Dr. Sandra Lee treats Heather, who has a huge growth on her leg and fears removing it could leave a keloid scar; Paul has a giant hump on his back.

Josh has a large knot on his head resulting from a car crash from 18 years ago; Brittney is covered in mysterious bumps; TJ has a hard, curious lump protruding from his side; Luis has a bump on his shoulder and his daughters fear it's dangerous.

Barbara's back lump became more noticeable after she lost 131 pounds; Bob has two painful bumps on his back; Hilda's depression is a result of the multitude of bumps on her eyelids; Art has one big bump on his head that he covers up with hats.

Leonard has an alarming bump hanging off of his arm that looks like it's breaking through the skin; Brandon has several lumps on his head that make him fearful for his life; Jess gets a noticeable lump on her butt after falling down the stairs.

Dr. Sandra Lee treats Heather, who has a huge growth on her leg and fears removing it could leave a keloid scar; Paul has a giant hump on his back.

Lisa has a horn growing out of the back of her head and fears that it could be cancer; Victor has a bulbous lump on his chest; Chuck has a Popeye-shaped bump on his arm; Christian and Jonathan are teenage brothers with matching lumps.

Taylor is a beautiful young woman who has unsightly elf-like bumps on her ears; Jose never goes out because of the baseball-sized lump on his head; Ken is covered in painful bumps that make it difficult to do everyday things.

Boys Giovanni and Owen share the rare condition Schwartz-Jampel Syndrome, which permanently and painfully contracts their muscles; the two share hardships and triumphs, and strike up a friendship.

Tiffany and Destiny both live with the rare disease Osteogenesis Imperfecta, which causes brittle bones, and set out on a life-changing journey to meet each other.

Bobbi and Kenny have skin that painfully grows in thick scales due to the rare condition Lamellar Ichthyosis.

Deadly parasites attack a 9-year-old hockey player, a computer programmer and a marathon runner.

A mass of decaying worms is discovered in a dance instructor's colon; a vacationer suffers headaches and a seizure; parasites get under a scientist's skin.

A parasite attacks a schoolteacher from the inside out; a dancer becomes concerned when her allergic outbreaks become lumpy and infected.

A 3-year-old girl loses a third of her body weight due to extreme bouts of vomiting and diarrhea.

A cat scratch leads to a horrifying result for a veterinary volunteer; strange liquid oozes from a college student's arm.

The emergency room at Highland Hospital in Oakland, Calif., treats a large population of people struggling with poverty and substance abuse.

Doctors at the Good Samaritan Regional Medical Center treat a teenager who collided with a tractor-trailer; a stabbing victim.

Denver Health Medical Center's trauma unit, which handled the Columbine High School shooting victims, regularly treats accident victims.

How Minnesota's oldest emergency room at the Hennepin County Medical Center has kept up with the times.

Louisville's University Hospital sees the results of domestic violence.

A Halloween zombie with a problem below the belt mystifies doctors; two unconscious men are involved in an accident, a doctor makes a mistake that amazingly explains a patient's condition.

A man's face and body suddenly double in size; a young woman is burning up from the inside out after a day at the beach; a grumpy old man nearly dies before revealing an emotional secret.

A pianist's finger goes missing after getting accidentally sawed off; a man's pacemaker threatens to kill him; a man behaves bizarrely.

A pregnant woman is shot in the abdomen; a doctor is the victim of a car burglary; a storm is preventing a patient's life-saving surgery.

A woman risks losing her finger after trying on an ill-fitting engagement ring; a body builder can't breathe and doctors are shocked to discover why; a gunshot victim.

A man's face and body suddenly double in size; a young woman is burning up from the inside out after a day at the beach; a grumpy old man nearly dies before revealing an emotional secret.

A pianist's finger goes missing after getting accidentally sawed off; a man's pacemaker threatens to kill him; a man behaves bizarrely.

A pregnant woman is shot in the abdomen; a doctor is the victim of a car burglary; a storm is preventing a patient's life-saving surgery.

A woman risks losing her finger after trying on an ill-fitting engagement ring; a body builder can't breathe and doctors are shocked to discover why; a gunshot victim.

Louisville's University Hospital sees the results of domestic violence.

