Margaret succeeds in getting surgery, but Dr. Now is dismayed when a few months later she and her mom revert to their old ways; Megan grows impatient with her slow weight loss, and if Dr. Now doesn't approve her for surgery soon, she might quit.

Cindy is resistant to change and spends years creating a world that makes her feel safe; when her friend notices Cindy's health declining rapidly due to her size, she pushes Cindy to move to Houston and see Dr. Now.

Michael's massive body has left him dependent upon his family, and he must learn to control his anger issues around food, lose weight and address the root of his issues or risk losing everything.

A mother of two who is too ashamed of her size to be seen with her children; she is committed to regaining her confidence and being a proud mother.

Amber is 23, over 600-lbs, and relies on her family and boyfriend for even simple needs; her fear of dying young is so overwhelming that she decides to relocate 2,000 miles in hopes that weight loss surgery will give her life back.

Melissa has isolated herself at home and lost many friends to avoid feeling the shame of what her food addiction has done to her body; now, the only way to get her life back is to leave it behind to start a new one with Dr. Now's help in Houston.

Kenae' is already big before her weight gain takes off after the death of her beloved mother; refusing to deal with the pain, Kenae' turns to food to fill the void.

After meeting and falling in love at a bariatric rehab center, Lee and Rena are battling health and anger issues while taking a desperate, second attempt to save their relationship and their lives.

A woman whose extreme obesity has left her nearly immobile must overcome both her physical and emotional pain if she is ever to live a normal life again.

Shannon's husband loves her the way she is, but that may not help because she's 700 pounds and bedridden; Dr. Now knows it's not easy to break a toxic cycle of overfeeding and enabling, but that's what needs to happen if Shannon wants to live.

Irene had to move back in with her son because her weight made it unbearable to live on her own. When Dr. Now can't get through to her, the only thing that might help her break the cycle is a once-in-a-lifetime turn of events.

Through tough times, food has always been Tammy's friend; now she has gotten so big that her daughters and mother have moved home to care for her, and unless Dr. Now can get her to confront her grief, food might be her killer.

Irene had to move back in with her son because her weight made it unbearable to live on her own. When Dr. Now can't get through to her, the only thing that might help her break the cycle is a once-in-a-lifetime turn of events.

Through tough times, food has always been Tammy's friend; now she has gotten so big that her daughters and mother have moved home to care for her, and unless Dr. Now can get her to confront her grief, food might be her killer.

Shannon's husband loves her the way she is, but that may not help because she's 700 pounds and bedridden; Dr. Now knows it's not easy to break a toxic cycle of overfeeding and enabling, but that's what needs to happen if Shannon wants to live.

Cousins Casey, Amanda, Amy and Ed are morbidly obese; when Amanda decides to have bariatric surgery, the family considers doing the same.

Amanda undergoes bariatric surgery in the hopes of losing enough weight to treat her cancer; Casey meets with Dr. Procter and is told he'll die if he doesn't lose weight; the family has a pool party and Casey confronts Ed over his name-calling.

Casey reaches a boiling point with his parents when they blame his morbid obesity on video games; Amanda starts having pains post-surgery that send her to the E.R.; Amy makes major lifestyle changes in the hopes of being approved for surgery.

The family comes together to support Amy on her tough road to recovery; as Ed's surgery rapidly approaches, his daughters start expressing their concerns; Casey starts questioning surgery more than ever after watching Amy go through post-op.

Carlynda needs two full knee replacements but doctors won't perform surgery until the skin is gone; after extreme weight loss and marrying the love of her life, Karen wants to start a family, but her excess skin gets in her way.

Stephanie and her mom Darcy lost a combined weight of 320 lbs.; BJ overcame drug and food addiction to lose 350 lbs. and his body is now covered with excess skin.

Antonia overcame her food addiction to lose 190lbs, but the extra skin is keeping her from feeling confident and sexy; Natasha lost almost 300lbs after gastric bypass surgery, but now struggles with carrying a lot of saggy excess skin.

