspect's image caught by security cameras.

After a prominent Arizona surgeon is found stabbed to death outside his office, investigators uncover an unlikely suspect with deep pockets and an even deeper hatred for the doctor.

Photographs found in a dumpster lead to the killer of Los Angeles model Linda Sobek; the man claims he did not intentionally kill her despite evidence to the contrary.

A murder mystery theater performance in Easton, Md., turns into a real-life mystery when a body is found after the performance ends.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

When a young doctor is accused of sedating and sexually assaulting two of his female patients, DNA tests show him to be innocent, but the women persist with their claims; seven years later, a private investigation leads to a surprising discovery.

The search for the killer of two teenagers in Texas shows a behavioral study on how most serial killers also have a history of abusing animals.

When a farmer's wife disappears, the tests of a plant pathologist and a dendrochronologist lead to a surprising revelation.

A son who is convinced of his mother's innocence in the death of his father enrolls in law school to try and clear her name.

Despite a patient's claim that the cut to his hand had been caused by a dumpster, the doctor treating the injury recognizes it as something else - and soon becomes the chief witness in a murder case.

The pornography empire cultivated by brothers Artie and Jim Mitchell crumbles when one turns up dead and his brother confesses to shooting him; investigators question whether the shooting was premeditated.

When prison guard Donna Payant's body is discovered at a landfill, a medical examiner uses a "signature" clue to link her death to a murder the same examiner investigated 10 years earlier.

When a 9-year-old girl vanishes on her way to school, the entire community helps with the search; detectives believe her mother may be involved, and a hidden fingerprint seals the case.

The investigation of a murder case in New Jersey is stalled until a similar attack occurs on a state trooper in Maine.

A young woman goes missing without leaving many clues, but the advanced technology on offer makes it possible for cat hairs and insects to help build an image of the abductor.

Blood spatter analysis and an investigation lead police to the truth when a pregnant woman is found dead in her home.

A mother is determined to discover what happened when her daughter is injured in a hit-and-run accident.

Experts seek answers to a young businesswoman's death just before she was to testify in a criminal trial.

An anonymous caller reports the rape and murder of a dry cleaner employee; two eyewitnesses tell two similar but not identical stories.

Police blame a botched robbery when an eccentric elderly millionaire is found dead, but the motive could be wrong.

Woman disappears from grocery store parking lot in Boulder, Colo.; investigators find extraordinary clues in a pair of bloody gloves, unique tire tracks, and ordinary grass and pine needles.

A car carrying three men pulls up alongside another on an Alaskan highway and fires shots, leaving a passenger dead; one of the passengers in the killer's car agrees to testify against his friends; the resulting trials don't end the carnage.

Police suspect a gay college student's slaying is a hate crime until forensic evidence points the case in another direction.

In a wealthy area of Philadelphia, police are called to the scene of what seems like a regular accidental drowning; the investigation begins to focus on one person who has many reasons to want the victim dead.

Two women are murdered in the same town and police fear a serial killer is on the loose, further investigation finds that they were both close to the same man.

A young woman is found dead on a golf course in the Bahamas; the grass on that course is so distinctive that it had evidentiary value; the evidence leds police to two suspects; each blamed the other, and they have to find out who the killer is.

A teenager goes missing after an evening of horseback riding; her body is found a month later, three miles from her home; the killer unknowingly leaves a trace of evidence behind, tiny but unmistakable clues that pointed to him and him alone.

When a popular disc jockey is found murdered in a community garden, police swing into action; a sniffer dog and a blood spatter expert led police to the killer and he'd been much closer than they realize.

Investigators unravel a twisted tale of lust, greed and deception after a woman claims her husband was gunned down by intruders.

Three seemingly unrelated deaths proved to be serial murders; the killer had been careful, he uses poison which had no taste or odour, fortunately for investigators, it also has a unique chemical signature.

A man is murdered in his sleep but no fingerprints are anywhere to be found; a shoe impression outside could lead to the killer.

Police don't have a basis for comparison to match shoe impressions, blood drops and DNA evidence from a murder scene.

A masked gunman kills two members of a family and wounds two others after they interrupt his burglary at their upscale suburban home.

A killer leaves equally incriminating evidence at the scene when he meticulously wipes away his fingerprint and shoe impressions.

After a woman is found dead at a yacht club in California in an apparent case of love gone wrong, investigators discover her home life was as dramatic as films made in nearby Hollywood.

The brutal murder of a state park employee over $2,000 rattles her co-workers and tourists while leaving police to sift through hundreds of leads.

When evidence shows a woman's rape and murder, police must find the killer as well as the victim.

A week after a couple disappears from the beach, police get a mysterious lead from a robbery.

Fifteen years later, DNA technology leads to justice for a murdered woman and her savagely beaten 4-year-old daughter.

A quiet waitress who hasn't been to work in two days vanishes without a trace; police suspect a date gone wrong.

The search for a missing exotic dancer led police to an isolated 75-acre site where someone had been shot and cremated, thus destroying all evidence... almost; piece of a foot provided enough DNA for a genetic profile and positive ID.

After years of suffering domestic abuse, a young woman is found murdered in her bathtub; among numerous clues, a hamburger bun proves the most incriminating.

Evidence that includes threatening emails, a missing person and an abandoned truck lead police to a woman's suspected killer, but they don't have the victim's body.

A woman has an accidental fall down a flight of stairs and appears to have hit her head, but the lack of blood splatter and misplaced shoes lead police to believe the fall was staged.