A Halloween zombie with a problem below the belt mystifies doctors; two unconscious men are involved in an accident, a doctor makes a mistake that amazingly explains a patient's condition.

Lupe has spent the last 10 years in bed and is totally dependent on her husband, prompting a cross-country move that could save her life or end up backfiring.

Zsaylnn needs to lose weight to be the mother her daughter deserves; her husband loves large women and does not support her goals.

A woman battles severe depression and has not left her Chicago basement in two years; the hope of having a life-changing surgery.

Twins Kandi and Brandi have a combined weight of over 1,100 pounds and fear losing each other to obesity, so they decide to make a change together.

At 670 pounds, Ashley, who lives in her parents' home with her husband, decides she must make a drastic change to save her life and her marriage.

Erica regrets not keeping a promise to her mom and hopes her siblings will help, but they're reluctant based on her past failures.

Cynthia, a single mother focused on raising five kids, comes to realize what her death would mean for their future.

After overcoming a dependence on drugs and alcohol, sneaking food is Doug's last remaining vice; this husband and father must overcome his addictive personality to save his life and marriage.

As an Italian American, Geno was raised with lots of love, family and food; now, he's still living with his mom and eating himself to death, and it's time to make a change; Geno's cousin, Nico, joins the cause; they pledge to lose weight together.

Latonya found the man she wants to marry; the only problem is that, at almost 700 pounds, she can't walk down the aisle; Latonya doesn't want to give up the food that she's used to, but she may do it for love.

As an Italian American, Geno was raised with lots of love, family and food; now, he's still living with his mom and eating himself to death, and it's time to make a change; Geno's cousin, Nico, joins the cause; they pledge to lose weight together.

Latonya found the man she wants to marry; the only problem is that, at almost 700 pounds, she can't walk down the aisle; Latonya doesn't want to give up the food that she's used to, but she may do it for love.

After overcoming a dependence on drugs and alcohol, sneaking food is Doug's last remaining vice; this husband and father must overcome his addictive personality to save his life and marriage.

Chiropractor Dr. Colón treats Liana, a cane-bound woman suffering from involuntary tremors; Sarah's obsession with corsets causes her migraines; Amy, a little person, can no longer walk on her own; Brenda has uncontrollable gas.

Dr. Colón helps a woman who cannot keep her joints in place; a new mother suffers from a tragic boat accident; a bodybuilding leukemia survivor; a constipated baby.

Dr. Colón faces more chiropractic challenges when she treats a woman with CMT who hopes to stand at her daughter's wedding, a big breasted woman with extreme neck pain, and the show's sound man, who was born with cerebral palsy and an uneven body.

Dr. Meegan Gruber specializes in performing surgery while patients are completely awake; Derrick orders lunch while getting his "man boobs" removed; Genny has a request to get rid of both of her chins; Megan needs surgery to fix her "ball sack arms."

Dr. Meegan Gruber faces the most daunting awake surgery of her career: removing a giant hanging stomach; Jason looks for a butt lift to help him scandalize all of Kentucky; a patient calls her psychic mid-surgery.

Mother of eight Rubi stuns Dr. Meegan Gruber when she arrives with a hip condition unlike anything the doctor has ever seen; Ashley asks to have her bat wings clipped; Jim seeks a solution for a giant neck that's swallowing his jawline.

A college student comes down with a purple rash that literally spreads before his eyes; as his health deteriorates, the doctor must race to find the cause.

A young child blisters after exposure to a few minutes of sun; Doctors make a discovery that the child's inability to sweat is one symptom of a mysterious disorder.

After a young man blows his nose, he becomes violently ill and passes out; his condition progressively worsens while doctors try to diagnose what's wrong before one more sneeze kills him.

A healthy pastor feels like he has had a heart attack every day for years; a friend gives advice and doctors try to solve the mystery.

Decades after a car accident, a woman loses the ability to speak; when her speech returns, she speaks with a foreign accent; one doctor thinks he knows why.

Sean's nightmare keeps coming true, he can't stop pooping himself on stage; tired of dealing with explosive bowels, Sean asks Dr. Hodges for help; Latoya wants to spend time with her kids again which means the 10 pound mass between her legs needs to go.