Linda is hoping skin removal surgery will give her the self-esteem she needs to be an amazing role model to her daughters; Angel hates her extra skin because it's turning her into an introvert around her family.

Shantel needs to get rid of her excess skin to gain the confidence she needs to set a positive example for her daughter; Hope has an obsession with weight loss that could make her too unhealthy to have skin removal surgery.

Melissa tries to cover a huge lipoma with a sweatshirt for years; Tyler's fear of cancer keep him from having his huge head lumps diagnosed; Tahj is covered in painful boils; Amber has ear keloids that take control of her life.

Ronen's mysterious lump above his knee is one of the largest Dr. Lee has ever seen; Amber suffers from a debilitating skin disease that no one understands; Sandy has a neck lump she calls Tommy; Kristy's eyelid cyst is ruining her life.

Half of Mary's body is a size 18 while the other half is a size 8; Anthony's cyst is in the area called the "Triangle of Death;" Shane wants to get a lump off his back; Brandi is anxious about getting a lump removed from her chest.

Belinda's lump on her neck causes her to basically be immobile; Nicole won't get married until she gets her armpit lump removed; Adela's chest and back are covered in wisdom spots; Nick foolishly removes a lipoma at home and now needs Dr. Lee.

Diane has tumors all over her body that have ruined her life; Will fears his shoulder lump will be ripped open at work; Anthony's daughters force him to get his lump examined; a woman detests her hideous varicose veins.

Chiropractor Dr. Colón treats Liana, a cane-bound woman suffering from involuntary tremors; Sarah's obsession with corsets causes her migraines; Amy, a little person, can no longer walk on her own; Brenda has uncontrollable gas.

Dr. Colón helps a woman who cannot keep her joints in place; a new mother suffers from a tragic boat accident; a bodybuilding leukemia survivor; a constipated baby.

Dr. ColÃ3n faces more chiropractic challenges when she treats a woman with CMT who hopes to stand at her daughter's wedding, a big breasted woman with extreme neck pain, and the show's sound man, who was born with cerebral palsy and an uneven body.

Angelina has a huge chest lump under her left breast; Delano has a football-sized mass on his back.

Chiropractor Dr. Colón treats Liana, a cane-bound woman suffering from involuntary tremors; Sarah's obsession with corsets causes her migraines; Amy, a little person, can no longer walk on her own; Brenda has uncontrollable gas.

Dr. Colón helps a woman who cannot keep her joints in place; a new mother suffers from a tragic boat accident; a bodybuilding leukemia survivor; a constipated baby.

Dr. ColÃ3n faces more chiropractic challenges when she treats a woman with CMT who hopes to stand at her daughter's wedding, a big breasted woman with extreme neck pain, and the show's sound man, who was born with cerebral palsy and an uneven body.

Angelina has a huge chest lump under her left breast; Delano has a football-sized mass on his back.

Belinda's lump on her neck causes her to basically be immobile; Nicole won't get married until she gets her armpit lump removed; Adela's chest and back are covered in wisdom spots; Nick foolishly removes a lipoma at home and now needs Dr. Lee.

Diane has tumors all over her body that have ruined her life; Will fears his shoulder lump will be ripped open at work; Anthony's daughters force him to get his lump examined; a woman detests her hideous varicose veins.

Doctors retrieve a stolen Rolex from a very private spot; a pick-up turns deadly when a cabbie is shot multiple times; a dirt-bike accident in the desert leaves a 52-year-old thrill-seeker clinging to life.

A brutal assault could end a star athlete's career, a 28-year-old man is hit in the head by a flying baseball bat; and a Vegas chef falls asleep with a loaded gun.

Paramedics rescue a 25-year-old man from a burning vehicle; an out-of-control car smashes into the patio of a restaurant; and a Vegas ventriloquist narrowly escapes death in a head-on collision.

