In 1971, John List disappears after murdering his mother, wife and three children; he eludes the law for years until an age-scaled sculpture of the suspect and a true-crime TV program helps lead to his arrest in 1989.

An 11-year-old boy comes down with a fever and diarrhea after eating an undercooked burger; when his condition worsens, his mother drives him to a hospital and doctors discover E. coli destroying his body.

Florida police search for a serial rapist and murderer who left small red fibers on each of his 10 victims.

When an English couple go missing, police suspect their son killed them and must rely on mud and blood samples found in the couple's two cars to find their bodies.

Experts attempt to discover the source of heavy fog on Highway I-75 in Tennessee, which caused a 99-car accident and 12 deaths.

When a woman goes missing from her home, police focus on her husband when an airline luggage tag and luminol point to an affair and murder; footage from a TV crew and Coast Guard photographs lead investigators to the suspect's missing boat.

When a woman exhibits strange flu-like symptoms before dying, investigators discover someone added thallium to her soda; detectives initially suspect her husband, but the case takes a sinister turn.

When dozens of infants develop serious breathing problems in the Cleveland area, doctors and investigators search high and low for the cause.

A well-liked bank vice president collapses and dies after taking pain pills laced with cyanide; the search for a motive reveals a callous suspect who had murdered once before.

A 20-year-old woman sets out on her bike and never returns; her body is found a few miles from her house with a gunshot wound to the head; years go by without any evidence or leads, until new investigators and technology breaks the case.

A navy lieutenant is murdered while deployed out to sea; arsenic poisoning is the cause of death; investigators discover he had more than his fair share of enemies, but it takes years before investigators discover what really happened to him.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

Sammy the Bull Gravano was the right-hand man to mafia kingpin, John Gotti and carried out multiple murders; after his arrest, he breaks the sacred oath of silence and cuts a deal with the government, testifying against his former boss.

Sammy the Bull Gravano was the right-hand man to mafia kingpin, John Gotti and carried out multiple murders; after his arrest, he breaks the sacred oath of silence and cuts a deal with the government, testifying against his former boss.

In the fall of 1977, bodies of young women begin piling up in Los Angeles; almost all of the victims are nude, discarded on hillsides, and show signs of torture; it is nearly a year before two murders 1,200 miles away uncover the Hillside Stranglers.

In the fall of 1977, bodies of young women begin piling up in Los Angeles; almost all of the victims are nude, discarded on hillsides, and show signs of torture; it is nearly a year before two murders 1,200 miles away uncover the Hillside Stranglers.

Evidence reveals a teacher who complained of being stalked and harassed by another teacher was scamming police.

A man kills two people with bombs in an effort to get investors off his back, but authorities catch onto him and he becomes sentenced to life with no chance of parole.

A man arrested for the sexual assault and attempted murder of a boy in a European country becomes linked to a murder in Zurich, Switzerland, through analysis of microorganisms.

Heavy rains and snow run-off carry manure into Milwaukee's water supply in 1993, leading to an epidemic of gastrointestinal illness affecting 400,000 people.

Autopsies reveal that a string of unexplained deaths in Omaha resulted from poison-induced liver disintegration.

In a series of murders near Sacramento, Calif., a killer gags and molests prostitutes, cuts their clothes in random patterns and cuts off their hair; microscopic evidence helps solve the case.

After the discovery of a skull in the forest near a boy scout camp, police use facial reconstruction to identify the body.

Investigators use obscure evidence to find the person responsible for killing justice officials with mail bombs in the South.

Forensic scientists provide authorities with evidence that a death deemed accidental 20 years ago was actually murder.

Detectives learn that a genetic disorder caused the deaths of a woman's children, resulting in an overturned conviction.

When a young woman goes missing on the way to the train station, investigators use a strand of hair and a bloody pillowcase to find a suspect.

Investigators reopen a case from 1984 involving the rape of a young Virginia woman when DNA testing refutes her identification of the rapist and calls everything into question, leading to the accused person's exoneration.

A speck of bicycle paint and a speck of nickel left over from a collision with a twice-convicted child molester's car provide critical clues in the murder of a 9-year-old.

A 2-year-old boy's brain seizures and breathing problems baffle doctors until they learn the mother exhibits signs of Munchausen syndrome by proxy, a rare condition that led her to physically abuse her son and contributed to her daughter's death.

Two years after an 18-year-old's murder in Albion, Mich., a tiny drop of blood and burned bones lead police to her killers.

A mother claims that an intruder murdered her two sons, but lacking a motive, police use blood-spatter analysis and behavioral profiling to reconstruct a different scenario.

A routine missing persons report leads Texas police to discover a deadly love triangle; evidence found in a suspect's home matches the murder scene and leads to the indictment of the victim's girlfriend and her lover.

A 1995 fire razes the mansion of a Kansas doctor, killing two of her three children; disturbing accounts from an ex-husband lead investigators to believe the doctor set the blaze herself.

Autopsies reveal that a string of unexplained deaths in Omaha resulted from poison-induced liver disintegration.

In a series of murders near Sacramento, Calif., a killer gags and molests prostitutes, cuts their clothes in random patterns and cuts off their hair; microscopic evidence helps solve the case.

After the discovery of a skull in the forest near a boy scout camp, police use facial reconstruction to identify the body.

Investigators use obscure evidence to find the person responsible for killing justice officials with mail bombs in the South.

Forensic scientists provide authorities with evidence that a death deemed accidental 20 years ago was actually murder.

Detectives learn that a genetic disorder caused the deaths of a woman's children, resulting in an overturned conviction.

When a young woman goes missing on the way to the train station, investigators use a strand of hair and a bloody pillowcase to find a suspect.

Investigators reopen a case from 1984 involving the rape of a young Virginia woman when DNA testing refutes her identification of the rapist and calls everything into question, leading to the accused person's exoneration.

A speck of bicycle paint and a speck of nickel left over from a collision with a twice-convicted child molester's car provide critical clues in the murder of a 9-year-old.