A church member gets gunned down after leaving choir practice; although witnesses see little and not much evidence exists, investigators learn that she had been having affairs for years.

When a woman dies in a horseback riding accident, police uncover a web of lies in her husband's background after his suspicious behavior prompts a closer look.

A serial killer in Tampa, Fla., taunts police by strangling prostitutes and leaving their bodies in plain sight, but tire marks and fibers lead to the culprit.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

Forensic science and deductive reasoning determine what happened to a mother and daughter while they were on a shopping spree.

Exploring how an American hit single from 1966 - "The Cheater" by Bob Kuban and the In-Men - foreshadowed the demise of the group's lead singer, Walter Scott.

Eight years after a man confessed to the murder of a young woman, another man claims that he committed the crime, and investigators must use forensic evidence to determine the true killer.

Although a group of teenage thugs are suspected of attacking two boys on a fishing trip, there is no solid evidence until a murky fishing hole provides some answers.

When young prostitute's body turns up in an Ohio waterway, authorities have one tiny clue which could point to her killer, but face huge challenges due to her policemen clients and DNA evidence being washed away.

In a small South Carolina town in 1991, 17-year-old Crystal Faye Todd, a popular high school student, is raped, murdered and dumped in a deserted field; with few leads, authorities test the DNA of several friends, and one match shocks everyone.

In a groundbreaking case using animal DNA, investigators use forensic testing on a cat to help them solve the case of a woman who vanished from her home on Prince Edward Island.

A look into the 1984 Oregon food poisonings, where detectives track down the outbreak to a cult which aims to use germ warfare to take down the government.

A woman is found dead from a gunshot wound and police suspect her husband, however, forensic teams prove what really happened and the truth is stranger than fiction.

After American Atheists founder Madalyn Murray O'Hair disappears, the discovery of a mutilated body helps police catch the culprit.

Two people witness a truck driving over an unconscious man and flee into a nearby bar, but when the police turn up, the truck, the man and the witnesses are gone.

Insect evidence helps to solve the mystery of a woman found dead near a river bank.

With very little else to go on, investigators find that a show impression puts them on the right track to finding a killer in Lansing, Mich.

The owner of a restaurant is killed; investigators uncover tales of debt and deceit, but the case remains open, until one detective gets inspired by an earlier episode of "Forensic Files," and looks for clues in an empty holster.

A serial arsonist was on the loose in Washington, DC. Each of the fires was started with the same type of incendiary device. The perpetrator was very careful, and seemed to leave no evidence behind... but there were clues in the ashes and it was up to forensic scientists to find them.

A man becomes the prime suspect in his wife's death after forensic science raises questions about her apparent suicide.

Investigators on both sides of the Atlantic seek links between three homicides that look like professional executions.

Who put a bomb in the home of a 29-year-old woman and killed her?

A killer tried to destroy everything which could link them to the crime; but in doing so, they inadvertently created new forensic evidence, evidence which came to light using a technique never before used in a criminal investigation.

After a tycoon's wife is found dead in her SUV submerged in a half-frozen creek, police begin to suspect it wasn't an accident.

A Russian immigrant is found dead and a strange phone call to his office is the only lead investigators have.

Physical evidence intially condemns a prime suspect to a double homicide, but DNA from a discarded spoon points to another.

A young girl falls ill and dies; forensic investigators search for evidence halfway around the world to shed light on the tragic death.

Two bodies are discovered, shot to death in their car; the car windows are broken, but there's no sign of shattered glass.

Key suspect has a solid alibi in the murder of a war veteran; but police get a lead by finding a new suspect with a sweet tooth.

A woman who appeared to have taken her own life told her sister that, if anything were to happen to her, there was a note in the china cabinet.

When a man perishes in a fire while working in his garage, his death is initially ruled an accident until a forensic odontologist changes the direction of the case.

Lack of evidence compels investigators to look beyond the obvious when a woman is beaten to death at her in-laws house.

A man is found dead of an apparent suicide. But soon after, information emerges which reveals a much more menacing scenario.

A dismembered body is dumped on the side of the New Jersey Turnpike and before police realize it, bodies are turning up between two states.

A young bride-to-be is gunned down in her own home. The attack is personal and as investigators start digging, they uncover the man she loved was living a lie.

Tara Munsey went missing after a work shift at a Virginia restaurant and it is unknown if she ran away or if she was the victim of foul play.

An Ohio woman and her two daughters go missing while vacationing in Florida; their corpeses are found floating in Tampa Bay with a hand-written note by one of the victims; putting it on five billboards helps them find the killer.

Four young adults are murdered in an affluent Texas neighborhood, with little evidence but two people walking by dressed in black.

A young college student is found dead in her apartment and the autopsy rules the death a homicide by an unknown male suspect.

The killer removed the computer that links him to the murder of a woman and her soon-to-be ex-husband that he had met online.

A community is shocked when police discover a woman raped and murdered in broad daylight on a public trail.

A real estate developer is shot and his wife becomes the prime suspect, until the bullet is linked to a weapon reported missing 20 years ago.

A body is found stuffed into a suitcase forcing the police to search though the landfill for another missing victim.

A woman goes missing for a month with the only clues being a set of keys, a fingerprint and a code.

Missouri police are thrust into a bizarre web of homeless drifters and cattle auctions when they are called to retrieve a dead body.