A woman with twisted toes; a man with Frankenstein feet; a mother with extreme calluses.

Dr. Brad and Dr. Sarah have their hands full when they are faced with twins who have identical toe problems; a boy with extremely itchy feet and a woman born with a massively large toe are desperate for Dr. Ebonie's help.

A man with horns on his feet, a woman whose foot went through a windshield, and a guy who has dead man's feet create mysterious challenges for Dr. Brad and Dr. Ebonie.

A man loses his face to cancer; a baby born with a parasitic tumor; a girl's feet won't stop growing; a boy's face melts away.

In Thailand, a woman has the world's largest hands; an Ethiopian girl has a life-threatening neck tumor; 4-year-old conjoined twins risk surgery; a young woman has a body affected by vitiligo; in Spain, a woman's face is blistering away.

A Brazilian man with an elephant leg; a man is scared stiff; a Thai man could be the tallest man in the word; a child born with an unknown condition; a toddler is covered in hair.

A woman embraces her facial hair; a man is born with three legs; a woman covered in bubble shaped growths.

A newlywed couple is moving cross-country when the young wife, not knowing she is pregnant, discovers she is in labor.

Victoria suddenly goes into labor at her mother-in-law's house, never suspecting she was pregnant.

Ressa collapses and goes into a coma after a miscarriage five months earlier; she has an eclamptic seizure caused by her full term baby.

Alicia barely survives a harrowing car accident. Then, just 18 months later, a surprising pregnancy threatens the life of her newborn.

Melissa is rushed to the hospital thinking she might be having a miscarriage; she gives birth to an unexpected baby in the backseat.

Jenna is rushed to the hospital to find out she is in labor and at a hospital that hasn't delivered a baby in 15 years.

Kaitlyn is home alone in the tub when she suddenly feels her baby's head crowning; Myrna suffers a seizure and collapses into a coma.

Fifteen months after her son's birth, Emily fears her appendix has burst and her mother rushes her to the emergency room.

Chris and Lisa join forces in an attempt to solve the childhood mystery of why a woman was separated from her birth family at the age of two.

A woman enlists Lisa's help to find her birth mother, but unearths a 40-year-old secret in the process.

Chris tries to solve the 50-year-old mystery of why a woman was abandoned at a laundromat days after being born; a family enlists Lisa's help to track down the firstborn son that was placed for adoption, hoping to fulfill a father's dying wish.

Lisa tackles the challenging mystery of why a woman was abandoned in a trash can as a baby; unexpected DNA results throw a woman's entire identity into question.

Chris and Lisa join forces in an attempt to solve the childhood mystery of why a woman was separated from her birth family at the age of two.

A woman enlists Lisa's help to find her birth mother, but unearths a 40-year-old secret in the process.

Chris tries to solve the 50-year-old mystery of why a woman was abandoned at a laundromat days after being born; a family enlists Lisa's help to track down the firstborn son that was placed for adoption, hoping to fulfill a father's dying wish.

Lisa tackles the challenging mystery of why a woman was abandoned in a trash can as a baby; unexpected DNA results throw a woman's entire identity into question.

Melissa is rushed to the hospital thinking she might be having a miscarriage; she gives birth to an unexpected baby in the backseat.

Jenna is rushed to the hospital to find out she is in labor and at a hospital that hasn't delivered a baby in 15 years.

Kaitlyn is home alone in the tub when she suddenly feels her baby's head crowning; Myrna suffers a seizure and collapses into a coma.

Fifteen months after her son's birth, Emily fears her appendix has burst and her mother rushes her to the emergency room.

Tanisha weighs around 600-lbs and she's desperate to survive for her kids and avoid her mother's tragic fate of dying at age 50 from super obesity; now at 32, her future looks grim if she doesn't make a drastic change to save her life.

Susan, 37-year-old woman, has never lived on her own because of her weight, is finally seeking help to get out on her own.

