A boyfriend turns a door knob installation into a sexy chore that ends poorly; a couples' game night ends with a woman in severe pain and extreme worry; a paramedic rescues a young couple that fell into a well.

A pirate throws a party that causes a situation below deck; a couple gets in a tangle that leaves one of them tied up for the night; a woman could be permanently blind if her eyes aren't treated.

University of Tennessee Medical Center; digital technology; family support.

An eclectic and talented group of people make up the staff at St. Vincent's Emergency Room.

After a difficult childhood with an abusive stepfather and drug-addicted mother, Sarah is fighting for her life at only 24 years old.

Zsaylnn needs to lose weight to be the mother her daughter deserves; her husband loves large women and does not support her goals.

A woman battles severe depression and has not left her Chicago basement in two years; the hope of having a life-changing surgery.

Twins Kandi and Brandi have a combined weight of over 1,100 pounds and fear losing each other to obesity, so they decide to make a change together.

At 670 pounds, Ashley, who lives in her parents' home with her husband, decides she must make a drastic change to save her life and her marriage.

Cindy is resistant to change and spends years creating a world that makes her feel safe; when her friend notices Cindy's health declining rapidly due to her size, she pushes Cindy to move to Houston and see Dr. Now.

Melissa has isolated herself at home and lost many friends to avoid feeling the shame of what her food addiction has done to her body; now, the only way to get her life back is to leave it behind to start a new one with Dr. Now's help in Houston.

Kenae' is already big before her weight gain takes off after the death of her beloved mother; refusing to deal with the pain, Kenae' turns to food to fill the void.

Vianey and Allen have been on a weight-loss journey together; after Allen's surgery is a success and Vianey's is not, the couple struggle to get back on the same page to save their lives.

After regaining her mobility, Octavia is determined to never be stuck in the bed again, but difficult life circumstances threaten her ability to eat right and stay on track; Aaron is laid low by the death of his father, but true love saves him.

Vianey and Allen have been on a weight-loss journey together; after Allen's surgery is a success and Vianey's is not, the couple struggle to get back on the same page to save their lives.

After regaining her mobility, Octavia is determined to never be stuck in the bed again, but difficult life circumstances threaten her ability to eat right and stay on track; Aaron is laid low by the death of his father, but true love saves him.

Kenae' is already big before her weight gain takes off after the death of her beloved mother; refusing to deal with the pain, Kenae' turns to food to fill the void.

Lattyse was born with a mysterious growth above her eyebrow that gives her headaches. Robert has a tomato-sized growth on his butt cheek that causes him pain and discomfort. Sharon has an embarrassing, stinky, squirting cyst under her breast.

Keke is covered in bumps that make her embarrassed to be intimate with her husband; Jim is a widower with two lumps who wants them removed for himself and his late wife; Corey has been labeled a devil worshipper because of his forehead growth.

Monica returns for a second time in hopes that Dr. Lee can remove some more of her face growths; Ken has several large cysts on his head that he has tried to remove on his own; Maranda has a mystery skin sore that causes discomfort.

Corey is a drag queen and has a bump dangling from his booty; Adam has a semi-circle of about a dozen cysts on his head that he covers with a hat; Virginia has large growths on both of her upper arms that make it difficult to travel in her RV.

Terry's nose growth has prevented him from meeting his grandkids; Remi has alligator-like skin and is not used to taking care of herself; Austin has an embarrassing birthmark right next to his eyelid; Mary Jo has a throbbing bump on her neck.

Roger has enormous growths on his nose that drip pus, attract flies, and are so large that he can barely breathe; Sandra and Jessie are sisters who bonded over their many undiagnosed face bumps.

Roger returns with his gigantic nose growths in the hope that Dr. Lee and her colleagues can help before it's too late; Christine has lost her essence due to a large growth on her shoulder; Tiffany has a recurring cyst on her eyelid.