A 2-year-old boy's brain seizures and breathing problems baffle doctors until they learn the mother exhibits signs of Munchausen syndrome by proxy, a rare condition that led her to physically abuse her son and contributed to her daughter's death.

Two years after an 18-year-old's murder in Albion, Mich., a tiny drop of blood and burned bones lead police to her killers.

A mother claims that an intruder murdered her two sons, but lacking a motive, police use blood-spatter analysis and behavioral profiling to reconstruct a different scenario.

A routine missing persons report leads Texas police to discover a deadly love triangle; evidence found in a suspect's home matches the murder scene and leads to the indictment of the victim's girlfriend and her lover.

A 1995 fire razes the mansion of a Kansas doctor, killing two of her three children; disturbing accounts from an ex-husband lead investigators to believe the doctor set the blaze herself.

A building manager finds the lifeless body of a young woman in the bathtub; when questioned, an ex-con living downstairs lies to police; the lies do not prove murder and the case goes cold, then a new forensic tool examines the evidence.

A murder victim's final moments are caught on tape; the crime scene looks like a clear robbery-murder; text evidence at first points to a jilted lover, but police identify a second suspect with a motive.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

In 1974, college-age women from the Pacific Northwest begin to disappear without a trace.

While serving time for aggravated kidnapping in Utah and facing first degree murder charges in Colorado, Ted Bundy escapes not once but twice from authorities.

Ted Bundy helps prepare his own defense, and his amateurishness may help him beat the rap or send him to the electric chair.

While the clock winds down, Bundy makes death row confessions in a desperate attempt to save his own life.

A husband confesses to his wife's murder, only to be found not guilty a year later when a phone tip and forensic evidence point to another.

In Lorton, Va., police attempt to determine who abducted 5-year-old Melissa Brannen after she disappears from a Christmas party, but cannot be certain until they match hair from a rabbit-fur jacket Brannen wore that day.

When a Pennsylvania man checks into a hospital for leg pain and later dies of thallium poisoning, police investigate his wife and find her in the process of collecting an insurance payment for her previous husband's death.

Police exhume the body of Karla Brown, murdered in her home in 1978, to study bite wounds, which eventually lead to the killer.

A new life-insurance policy sparks suspicions of murder when a Nova Scotia schoolteacher's body is found at the bottom of her basement stairs.

A beverage company pleads guilty to violating federal safety laws when a baby dies from E. coli after drinking apple juice.

A woman who survived a deadly childhood fire sends police a letter charging that her father killed her mother 30 years ago.

After more than 20 people on a Native American reservation die suddenly from a flu-like disease, Navajo medicine men provide a clue that leads to a most unlikely killer.

While at a real estate conference in St. Louis, a man finds his wife drowned in the bathtub in their hotel room.

A cunning serial rapist who leaves no decisive evidence forces investigators to rely on geographical profiling in their search for an identity; DNA from a cigarette butt may provide the final piece of evidence needed to catch the suspect.

New evidence including fibers and weather patterns point to a different killer in the 1986 case of a Pennsylvania dentist's murdered wife.

Insects and a single strand of hair uncover an additional suspect in the killing of a young mother and her baby in Lehigh Valley, Pa.

A decomposed body is found in a barrel, and a dilapidated address book may hold the answer, but investigators must find a way to read the pages because the passage of 30 years has turned them blank.

When a policeman's home burns to the ground, he later arrests a man who confesses to arson, but the confession seems dubious.

A woman identifies her husband as her attacker, but questions arise 16 years later regarding her recollections.

A young girl is found dead, the victim of an apparent sex killer; there are few clues to the killer's identity, but authorities are intrigued by unusual orange fibers embedded in clothing found near the victim.

Police charge Alan "The Zenith Man" Ridley with murdering his wife, Virginia, but following an autopsy, medical detectives believe he may not have killed his wife after all.

With children dying at an alarming rate at a Texas hospital, authorities narrow down their probe to one nurse, but the murder weapon remains elusive.

A new life-insurance policy sparks suspicions of murder when a Nova Scotia schoolteacher's body is found at the bottom of her basement stairs.

A beverage company pleads guilty to violating federal safety laws when a baby dies from E. coli after drinking apple juice.

A woman who survived a deadly childhood fire sends police a letter charging that her father killed her mother 30 years ago.

After more than 20 people on a Native American reservation die suddenly from a flu-like disease, Navajo medicine men provide a clue that leads to a most unlikely killer.

While at a real estate conference in St. Louis, a man finds his wife drowned in the bathtub in their hotel room.

A cunning serial rapist who leaves no decisive evidence forces investigators to rely on geographical profiling in their search for an identity; DNA from a cigarette butt may provide the final piece of evidence needed to catch the suspect.

New evidence including fibers and weather patterns point to a different killer in the 1986 case of a Pennsylvania dentist's murdered wife.

Insects and a single strand of hair uncover an additional suspect in the killing of a young mother and her baby in Lehigh Valley, Pa.

A decomposed body is found in a barrel, and a dilapidated address book may hold the answer, but investigators must find a way to read the pages because the passage of 30 years has turned them blank.

When a policeman's home burns to the ground, he later arrests a man who confesses to arson, but the confession seems dubious.

A woman identifies her husband as her attacker, but questions arise 16 years later regarding her recollections.

A young girl is found dead, the victim of an apparent sex killer; there are few clues to the killer's identity, but authorities are intrigued by unusual orange fibers embedded in clothing found near the victim.

Police charge Alan "The Zenith Man" Ridley with murdering his wife, Virginia, but following an autopsy, medical detectives believe he may not have killed his wife after all.

With children dying at an alarming rate at a Texas hospital, authorities narrow down their probe to one nurse, but the murder weapon remains elusive.

A wounded woman calls 911; her husband, who wants a divorce, gets a hard look from police, but he has an airtight alibi during the murder; forensic science of ballistics draws a direct connection.