Pauline is 51-years-old and nearly 700 pounds; her addiction to food has taken over the life of her son and primary caretaker.

Alicia, all smiles and laughter on the outside, secretly fears that her food addiction will kill her before she can marry her long-time love or watch her nieces grow up.

Liz, completely bed-bound, has severe lymphedema that makes it impossible to walk; utterly isolated, Liz has no friends, battles depression and lives with a mother too ill to take care of her.

Unable to stand for more than a short period of time, Karina's weight places a burden on her parents and drives a wedge between her and her sister.

Lisa's struggle with her weight begins as a child and significantly worsens after witnessing her brother's murder; now bedridden and unable to care for herself, Lisa must find a way to lose the weight or she will never see her grandchildren grow up.

After years of a tumultuous relationship with her husband, Tamy's eating addiction has caused her weight to balloon to over 500 pounds; she has become a hermit and hopes to restart her life so she can better care for her son, Zachary.

Siblings Carlton and Shantel have always been close, but with their eating habits enabling each other, they need to make a change; Shantel is sad to grow apart from her little brother, but it might be the one thing they both need the most.

Ontreon hopes that surgery can make him a better husband to his wife Musa, but he struggles to move past the grief that's blocked him for years; Wess is doing great post-surgery, but his next goal is crucial to his success.

Siblings Carlton and Shantel have always been close, but with their eating habits enabling each other, they need to make a change; Shantel is sad to grow apart from her little brother, but it might be the one thing they both need the most.

Ontreon hopes that surgery can make him a better husband to his wife Musa, but he struggles to move past the grief that's blocked him for years; Wess is doing great post-surgery, but his next goal is crucial to his success.

After years of a tumultuous relationship with her husband, Tamy's eating addiction has caused her weight to balloon to over 500 pounds; she has become a hermit and hopes to restart her life so she can better care for her son, Zachary.

Brittany has been called a monster due to her genetic condition that causes head-to-toe bumps; Leonardo has a fist-size growth on his head, but he is terrified of doctors; Tamyra has skin so thick that she shaves the bottom of her feet for relief.

Jaclyn has a lump on the back of her head that causes her emotional distress; Shane has a growth between his eyes that could put him in danger at his electrician job; Brittany has seen multiple doctors about the sores on her body with no answers.

Stacey's shoulder growth prevents her from being the playful teacher she once was; Matthew worries that his mysterious shin rash may be dangerous.

Lattyse was born with a mysterious growth above her eyebrow that gives her headaches. Robert has a tomato-sized growth on his butt cheek that causes him pain and discomfort. Sharon has an embarrassing, stinky, squirting cyst under her breast.

Keke is covered in bumps that make her embarrassed to be intimate with her husband; Jim is a widower with two lumps who wants them removed for himself and his late wife; Corey has been labeled a devil worshipper because of his forehead growth.

Monica returns for a second time in hopes that Dr. Lee can remove some more of her face growths; Ken has several large cysts on his head that he has tried to remove on his own; Maranda has a mystery skin sore that causes discomfort.

Corey is a drag queen and has a bump dangling from his booty; Adam has a semi-circle of about a dozen cysts on his head that he covers with a hat; Virginia has large growths on both of her upper arms that make it difficult to travel in her RV.

Terry's nose growth has prevented him from meeting his grandkids; Remi has alligator-like skin and is not used to taking care of herself; Austin has an embarrassing birthmark right next to his eyelid; Mary Jo has a throbbing bump on her neck.

Roger has enormous growths on his nose that drip pus, attract flies, and are so large that he can barely breathe; Sandra and Jessie are sisters who bonded over their many undiagnosed face bumps.

Roger returns with his gigantic nose growths in the hope that Dr. Lee and her colleagues can help before it's too late; Christine has lost her essence due to a large growth on her shoulder; Tiffany has a recurring cyst on her eyelid.