Gabriel has a huge growth on his clavicle but is terrified of surgery; Karen has dealt with painful, scaly feet for 22 years with no diagnosis; Lorne has embarrassing tumors on his face and body and believes this is why he hasn't met the one yet.

Ruben is a personal trainer whose head growth has prevented him from seeing clients; Kaitlin has blue marks and scars up and down her arms due to long-term drug use; Adrian was left with a disfiguring bump on her behind after falling down stairs.

Margarita is a matriarch who has been hiding her armpit lump from her family; Kayla is an aspiring musician with a promising career that her painful eczema has brought to a halt; Bradley has a concerning growth that looks like raw meat on his leg.

Jeremy is a pastor with a hanging growth in an embarrassing location; Evelyn has recurring keloids that have been removed three times and come back bigger each time; Todd has a bump protruding from his forehead.

Tameru is a drag queen, but he has a myriad of cysts that are the real drag; Devon has uneven skin she thinks may be the result of a hysterectomy a decade ago; Amy has large growths all over her head that make her look like a "hot mess."

Jason lost their confidence and motivation due to the large growth on his neck; Shawnell's multiple mystery bumps on her head destroy her self-esteem; Jim's growth protruding off of his nose makes it hard to breathe.

Roger has a growth on his shoulder that he calls his second head; Jenna is a teenager with a bubble behind her ear; Susan is covered in bumps that effect her everyday life.

Robert has a small keloid on his ear and a large, snakelike keloid on the back of his head that has been removed and returned three times; Angela has four growths on her head and hides away from those she loves out of embarrassment.

Robert is back to see if Dr. Lee and Dr. Umar can remove his recurring head keloid for good; Justice has small lesions all over her body; Mike has hundreds of lipomas that bring him great discomfort.

Debra has a large, brain-like growth on the side of her head that feels like a sponge, has crevices and emits an odor; Dusten is a cowboy looking to remove the painful lump on his knee; Ramiro has a bump on his jaw that has already been removed once.

Eric hopes Dr. Lee is able to remove the giant growth from his behind; Breanna suffers from itchy dry skin she can't help but scratch; Michael makes jokes, but he knows the bump on his head is anything but funny.

Robert has a small keloid on his ear and a large, snakelike keloid on the back of his head that has been removed and returned three times; Angela has four growths on her head and hides away from those she loves out of embarrassment.

Robert is back to see if Dr. Lee and Dr. Umar can remove his recurring head keloid for good; Justice has small lesions all over her body; Mike has hundreds of lipomas that bring him great discomfort.

Debra has a large, brain-like growth on the side of her head that feels like a sponge, has crevices and emits an odor; Dusten is a cowboy looking to remove the painful lump on his knee; Ramiro has a bump on his jaw that has already been removed once.

Eric hopes Dr. Lee is able to remove the giant growth from his behind; Breanna suffers from itchy dry skin she can't help but scratch; Michael makes jokes, but he knows the bump on his head is anything but funny.

Jason lost their confidence and motivation due to the large growth on his neck; Shawnell's multiple mystery bumps on her head destroy her self-esteem; Jim's growth protruding off of his nose makes it hard to breathe.

Roger has a growth on his shoulder that he calls his second head; Jenna is a teenager with a bubble behind her ear; Susan is covered in bumps that effect her everyday life.

A patient fights for his life after a four-story fall; a 12-year-old boy is hit by a car and injures his foot.

A heart attack victim is brought back to life; a mother and her newborn survive a horrific crash; a 65-year-old man falls two floors down an elevator shaft.

Two brothers arrive at the ER after being crushed by a falling building; a victim of a gang-related incident; a patient who fell 40 feet.

A jail newcomer gets more than she bargains for; a young mother's release is postponed; the tenth trip for a heroin addict.

A crack-addicted pregnant prostitute finds safe haven in jail; two best friends share a heroin addiction; a prostitute struggles to overcome her past.

A woman is arrested for smuggling drug paraphernalia into court; two heroin addicts turn to each other for support; a life of prostitution supports a woman's drug habit.

