Kathy's extreme hoarding forced her 12-year-old son to move out of their home.

Severe debt and clutter has Dennis moments away from losing everything; Monte's clothing hoard has destroyed a relationship with her son.

Cary's paralyzing obsession with Elvis memorabilia has left his New York City apartment virtually uninhabitable.

Randy is being forced to leave the apartment he has lived in for more than 20 years.

Dominic's life is falling apart due to his food addiction; over 600 pounds and living in a van with his brother, he decides to leave California for Texas, where only Dr. Now can help him learn to face life's challenges without using food to cope.

James comes from a long line of family obesity; he is determined not to die as his sister and father did; he hopes to get gastric bypass and even start dating again.

With her weight loss, Laura is much less dependent on her husband Joey, who is now having trouble finding his place in their relationship; challenging patient Marla returns and the fireworks begin once again.

At 24 years old and over 600 lbs, Megan lives at home with her mom, who cooks for her since Megan can't do much on her own; Megan must travel to Houston to meet Dr Now and change her eating habit or her life may end before it ever begins.

Ashley is 24 and lives alone; her only sources of comfort are food and the relationships she has online; but not a single one of her profiles is real; Ashley learns that Dr Now isn't someone she can lie to like her online friends.

For 23 years, Leneatha has worked as a pharmacy tech at a local hospital; now, she has a young daughter to support, but she's so big that it's hard to move; if Dr Now can't help her stop eating, losing her job could be the least of her worries.

At nearly 1,000 pounds, Samantha is dangerously close to dying; to make matters worse, she's paid to eat by making videos online; if Samantha doesn't overcome her toxic relationship with food, she worries she will leave her daughter motherless.

Twenty years after her father died as the result of a botched weight-loss surgery, Carrie is on the brink of eating herself to death; she must face the fear and grief of losing her father and end a cycle of toxic behavior with her husband, Chris.

Thederick has become housebound from eating and only goes outside to greet the ice cream man; after a recent hospital scare, it's finally clicked that if Dr. Now's program doesn't work for him, then nothing will.

Cindy is resistant to change and spends years creating a world that makes her feel safe; when her friend notices Cindy's health declining rapidly due to her size, she pushes Cindy to move to Houston and see Dr. Now.

Thederick has become housebound from eating and only goes outside to greet the ice cream man; after a recent hospital scare, it's finally clicked that if Dr. Now's program doesn't work for him, then nothing will.

Cindy is resistant to change and spends years creating a world that makes her feel safe; when her friend notices Cindy's health declining rapidly due to her size, she pushes Cindy to move to Houston and see Dr. Now.

Twenty years after her father died as the result of a botched weight-loss surgery, Carrie is on the brink of eating herself to death; she must face the fear and grief of losing her father and end a cycle of toxic behavior with her husband, Chris.

Melissa has isolated herself at home and lost many friends to avoid feeling the shame of what her food addiction has done to her body; now, the only way to get her life back is to leave it behind to start a new one with Dr. Now's help in Houston.

Chuck weighs almost 700 pounds; he has had to downsize his business and his wife feels like a single-parent who is ready to leave him.

Milla is bedridden and dependent on her husband and five kids, who can't resist her unending requests for junk food.

Kenae' is already big before her weight gain takes off after the death of her beloved mother; refusing to deal with the pain, Kenae' turns to food to fill the void.

Krystal begins overeating to shield herself with a protective layer of obesity after suffering years of abuse; once a means of protection, her pathological eating now threatens to destroy her life if she doesn't get help.

Isaac helped raise his siblings after his mom suffered a debilitating stroke when he was 10. While learning to cook for his family, he began comfort-eating. Now to avoid eating himself to death, Isaac must learn to take care of himself for a change.

A lifetime of abuse has left Michael anxious and afraid to leave the house; with the help of his devoted wife, he must follow Dr. Now's program to keep from eating himself to death.

Shannon's husband loves her the way she is, but that may not help because she's 700 pounds and bedridden; Dr. Now knows it's not easy to break a toxic cycle of overfeeding and enabling, but that's what needs to happen if Shannon wants to live.

Irene had to move back in with her son because her weight made it unbearable to live on her own. When Dr. Now can't get through to her, the only thing that might help her break the cycle is a once-in-a-lifetime turn of events.

Through tough times, food has always been Tammy's friend; now she has gotten so big that her daughters and mother have moved home to care for her, and unless Dr. Now can get her to confront her grief, food might be her killer.