Alice Jean's botched lap band removal left her with six belly buttons that form a golf course on her stomach; Simone seeks help for her uncontrollable vomiting.

After a botched lap band surgery, Christina has been blending her meals for over a decade; Dr. Caplin assists a patient whose tummy tuck has left her with a butt crack for a stomach.

Podiatrist Marion solves the mystery of Jonathan's twisted toes, gets marathon runner Robert's feet fit for his next race and helps a drag queen back into heels.

Marion solves the mystery of the V-shaped gap in Debra's toes; she has a surprising treatment for a psoriasis patient to stop the itch.

Marion and Kenny wage war on beastly bunions; they combat stubborn verrucae, persistent calluses and fungal nails that have outstayed their welcome.

Sharon's smelly feet make her and her husband's lives a misery; however, strange smells, verrucae and hooked toes are all in a day's work for Marion.

Podiatrist Marion solves the mystery of Jonathan's twisted toes, gets marathon runner Robert's feet fit for his next race and helps a drag queen back into heels.

Marion solves the mystery of the V-shaped gap in Debra's toes; she has a surprising treatment for a psoriasis patient to stop the itch.

Marion and Kenny wage war on beastly bunions; they combat stubborn verrucae, persistent calluses and fungal nails that have outstayed their welcome.

Sharon's smelly feet make her and her husband's lives a misery; however, strange smells, verrucae and hooked toes are all in a day's work for Marion.

Alice Jean's botched lap band removal left her with six belly buttons that form a golf course on her stomach; Simone seeks help for her uncontrollable vomiting.

After a botched lap band surgery, Christina has been blending her meals for over a decade; Dr. Caplin assists a patient whose tummy tuck has left her with a butt crack for a stomach.

Diana, a once thin and active woman, is now a prisoner to her body and trades the comfort of her apartment for a weight loss journey under the strict authority of her niece.

Penny has been bedridden for four years and moves to Texas to have gastric bypass; her unwillingness to make lifestyle changes could mean failure.

Chuck weighs almost 700 pounds; he has had to downsize his business and his wife feels like a single-parent who is ready to leave him.

James becomes bedridden, unable to stand and can barely move his legs; Holly and Mark prepare for skin removal surgery.

Weighing over 700 lbs, Nicole is on the verge of leaving her two young children motherless; trying to survive a family of addicts, she commits to Dr. Nowzaradan's diet program, but crisis threatens to derail all her hopes for weight loss.

Kirsten is close to losing all her mobility, and while she's trying to control of her obesity, she's also in danger of losing her troubled son.

Michael's massive body has left him dependent upon his family, and he must learn to control his anger issues around food, lose weight and address the root of his issues or risk losing everything.

Tanisha weighs around 600-lbs, and she's desperate to survive for her kids and avoid her mother's tragic fate of dying at age 50 from super obesity; now at 32, her future looks grim if she doesn't make a drastic change to save her life.

After a lifelong struggle with obesity, the three Perrio siblings travel to Houston in a last-chance journey to lose weight.

While the Perrios struggle with weight loss, the revelation of a past tragedy explains their resistance to recovery; the siblings must come together to overcome their fears and forge a path to a healthy future.

After a lifelong struggle with obesity, the three Perrio siblings travel to Houston in a last-chance journey to lose weight.

While the Perrios struggle with weight loss, the revelation of a past tragedy explains their resistance to recovery; the siblings must come together to overcome their fears and forge a path to a healthy future.

Tanisha weighs around 600-lbs, and she's desperate to survive for her kids and avoid her mother's tragic fate of dying at age 50 from super obesity; now at 32, her future looks grim if she doesn't make a drastic change to save her life.

A teen sleeps for 10 days.

A tumor hides another malady; a marathon runner experiences chronic fatigue.

A woman undergoes a risky craniotomy; a man searches for answers.

A teenager is rushed to the hospital after taking aspirin to help alleviate altitude sickness; a woman has pain in her arm that mysteriously spreads.

A woman and her husband decide to start a family after numerous negative pregnancy tests; a man appears to suffer an embolism.

Dr. Schaeffer has to straighten a woman's serpentine foot to reset her life, as Dr. Vincent gets a drummer's foot back on the beat.