A elder playboy has a minor injury that turns deadly; a health fanatic's juice diet leaves him in a comatose state; while juggling multiple critical patients, doctors nearly misdiagnose one who has suddenly deteriorated.

A man injured by a boat propeller; a deadly chain of events; the ER comes to a standstill.

Two gunshot victims; a jogger goes into a coma; the ER staff becomes detectives.

A newlywed's hand gets stuck in a kitchen appliance; a student with an injury down under; a heavy drinker has complications.

Two families welcome a new child; two defiant boyfriends return while another slips away.

Nicole has a c-section and Mariah refuses to help; Kim goes through a painful labor and delivery; Lemhele and Shaniyah go back to therapy.

Nicole makes a controversial announcement; Kim deals with her grandmother; Shaniyah gets induced.

Kim's boyfriend is released from rehab; Nicole and AJ get married; Shaniyah and Lemhele struggle with two new babies in the house; Lorna has a difficult birth.

Chris and Lisa join forces in an attempt to solve the childhood mystery of why a woman was separated from her birth family at the age of two.

A woman enlists Lisa's help to find her birth mother, but unearths a 40-year-old secret in the process.

Chris tries to solve the 50-year-old mystery of why a woman was abandoned at a laundromat days after being born; a family enlists Lisa's help to track down the firstborn son that was placed for adoption, hoping to fulfill a father's dying wish.

Lisa tackles the challenging mystery of why a woman was abandoned in a trash can as a baby; unexpected DNA results throw a woman's entire identity into question.

Chris and Lisa join forces in an attempt to solve the childhood mystery of why a woman was separated from her birth family at the age of two.

A woman enlists Lisa's help to find her birth mother, but unearths a 40-year-old secret in the process.

Chris tries to solve the 50-year-old mystery of why a woman was abandoned at a laundromat days after being born; a family enlists Lisa's help to track down the firstborn son that was placed for adoption, hoping to fulfill a father's dying wish.

Lisa tackles the challenging mystery of why a woman was abandoned in a trash can as a baby; unexpected DNA results throw a woman's entire identity into question.

Nicole makes a controversial announcement; Kim deals with her grandmother; Shaniyah gets induced.

Kim's boyfriend is released from rehab; Nicole and AJ get married; Shaniyah and Lemhele struggle with two new babies in the house; Lorna has a difficult birth.

With the support of his fiancé, Kathryn, Robert turns to Dr. Nowzaradan in a final, desperate attempt to save his life; he tries to reverse a lifelong food addiction that has left him bed-bound, saddled with grotesque lymphedema, and nearly 900-lbs.

Melissa, mother of four, finds herself feeling overwhelmed due to a rocky marriage and an unexpected pregnancy; when Ashley's weight-loss journey hits a wall, she sets out to find new inspiration to get herself back on track.

Christina's weight loss threatens her life; after losing 300 pounds, Paula must endure more surgery to deal with a body entirely covered in loose and sagging skin.

Back on Dr. Nowzaradan's program, James is suspected of cheating as he continues to gain weight and suffers a series of life-threatening illnesses; Cynthia continues to lose weight but seems satisfied to do so at her own pace.

Brittani has lost over 400 pounds in two years, so she and husband Bill think about expanding their family; Lupe has struggled since surgery, but, having left her husband, may finally start to make the permanent changes she needs.

Sean must overcome recent tragedies in his life before he loses all the progress he made over the last two years; Dottie struggles to stay on track while maintaining her family life.

Milla is dependent on her children and seeks to lose enough weight to be able to walk; Charity is mired in a deep depression, while her daughter, Charly, battles a food addiction; they strive to turn things around and reach their goal weight.

Krystal begins overeating to shield herself with a protective layer of obesity after suffering years of abuse; once a means of protection, her pathological eating now threatens to destroy her life if she doesn't get help.