Irene had to move back in with her son because her weight made it unbearable to live on her own. When Dr. Now can't get through to her, the only thing that might help her break the cycle is a once-in-a-lifetime turn of events.

Through tough times, food has always been Tammy's friend; now she has gotten so big that her daughters and mother have moved home to care for her, and unless Dr. Now can get her to confront her grief, food might be her killer.

Shannon's husband loves her the way she is, but that may not help because she's 700 pounds and bedridden; Dr. Now knows it's not easy to break a toxic cycle of overfeeding and enabling, but that's what needs to happen if Shannon wants to live.

Having her daughters help bathe her is not how Chrystal pictured parenting but she is so large that there's no other option; Chrystal wants Dr. Now's help but she didn't know that bringing her childhood trauma to light would be part of the deal.

Donald has difficulty walking and relies on his parents to take care of him, so he gets motivated to begin his weight loss journey.

Dottie wants to be a better mom, so she agrees to a drastic new diet, but her child's life-threatening emergency and her own self-sabotage threaten to derail all hopes for weight-loss.

Ryan moved to Montana to keep himself from going down a dark path of drug addiction but his new path may be no less lethal than the last if he can't find a way to curb his eating habits before they kill him.

Paul weighs in at 700 pounds, and his girlfriend struggles with how this limits their ability to live a normal life; he thinks their relationship won't survive if he moves to work with Dr. Now, but prioritizing his own health is the only option.

When Nathan's weight gets in the way of his job as a drama teacher, it's a wake-up call for him; changing his life might mean a falling out with his wife, Amber, who is also overweight, unless she can lose, too.

Lacey is so big from overeating that she can barely leave the house, but that hasn't stopped her from finding love with Ricky; Lacey's weight isn't the only thing between her and a happy husband, however, with Ricky's sister Sharon in the picture.

For Julian and his wife, Irma, it was love at first sight; in order to grow old together, Julian will have to overcome the food addiction that made him more than 800 pounds.

Bianca is all in for a move to Houston with her boyfriend and two young kids to get Dr. Now's help with a second weight-loss surgery.

Mike was born with a talent for sports and an omnivorous appetite to match; after his football dreams were dashed by multiple concussions, Mike packed on over 700 pounds, now he must find a new purpose in life to avoid succumbing to pain and regret.

Bianca is all in for a move to Houston with her boyfriend and two young kids to get Dr. Now's help with a second weight-loss surgery.

Mike was born with a talent for sports and an omnivorous appetite to match; after his football dreams were dashed by multiple concussions, Mike packed on over 700 pounds, now he must find a new purpose in life to avoid succumbing to pain and regret.

For Julian and his wife, Irma, it was love at first sight; in order to grow old together, Julian will have to overcome the food addiction that made him more than 800 pounds.

After a night of terrible cramps, Nicole takes a hot bath and realizes she is in labor and the baby is breech.

A teenager believes that she is unable to bear children after having an aggressive chemotherapy treatment; a nursing student learns she is pregnant after an emergency appendectomy.

While attempting to recover from the stress of getting mugged and a bad fall, Nikki finds out she is pregnant and full term.

Stabbing pains in the pelvis send a woman to an ER, where she discovers she has given birth, without realizing she was pregnant.

A new mother struggles to lose her baby weight; a mother gets a surprise after having her tubes tied.

A teacher's aide fails to recognize the signs of pregnancy; a 40-year-old is shocked to learn that she is pregnant.

Four mothers and four daughters who are all pregnant at the same time.

Tensions run high at Lorna and Chae's baby shower; Kim's boyfriend violates probation; Nicole is newly single; Lemhele races to the hospital to give birth.

Two families welcome a new child; two defiant boyfriends return while another slips away.

Jessica is stricken with chills, fever, and migraines; Jake starts military training and finds painful lumps on his body.

Since childhood a man has been victim to joint pain, rashes, and an inability to sweat.

A newborn has an indentation in his chest; another baby exhibits troubling symptoms.

A toddler has unexplained bleeding; a college student has intense cramps.

An aspiring actress awakens to an excruciating pain on the right side of her face; Bill experiences nausea and strange tingling in his legs; doctor visits and MRI tests show how these two different cases reveal paralysis.

A woman hopes the tooth transplanted in her eye will stop her from going blind; conjoined twins share a single body; a boy with gigantism in his legs turns to doctors for a cure; a mother has surgery to remove the massive fatty tumors in her neck.