A religious woman is shot execution style in the suburbs of Michigan; surveillance video reveals it was a trio of killers; eventually, detectives get a break: a handwritten note.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

19-year-old Sarah Stern vanishes just before Christmas and her car is found abandoned by Shark River; but the missing persons case soon turns into a homicide, and cops start focusing on a prom date.

Young mom of two, Kelley Stage, is found brutally murdered in her home after her husband returns from a night of poker; her young child witnesses the crime and reveals shocking details to investigators.

A young Colorado mom disappears on Thanksgiving Day and was last seen on grocery store surveillance with her baby; police soon uncover a brutal crime scene at her home and expose a twisted love triangle.

Tina Herrmann, her two children and a family friend disappear.

When the decomposed body of a young girl is discovered, police have no clues to her identity, but days earlier, a stabbing victim told them she thought she might have witnessed a murder.

When a doctor's wife disappears, investigators use concrete from the doctor's yard and the recollections of a child to determine what happened.

Romanian archbishop Valerian D. Trifa, living in the U.S., is accused of being a Nazi war criminal, and forensic experts find evidence on an incriminating, 40-year-old postcard.

Investigators look into the shooting death of Russ Stager, a popular gym teacher, and discover that his death was not an accident; a message the victim recorded before his death reveals a story of greed.

A money launderer is found dead in the ocean and the only obvious clues to his identity are a Rolex watch and a tattoo; the anchor with which he is weighed down proves most helpful in solving the crime.

The apparent suicide of Dr. Darryl Sutorius, a respected heart surgeon, is questioned when an investigation reveals his new wife's violent history.

The 1992 hit-and-run death of 6-year-old Nicole Rae Walker leads to a groundbreaking trial as experts submit a video reconstruction of the incident, implicating a drunk driver and demonstrating the viability of video testimony.

Specialists including a NASA vendor help police reconstruct a damaged surveillance video to catch the murderer of convenience store employee Wanda Mason in Lansing, Mich.

When a young woman goes missing, the police investigation reveals that she led a double life - student by day, call girl by night - but when her body is discovered, even more strange truths are uncovered.

A tiny clue inside a suspect's watchband and a popular television show help solve the case of a woman's disappearance.

One year after Maine resident Pearl A. Bruns' disappearance, forensic technology helps to find her body and determine who was responsible for her death.

When 4-year-old April Renee Tucker is found dead in her backyard, her parents tell the police that neighborhood dogs attacked and killed her, but the injuries on her body don't match their account of what happened.

San Diego police investigate the murder of a missing person whose hands turn up in a dumpster; an anonymous letter, containing details only the killer would know, offers clues to solving the case.

One year after her father's death, a teen's role in a high school production of "Hamlet" causes her to reveal the chilling truth behind her family's tragedy.

A mother puts her hope in the internet and an independent investigation to clear her name after authorities charge her with murdering her 17-month-old son in a fire considered to be intentionally set.

A forensic scientist uses his skills to preserve a footprint left in snow to help authorities nab two men suspected of robbing an Ontario couple and shooting the husband in the head.

Fingerprints taken from a piece of cloth help solve the rape and murder of a 22-year-old woman in Henrico County, Va.

The FBI profiles a suspect in the kidnapping and murder of a 6-year-old girl during an evening church service; a witness leads authorities to the likely killer, but then becomes a victim herself.

A money launderer is found dead in the ocean and the only obvious clues to his identity are a Rolex watch and a tattoo; the anchor with which he is weighed down proves most helpful in solving the crime.

The apparent suicide of Dr. Darryl Sutorius, a respected heart surgeon, is questioned when an investigation reveals his new wife's violent history.

The 1992 hit-and-run death of 6-year-old Nicole Rae Walker leads to a groundbreaking trial as experts submit a video reconstruction of the incident, implicating a drunk driver and demonstrating the viability of video testimony.

Specialists including a NASA vendor help police reconstruct a damaged surveillance video to catch the murderer of convenience store employee Wanda Mason in Lansing, Mich.

When a young woman goes missing, the police investigation reveals that she led a double life - student by day, call girl by night - but when her body is discovered, even more strange truths are uncovered.

A tiny clue inside a suspect's watchband and a popular television show help solve the case of a woman's disappearance.

One year after Maine resident Pearl A. Bruns' disappearance, forensic technology helps to find her body and determine who was responsible for her death.

When 4-year-old April Renee Tucker is found dead in her backyard, her parents tell the police that neighborhood dogs attacked and killed her, but the injuries on her body don't match their account of what happened.

San Diego police investigate the murder of a missing person whose hands turn up in a dumpster; an anonymous letter, containing details only the killer would know, offers clues to solving the case.

One year after her father's death, a teen's role in a high school production of "Hamlet" causes her to reveal the chilling truth behind her family's tragedy.

A mother puts her hope in the internet and an independent investigation to clear her name after authorities charge her with murdering her 17-month-old son in a fire considered to be intentionally set.

A forensic scientist uses his skills to preserve a footprint left in snow to help authorities nab two men suspected of robbing an Ontario couple and shooting the husband in the head.

Fingerprints taken from a piece of cloth help solve the rape and murder of a 22-year-old woman in Henrico County, Va.

The FBI profiles a suspect in the kidnapping and murder of a 6-year-old girl during an evening church service; a witness leads authorities to the likely killer, but then becomes a victim herself.

Three sex workers are murdered and left along a river; a serial killer was on the loose and for years the perp was never identified.

He is a sex offender and a murderer who attacks in a terrifying rage; this predator manages to evade capture for years, but he leaves evidence behind, his palm print; detectives are determined to put a face to the print.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

Almost two years after a romance begins between small-town waitress Jodi Arias and successful businessman Travis Alexander, Travis is found brutally murdered in his shower at home.

Four years after the vicious killing of Travis Alexander, ex-girlfriend Jodi Arias stands trial for his murder; millions of people are captivated by the emerging lurid details of Jodi and Travis' erotic relationship.