Dr. Ebonie's skills are tested as she attempts to diagnose a patient with feet covered in huge, wart-like masses; Dr. Brad is confronted with a mystery case that could be related to the elephant man as well as a patient with paper-thin skin.

Nate sees Dr. Brad for help with the raging calluses on his feet; Savannah has a rare condition that made her big toe grow to an enormous size and hopes Dr. Ebonie can help; Dr. Brad is determined to uncover the mystery behind John's foot growth.

Troy's extra toe causes him pain, and he hopes Dr. Ebonie can provide him with relief; Dr. Brad does his best to untangle a ballet dancer's twisted feet; Ramon turns to Dr. Ebonie for help with the sacks of fluid hanging from his leg and ankle.

Charmaine from Trinidad suffers from one of the most extreme cases of neurofibromatosis ever recorded; tumors cover every inch of her body and obstruct her ability to breathe and swallow; without surgery, these growing tumors threaten her life.

Thirty-year-old Alexandra has a 20-pound, sagging tumor that starts at the back of her neck and now reaches below her waist; as the tumor on Claudia's backside continues to grow, so does the urgency for surgeons to remove it.

Despite his family's pleas, Marlow explores a high-risk surgery to remove a facial tumor; Amy has let the tumor on her back grow for more than 17 years; after finally making the decision to remove it, she learns that now it might be too late.

The bulbous tumor growing from Jennifer's stomach threatens her relationship with her long-time boyfriend; fifteen-year-old Marcelo travels from Angola to Los Angeles to have a massive neck tumor removed, but the operation may be too risky.

Louise's skin condition has taken over her life, now she desperately needs help; the cysts, blackheads and acne on 43-year-old Scott's back are ruining his life.

24-year-old Elise visits Dr. Emma in a last-ditch attempt to fix her excruciatingly painful skin condition. Plus, Gary wants a lump on the back of his head removed.

Rachael's body is covered in hundreds of lumps and bumps and maybe Dr. Emma can help her live a more normal life; John seeks surgery for his nose, which has become big and bulbous.

Gavin visits Dr. Emma about the smelly blisters in his armpits and groin; Abi suffers from severe acne, but has a fear of needles and swallowing tablets.

20-year-old Mariah visits Dr Emma about her severe acne; Jonathan has around 40 fatty lumps under his skin; young mom Holly worries she has two extra nipples.

24-year-old Elise visits Dr. Emma in a last-ditch attempt to fix her excruciatingly painful skin condition. Plus, Gary wants a lump on the back of his head removed.

Rachael's body is covered in hundreds of lumps and bumps and maybe Dr. Emma can help her live a more normal life; John seeks surgery for his nose, which has become big and bulbous.

Gavin visits Dr. Emma about the smelly blisters in his armpits and groin; Abi suffers from severe acne, but has a fear of needles and swallowing tablets.

20-year-old Mariah visits Dr Emma about her severe acne; Jonathan has around 40 fatty lumps under his skin; young mom Holly worries she has two extra nipples.

The bulbous tumor growing from Jennifer's stomach threatens her relationship with her long-time boyfriend; fifteen-year-old Marcelo travels from Angola to Los Angeles to have a massive neck tumor removed, but the operation may be too risky.

Louise's skin condition has taken over her life, now she desperately needs help; the cysts, blackheads and acne on 43-year-old Scott's back are ruining his life.

Most of the extreme weight on Tracey's body resides in her shockingly misshapen legs, which are massive with severe lymphedema, and gastric surgery is her only chance of survival; Brenda and Melissa prepare for skin removal surgery.

Christina has not left her house in two years due to her size; she has eaten herself into a state that will soon kill her if she does not change.

Paula has built a wall around herself to push people away; when she suddenly loses a loved one she can no longer ignore the threat of losing her own life.

Steven Assanti weighs nearly 800 pounds and his brother Justin almost 600 pounds, and although they can't stand each other, their father packs up the family to travel across the country and seek help.

After a year on a weight loss program, Steven remains completely non-compliant and Justin focuses on a new career instead of his diet, but time is quickly running out for surgery.

After meeting and falling in love at a bariatric rehab center, Lee and Rena are battling health and anger issues while taking a desperate, second attempt to save their relationship and their lives.