Isaac helped raise his siblings after his mom suffered a debilitating stroke when he was 10. While learning to cook for his family, he began comfort-eating. Now to avoid eating himself to death, Isaac must learn to take care of himself for a change.

A lifetime of abuse has left Michael anxious and afraid to leave the house; with the help of his devoted wife, he must follow Dr. Now's program to keep from eating himself to death.

Isaac helped raise his siblings after his mom suffered a debilitating stroke when he was 10. While learning to cook for his family, he began comfort-eating. Now to avoid eating himself to death, Isaac must learn to take care of himself for a change.

A lifetime of abuse has left Michael anxious and afraid to leave the house; with the help of his devoted wife, he must follow Dr. Now's program to keep from eating himself to death.

Krystal begins overeating to shield herself with a protective layer of obesity after suffering years of abuse; once a means of protection, her pathological eating now threatens to destroy her life if she doesn't get help.

Twins Kandi and Brandi have a combined weight of over 1,100 pounds and fear losing each other to obesity, so they decide to make a change together.

Penny has been bedridden for four years and moves to Texas to have gastric bypass; her unwillingness to make lifestyle changes could mean failure.

Chuck weighs almost 700 pounds; he has had to downsize his business and his wife feels like a single-parent who is ready to leave him.

At over 700 pounds, Brianne undertakes a weight-loss journey to save her own life; she faces an unexpected challenge to her fragile progress when her husband suffers a heart attack on a birthday she will never forget.

Octavia has been bedbound for nearly a year when she decides to make the trip to Houston to get help from Dr. Now, but when it turns out that her best friend is also her worst enabler, Octavia will have to choose between old habits and a new life.

Robin and her brother Chris are both obese and already lost a sibling to obesity; they plan to visit Dr. Now together when Chris suffers a stroke and can't go; Chris' son Garrett, already 600 pounds at age 20, is game to join the journey.

A college graduate with a once-promising career, Justin has eaten his life away to the point of never leaving the house for anything but food; only the help of Dr. Now's weight-loss program can restore his hopes of living a happy, productive life.

Holly already has one failed weight loss surgery, so to succeed this time, she must do more than change her eating habits, she must address the childhood issues that continue to plague her.

Lacey wants skin removal surgery, but Dr. Now begins to wonder if she even wants to lose weight; in Houston, Mercedes and her kids face destitution.

After a year of isolation due to COVID-19, brothers John and Lonnie return to see Dr. Now with a collective weight loss that makes them some of his most successful patients ever.

Lacey wants skin removal surgery, but Dr. Now begins to wonder if she even wants to lose weight; in Houston, Mercedes and her kids face destitution.

After a year of isolation due to COVID-19, brothers John and Lonnie return to see Dr. Now with a collective weight loss that makes them some of his most successful patients ever.

Holly already has one failed weight loss surgery, so to succeed this time, she must do more than change her eating habits, she must address the childhood issues that continue to plague her.

Pregnant detainees await trial; Jamie, a mother of four struggles for visitation rights; Tanya requests house arrest to prepare for the birth of her son.

Latoya struggles with giving up her baby for adoption; Esther is sent to disciplinary segregation.

A pianist's finger goes missing after getting accidentally sawed off; a man's pacemaker threatens to kill him; a man behaves bizarrely.

A pregnant woman is shot in the abdomen; a doctor is the victim of a car burglary; a storm is preventing a patient's life-saving surgery.

A woman risks losing her finger after trying on an ill-fitting engagement ring; a body builder can't breathe and doctors are shocked to discover why; a gunshot victim.

Trauma surgeon Kris Gebrowski and Dr. Steve Nishida handle a wide variety of cases at Honolulu's Queens Medical Center.

Patients at the University Hospital trauma center in Albuquerque, N.M., often come from great distances.

Louisville's University Hospital sees the results of domestic violence.

The Elvis Presley Trauma Center in Memphis, Tenn.; butcher-knife injury; teen injured in car accident; man breaks hip.