Behind the scenes of singer Selena's red-hot career, ambitions and tragic demise; includes interviews with a close friend, a back-up singer and the nurse who spoke to Selena and her killer.

On Oct. 28, 2007, 23-year-old Stacy Peterson, the wife of veteran police sergeant Drew Peterson, goes missing. as police launch an intensive search to find Stacy, the case raises shocking new questions about her husband.

Photographs found in a dumpster lead to the killer of Los Angeles model Linda Sobek; the man claims he did not intentionally kill her despite evidence to the contrary.

A murder mystery theater performance in Easton, Md., turns into a real-life mystery when a body is found after the performance ends.

When a woman dies in a horseback riding accident, police uncover a web of lies in her husband's background after his suspicious behavior prompts a closer look.

A serial killer in Tampa, Fla., taunts police by strangling prostitutes and leaving their bodies in plain sight, but tire marks and fibers lead to the culprit.

Missouri police are thrust into a bizarre web of homeless drifters and cattle auctions when they are called to retrieve a dead body.

A killer wants to outwit the police and keep the identity of his victim secret so he removes the teeth; however, lab tests on the skull reveal not just the horrific nature of the murder, but the identity of the victim too.

When a fundamentalist group is accused of robbing banks, authorities know they are dealing with experienced criminals and overwhelming evidence, but the defense is very well-funded.

When a young doctor is accused of sedating and sexually assaulting two of his female patients, DNA tests show him to be innocent, but the women persist with their claims; seven years later, a private investigation leads to a surprising discovery.

The search for the killer of two teenagers in Texas shows a behavioral study on how most serial killers also have a history of abusing animals.

When a farmer's wife disappears, the tests of a plant pathologist and a dendrochronologist lead to a surprising revelation.

A son who is convinced of his mother's innocence in the death of his father enrolls in law school to try and clear her name.

Despite a patient's claim that the cut to his hand had been caused by a dumpster, the doctor treating the injury recognizes it as something else - and soon becomes the chief witness in a murder case.

The pornography empire cultivated by brothers Artie and Jim Mitchell crumbles when one turns up dead and his brother confesses to shooting him; investigators question whether the shooting was premeditated.

When prison guard Donna Payant's body is discovered at a landfill, a medical examiner uses a "signature" clue to link her death to a murder the same examiner investigated 10 years earlier.

When a 9-year-old girl vanishes on her way to school, the entire community helps with the search; detectives believe her mother may be involved, and a hidden fingerprint seals the case.

The investigation of a murder case in New Jersey is stalled until a similar attack occurs on a state trooper in Maine.

A young woman goes missing without leaving many clues, but the advanced technology on offer makes it possible for cat hairs and insects to help build an image of the abductor.

Blood spatter analysis and an investigation lead police to the truth when a pregnant woman is found dead in her home.

Missouri police are thrust into a bizarre web of homeless drifters and cattle auctions when they are called to retrieve a dead body.

A killer wants to outwit the police and keep the identity of his victim secret so he removes the teeth; however, lab tests on the skull reveal not just the horrific nature of the murder, but the identity of the victim too.

When a fundamentalist group is accused of robbing banks, authorities know they are dealing with experienced criminals and overwhelming evidence, but the defense is very well-funded.

When a young doctor is accused of sedating and sexually assaulting two of his female patients, DNA tests show him to be innocent, but the women persist with their claims; seven years later, a private investigation leads to a surprising discovery.

The search for the killer of two teenagers in Texas shows a behavioral study on how most serial killers also have a history of abusing animals.

When a farmer's wife disappears, the tests of a plant pathologist and a dendrochronologist lead to a surprising revelation.

A son who is convinced of his mother's innocence in the death of his father enrolls in law school to try and clear her name.

Despite a patient's claim that the cut to his hand had been caused by a dumpster, the doctor treating the injury recognizes it as something else - and soon becomes the chief witness in a murder case.

The pornography empire cultivated by brothers Artie and Jim Mitchell crumbles when one turns up dead and his brother confesses to shooting him; investigators question whether the shooting was premeditated.

When prison guard Donna Payant's body is discovered at a landfill, a medical examiner uses a "signature" clue to link her death to a murder the same examiner investigated 10 years earlier.

When a 9-year-old girl vanishes on her way to school, the entire community helps with the search; detectives believe her mother may be involved, and a hidden fingerprint seals the case.

The investigation of a murder case in New Jersey is stalled until a similar attack occurs on a state trooper in Maine.

A young woman goes missing without leaving many clues, but the advanced technology on offer makes it possible for cat hairs and insects to help build an image of the abductor.

Blood spatter analysis and an investigation lead police to the truth when a pregnant woman is found dead in her home.

When a house fire kills the only doctor in a small town, an arson investigation leads to the son of the doctor's nurse; the prosecutor worries this might have been a miscarriage of justice.

A young woman is found murdered on the side of a rural driveway; the victim had been out with friends; the investigation would remain unsolved; until three decades later, when forensics from an unrelated crime helps break the case.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

A hearing impaired 77-year-old on a road trip is shot to death because the man cannot hear his assailant's demands; random murders are among the hardest crimes to solve, but investigators are determined to bring this case to justice.

A massive explosion claims the life of a California farmhand, and authorities think it's an accidental death, but analysis of debris shows it's a bomb; investigators have few suspects until they hear ominous rumors about a jealous rage.

When a beautiful college student is stabbed to death in her Knoxville apartment, suspicion immediately falls on her roommate; a bloody shoe print left by the killer exposes a murderer with no history of violence and no reason to kill.

Numerous suspects emerge after someone starts targeting law enforcement officers in a peaceful Texas county.

An Illinois mother and her two young children are brutally murdered in their beds, and lurid threats are spray painted all over the walls of the crime scene.

A young Texas teenager and her boyfriend are brutally attacked on Valentine's Day; she is found dead while her boyfriend escapes; the case goes cold for nearly 50 years before a new forensic test exposes a family man with a dark secret.