A woman whose extreme obesity has left her nearly immobile must overcome both her physical and emotional pain if she is ever to live a normal life again.

Alicia, all smiles and laughter on the outside, secretly fears that her food addiction will kill her before she can marry her long-time love or watch her nieces grow up.

Wess gets off to a great start in Dr. Now's program, but when the cravings continue after surgery, Dr. Now sends him to therapy to confront his demons; Wess must ask himself whether he is ready to live his truth as a gay man in small-town Texas.

Syreeta thinks that anyone trying to help has an ulterior motive, but she's gotten so big she desperately needs help; she's learning to let down her guard for her husband, but weight-loss surgery will be tough if she can't learn to trust the surgeon.

Wess gets off to a great start in Dr. Now's program, but when the cravings continue after surgery, Dr. Now sends him to therapy to confront his demons; Wess must ask himself whether he is ready to live his truth as a gay man in small-town Texas.

Syreeta thinks that anyone trying to help has an ulterior motive, but she's gotten so big she desperately needs help; she's learning to let down her guard for her husband, but weight-loss surgery will be tough if she can't learn to trust the surgeon.

Alicia, all smiles and laughter on the outside, secretly fears that her food addiction will kill her before she can marry her long-time love or watch her nieces grow up.

Gabriel has a huge growth on his clavicle but is terrified of surgery; Karen has dealt with painful, scaly feet for 22 years with no diagnosis; Lorne has embarrassing tumors on his face and body and believes this is why he hasn't met the one yet.

Rhonda has bumps all over her head, including a horned growth that has her deeply concerned; Fred has a mysterious condition on his hands and has not been able to get answers from any doctors; Kevin has a huge lump protruding from his hip.

Jen has substantial growths on her ears that cause her depression, pain and vertigo; Juliet is under emotional distress because of the bumps all over her neck and chest; Gerald has a mysterious, kiwi-size lump on his middle finger.

Gerald is back to see Dr. Lee and a hand specialist about a huge, intrusive bump on his middle finger; Vinnie has a large, embarrassing birthmark on his neck; Leta has a lump on the back of her thigh that she has been hiding from her fiancée.

Tony has large growths on his nose that impair his breathing; Kevin has a bump in his jawline that is a lady deterrent; Marie has an unsightly lump on her forehead that makes her a hermit; Tommy's leg bump makes it difficult for him to work.

Gerard has nearly a hundred lumps varying in size all over his body; Gina has bloody lesions all over; Eric has a large bump on his head that he calls his on and off button.

Traci's confidence has been destroyed after years of bullying from the bumps on her face; Ravon has a unique dangling growth on his leg; David has a large lump.

David is back to see Dr. Lee after she spots a suspicious growth under his eye; Nicole is depressed because of the bumps all over her neck; Steve has a noticeable lump on his forehead; Allen has a growth on his biceps but is terrified of doctors.

Tim has a massive growth on his back that affects his ability to work and socialize; Daniel has debilitating psoriasis that covers most of his body; Gloriana and Yolanda are a mother and daughter duo who have bonded over their bumps.

Inoke has a huge, possibly life-threatening bulge on his shoulder; Delano returns with his back lump after Dr. Lee removed a liter of fluid from it; Reed has hundreds of bumps on his chest that burst and leave nasty scars.

With pandemic safety protocols in place, Dr. Lee reopens her office; Monica has a large birthmark growing on the side of her face; Jackie has a melon-sized lump on the back of her shoulder; Reginald has large, rare growths on the back of his head.

Dr. Lee tries to provide the help Reginald needs to remove the large, rare growths on the back of his head; Che're has a prominent bump on her face that has put her in a dark place; Juan has several painful boils on the back of his neck.

Dennis has several giant growths on the back of his head; Juan has a rare condition he hopes Dr. Lee will understand; Natalie searches for answers as to why her body is covered in hundreds of mysterious dark bumps.

Audrey pops the painful bumps that cover her body so she can feel relief; Felicia has a peculiar-looking dark growth on her forehead; Krista's excessive sweating is so severe that on any given day she could fill up an entire milk jug with her sweat.

John fears the large lump on his neck could become so big that it may eventually suffocate him; Shoshana is depressed because of the big growth on her forehead; Ashley hopes Dr. Lee can provide some relief from her three painful skin conditions.