Gabriel has a huge growth on his clavicle but is terrified of surgery; Karen has dealt with painful, scaly feet for 22 years with no diagnosis; Lorne has embarrassing tumors on his face and body and believes this is why he hasn't met the one yet.

Ruben is a personal trainer whose head growth has prevented him from seeing clients; Kaitlin has blue marks and scars up and down her arms due to long-term drug use; Adrian was left with a disfiguring bump on her behind after falling down stairs.

Margarita is a matriarch who has been hiding her armpit lump from her family; Kayla is an aspiring musician with a promising career that her painful eczema has brought to a halt; Bradley has a concerning growth that looks like raw meat on his leg.

Jeremy is a pastor with a hanging growth in an embarrassing location; Evelyn has recurring keloids that have been removed three times and come back bigger each time; Todd has a bump protruding from his forehead.

Tameru is a drag queen, but he has a myriad of cysts that are the real drag; Devon has uneven skin she thinks may be the result of a hysterectomy a decade ago; Amy has large growths all over her head that make her look like a "hot mess.".

Jason lost their confidence and motivation due to the large growth on his neck; Shawnell's multiple mystery bumps on her head destroy her self-esteem; Jim's growth protruding off of his nose makes it hard to breathe.

Roger has a growth on his shoulder that he calls his second head; Jenna is a teenager with a bubble behind her ear; Susan is covered in bumps that effect her everyday life.

Robert has a small keloid on his ear and a large, snakelike keloid on the back of his head that has been removed and returned three times; Angela has four growths on her head and hides away from those she loves out of embarrassment.

Tameru is a drag queen, but he has a myriad of cysts that are the real drag; Devon has uneven skin she thinks may be the result of a hysterectomy a decade ago; Amy has large growths all over her head that make her look like a "hot mess.".

Jason lost their confidence and motivation due to the large growth on his neck; Shawnell's multiple mystery bumps on her head destroy her self-esteem; Jim's growth protruding off of his nose makes it hard to breathe.

Roger has a growth on his shoulder that he calls his second head; Jenna is a teenager with a bubble behind her ear; Susan is covered in bumps that effect her everyday life.

Robert has a small keloid on his ear and a large, snakelike keloid on the back of his head that has been removed and returned three times; Angela has four growths on her head and hides away from those she loves out of embarrassment.

Margarita is a matriarch who has been hiding her armpit lump from her family; Kayla is an aspiring musician with a promising career that her painful eczema has brought to a halt; Bradley has a concerning growth that looks like raw meat on his leg.

Jeremy is a pastor with a hanging growth in an embarrassing location; Evelyn has recurring keloids that have been removed three times and come back bigger each time; Todd has a bump protruding from his forehead.

A young mother faces the idea of seeing her son through visitation glass; an inmate promises not to return but finds herself back in jail; a desperate inmate only needs a small amount of money to get released.

A current inmate learns that her son has died in a car crash; an inmate's first Mother's Day behind bars; female inmate almost nine months pregnant.

A woman cracks under the pressure of jail life; a woman who is pregnant finds herself in the middle of a jailhouse brawl; a heroin addict chooses to stay in jail.

A woman works through the fallout of her addiction; a woman involved in a drug cartel seeks redemption; a pregnant woman prays; a woman attempts to smuggle contraband.

A doctor treats three gunshot victims who claim be innocent bystanders; a doctor must perform emergency brain surgery on his first day; a bride-to-be suddenly slips into a diabetic coma.

A woman stops eating because she believes she is dead; a runner goes blind in one eye during a marathon; an ER tech's stroke-like symptoms.

A woman believes her neighbors want to kill her; a man is near death after an arrow pierces his chest; two women with swollen abdomens refuse to explain the cause of their pain.

Greg's obsession with 60s pop-culture has taken over his home; Kelly's life revolves around her pet squirrel and his photo appearances.