Three Indiana construction workers are found shot on a work site.

A Texan who vows to live a reformed life after being released from prison is subsequently convicted of murder, despite insisting his innocence, so he uses forensic science from behind bars to try to prove his case.

A mother is determined to discover what happened when her daughter is injured in a hit-and-run accident.

Forensic science and deductive reasoning determine what happened to a mother and daughter while they were on a shopping spree.

Exploring how an American hit single from 1966 - "The Cheater" by Bob Kuban and the In-Men - foreshadowed the demise of the group's lead singer, Walter Scott.

Eight years after a man confessed to the murder of a young woman, another man claims that he committed the crime, and investigators must use forensic evidence to determine the true killer.

Although a group of teenage thugs are suspected of attacking two boys on a fishing trip, there is no solid evidence until a murky fishing hole provides some answers.

When young prostitute's body turns up in an Ohio waterway, authorities have one tiny clue which could point to her killer, but face huge challenges due to her policemen clients and DNA evidence being washed away.

In a small South Carolina town in 1991, 17-year-old Crystal Faye Todd, a popular high school student, is raped, murdered and dumped in a deserted field; with few leads, authorities test the DNA of several friends, and one match shocks everyone.

In a groundbreaking case using animal DNA, investigators use forensic testing on a cat to help them solve the case of a woman who vanished from her home on Prince Edward Island.

A look into the 1984 Oregon food poisonings, where detectives track down the outbreak to a cult which aims to use germ warfare to take down the government.

A woman is found dead from a gunshot wound and police suspect her husband, however, forensic teams prove what really happened and the truth is stranger than fiction.

After American Atheists founder Madalyn Murray O'Hair disappears, the discovery of a mutilated body helps police catch the culprit.

Two people witness a truck driving over an unconscious man and flee into a nearby bar, but when the police turn up, the truck, the man and the witnesses are gone.

Insect evidence helps to solve the mystery of a woman found dead near a river bank.

A girl who is abducted and then released soon afterwards uses her knowledge of forensics to lead police to the kidnapper.

A trash collector finds a severed human leg in a trash bin but police cannot use conventional methods of victim identification; investigators turn to toxicology and DNA tests to find the murder-mutilator.

A coroner finds telltale clues on the badly burned body of a murder victim, sending police in pursuit of a couple of killers.

A man is arrested and convicted for a series of sexual assaults in Indiana; years later, forensic developments reveal new facts about the case.

The murder of a young Seattle couple puzzles investigators until the victims' dog, Chief, leads police to the killer.

Although a group of teenage thugs are suspected of attacking two boys on a fishing trip, there is no solid evidence until a murky fishing hole provides some answers.

When young prostitute's body turns up in an Ohio waterway, authorities have one tiny clue which could point to her killer, but face huge challenges due to her policemen clients and DNA evidence being washed away.

In a small South Carolina town in 1991, 17-year-old Crystal Faye Todd, a popular high school student, is raped, murdered and dumped in a deserted field; with few leads, authorities test the DNA of several friends, and one match shocks everyone.

In a groundbreaking case using animal DNA, investigators use forensic testing on a cat to help them solve the case of a woman who vanished from her home on Prince Edward Island.

A look into the 1984 Oregon food poisonings, where detectives track down the outbreak to a cult which aims to use germ warfare to take down the government.

A woman is found dead from a gunshot wound and police suspect her husband, however, forensic teams prove what really happened and the truth is stranger than fiction.

After American Atheists founder Madalyn Murray O'Hair disappears, the discovery of a mutilated body helps police catch the culprit.

Two people witness a truck driving over an unconscious man and flee into a nearby bar, but when the police turn up, the truck, the man and the witnesses are gone.

Insect evidence helps to solve the mystery of a woman found dead near a river bank.

A girl who is abducted and then released soon afterwards uses her knowledge of forensics to lead police to the kidnapper.

A trash collector finds a severed human leg in a trash bin but police cannot use conventional methods of victim identification; investigators turn to toxicology and DNA tests to find the murder-mutilator.

A coroner finds telltale clues on the badly burned body of a murder victim, sending police in pursuit of a couple of killers.

A man is arrested and convicted for a series of sexual assaults in Indiana; years later, forensic developments reveal new facts about the case.

The murder of a young Seattle couple puzzles investigators until the victims' dog, Chief, leads police to the killer.

Stories from across the world and refreshing conversations with Audie Cornish.

Stories from across the world and refreshing conversations with Audie Cornish.

While closing shop in Anchorage, Alaska, Samantha Koenig is approached by a man known in the community as a business owner and caring father who kidnaps her, triggering a manhunt.

While closing shop in Anchorage, Alaska, Samantha Koenig is approached by a man known in the community as a business owner and caring father who kidnaps her, triggering a manhunt.

John Gotti's expensive suits and swagger earn him the nickname Dapper Don; in reality, he is a man to be feared, a ruthless, dangerous Mafia gangster who orders hits on his enemies, his friends, and anyone who crosses him.

John Gotti's expensive suits and swagger earn him the nickname Dapper Don; in reality, he is a man to be feared, a ruthless, dangerous Mafia gangster who orders hits on his enemies, his friends, and anyone who crosses him.

In Chicago, community leader and part-time clown John Wayne Gacy leads a double life, transforming into a monster who preys on male teenagers and becomes the most prolific serial killer of his day.

In Chicago, community leader and part-time clown John Wayne Gacy leads a double life, transforming into a monster who preys on male teenagers and becomes the most prolific serial killer of his day.

A handsome young doctor's fiancee experiences severe illness after revealing that she is pregnant, and launches her own investigation to determine if the doctor is somehow responsible.

A seemingly model citizen turns out to be a serial killer.

An abandoned, still-running car leads investigators to a body with unusual marks and a DNA trail that lead to the killer.

Police find fragments of deleted computer files leading them to suspect a woman's suicide is really murder.

A suspicious neighbor gives police a break in a cold case.