A killer wants to outwit the police and keep the identity of his victim secret so he removes the teeth; however, lab tests on the skull reveal not just the horrific nature of the murder, but the identity of the victim too.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

A girl who is abducted and then released soon afterwards uses her knowledge of forensics to lead police to the kidnapper.

A trash collector finds a severed human leg in a trash bin but police cannot use conventional methods of victim identification; investigators turn to toxicology and DNA tests to find the murder-mutilator.

A coroner finds telltale clues on the badly burned body of a murder victim, sending police in pursuit of a couple of killers.

A man is arrested and convicted for a series of sexual assaults in Indiana; years later, forensic developments reveal new facts about the case.

The murder of a young Seattle couple puzzles investigators until the victims' dog, Chief, leads police to the killer.

A handsome young doctor's fiancee experiences severe illness after revealing that she is pregnant, and launches her own investigation to determine if the doctor is somehow responsible.

A seemingly model citizen turns out to be a serial killer.

An abandoned, still-running car leads investigators to a body with unusual marks and a DNA trail that lead to the killer.

Police find fragments of deleted computer files leading them to suspect a woman's suicide is really murder.

A suspicious neighbor gives police a break in a cold case.

A family suspects their teenage daughter's new friends were involved in her disappearance.

When a 62-year-old man opens a car restoration business and becomes seriously ill, his doctors cannot find the cause, but forensics can; identification of a highly toxic metal in the victim's blood leads to his poisoner.

When an aspiring model turns up dead, police suspect her boyfriend. But must dig deeper for clues when he is cleared.

Tiny fibers and an asthma inhaler are the clues that lead officers to the killer of an off-duty policeman.

Investigators search the world of high rollers and offshore betting to solve the first triple homicide in Verona, Wisc.

Police search every apartment building in town when the body of a young girl found on an isolated farm holds a set of keys but no ID.

A man denies killing a pedestrian in hit-and-run, claiming he sold the car in question; authorities track down the car to find critical evidence.

Three years later, a second autopsy determines who's right when a medical examiner and detectives disagree on the cause of death.

Hit-and-run boating accident that kills a popular young man causes investigators to search for one boat out of thousands.

A woman is found dead on her bedroom floor, the only clue is a bloodstained sheet; breakthrough forensics enable police to identify the killer.

A young man is killed in a mysterious car crash, but the evidence at the scene lead investigators to believe it is not an accident; forensic science reveals what really happens, and the truth devastates three families.

A woman is found dead, police use blood evidence and computer forensics to convince a jury that the murderer is guilty.

When an elderly woman dies in an apparent robbery-homicide, evidence suggests the suspect broke out of the house rather than breaking in.

Wealthy man is shot dead while his wife is forced to open their hidden safe, but they couldn't be identified because they were wearing ski masks.

The bomb was constructed to cause as much damage as possible and it did, killing the victim with deadly force and flame; a painstaking search yielded tiny clues, which identified the killer as surely as if he'd signed them.

A twelve-year-old girl claims that she was abducted and sexually assaulted; her story seems unbelievable until police discover fibers on her clothing.

Police discover a mask near the crime scene and hope that it leads to the killer of a funeral director.

A killer assaults a young mother in her home, but despite meticulous washing of the crime scene, a single hair remains to lead authorities to the culprit.

The investigation into the disappearance of flight attendant Helle Crafts leads to the murder conviction of her pilot husband.

Scientists and detectives use DNA to solve a string of rapes and murders.

Police use DNA profiles of seed pods from a truck to catch a killer.

Police believe they have a serial rapist and murderer, but DNA testing and research leads to another arrest and conviction.

In 1976, 182 war veterans in Philadelphia become hospitalized with pneumonia-like symptoms and 29 die; the disease resurfaces every few years.

After a wealthy Southern physician gets murdered with a baseball bat, his wife and a handyman become convicted of the crime.

In 1971, John List disappears after murdering his mother, wife and three children; he eludes the law for years until an age-scaled sculpture of the suspect and a true-crime TV program helps lead to his arrest in 1989.

An 11-year-old boy comes down with a fever and diarrhea after eating an undercooked burger; when his condition worsens, his mother drives him to a hospital and doctors discover E. coli destroying his body.

Florida police search for a serial rapist and murderer who left small red fibers on each of his 10 victims.

When an English couple go missing, police suspect their son killed them and must rely on mud and blood samples found in the couple's two cars to find their bodies.

Experts attempt to discover the source of heavy fog on Highway I-75 in Tennessee, which caused a 99-car accident and 12 deaths.

When a woman goes missing from her home, police focus on her husband when an airline luggage tag and luminol point to an affair and murder; footage from a TV crew and Coast Guard photographs lead investigators to the suspect's missing boat.

When a fundamentalist group is accused of robbing banks, authorities know they are dealing with experienced criminals and overwhelming evidence, but the defense is very well-funded.

When a young doctor is accused of sedating and sexually assaulting two of his female patients, DNA tests show him to be innocent, but the women persist with their claims; seven years later, a private investigation leads to a surprising discovery.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

When a 6-year-old disappears, her father becomes the prime suspect; he fails a polygraph test and even confesses, but 10 years later, the investigation gets turned on its head.

Investigators build a makeshift tent around a woman's body and use super glue fumes to lift the killer's palm print from the victim's skin.

The disappearance of a mail-order bride proves suspicious when detectives learn that two of the Texas husband's previous wives had died in mysterious circumstances.