Yaellie, 9, has itchy psoriasis on over 90 percent of her body; former U.S. Marine Matt has a large recurring lump in his armpit; twins Tracie and Stacie have numerous matching bumps on their heads that sometimes leak.

Joanne has been held back from success because of her forehead growth; Shakisha split her left earlobe after stretching it with gauges; Mike is a tough guy with a soft bump on his head; Dania's rhinophyma has kept her from enjoying her life.

James has a large, squishy lump on his forehead; Tanisha has a growth on her arm and itchy scars all over her body; Ed wants his stomach lump removed before his girlfriend gets out of prison; Justin has painful mystery bumps all over his head.

John fears the large lump on his neck could become so big that it may eventually suffocate him; Shoshana is depressed because of the big growth on her forehead; Ashley hopes Dr. Lee can provide some relief from her three painful skin conditions.

Yaellie, 9, has itchy psoriasis on over 90 percent of her body; former U.S. Marine Matt has a large recurring lump in his armpit; twins Tracie and Stacie have numerous matching bumps on their heads that sometimes leak.

Joanne has been held back from success because of her forehead growth; Shakisha split her left earlobe after stretching it with gauges; Mike is a tough guy with a soft bump on his head; Dania's rhinophyma has kept her from enjoying her life.

James has a large, squishy lump on his forehead; Tanisha has a growth on her arm and itchy scars all over her body; Ed wants his stomach lump removed before his girlfriend gets out of prison; Justin has painful mystery bumps all over his head.

Dennis has several giant growths on the back of his head; Juan has a rare condition he hopes Dr. Lee will understand; Natalie searches for answers as to why her body is covered in hundreds of mysterious dark bumps.

Audrey pops the painful bumps that cover her body so she can feel relief; Felicia has a peculiar-looking dark growth on her forehead; Krista's excessive sweating is so severe that on any given day she could fill up an entire milk jug with her sweat.

A woman calls 911 after being locked inside her own vehicle; a man has too much fun in a pool.

A mom calls after a fast food restaurant makes her food wrong; a man needs help getting out of handcuffs.

Lisa helps a man yearning to discover his biological roots, but fearful of rejection from the family he has never met; Chris reveals the truth to a woman who has felt guilty that her birth might have devastated the life of her 14-year-old mom.

A tough Texas lawman seeks Lisa's help to tackle the one investigation he's never been able to solve: the story of his own birth and adoption.

Chris tries to unravel a legal mystery involving a woman's sister who she last saw across a New York courtroom 30 years ago.

A Vietnam vet hopes Lisa can help him make amends for the past by locating the daughter he lost custody of forty years ago; a woman's struggle to fit in takes a surprising turn when Chris reveals a series of stunning coincidences very close to home.

The recent revelation of a 49-year-old man's adoption sends Chris searching for answers to a secret his adoptive parents took to the grave; a biracial woman enlists Lisa's help to find her birth family, revealing some unfortunate tragedies.

Pat and Joe have an extreme collection of infamous kid dolls; Kitty Kay Sera is obsessed with the color pink.

A woman collects Mickey Mouse memorabilia; a collection of more than 2,000 wigs.

Bob and Lizzie love to flaunt their collection of love dolls around town; Everything about Doris is from 1950.

Frances and Bob have transformed their entire home into a feline fantasy land; Ron has built a replica of the Oval Office in his home.

Stanley has been obsessed with being an adult baby for the past 18 years;.

Over 300 mannequins have taken over Chad Michael's house; Zizi is obsessed with carrots, from tattoos to decorating every room in her house with them.

Megan is a 33-year-old alcoholic with social anxiety and a troubled past.

Phil is a 58-year-old meth user whose addiction spans over three decades.

Theresa is a homeless alcoholic whose addiction puts her life at risk.

Phyllis and Patty aren't just identical twins, they are identical hoarders as well.

Lalie and her children suffer from mold, mice and flea infestations due to their upstairs neighbor and landlord, Denise, who is a massive hoarder.

Beverly's clutter has filled up her entire home and her three beloved dogs have helped make the space completely unlivable.

Terry and Bill seem to be the perfect couple; the murder of her daughter has led Nancy to hoard.