A family suspects their teenage daughter's new friends were involved in her disappearance.

When a 62-year-old man opens a car restoration business and becomes seriously ill, his doctors cannot find the cause, but forensics can; identification of a highly toxic metal in the victim's blood leads to his poisoner.

When a 6-year-old disappears, her father becomes the prime suspect; he fails a polygraph test and even confesses, but 10 years later, the investigation gets turned on its head.

Investigators build a makeshift tent around a woman's body and use super glue fumes to lift the killer's palm print from the victim's skin.

The disappearance of a mail-order bride proves suspicious when detectives learn that two of the Texas husband's previous wives had died in mysterious circumstances.

A jeweler's search through old sales records helps police find likely suspects in the murder of elderly couple Edward Kowalzck and Gertrude Thompson.

A garbage bag leads police to a child's killer.

An investigation into the disappearance of a young woman uncovers a tooth that helps police solve a crime without a body.

The sensitive nose of a forensic examiner sniffs out murder.

Discovering that an assault suspect is left-handed is crucial to a police investigation dating back 16 years.

Forensic scientists try to find a way to "lift" the serial number from a shotgun that's their only clue in a case.

Investigating the worst arson spree in U.S. history - a rash of more than 75 fires near Seattle.

Computers aid the police and FBI in solving a string of crimes.

A suspicious neighbor gives police a break in a cold case.

A family suspects their teenage daughter's new friends were involved in her disappearance.

When a 62-year-old man opens a car restoration business and becomes seriously ill, his doctors cannot find the cause, but forensics can; identification of a highly toxic metal in the victim's blood leads to his poisoner.

When a 6-year-old disappears, her father becomes the prime suspect; he fails a polygraph test and even confesses, but 10 years later, the investigation gets turned on its head.

Investigators build a makeshift tent around a woman's body and use super glue fumes to lift the killer's palm print from the victim's skin.

The disappearance of a mail-order bride proves suspicious when detectives learn that two of the Texas husband's previous wives had died in mysterious circumstances.

A jeweler's search through old sales records helps police find likely suspects in the murder of elderly couple Edward Kowalzck and Gertrude Thompson.

A garbage bag leads police to a child's killer.

An investigation into the disappearance of a young woman uncovers a tooth that helps police solve a crime without a body.

The sensitive nose of a forensic examiner sniffs out murder.

Discovering that an assault suspect is left-handed is crucial to a police investigation dating back 16 years.

Forensic scientists try to find a way to "lift" the serial number from a shotgun that's their only clue in a case.

Investigating the worst arson spree in U.S. history - a rash of more than 75 fires near Seattle.

Computers aid the police and FBI in solving a string of crimes.

Stories from across the world and refreshing conversations with Audie Cornish.

Stories from across the world and refreshing conversations with Audie Cornish.

Melanie Zanona; Catherine Lucey; Isaac Arnsdorf.

Newlywed Lauren Phelps is stabbed 123 times as she fights for her life; her killer may blame his deadly rampage on cold medicine.

After Florida mother Gretchen Anthony, 51, goes missing from her home, surveillance video tells a twisted tale of her final hours.

A romantic and scenic early morning boat ride turns deadly when Larry Isenberg falls overboard; investigators reveal the disappearance of half a million dollars, which could be motive for murder.

Twenty-four-year-old Alex Woodworth is brutally stabbed 16 times and left for dead hanging halfway out of the killer's car; as investigators peel back the layers, it's revealed the killer's many lovers is motive for murder.

Recently divorced mom-of-three Ingrid Lyne goes back into the dating scene and meets a man online, but her date at a baseball game will be her last; Seattle residents and investigators are shocked by a chilling crime scene.

Using an anonymous letter and geographical profiling, investigators close in on a serial rapist, and a cleverly obtained DNA sample confirms their suspicions.

When a young boy has serious respiratory problems and his father shows signs of early Alzheimer's disease, a chance encounter with a stranger kicks off an investigation into the cause.

Police in St. Petersburg, Fla., use cell phone mapping, wiretapping and a host of forensic evidence to find a surgeon's killer.

A woman wins her release after being imprisoned for allegedly killing her mother in a car fire.

Authorities are able to apprehend a kidnapper because he allowed his victim to write a will on a telltale pad of paper.

Experts debate whether an apparent heart attack victim died from natural causes or alleged poisoning by his girlfriend.

When a 12-year-old was found dead in her home, police were left clueless until a string of burglaries months later. A trail of stolen goods may help solve a murder.

When 15 year-old Marlene Miller was murdered, it would take 24 years and several retrials before forensic scientists discovered the evidence to bring her killer to justice.

Detectives use a forged signature to find a woman's abductor.

A woman is killed two days before she was scheduled to testify against a man accused of assaulting her and the prime suspect has an alibi.

A bite mark is all the evidence needed to convict a suspect who was robbing tourists in Florida.

Technology able to analyze human bite-marks yields information on a woman's death.

A death in Pennsylvania is strikingly similar to one in North Carolina.

When a nurse starts experiencing a variety of flu-like symptoms, she discovers that she is HIV-positive; she learns that her infection was not accidental.

time of death becomes pivotal when a pregnant woman is found murdered in her air-conditioned bedroom.

An obscure print found at a crime scene.

A diner in a small town, an endocrinologist and a forensic botanist help destroy a prime suspect's alibi.

Neighbors do not hear the gunshots when a union official is killed in his home.

Authorities are able to apprehend a kidnapper because he allowed his victim to write a will on a telltale pad of paper.

Experts debate whether an apparent heart attack victim died from natural causes or alleged poisoning by his girlfriend.

When a 12-year-old was found dead in her home, police were left clueless until a string of burglaries months later. A trail of stolen goods may help solve a murder.

When 15 year-old Marlene Miller was murdered, it would take 24 years and several retrials before forensic scientists discovered the evidence to bring her killer to justice.

Detectives use a forged signature to find a woman's abductor.