A jeweler's search through old sales records helps police find likely suspects in the murder of elderly couple Edward Kowalzck and Gertrude Thompson.

A garbage bag leads police to a child's killer.

An investigation into the disappearance of a young woman uncovers a tooth that helps police solve a crime without a body.

The sensitive nose of a forensic examiner sniffs out murder.

Discovering that an assault suspect is left-handed is crucial to a police investigation dating back 16 years.

Forensic scientists try to find a way to "lift" the serial number from a shotgun that's their only clue in a case.

Investigating the worst arson spree in U.S. history - a rash of more than 75 fires near Seattle.

Computers aid the police and FBI in solving a string of crimes.

Using an anonymous letter and geographical profiling, investigators close in on a serial rapist, and a cleverly obtained DNA sample confirms their suspicions.

A man calls for help when his wife has a fatal fall down the stairs; numerous amount of bloodstains make police suspicious.

A decade old case reopens, and a few seconds of a 911 call enable investigators to determine who is responsible for a murder.

A flawed envelope is an unlikely clue to identifying a killer who laced a water cooler with cyanide and caused the death of a woman.

A mussel diver and his fiancée are found dead in their burnt home; a tiny clue points to arson and murder.

For ten years, the disappearance of a college co-ed remained a mystery; new scientific testing cast a different light on a man who had been a suspect all along.

Tipster is found dead after revealing that a woman's death 16 years ago was murder.

The murder of 53-year-old Paul Gruber is examined and the evidence points to Darryl Robin Kuehl, who was later convicted of the crime.

A man states that a robber shot and killed his wife while they were on the beach, but a song he downloaded makes investigators suspicious.

Detectives discover new clues left by a stalker's letter to his victim.

The body of an insurance assessor is found in a river in Tampa, Fla.; a unique murder weapon and blatant clues lead the police straight to her careless killer.

When a high school athlete is killed in a hit and run accident, investigators hoped tiny paint chips and shards of plastic would lead them to the driver.

A woman is abducted and a month later found dead, then a tip leads investigators in the right direction.

How the bombs were made leads investigators in Colorado to find the perpetrator.

DNA profiling reveals clues leading to a killer's identity 20 years later.

When a woman exhibits strange flu-like symptoms before dying, investigators discover someone added thallium to her soda; detectives initially suspect her husband, but the case takes a sinister turn.

Handwriting and simple doodles complicate a car-bomb case and an alleged self-defense shooting in a peaceful British farming village as police uncover a husband's plot to kill his wife for insurance money.

When dozens of infants develop serious breathing problems in the Cleveland area, doctors and investigators search high and low for the cause.

A well-liked bank vice president collapses and dies after taking pain pills laced with cyanide; the search for a motive reveals a callous suspect who had murdered once before.

Evidence reveals a teacher who complained of being stalked and harassed by another teacher was scamming police.

A man kills two people with bombs in an effort to get investors off his back, but authorities catch onto him and he becomes sentenced to life with no chance of parole.

A man arrested for the sexual assault and attempted murder of a boy in a European country becomes linked to a murder in Zurich, Switzerland, through analysis of microorganisms.

Heavy rains and snow run-off carry manure into Milwaukee's water supply in 1993, leading to an epidemic of gastrointestinal illness affecting 400,000 people.

Autopsies reveal that a string of unexplained deaths in Omaha resulted from poison-induced liver disintegration.

In a series of murders near Sacramento, Calif., a killer gags and molests prostitutes, cuts their clothes in random patterns and cuts off their hair; microscopic evidence helps solve the case.

After the discovery of a skull in the forest near a boy scout camp, police use facial reconstruction to identify the body.

Investigators use obscure evidence to find the person responsible for killing justice officials with mail bombs in the South.

Forensic scientists provide authorities with evidence that a death deemed accidental 20 years ago was actually murder.

Detectives learn that a genetic disorder caused the deaths of a woman's children, resulting in an overturned conviction.

The search for the killer of two teenagers in Texas shows a behavioral study on how most serial killers also have a history of abusing animals.

When a farmer's wife disappears, the tests of a plant pathologist and a dendrochronologist lead to a surprising revelation.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

Three sex workers are murdered and left along a river; a serial killer was on the loose and for years the perp was never identified.

He is a sex offender and a murderer who attacks in a terrifying rage; this predator manages to evade capture for years, but he leaves evidence behind, his palm print; detectives are determined to put a face to the print.

When a house fire kills the only doctor in a small town, an arson investigation leads to the son of the doctor's nurse; the prosecutor worries this might have been a miscarriage of justice.

A young woman is found murdered on the side of a rural driveway; the victim had been out with friends; the investigation would remain unsolved; until three decades later, when forensics from an unrelated crime helps break the case.

A hearing impaired 77-year-old on a road trip is shot to death because the man cannot hear his assailant's demands; random murders are among the hardest crimes to solve, but investigators are determined to bring this case to justice.

A massive explosion claims the life of a California farmhand, and authorities think it's an accidental death, but analysis of debris shows it's a bomb; investigators have few suspects until they hear ominous rumors about a jealous rage.

When a beautiful college student is stabbed to death in her Knoxville apartment, suspicion immediately falls on her roommate; a bloody shoe print left by the killer exposes a murderer with no history of violence and no reason to kill.

Numerous suspects emerge after someone starts targeting law enforcement officers in a peaceful Texas county.