Barry owns the world's largest mustard collection; Ralph has a rare collection of ketchup bottles.

Bugs have been a part of David's diet for over twelve years; Kelly's daily diet consists of food gathered from the dumpster.

A man obsessed with mermaids has turned himself into a merman; Vanessa is obsessed with celebrities and spends her day searching for them.

Rhonda's home is filled with items she's found in the dumpster; neighbors are threatening lawsuits.

Compulsive hoarder Valerie risks eviction when her next-door neighbor reports her to the health department; Ann's house is so filled with clutter she has been reduced to a small space in her living room.

Kay denies she is a hoarder but her cluttered home with deadly vermin tells another story.

Louise and her lavish hoarding could end up on the street.

A woman has been sent to jail four times for her hoarding; people purchase a house.

A woman has seizures whenever she hears her favorite pop tunes; a young athlete loses all his body fat and almost starves to death.

A beautiful model turns into a raging monster and starts attacking everyone around her; a man's life is nearly destroyed when he can't stop burping.

A woman's life is ruined by extreme sweating day and night; a young teacher prays to stop living when he feels invisible bugs crawling all over him.

A woman has seizures whenever she hears her favorite pop tunes; a young athlete loses all his body fat and almost starves to death.

A man faces amputation when a mystery disease turns his extremities black; a young woman develops paralyzing fears about ordinary objects.

A beautiful model turns into a raging monster and starts attacking everyone around her; a man's life is nearly destroyed when he can't stop burping.

A woman's life is ruined by extreme sweating day and night; a young teacher prays to stop living when he feels invisible bugs crawling all over him.

Louise and her lavish hoarding could end up on the street.

A woman has been sent to jail four times for her hoarding; people purchase a house.

Most of the extreme weight on Tracey's body resides in her shockingly misshapen legs, which are massive with severe lymphedema, and gastric surgery is her only chance of survival; Brenda and Melissa prepare for skin removal surgery.

Zsalynn's 360-body lift procedure proves to be more challenging than expected; lonely and depressed since her gastric surgery, Olivia wants skin removal surgery but struggles to lose the weight to qualify.

Diagnosed with cancer and battling depression, Bettie Jo finds out she's pregnant, and she must find a way to cope with the help of her husband; Susan suffers a major setback after surgery for her excess skin.

Fearing he'll suffer the same fate as 700-pound brother David, Benji hopes to be able to support both himself and his brother on their life-or-death weight loss journey.

Former plus-size model and advocate Renee realizes the mortal mistakes she has made as her weight swells to 600 pounds and her health crumbles.

Jennifer and her daughter Marissa are stuck in a co-dependent relationship and, with a combined weight of over 900-lbs., both of their lives are in jeopardy; Jennifer must regain control and save both of their lives before it is too late.

Devastated by two miscarriages due to her weight, Schenee is desperate to start a family and stop relying on her husband, Freddie, to take care of her; she hopes weight loss surgery will be able to fix her fertility issues as well as her marriage.

Having her daughters help bathe her is not how Chrystal pictured parenting but she is so large that there's no other option; Chrystal wants Dr. Now's help but she didn't know that bringing her childhood trauma to light would be part of the deal.

Ryan moved to Montana to keep himself from going down a dark path of drug addiction but his new path may be no less lethal than the last if he can't find a way to curb his eating habits before they kill him.

Paul weighs in at 700 pounds, and his girlfriend struggles with how this limits their ability to live a normal life; he thinks their relationship won't survive if he moves to work with Dr. Now, but prioritizing his own health is the only option.

Ryan moved to Montana to keep himself from going down a dark path of drug addiction but his new path may be no less lethal than the last if he can't find a way to curb his eating habits before they kill him.

Paul weighs in at 700 pounds, and his girlfriend struggles with how this limits their ability to live a normal life; he thinks their relationship won't survive if he moves to work with Dr. Now, but prioritizing his own health is the only option.