A woman is killed two days before she was scheduled to testify against a man accused of assaulting her and the prime suspect has an alibi.

A bite mark is all the evidence needed to convict a suspect who was robbing tourists in Florida.

Technology able to analyze human bite-marks yields information on a woman's death.

A death in Pennsylvania is strikingly similar to one in North Carolina.

When a nurse starts experiencing a variety of flu-like symptoms, she discovers that she is HIV-positive; she learns that her infection was not accidental.

time of death becomes pivotal when a pregnant woman is found murdered in her air-conditioned bedroom.

An obscure print found at a crime scene.

A diner in a small town, an endocrinologist and a forensic botanist help destroy a prime suspect's alibi.

Neighbors do not hear the gunshots when a union official is killed in his home.

An extremely successful California career woman keeps falling ill and doctors can't determine why, then after she dies they still have no explanation until they find a key figure in her life has been lying about his past.

The body of a 24-year-old criminology student is found wrapped in a blanket alongside a desolate road in Brooklyn, N.Y.; police discover that the bouncer at a bar is her killer.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

Charles Manson is a violent predator who has powers of persuasion that make it possible for him to convince his hippie followers to brutally murder innocent strangers.

Charles Manson is a violent predator who has powers of persuasion that make it possible for him to convince his hippie followers to brutally murder innocent strangers.

In Northern California, a masked predator meticulously plans his sexual assaults by studying the habits and routines of his female prey; after 27 years on the loose, police close in on the man they believe to be the NorCal Rapist.

In Northern California, a masked predator meticulously plans his sexual assaults by studying the habits and routines of his female prey; after 27 years on the loose, police close in on the man they believe to be the NorCal Rapist.

A man tells police he shot an intruder who murdered his wife; forensic evidence leads police to re-examine the man's motives.

A police officer claims his estranged wife's shooting death was a suicide, but investigators think it was a murder.

When fire fighters find a family dead inside their home, it appears to be a murder-suicide; clues at the scene lead investigators to believe otherwise.

A couple's murder leads investigators into the world of white supremacists and a string of hate crimes.

A rare gun and a victim's beloved dog help investigators trying to solve a multi-year long murder case where most of the witnesses were admitted drug users.

A search in Virginia's DNA databank reveals the identity of a news producer's murderer.

A homicide detective claims his wife accidentally shot herself in the head, but the evidence indicates otherwise.

Officials probe the death of a woman investigating the possible side effects of the drug she was prescribed for bipolar disorder.

A chip of stainless steel brings a killer to justice 20 years after a woman's body is found in a ravine.

An 11-year-old girl is sexually assaulted and shot twice at close range.

A woman is killed weeks before testifying against the man who sexually assaulted her.

New York police hunt the Zodiac killer after a series of deadly attacks.

When a healthy young man dies mysteriously in his sleep, toxicology tests reveal that it may have been foul play. Could a `suicide note' hold the key to solving the case.

A child's memory, a diary and a forensic psychologist help investigators solve a young woman's murder.

Investigators weigh several theories while probing the death of a retired police officer, including a botched robbery and suicide.

The bodies of two young women are found in the ashes of an apartment fire.

Two different men report the murder of a single mother and when the case's other anomalies stall the police, a candy wrapper and seeds help expose the killer.

After a Connecticut man's body is found in a burning rental car on a Mexican highway, an insurance company suspects a scam.

A rare gun and a victim's beloved dog help investigators trying to solve a multi-year long murder case where most of the witnesses were admitted drug users.

A search in Virginia's DNA databank reveals the identity of a news producer's murderer.

A homicide detective claims his wife accidentally shot herself in the head, but the evidence indicates otherwise.

Officials probe the death of a woman investigating the possible side effects of the drug she was prescribed for bipolar disorder.

A chip of stainless steel brings a killer to justice 20 years after a woman's body is found in a ravine.

An 11-year-old girl is sexually assaulted and shot twice at close range.

A woman is killed weeks before testifying against the man who sexually assaulted her.

New York police hunt the Zodiac killer after a series of deadly attacks.

When a healthy young man dies mysteriously in his sleep, toxicology tests reveal that it may have been foul play. Could a `suicide note' hold the key to solving the case.

A child's memory, a diary and a forensic psychologist help investigators solve a young woman's murder.

Investigators weigh several theories while probing the death of a retired police officer, including a botched robbery and suicide.

The bodies of two young women are found in the ashes of an apartment fire.

Two different men report the murder of a single mother and when the case's other anomalies stall the police, a candy wrapper and seeds help expose the killer.

After a Connecticut man's body is found in a burning rental car on a Mexican highway, an insurance company suspects a scam.

When a 79-year-old woman is found shot to death in her home, investigators initially suspect her husband or a violent neighbor; shell casings recovered at the scene and a high-tech database reveal an unlikely killer.

A young single mother is abducted from a gas station and is later found stabbed to death near an oil field; the detectives use shoe and tire impressions to weed out numerous suspects.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

Actor-musician David Cassidy ("The Partridge Family") experiences the pressures of fame as a teen idol in the 1970s; in the end, his death is surrounded by mystery, leaving his family, friends and fans with more questions than answers.

On April 19, 1995, Timothy McVeigh, a 26-year-old U.S. army veteran, detonated a 7,000 pound truck bomb outside the Alfred Murrah Federal Building in downtown Oklahoma City, claiming the lives of 168 innocent people.

Timothy McVeigh himself describes how events in his personal life inspired him to take action against his fellow Americans.

A deeper look into Tom Petty's life reveals physical and emotional afflictions that may have led to his death at age 66.

When a pipe bomb rips through a rural home, killing a young man and seriously injuring his mother, detectives hope that the remnants of a mailing label will lead them to a killer.

A quiet residential community, shattered by the murder of a neighbor. See how modern techniques helped investigators catch the culprit in less than 12 hours.

A man is found dead in his Michigan auto-salvage shop.

A man is murdered in a drive-by shooting. When a mobile phone trace incriminates a killer, it's up to a forensic geologist to find evidence that he was at the scene.