An Illinois mother and her two young children are brutally murdered in their beds, and lurid threats are spray painted all over the walls of the crime scene.

A young Texas teenager and her boyfriend are brutally attacked on Valentine's Day; she is found dead while her boyfriend escapes; the case goes cold for nearly 50 years before a new forensic test exposes a family man with a dark secret.

Three Indiana construction workers are found shot on a work site.

A Texan who vows to live a reformed life after being released from prison is subsequently convicted of murder, despite insisting his innocence, so he uses forensic science from behind bars to try to prove his case.

A murder in Australia baffles police, until they find a device intended to save lives is the only witness to the man's death.

When a man dies after falling down the stairs, a witness says one thing and the evidence says another.

A wax bullet, white blanket and olive colored carpeting tell a lot about the murder of a young woman found in a ravine.

When a house burns to the ground and a woman's charred remains are found, investigators must determine whether it was an accident or arson.

An ammunition box and fluorescent fibers reveal the betrayal that led to the murder of a millionaire's family.

The 1960 kidnapping and murder of brewery heir Adolph Coors III leads to one of the most intense manhunts in U.S. history.

A used tissue, 12 years after the murder of a young Missouri woman, may be what cracks the case with a suspect list a mile long.

When murder strikes a young girl, police quickly make an arrest, but cutting-edge technology from NASA proves they have the wrong suspect behind bars.

A man is found strangled and burned in his San Antonio apartment and the killer thinks he has destroyed all the evidence.

When two men appear to die of heart disease six years apart, police notice they have one thing in common, they were each married to the same woman.

Casino security cameras offer the final images of a woman, just before she vanishes without a trace; can these grainy images lead police to her killer?

A squashed tomato and a pinpoint reflection of light in a photo help catch a killer.

An ATM transaction allows Texas detectives to pinpoint a suspect in the slaying of a teacher, but a shoelace stolen from the victim's home proves to be the tie that binds her killer to the crime.

Ten years after the murder of a rock singer, forensic scientists use evidence collected to finally bring her killer to justice.

When a young woman goes missing on the way to the train station, investigators use a strand of hair and a bloody pillowcase to find a suspect.

Investigators reopen a case from 1984 involving the rape of a young Virginia woman when DNA testing refutes her identification of the rapist and calls everything into question, leading to the accused person's exoneration.

A speck of bicycle paint and a speck of nickel left over from a collision with a twice-convicted child molester's car provide critical clues in the murder of a 9-year-old.

A 2-year-old boy's brain seizures and breathing problems baffle doctors until they learn the mother exhibits signs of Munchausen syndrome by proxy, a rare condition that led her to physically abuse her son and contributed to her daughter's death.

Two years after an 18-year-old's murder in Albion, Mich., a tiny drop of blood and burned bones lead police to her killers.

A mother claims that an intruder murdered her two sons, but lacking a motive, police use blood-spatter analysis and behavioral profiling to reconstruct a different scenario.

A routine missing persons report leads Texas police to discover a deadly love triangle; evidence found in a suspect's home matches the murder scene and leads to the indictment of the victim's girlfriend and her lover.

A 1995 fire razes the mansion of a Kansas doctor, killing two of her three children; disturbing accounts from an ex-husband lead investigators to believe the doctor set the blaze herself.

A husband confesses to his wife's murder, only to be found not guilty a year later when a phone tip and forensic evidence point to another.

In Lorton, Va., police attempt to determine who abducted 5-year-old Melissa Brannen after she disappears from a Christmas party, but cannot be certain until they match hair from a rabbit-fur jacket Brannen wore that day.

When a Pennsylvania man checks into a hospital for leg pain and later dies of thallium poisoning, police investigate his wife and find her in the process of collecting an insurance payment for her previous husband's death.

Police exhume the body of Karla Brown, murdered in her home in 1978, to study bite wounds, which eventually lead to the killer.

A new life-insurance policy sparks suspicions of murder when a Nova Scotia schoolteacher's body is found at the bottom of her basement stairs.

A beverage company pleads guilty to violating federal safety laws when a baby dies from E. coli after drinking apple juice.

Stories from across the world and refreshing conversations with Audie Cornish.

Stories from across the world and refreshing conversations with Audie Cornish.

When a young boy has serious respiratory problems and his father shows signs of early Alzheimer's disease, a chance encounter with a stranger kicks off an investigation into the cause.

Police in St. Petersburg, Fla., use cell phone mapping, wiretapping and a host of forensic evidence to find a surgeon's killer.

A woman wins her release after being imprisoned for allegedly killing her mother in a car fire.

Authorities are able to apprehend a kidnapper because he allowed his victim to write a will on a telltale pad of paper.

Experts debate whether an apparent heart attack victim died from natural causes or alleged poisoning by his girlfriend.

When a 12-year-old was found dead in her home, police were left clueless until a string of burglaries months later. A trail of stolen goods may help solve a murder.

When 15 year-old Marlene Miller was murdered, it would take 24 years and several retrials before forensic scientists discovered the evidence to bring her killer to justice.

Detectives use a forged signature to find a woman's abductor.

A woman is killed two days before she was scheduled to testify against a man accused of assaulting her and the prime suspect has an alibi.

A bite mark is all the evidence needed to convict a suspect who was robbing tourists in Florida.

Technology able to analyze human bite-marks yields information on a woman's death.

A death in Pennsylvania is strikingly similar to one in North Carolina.