Having her daughters help bathe her is not how Chrystal pictured parenting but she is so large that there's no other option; Chrystal wants Dr. Now's help but she didn't know that bringing her childhood trauma to light would be part of the deal.

Steven Assanti weighs nearly 800 pounds and his brother Justin almost 600 pounds, and although they can't stand each other, their father packs up the family to travel across the country and seek help.

At 24-years-old, Bettie Jo is on her way to reaching 700 pounds and relies on her husband for her basic needs.

An 800-pound man who lost his job and is mostly housebound looks to find the strength to face his past and save his own life.

After a difficult childhood with an abusive stepfather and drug-addicted mother, Sarah is fighting for her life at only 24 years old.

With the support of his fiancé, Kathryn, Robert turns to Dr. Nowzaradan in a final, desperate attempt to save his life; he tries to reverse a lifelong food addiction that has left him bed-bound, saddled with grotesque lymphedema, and nearly 900-lbs.

At over 700 pounds, Brianne undertakes a weight-loss journey to save her own life; she faces an unexpected challenge to her fragile progress when her husband suffers a heart attack on a birthday she will never forget.

Octavia has been bedbound for nearly a year when she decides to make the trip to Houston to get help from Dr. Now, but when it turns out that her best friend is also her worst enabler, Octavia will have to choose between old habits and a new life.

Robin and her brother Chris are both obese and already lost a sibling to obesity; they plan to visit Dr. Now together when Chris suffers a stroke and can't go; Chris' son Garrett, already 600 pounds at age 20, is game to join the journey.

Maja cannot be allowed to undergo bariatric surgery unless she quits emotional eating. However, it seems like Justin may end up making Dr. Now proud.

There is much to be gained and lost for Brianne in year two of her journey, in which she both loses weight and gains independence; getting back with Erica becomes the top priority for Annjeanette, who chooses love over even her own health.

Maja cannot be allowed to undergo bariatric surgery unless she quits emotional eating. However, it seems like Justin may end up making Dr. Now proud.

There is much to be gained and lost for Brianne in year two of her journey, in which she both loses weight and gains independence; getting back with Erica becomes the top priority for Annjeanette, who chooses love over even her own health.

Robin and her brother Chris are both obese and already lost a sibling to obesity; they plan to visit Dr. Now together when Chris suffers a stroke and can't go; Chris' son Garrett, already 600 pounds at age 20, is game to join the journey.

Doctors treat a gunshot victim who has a life-threatening wound to the head.

Staff treats patient injured while engaging in risky behavior at night.

Jamie's tiredness leads to shocking news; David has joint pain and low stamina.

Bonnie's tingling foot; Shannon's high fever causes her to black out.

Jordan has bleeding gums and bruises; Tannis has headaches and high blood pressure.

Kurt's body lumps; Jessica's cheek numbness and dizziness.

A girl with a paralyzed face tries to find a new smile; a man with a crippling skin condition lives life on his own terms; a man with a form of dwarfism fears his back pain will stop him from running marathons.

A man whose body is eating itself hopes surgery can cure him and save his life; a gymnast who lost her leg to cancer hopes her new prosthetic will keep her performing; the shortest living man in the world looks for a diagnosis.

Parents of a 44-pound baby seek to understand why their son can't stop eating; a man travels to get his giant neck tumor removed; a young girl lives trapped inside her body; a woman with a severe chemical allergy can't go outside.

A man who had a full-face transplant faces another life-threatening challenge; a boy with a talent for singing is prematurely aging; in a Peruvian village, boys and men go blind by the age of 50.

Melanie wants to feel normal and date, but her layers of skin are dragging her down; Lauren is so uncomfortable in her excess skin that she can't have the normal life she wants with her boyfriend.

After losing 275 lbs., Mikki became a fitness fanatic, but the weight loss left her with a lot of sagging skin; Denise's obesity always made her feel invisible, but after losing 200 lbs. the skin still hinders her from fitting in with her family.