Doctors seek to restore the face of a little girl with a giant facial cleft; a pregnant little person and her husband find out if their son will have two forms of dwarfism; a woman's face is slowly being destroyed by a tumor.

Doctors attempt to separate twins who were born joined at the head; a woman with a rare brittle bone disorder doesn't let her disease control her life; a man with a huge facial tumor undergoes major surgery to save his life.

A man loses his face to cancer; a baby born with a parasitic tumor; a girl's feet won't stop growing; a boy's face melts away.

A Brazilian man with an elephant leg; a man is scared stiff; a Thai man could be the tallest man in the word; a child born with an unknown condition; a toddler is covered in hair.

A woman with backwards hands and feet; a young girl gets a new face; an enormous mystery tumor.

A woman has over 50 orgasms a day, which makes sex painful; in the United States, a man is only 2 feet, eleven inches tall due to a rare condition called primordial dwarfism.

A man loses his face to cancer; a baby born with a parasitic tumor; a girl's feet won't stop growing; a boy's face melts away.

A Brazilian man with an elephant leg; a man is scared stiff; a Thai man could be the tallest man in the word; a child born with an unknown condition; a toddler is covered in hair.

A woman with backwards hands and feet; a young girl gets a new face; an enormous mystery tumor.

A woman has over 50 orgasms a day, which makes sex painful; in the United States, a man is only 2 feet, eleven inches tall due to a rare condition called primordial dwarfism.

Doctors seek to restore the face of a little girl with a giant facial cleft; a pregnant little person and her husband find out if their son will have two forms of dwarfism; a woman's face is slowly being destroyed by a tumor.

Doctors attempt to separate twins who were born joined at the head; a woman with a rare brittle bone disorder doesn't let her disease control her life; a man with a huge facial tumor undergoes major surgery to save his life.

Emergency room doctors deal with mayhem on a daily basis at the University of California at Davis Medical Center.

Doctors from King Drew Medical Center in South Central Los Angeles represent a number of races and creeds.

Trauma center at the University of New Mexico Hospital in Albuquerque.

A year after the Anderson family started their weight loss journey, they find that the honeymoon period is over as they begin to struggle; their 600-pound cousin Shavonne wants to follow in their footsteps.

Shavonne calls out the family for not losing weight; Naomi gets devastating news that might derail her goals for good; Drew attempts to re-enter the dating world for the first time in a decade; Chitoka tries to get back on track.

The members of the Anderson family work through their issues in group therapy; Chitoka and Shavonne face the painful memories that have kept them from losing more weight.

Shavonne undergoes high-risk bariatric surgery; Chitoka struggles to lose enough weight to be approved for skin tightening surgery; Drew works up the courage to go on another date; the family throws a party for Shavonne to reveal her weight loss.

A patient fights for his life after a four-story fall; a 12-year-old boy is hit by a car and injures his foot.

A heart attack victim is brought back to life; a mother and her newborn survive a horrific crash; a 65-year-old man falls two floors down an elevator shaft.

A newborn with a potentially life-threatening infection; the victim of a gang-related attack; a patient who has survived a bullet passing through all of his vital organs.

A man falls five stories; a shopkeeper is shot in the head at point-blank range; a woman accidentally drinks a bottle of cleaning fluid.

A man wounded in a drive-by shooting; a patient with flesh-eating bacteria; a woman hit by a car.

Two brothers arrive at the ER after being crushed by a falling building; a victim of a gang-related incident; a patient who fell 40 feet.

A man is impaled on a fence post; a farmer has an object lodged in his brain; a woman is skewered on a hooked pole when she feeds the birds.

A man gets a wire embedded in his heart; three year old swallows magnets; woman has pencil in her brain; man has a five centimeter splinter removed from eye.

A woman is impaled on an iron spike; a man spears his friend on a fishing trip; an elderly gardener's shears are lodged in his eye.

A car accident leaves a pole penetrating a man's mouth and neck, a man accidentally eats a sewing needle, a 75-year-old man finds out he has had a nail in his face.

A woman gets a Christmas tree imbedded in her neck; a boy out fishing almost chokes on a barb; a man is filled with enough air to fill 1000 balloons; learn how they survived.

A man gets a wire embedded in his heart; three year old swallows magnets; woman has pencil in her brain; man has a five centimeter splinter removed from eye.