When a teenage girl is found dead, her boyfriend confesses to her murder. However, in a strange twist, so does another man; police must determine which is the killer.

A high school gym teacher gives his friend a ride home but never returns; his wife and friend receive letters saying he started a new life, but they suspect foul play despite no body being discovered.

A 16-year-old girl is killed in her own home by her mother and father. Her parents said they acted in self-defense, but the forensic evidence indicates otherwise.

Investigators determine if a computer crash which almost ruined a manufacturing company was accidental or deliberate sabotage.

Car with three Secret Service agents collides with local deputy's car; investigation launched into who was responsible for the deadly car accident finds two very different conclusions.

The derailment of the Sunset Limited was the deadliest train crash in U.S. history killing 47 passengers and crew with several more injured.

Arson investigators attempt to determine the cause of the 1987 fire at the Kings Cross Underground Station in London.

A discarded sleeping bag, containing bloody sneakers and a purse, leads police to the body of a young woman; a mark found on the victim's body enables police to track the killer.

A woman's apparent accidental death begins to look fishy after police uncover a letter written by the victim days before her untimely death.

An Alaskan trooper finds a woman's body beside a frozen road, but evidence is scant even after a suspected murder weapon is found.

Police link a clump of hair discovered in an isolated area with a woman who disappeared 20 years ago.

A news anchor is shot to death outside her home in an apparent crime of passion by a fan; a police dog tracks the scent of the killer back to the crime scene.

A fire, caused by an unattended cigarette, kills the estranged wife of a police officer; forensic scientists discover that the cause is far more complicated.

A trio of men, responsible for several bank robberies, leaves no evidence behind; forensic scientists help catch them by looking at the criminals' posture and clothing.

When a teenage girl is found dead, her boyfriend confesses to her murder. However, in a strange twist, so does another man; police must determine which is the killer.

A high school gym teacher gives his friend a ride home but never returns; his wife and friend receive letters saying he started a new life, but they suspect foul play despite no body being discovered.

A 16-year-old girl is killed in her own home by her mother and father. Her parents said they acted in self-defense, but the forensic evidence indicates otherwise.

Investigators determine if a computer crash which almost ruined a manufacturing company was accidental or deliberate sabotage.

Car with three Secret Service agents collides with local deputy's car; investigation launched into who was responsible for the deadly car accident finds two very different conclusions.

The derailment of the Sunset Limited was the deadliest train crash in U.S. history killing 47 passengers and crew with several more injured.

Arson investigators attempt to determine the cause of the 1987 fire at the Kings Cross Underground Station in London.

A discarded sleeping bag, containing bloody sneakers and a purse, leads police to the body of a young woman; a mark found on the victim's body enables police to track the killer.

A woman's apparent accidental death begins to look fishy after police uncover a letter written by the victim days before her untimely death.

An Alaskan trooper finds a woman's body beside a frozen road, but evidence is scant even after a suspected murder weapon is found.

Police link a clump of hair discovered in an isolated area with a woman who disappeared 20 years ago.

A news anchor is shot to death outside her home in an apparent crime of passion by a fan; a police dog tracks the scent of the killer back to the crime scene.

A fire, caused by an unattended cigarette, kills the estranged wife of a police officer; forensic scientists discover that the cause is far more complicated.

A trio of men, responsible for several bank robberies, leaves no evidence behind; forensic scientists help catch them by looking at the criminals' posture and clothing.

When a 23-year-old Marine dies in his bedroom, doctors initially believe a heart attack is to blame; when arsenic is found in his organs, his wife is charged with murder; a sharp attorney and toxicological testing uncover the truth.

When an 18-year-old girl is abducted while talking on a pay phone, forensic evidence found on her clothing points police in the direction of a suspect who shockingly confesses that he didn't act alone.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

The anchors share the latest stories about significant events that take place across the world and interview prominent figures.

Barbara Kendhammer suffers fatal injuries after a heavy pipe impales the windshield of her car, but evidence at the crime scene tells a different story.

10-year-old Zahra Baker survived cancer twice but lost her leg and hearing; when she disappears from her bedroom in the middle of the night, investigators are puzzled by a ransom note left at the scene, but her fate is worse than imagined.

A young mother of two perishes in a raging house fire, but her autopsy reveals the cause of death was not asphyxiation but a bullet wound to the head; forensics uncover the killer.

Shayna Hubers and Ryan Poston have a match made in heaven, then Ryan winds up dead in a pool of blood with a gunshot wound to his face; stunning interrogation tapes leave police in disbelief and lead investigators to a surprising motive.

When a woman's bone marrow test reveals arsenic poisoning, investigators try to determine if it is due to groundwater contamination or something more sinister.

A missing bank president's body is found floating in a lake; the duct tape used in binding him to a chair helps solve the crime.

A husband was shot and killed, forensic psychiatry helped the wife to remember the details for what happened.

The body of a 16-year-old girl is discovered nine months after her disappearance; forensic scientists find clues that paint a virtual portrait of her killer.

A young woman falls to her death in what appears to be a tragic accident; a forensic exam of photos taken at the scene tells a different story.

Haunted by her mother's long-ago disappearance, a woman undertakes an investigation of her own and stumbles upon a dark family secret.

The robbery and brutal murder of an elderly couple goes unsolved for 10 years; a forensic scientist makes history when he solves the crime.

A man is charged with the murder of a wrestling champion; six years later, a forensic animator testifies on his behalf.

A 19-year-old girl is found dead in her car in what appears to be a suicide; police discover that the victime was involved in a love quadrangle, giving several people motive to kill.

Fifteen years after a man disappears, using a metal detector, police find evidence which proves what had happened.

The body of a young California co-ed under an isolated interstate ramp sets off an investigation; San Diego police have no idea who would want her dead, but they discover a tiny, unique fiber on the victim's clothing.

Police become suspicious of a man who reported his wife missing 15 years after doing the same thing with his first wife.