When a nurse starts experiencing a variety of flu-like symptoms, she discovers that she is HIV-positive; she learns that her infection was not accidental.

time of death becomes pivotal when a pregnant woman is found murdered in her air-conditioned bedroom.

An obscure print found at a crime scene.

A diner in a small town, an endocrinologist and a forensic botanist help destroy a prime suspect's alibi.

After a Michigan State University grad student disappears and is presumed dead, a professor of geological sciences helps police get the dirt on her killer.

When a man's wife kills herself 14 years after his college sweetheart commits suicide, police start to get suspicious.

A woman gets shot in her driveway; she may have been the victim of a co-worker half her age that she had recently rejected.

A pair of tennis shoes are found near a victim who had been stabbed on the beach, less than ten yards from her hotel.

Three fingerprints on a window screen are enough for a print examiner to uncover the work of a serial killer.

With a long list of suspects, forensic experts agree on one thing in this brutal murder: the killer knew his victim.

The only lead to finding a serial killer on the loose is a bloody fingerprint on the body of a victim.

Tests reveal the race, eye color and hair color of the person responsible for killing two young women on Halloween night.

A convicted arsonist claims his innocence and with no lawyer, no money and only a fifth-grade education, sets out to prove it.

A canine behaviorist uses the family dogs, who are the only witnesses, to find the murderer of their owner.

Investigators see through a killer trying to cover his tracks by staging the crime scene to learn what really happened.

A young girl beaten after watching her grandmother killed, identifies the wrong person; years later she tries to change her statement.

In 1984 police failed to convict the murderer of a college student; new technology may finally help the police to catch her killer.

Police investigate a young woman found murdered two weeks after reporting a road rage incident; evidence leads not to the aggressive driver, but one of their own.

A woman who survived a deadly childhood fire sends police a letter charging that her father killed her mother 30 years ago.

After more than 20 people on a Native American reservation die suddenly from a flu-like disease, Navajo medicine men provide a clue that leads to a most unlikely killer.

While at a real estate conference in St. Louis, a man finds his wife drowned in the bathtub in their hotel room.

A cunning serial rapist who leaves no decisive evidence forces investigators to rely on geographical profiling in their search for an identity; DNA from a cigarette butt may provide the final piece of evidence needed to catch the suspect.

New evidence including fibers and weather patterns point to a different killer in the 1986 case of a Pennsylvania dentist's murdered wife.

Insects and a single strand of hair uncover an additional suspect in the killing of a young mother and her baby in Lehigh Valley, Pa.

A decomposed body is found in a barrel, and a dilapidated address book may hold the answer, but investigators must find a way to read the pages because the passage of 30 years has turned them blank.

When a policeman's home burns to the ground, he later arrests a man who confesses to arson, but the confession seems dubious.

A woman identifies her husband as her attacker, but questions arise 16 years later regarding her recollections.

A young girl is found dead, the victim of an apparent sex killer; there are few clues to the killer's identity, but authorities are intrigued by unusual orange fibers embedded in clothing found near the victim.

Police charge Alan "The Zenith Man" Ridley with murdering his wife, Virginia, but following an autopsy, medical detectives believe he may not have killed his wife after all.

With children dying at an alarming rate at a Texas hospital, authorities narrow down their probe to one nurse, but the murder weapon remains elusive.

When the decomposed body of a young girl is discovered, police have no clues to her identity, but days earlier, a stabbing victim told them she thought she might have witnessed a murder.

When a doctor's wife disappears, investigators use concrete from the doctor's yard and the recollections of a child to determine what happened.

Stories from across the world and refreshing conversations with Audie Cornish.

Stories from across the world and refreshing conversations with Audie Cornish.

Melanie Zanona; Catherine Lucey; Isaac Arnsdorf.

Neighbors do not hear the gunshots when a union official is killed in his home.

A man tells police he shot an intruder who murdered his wife; forensic evidence leads police to re-examine the man's motives.

A police officer claims his estranged wife's shooting death was a suicide, but investigators think it was a murder.

When fire fighters find a family dead inside their home, it appears to be a murder-suicide; clues at the scene lead investigators to believe otherwise.

A couple's murder leads investigators into the world of white supremacists and a string of hate crimes.

A rare gun and a victim's beloved dog help investigators trying to solve a multi-year long murder case where most of the witnesses were admitted drug users.

A search in Virginia's DNA databank reveals the identity of a news producer's murderer.

A homicide detective claims his wife accidentally shot herself in the head, but the evidence indicates otherwise.

Officials probe the death of a woman investigating the possible side effects of the drug she was prescribed for bipolar disorder.

A chip of stainless steel brings a killer to justice 20 years after a woman's body is found in a ravine.

An 11-year-old girl is sexually assaulted and shot twice at close range.

A woman is killed weeks before testifying against the man who sexually assaulted her.

New York police hunt the Zodiac killer after a series of deadly attacks.

When a healthy young man dies mysteriously in his sleep, toxicology tests reveal that it may have been foul play. Could a `suicide note' hold the key to solving the case.

When a single mother is murdered, her brother vows to find the person responsible for the death of his sister, even if it takes more than 30 years.

A husband and wife get shot and their 16-year-old daughter manages to escape, but investigators suspect she may be involved in the murder.

After 10 years, a witness decides to do the right thing about the rape and murder of a young hairdresser.

Police investigate the possibility of a hate crime when two women go missing and are later found murdered.

When a human skeleton is found on marshland and determined to be at least 18 months old, a computer consultant gives her a face and name.