A man seeking redemption from his troubled past longs to reunite with the grown son he only got to hold for a few minutes; 46 years after placing her daughter up for adoption, a woman still carries the feeling of guilt for being an unwed mother.

A couple longs to find the daughter they had as young teens; a woman learns her birth was a secret; taking place live, a bride and groom reveal a momentous surprise to their wedding guests and someone gets reunited with a long-lost family member.

A woman whose daughter perished in a car accident hopes to find comfort in locating her granddaughter, who was placed for adoption 26 years ago; a woman yearning to meet her birth mother is stunned by an unlikely figure in the search.

Two brothers navigate a painful past as they search for the family they've longed for their entire lives, and their journey reopens decades-old family mysteries about their birth mother, twin siblings and a baby who was only rumored to exist.

Lisa meets a woman who was left on a curb by her mother when she was just four years old; Chris uncovers stunning information for a woman searching for her family that leads to an unexpected reunion.

A teacher's aide fails to recognize the signs of pregnancy; a 40-year-old is shocked to learn that she is pregnant.

A mother mistakes labor pains for kidney stones; after losing weight, a woman discovers she is pregnant.

A newlywed couple is moving cross-country when the young wife, not knowing she is pregnant, discovers she is in labor.

Victoria suddenly goes into labor at her mother-in-law's house, never suspecting she was pregnant.

Ressa collapses and goes into a coma after a miscarriage five months earlier; she has an eclamptic seizure caused by her full term baby.

Alicia barely survives a harrowing car accident. Then, just 18 months later, a surprising pregnancy threatens the life of her newborn.

Melissa is rushed to the hospital thinking she might be having a miscarriage; she gives birth to an unexpected baby in the backseat.

Jenna is rushed to the hospital to find out she is in labor and at a hospital that hasn't delivered a baby in 15 years.

A teacher's aide fails to recognize the signs of pregnancy; a 40-year-old is shocked to learn that she is pregnant.

A mother mistakes labor pains for kidney stones; after losing weight, a woman discovers she is pregnant.

A newlywed couple is moving cross-country when the young wife, not knowing she is pregnant, discovers she is in labor.

Victoria suddenly goes into labor at her mother-in-law's house, never suspecting she was pregnant.

Ressa collapses and goes into a coma after a miscarriage five months earlier; she has an eclamptic seizure caused by her full term baby.

Alicia barely survives a harrowing car accident. Then, just 18 months later, a surprising pregnancy threatens the life of her newborn.

Melissa is rushed to the hospital thinking she might be having a miscarriage; she gives birth to an unexpected baby in the backseat.

Jenna is rushed to the hospital to find out she is in labor and at a hospital that hasn't delivered a baby in 15 years.

Two brothers navigate a painful past as they search for the family they've longed for their entire lives, and their journey reopens decades-old family mysteries about their birth mother, twin siblings and a baby who was only rumored to exist.

Lisa meets a woman who was left on a curb by her mother when she was just four years old; Chris uncovers stunning information for a woman searching for her family that leads to an unexpected reunion.

A woman gets a Christmas tree imbedded in her neck; a boy out fishing almost chokes on a barb; a man is filled with enough air to fill 1000 balloons; learn how they survived.

A man gets a wire embedded in his heart; three year old swallows magnets; woman has pencil in her brain; man has a five centimeter splinter removed from eye.

A car accident leaves a pole penetrating a man's mouth and neck, a man accidentally eats a sewing needle, a 75-year-old man finds out he has had a nail in his face.

Melanie wants to feel normal and date, but her layers of skin are dragging her down; Lauren is so uncomfortable in her excess skin that she can't have the normal life she wants with her boyfriend.

After losing 275 lbs., Mikki became a fitness fanatic, but the weight loss left her with a lot of sagging skin; Denise's obesity always made her feel invisible, but after losing 200 lbs. the skin still hinders her from fitting in with her family.