A woman is impaled on an iron spike; a man spears his friend on a fishing trip; an elderly gardener's shears are lodged in his eye.

A car accident leaves a pole penetrating a man's mouth and neck, a man accidentally eats a sewing needle, a 75-year-old man finds out he has had a nail in his face.

A woman gets a Christmas tree imbedded in her neck; a boy out fishing almost chokes on a barb; a man is filled with enough air to fill 1000 balloons; learn how they survived.

A man is impaled on a fence post; a farmer has an object lodged in his brain; a woman is skewered on a hooked pole when she feeds the birds.

A man is impaled on a fence post; a farmer has an object lodged in his brain; a woman is skewered on a hooked pole when she feeds the birds.

After moving houses, and months of strange behavior, 11-year-old Sammy stops walking and only hops. Can doctors bring him out of the bizarre world he is slipping into?

A woman surviving blindness and albinism suffers another disease.

A young man has strange growths; toddler rapidly gains weight.

A 14-year-old develops a rash that leaves her fighting for her life; a young father's body begins to shut down.

A 5-year-old boy has a persistent, mysterious fever and stomach ache.

A woman and her husband decide to start a family after numerous negative pregnancy tests; a man appears to suffer an embolism.

A teenager's hair begins to fall out.

Tameru is a drag queen, but he has a myriad of cysts that are the real drag; Devon has uneven skin she thinks may be the result of a hysterectomy a decade ago; Amy has large growths all over her head that make her look like a "hot mess.".

Jason lost their confidence and motivation due to the large growth on his neck; Shawnell's multiple mystery bumps on her head destroy her self-esteem; Jim's growth protruding off of his nose makes it hard to breathe.

Roger has a growth on his shoulder that he calls his second head; Jenna is a teenager with a bubble behind her ear; Susan is covered in bumps that effect her everyday life.

Robert has a small keloid on his ear and a large, snakelike keloid on the back of his head that has been removed and returned three times; Angela has four growths on her head and hides away from those she loves out of embarrassment.

Robert is back to see if Dr. Lee and Dr. Umar can remove his recurring head keloid for good; Justice has small lesions all over her body; Mike has hundreds of lipomas that bring him great discomfort.

Debra has a large, brain-like growth on the side of her head that feels like a sponge, has crevices and emits an odor; Dusten is a cowboy looking to remove the painful lump on his knee; Ramiro has a bump on his jaw that has already been removed once.

Eric hopes Dr. Lee is able to remove the giant growth from his behind; Breanna suffers from itchy dry skin she can't help but scratch; Michael makes jokes, but he knows the bump on his head is anything but funny.

Robert has thousands of unique bumps on his arms that Dr. Lee has never seen; Alexis has a painful cheek cyst that oozes and has a pungent odor; Stuart's cluster of back bumps disgusts his wife but thrills Dr. Lee.

Elaine calls the growth on her love handle her third breast; Jessica's cyst is close to her eye and could be dangerous for Dr. Lee to remove; Dwayne wants his nose bumps removed, but he may not be able to make it through the pain of the procedure.

Troy's extra toe causes him pain, and he hopes Dr. Ebonie can provide him with relief; Dr. Brad does his best to untangle a ballet dancer's twisted feet; Ramon turns to Dr. Ebonie for help with the sacks of fluid hanging from his leg and ankle.

Despite having the longest big toes Dr. Brad has ever seen, Anna hopes for the feet she's always wanted; Russell visits Dr. Ebonie with feet that look like hooves; Patty lost most of her foot in an extreme amputation, and she needs Dr. Sarah's help.

Robert has thousands of unique bumps on his arms that Dr. Lee has never seen; Alexis has a painful cheek cyst that oozes and has a pungent odor; Stuart's cluster of back bumps disgusts his wife but thrills Dr. Lee.

Elaine calls the growth on her love handle her third breast; Jessica's cyst is close to her eye and could be dangerous for Dr. Lee to remove; Dwayne wants his nose bumps removed, but he may not be able to make it through the pain of the procedure.

Troy's extra toe causes him pain, and he hopes Dr. Ebonie can provide him with relief; Dr. Brad does his best to untangle a ballet dancer's twisted feet; Ramon turns to Dr. Ebonie for help with the sacks of fluid hanging from his leg and ankle.