A killer places all the incriminating evidence to the murder in a plastic bag, hoping it will float down the river.

A woman's body is found inside a burned mobile home and the autopsy reveals she was beaten, making this a murder.

Security guard who disappeared from his post was found a year later in a remote camp site; a decade later, a phone call and a paint smear on his boot helped scientists determine what happened during his final moments.

When three students are brutally murdered close to campus, investigators must determine what the women had in common before their serial killer strikes again.

A bag full of evidence recovered from an iced-over river helps to reveal the murderer of a businesswoman in her own shop.

Eyewitness to real estate agent's murder is put under forensic hypnosis in an attempt to help him recall the killer's face.

Police launch a search for a killer after a teenager returns home to find his father's body in a pool of blood.

Pathologist examining the death of a politician who was running for re-election finds tiny puncture wounds at the autopsy.

A Naval officer who threatened to go public with tales of on-the-job sexual harassment and assault is brutally murdered, but when investigators find the allegations could be part of an elaborate scheme for money, they turn to forensic science.

Romanian archbishop Valerian D. Trifa, living in the U.S., is accused of being a Nazi war criminal, and forensic experts find evidence on an incriminating, 40-year-old postcard.

Investigators look into the shooting death of Russ Stager, a popular gym teacher, and discover that his death was not an accident; a message the victim recorded before his death reveals a story of greed.

A money launderer is found dead in the ocean and the only obvious clues to his identity are a Rolex watch and a tattoo; the anchor with which he is weighed down proves most helpful in solving the crime.

The apparent suicide of Dr. Darryl Sutorius, a respected heart surgeon, is questioned when an investigation reveals his new wife's violent history.

The 1992 hit-and-run death of 6-year-old Nicole Rae Walker leads to a groundbreaking trial as experts submit a video reconstruction of the incident, implicating a drunk driver and demonstrating the viability of video testimony.

Specialists including a NASA vendor help police reconstruct a damaged surveillance video to catch the murderer of convenience store employee Wanda Mason in Lansing, Mich.

When a young woman goes missing, the police investigation reveals that she led a double life - student by day, call girl by night - but when her body is discovered, even more strange truths are uncovered.

A tiny clue inside a suspect's watchband and a popular television show help solve the case of a woman's disappearance.

One year after Maine resident Pearl A. Bruns' disappearance, forensic technology helps to find her body and determine who was responsible for her death.

When 4-year-old April Renee Tucker is found dead in her backyard, her parents tell the police that neighborhood dogs attacked and killed her, but the injuries on her body don't match their account of what happened.

San Diego police investigate the murder of a missing person whose hands turn up in a dumpster; an anonymous letter, containing details only the killer would know, offers clues to solving the case.

One year after her father's death, a teen's role in a high school production of "Hamlet" causes her to reveal the chilling truth behind her family's tragedy.

A mother puts her hope in the internet and an independent investigation to clear her name after authorities charge her with murdering her 17-month-old son in a fire considered to be intentionally set.

When a man dies unexpectedly in the office of a noted California doctor, police begin what they think will be a routine investigation, but discoveries of false identities and insurance fraud raise questions about the doctor's role.

A son who is convinced of his mother's innocence in the death of his father enrolls in law school to try and clear her name.

Despite a patient's claim that the cut to his hand had been caused by a dumpster, the doctor treating the injury recognizes it as something else - and soon becomes the chief witness in a murder case.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

A child's memory, a diary and a forensic psychologist help investigators solve a young woman's murder.

Investigators weigh several theories while probing the death of a retired police officer, including a botched robbery and suicide.

The bodies of two young women are found in the ashes of an apartment fire.

Two different men report the murder of a single mother and when the case's other anomalies stall the police, a candy wrapper and seeds help expose the killer.

After a Connecticut man's body is found in a burning rental car on a Mexican highway, an insurance company suspects a scam.

When a pipe bomb rips through a rural home, killing a young man and seriously injuring his mother, detectives hope that the remnants of a mailing label will lead them to a killer.

A quiet residential community, shattered by the murder of a neighbor. See how modern techniques helped investigators catch the culprit in less than 12 hours.

A man is found dead in his Michigan auto-salvage shop.

A man is murdered in a drive-by shooting. When a mobile phone trace incriminates a killer, it's up to a forensic geologist to find evidence that he was at the scene.

When a teenage girl is found dead, her boyfriend confesses to her murder. However, in a strange twist, so does another man; police must determine which is the killer.

A high school gym teacher gives his friend a ride home but never returns; his wife and friend receive letters saying he started a new life, but they suspect foul play despite no body being discovered.

A 16-year-old girl is killed in her own home by her mother and father. Her parents said they acted in self-defense, but the forensic evidence indicates otherwise.

A man is found stabbed to death after a night in a strip club; a drop of blood on a bedspread becomes critical evidence five years later.

After police identify a murder victim thanks to her butterfly necklace, they discover several co-workers had vendettas against the victim.

The brutal murder of a construction site foreman looks like the work of a disgruntled employee, but forensic science points to an unlikely suspect.

A shooting victim mutters the name of her apparent assailant before dying, but fingerprint comparisons, handwriting analysis, ballistics and DNA testing show someone else close to home is the true killer.

A woman's story seemed far fetched; she tells investigators that a man broke into her home wearing only underwear and gloves, killed her boyfriend and raped and terrorized her.