Rebecca lost her weight to be more active with her young son, but the plan backfired because she's now trapped in her excess skin; after his dad died, Sal dropped a ton of weight, but with all the excess skin, he fears he will never become a dad.

Autumn wants to make up for lost time with her son, but the excess skin from major weight loss is holding her back; Cody always pretended to be happy when he was 500-lbs, but after losing the weight, he's covered in skin and is sick of pretending.

A patient's pet causes pandemonium; a man experiences paralysis that climbs up his legs to his chest until he can no longer breathe; a war veteran suffers from phantom pain in his amputated hand.

A patient appears to be hallucinating and sends ER staff on a wild goose chase; a new nurse makes a shocking mistake; doctors try to help a former EMT who was found lethargic and slurring his words.

A surfer is impaled between the legs; a football player's severe leg pain leads to an unexpected diagnosis; a woman is given a clot-busting drug to cure her stroke, but she has another condition that could cause that same drug to kill her.

A boa constrictor has wrapped around a man's arm and won't let go; a young woman has a severe laceration, but doctors begin to suspect there may be more to her case than the injury; a young man goes into anaphylactic shock after a dinner out.

A patient's pet causes pandemonium; a man experiences paralysis that climbs up his legs to his chest until he can no longer breathe; a war veteran suffers from phantom pain in his amputated hand.

A patient appears to be hallucinating and sends ER staff on a wild goose chase; a new nurse makes a shocking mistake; doctors try to help a former EMT who was found lethargic and slurring his words.

A surfer is impaled between the legs; a football player's severe leg pain leads to an unexpected diagnosis; a woman is given a clot-busting drug to cure her stroke, but she has another condition that could cause that same drug to kill her.

A boa constrictor has wrapped around a man's arm and won't let go; a young woman has a severe laceration, but doctors begin to suspect there may be more to her case than the injury; a young man goes into anaphylactic shock after a dinner out.

Rebecca lost her weight to be more active with her young son, but the plan backfired because she's now trapped in her excess skin; after his dad died, Sal dropped a ton of weight, but with all the excess skin, he fears he will never become a dad.

Autumn wants to make up for lost time with her son, but the excess skin from major weight loss is holding her back; Cody always pretended to be happy when he was 500-lbs, but after losing the weight, he's covered in skin and is sick of pretending.

A knee injury leaves Lindsay addicted to pain killers.

A 22-year-old heroin addict has been a substance abuser since elementary school.

Josh is a 37-year-old meth addict; his addiction began at age 15.

A newborn with a potentially life-threatening infection; the victim of a gang-related attack; a patient who has survived a bullet passing through all of his vital organs.

A patient fights for his life after a four-story fall; a 12-year-old boy is hit by a car and injures his foot.

A heart attack victim is brought back to life; a mother and her newborn survive a horrific crash; a 65-year-old man falls two floors down an elevator shaft.

A couple longs to find the daughter they had as young teens; a woman learns her birth was a secret; taking place live, a bride and groom reveal a momentous surprise to their wedding guests and someone gets reunited with a long-lost family member.

A woman whose daughter perished in a car accident hopes to find comfort in locating her granddaughter, who was placed for adoption 26 years ago; a woman yearning to meet her birth mother is stunned by an unlikely figure in the search.

Two brothers navigate a painful past as they search for the family they've longed for their entire lives, and their journey reopens decades-old family mysteries about their birth mother, twin siblings and a baby who was only rumored to exist.

Lisa meets a woman who was left on a curb by her mother when she was just four years old; Chris uncovers stunning information for a woman searching for her family that leads to an unexpected reunion.

Horseback-riding accident; broken wrist; crash victims.

Cardiac arrest after a DWI crash; ATV accident; drug overdose.

Brain death; life support; organ donation; transplants.

Shooting victim; teen is severely injured.