Rebecca lost her weight to be more active with her young son, but the plan backfired because she's now trapped in her excess skin; after his dad died, Sal dropped a ton of weight, but with all the excess skin, he fears he will never become a dad.

Autumn wants to make up for lost time with her son, but the excess skin from major weight loss is holding her back; Cody always pretended to be happy when he was 500-lbs, but after losing the weight, he's covered in skin and is sick of pretending.

A teenager's hair begins to fall out.

An elderly woman cannot walk straight; a baby cries incessantly.

A woman's legs may need amputation; one side of a woman's face is numb.

A man faces amputation when a mystery disease turns his extremities black; a young woman develops paralyzing fears about ordinary objects.

A beautiful model turns into a raging monster and starts attacking everyone around her; a man's life is nearly destroyed when he can't stop burping.

A woman's life is ruined by extreme sweating day and night; a young teacher prays to stop living when he feels invisible bugs crawling all over him.

Meet three of the tallest teenagers in America who haven't finished growing.

A woman who slept through the birth of her child, hopes to find a diagnosis for her sleeping condition; a man with giant genitals seeks help; a 2.5ft teenager hopes to find out what stalled his growth.

A boy can't stop his giant foot from growing; a woman with bubbly skin and her kids embrace their condition; a dwarf boy who defied the odds has one more challenge to face; a man with a facial tumor must conquer his fear of surgery.

A boy born with no eyes; a separated conjoined twin adjusts to life after losing his twin brother; two brothers suffer from a very rare bone condition; a boy living with a huge facial growth finally gets a diagnosis.

In India, Hemlata Singh, gave birth to a boy with the head and arms of his dead twin attached to his chest; doctors try to save the newborn and separate him from his sibling's body.

A woman who slept through the birth of her child, hopes to find a diagnosis for her sleeping condition; a man with giant genitals seeks help; a 2.5ft teenager hopes to find out what stalled his growth.

A boy can't stop his giant foot from growing; a woman with bubbly skin and her kids embrace their condition; a dwarf boy who defied the odds has one more challenge to face; a man with a facial tumor must conquer his fear of surgery.

A boy born with no eyes; a separated conjoined twin adjusts to life after losing his twin brother; two brothers suffer from a very rare bone condition; a boy living with a huge facial growth finally gets a diagnosis.

In India, Hemlata Singh, gave birth to a boy with the head and arms of his dead twin attached to his chest; doctors try to save the newborn and separate him from his sibling's body.

A woman's life is ruined by extreme sweating day and night; a young teacher prays to stop living when he feels invisible bugs crawling all over him.

Meet three of the tallest teenagers in America who haven't finished growing.

At 670 pounds, Ashley, who lives in her parents' home with her husband, decides she must make a drastic change to save her life and her marriage.

Zsalynn's 360-body lift procedure proves to be more challenging than expected; lonely and depressed since her gastric surgery, Olivia wants skin removal surgery but struggles to lose the weight to qualify.

Diagnosed with cancer and battling depression, Bettie Jo finds out she's pregnant, and she must find a way to cope with the help of her husband; Susan suffers a major setback after surgery for her excess skin.

Doug has lost over 200 pounds and is more involved with his family life. He is now an example of healthy habits, but eating disorders threaten to derail his progress.

Pauline's self-destructive behavior continues to be a problem; Chad strives to be a better father and husband as he continues his journey; June's progress stalls when frequent travel and wedding plans cause her to slip back into bad habits.

After a year on a weight loss program, Steven remains completely non-compliant and Justin focuses on a new career instead of his diet, but time is quickly running out for surgery.

A year since her weight-loss journey began, Janine is still in the 500s and mostly immobile, and now, Dr. Nowzaradan is running out of options for how to treat her if she can't find a way to control her eating habit and start walking again.

Having her daughters help bathe her is not how Chrystal pictured parenting but she is so large that there's no other option; Chrystal wants Dr. Now's help but she didn't know that bringing her childhood trauma to light would be part of the deal.