After a Delaware man's mother is found dead, he tells a story that's so improbable police think it can't possibly be true.

A family vacation turns into a terrifying search for a missing wife and baby, then becomes a manhunt for a killer who committed a horrific crime.

A DNA dragnet catches a killer eight years after the kidnapping, rape and murder of a college coed in Oklahoma.

A nosy neighbor with a disturbing obsession becomes a suspect in a woman's murder at an upscale apartment complex; police discover an incredible link to an unrelated murder thousands of miles away.

A college student turns up dead and her boyfriend becomes a prime suspect when blood splatters are discovered on his wall.

Texas police hunt frantically for a brutal rapist. No one knows where he'll strike next, but given the increasingly violent nature of his crimes, he must be found soon.

When detectives find a mismatched button in relation to a woman's death, they know they can follow the clue back to the killer.

A woman heads home after church, but never makes it there alive, triggering a homicide investigation.

Volunteers and police spend weeks searching for a missing girl. A psychic later leads them to a field where the body was found.

A forensic scientist uses his skills to preserve a footprint left in snow to help authorities nab two men suspected of robbing an Ontario couple and shooting the husband in the head.

Fingerprints taken from a piece of cloth help solve the rape and murder of a 22-year-old woman in Henrico County, Va.

The FBI profiles a suspect in the kidnapping and murder of a 6-year-old girl during an evening church service; a witness leads authorities to the likely killer, but then becomes a victim herself.

Photographs found in a dumpster lead to the killer of Los Angeles model Linda Sobek; the man claims he did not intentionally kill her despite evidence to the contrary.

A murder mystery theater performance in Easton, Md., turns into a real-life mystery when a body is found after the performance ends.

When a woman dies in a horseback riding accident, police uncover a web of lies in her husband's background after his suspicious behavior prompts a closer look.

A serial killer in Tampa, Fla., taunts police by strangling prostitutes and leaving their bodies in plain sight, but tire marks and fibers lead to the culprit.

Missouri police are thrust into a bizarre web of homeless drifters and cattle auctions when they are called to retrieve a dead body.

A killer wants to outwit the police and keep the identity of his victim secret so he removes the teeth; however, lab tests on the skull reveal not just the horrific nature of the murder, but the identity of the victim too.

When a fundamentalist group is accused of robbing banks, authorities know they are dealing with experienced criminals and overwhelming evidence, but the defense is very well-funded.

When a young doctor is accused of sedating and sexually assaulting two of his female patients, DNA tests show him to be innocent, but the women persist with their claims; seven years later, a private investigation leads to a surprising discovery.

The search for the killer of two teenagers in Texas shows a behavioral study on how most serial killers also have a history of abusing animals.

When a farmer's wife disappears, the tests of a plant pathologist and a dendrochronologist lead to a surprising revelation.

A son who is convinced of his mother's innocence in the death of his father enrolls in law school to try and clear her name.

The pornography empire cultivated by brothers Artie and Jim Mitchell crumbles when one turns up dead and his brother confesses to shooting him; investigators question whether the shooting was premeditated.

When prison guard Donna Payant's body is discovered at a landfill, a medical examiner uses a "signature" clue to link her death to a murder the same examiner investigated 10 years earlier.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

Investigators determine if a computer crash which almost ruined a manufacturing company was accidental or deliberate sabotage.

Car with three Secret Service agents collides with local deputy's car; investigation launched into who was responsible for the deadly car accident finds two very different conclusions.

The derailment of the Sunset Limited was the deadliest train crash in U.S. history killing 47 passengers and crew with several more injured.

Arson investigators attempt to determine the cause of the 1987 fire at the Kings Cross Underground Station in London.

A discarded sleeping bag, containing bloody sneakers and a purse, leads police to the body of a young woman; a mark found on the victim's body enables police to track the killer.

A woman's apparent accidental death begins to look fishy after police uncover a letter written by the victim days before her untimely death.

An Alaskan trooper finds a woman's body beside a frozen road, but evidence is scant even after a suspected murder weapon is found.

Police link a clump of hair discovered in an isolated area with a woman who disappeared 20 years ago.

A news anchor is shot to death outside her home in an apparent crime of passion by a fan; a police dog tracks the scent of the killer back to the crime scene.

A fire, caused by an unattended cigarette, kills the estranged wife of a police officer; forensic scientists discover that the cause is far more complicated.

A trio of men, responsible for several bank robberies, leaves no evidence behind; forensic scientists help catch them by looking at the criminals' posture and clothing.

When a woman's bone marrow test reveals arsenic poisoning, investigators try to determine if it is due to groundwater contamination or something more sinister.

Forensic investigators try to stop a killer who is apparently responsible for two slayings in a community in South Carolina.

When DNA proves that a man who practically admits to a brutal attack is innocent, police wonder why he is willing to take the blame.

When a businessman is murdered, motives and suspects are plentiful. Was it simply a disgruntled employee or client? Or do some racy photos hold the clue to the crime?

A family break turns into a nightmare when the wife is found face-down in a lake; with no idea whether it was murder, an accident or suicide, police turn to a new forensic technique.

When friends see a woman in the back of a car flailing her arms and screaming, they assume she is having fun, but when they later come upon a jacket and a pool of blood, they realize they witnessed an abduction in progress.

An attack on a couple's home leaves the husband dead, the wife gravely injured and their son as a prime suspect; hundreds of miles away, a DNA sample may lead to the killer.