Property investors purchase a house that is occupied by a hoarder; rat infestation compromises the building's foundation.

Lalie and her children suffer from mold, mice and flea infestations due to their upstairs neighbor and landlord, Denise, who is a massive hoarder.

Beverly's clutter has filled up her entire home and her three beloved dogs have helped make the space completely unlivable.

Terry and Bill seem to be the perfect couple; the murder of her daughter has led Nancy to hoard.

Property investors purchase a house that is occupied by a hoarder; rat infestation compromises the building's foundation.

Theresa is a homeless alcoholic whose addiction puts her life at risk.

Phyllis and Patty aren't just identical twins, they are identical hoarders as well.

Liz, completely bed-bound, has severe lymphedema that makes it impossible to walk; utterly isolated, Liz has no friends, battles depression and lives with a mother too ill to take care of her.

James comes from a long line of family obesity; he is determined not to die as his sister and father did; he hopes to get gastric bypass and even start dating again.

A mother of two who is too ashamed of her size to be seen with her children; she is committed to regaining her confidence and being a proud mother.

Unable to stand for more than a short period of time, Karina's weight places a burden on her parents and drives a wedge between her and her sister.

Lisa's struggle with her weight begins as a child and significantly worsens after witnessing her brother's murder; now bedridden and unable to care for herself, Lisa must find a way to lose the weight, or she will never see her grandchildren grow up.

After years of a tumultuous relationship with her husband, Tamy's eating addiction has caused her weight to balloon to over 500 pounds; she has become a hermit and hopes to restart her life so she can better care for her son, Zachary.

Fearing he'll suffer the same fate as 700-pound brother David, Benji hopes to be able to support both himself and his brother on their life-or-death weight loss journey.

Former plus-size model and advocate Renee realizes the mortal mistakes she has made as her weight swells to 600 pounds and her health crumbles.

Mark sets out with a goal for weight-loss surgery, but as weight loss gets easier, he turns down medical advice and decides to do it on his own; Mark thinks he can lose 500 pounds by himself, but Dr. Now sees this as another excuse not to change.

With her weight spiraling, Stephanie needs her mom's help to care for her three kids; she's at the point where she'll have to lose weight or risk not having the chance to see her kids grow up.

Mark sets out with a goal for weight-loss surgery, but as weight loss gets easier, he turns down medical advice and decides to do it on his own; Mark thinks he can lose 500 pounds by himself, but Dr. Now sees this as another excuse not to change.

With her weight spiraling, Stephanie needs her mom's help to care for her three kids; she's at the point where she'll have to lose weight or risk not having the chance to see her kids grow up.

Former plus-size model and advocate Renee realizes the mortal mistakes she has made as her weight swells to 600 pounds and her health crumbles.

A knee injury leaves Lindsay addicted to painkillers.

A 22-year-old heroin addict has been a substance abuser since elementary school.

Josh is a 37-year-old meth addict; his addiction began at age 15.

A 20-year meth addict's addiction worsens after the sudden death of his father.

A man has an upside-down head; a girl's face tumor; triplets undergo surgery; a man with misshapen tumors and giant-sized limbs; a man who eats but can't gain any weight.

A man loses his face to cancer; a baby born with a parasitic tumor; a girl's feet won't stop growing; a boy's face melts away.

In Thailand, a woman has the world's largest hands; an Ethiopian girl has a life-threatening neck tumor; 4-year-old conjoined twins risk surgery; a young woman has a body affected by vitiligo; in Spain, a woman's face is blistering away.

A Brazilian man with an elephant leg; a man is scared stiff; a Thai man could be the tallest man in the world; a child born with an unknown condition; a toddler is covered in hair.

A woman embraces her facial hair; a man is born with three legs; a woman covered in bubble shaped growths.

A gunman opens fire outside a strip club; a street performer's magic trick goes horribly wrong; BMX superstar T.J. Lavin's routine jump has a shocking outcome.

A maintenance worker falls from an iconic hotel sign; a rat bite has horrifying implications for its trainer and a plane crashes on a residential street.

A shootout leaves a police officer clinging to life; a cowboy and cupid help a she-devil in distress; a zip-line guide falls 80 feet to the canyon floor.