Despite having the longest big toes Dr. Brad has ever seen, Anna hopes for the feet she's always wanted; Russell visits Dr. Ebonie with feet that look like hooves; Patty lost most of her foot in an extreme amputation, and she needs Dr. Sarah's help.

Debra has a large, brain-like growth on the side of her head that feels like a sponge, has crevices and emits an odor; Dusten is a cowboy looking to remove the painful lump on his knee; Ramiro has a bump on his jaw that has already been removed once.

Eric hopes Dr. Lee is able to remove the giant growth from his behind; Breanna suffers from itchy dry skin she can't help but scratch; Michael makes jokes, but he knows the bump on his head is anything but funny.

Organ donor recipients share similar symptoms before lapsing into coma; pox outbreak in the Midwest.

A deadly fever spreads in California after an earthquake; a bacterial outbreak forces a giant food recall.

Flu symptoms strike down men in Fort Collins; an elderly woman returns from China with a disease.

A disease that kills 17,000 crows and zoo birds also fills a city's emergency room; an unidentified virus in the Southwest.

The CDC, NYPD and FBI team up to deal with anthrax; a mysterious illness targets young girls.

A surfer is impaled between the legs; a football player's severe leg pain leads to an unexpected diagnosis; a woman is given a clot-busting drug to cure her stroke, but she has another condition that could cause that same drug to kill her.

A boa constrictor has wrapped around a man's arm and won't let go; a young woman has a severe laceration, but doctors begin to suspect there may be more to her case than the injury; a young man goes into anaphylactic shock after a dinner out.

An urgent care physician must think outside the box to care for two emergencies at once; a woman with abdominal pain receives an unexpected diagnosis; a yoga instructor has a dangerously high temperature for no obvious reason.

A patient gets brought in with a live shark clamped onto his thigh, and he wants to save the shark; complications arise for a woman with a life-threatening condition; a mysterious condition causes a man to pass out.

Police officers bring in a criminal that is comatose; a man found passed out in the snow with no jacket or shoes arrives in the ER and a doctor is faced with a family emergency on her day-off.

A fishing lure embedded in a man's face turns out to be the least of his problems; a pair of unconscious teenagers get brought to the ER, where dramatic family secrets come out; an ER technician collapses and refuses traditional medical treatment.

Eileen's secret escalates to a matter of life and death; Dale has packed five houses full of clutter.

When Child Protection Services removes Karen's children from her home, she has 48 hours to clean up or risks losing custody of her kids permanently.

Hot-tempered David moved back in with his 93-year old mother and has quickly filled her home with clutter.

After their mother's death, siblings Aimee, Cheryl and Jimmy are left to deal with a house filled with clutter; they bring the aid of a medium to help locate important documents.

Rhonda's home is filled with items she's found in the dumpster; neighbors are threatening lawsuits.

Compulsive hoarder Valerie risks eviction when her next-door neighbor reports her to the health department; Ann's house is so filled with clutter she has been reduced to a small space in her living room.

Kay denies she is a hoarder but her cluttered home with deadly vermin tells another story.

After their mother's death, siblings Aimee, Cheryl and Jimmy are left to deal with a house filled with clutter; they bring the aid of a medium to help locate important documents.

Rhonda's home is filled with items she's found in the dumpster; neighbors are threatening lawsuits.

Kay denies she is a hoarder but her cluttered home with deadly vermin tells another story.

When Child Protection Services removes Karen's children from her home, she has 48 hours to clean up or risks losing custody of her kids permanently.

Hot-tempered David moved back in with his 93-year old mother and has quickly filled her home with clutter.

James B, grew up eating rich Haitian food and loves it with a passion; James needs Dr. Now's help to diminish that love in order to survive, but a death in the family sends James retreating back to the comforts he knows.

At 24-years-old, Bettie Jo is on her way to reaching 700 pounds and relies on her husband for her basic needs.

Susan, 37-year-old woman, has never lived on her own because of her weight, is finally seeking help to get out on her own.

Living with his family, Lucas wants to spread his wings and fly, but at 600 pounds, he can't take off. All he does is eat and game, and if he wants to leave the nest and live a normal life, he needs Dr. Now's help to lose over 400 pounds.

Margaret's life at 700 pounds is in need of a jump-start; at age 35, she is a mama's girl; it's time for Margaret to get out of bed, overcome her food addiction and break away from the comfort of her mother so she can finally live her life.

At 700 pounds, Ontreon has managed to keep going thanks to his faith in God, and he's training to become a minister; Onteon is hopeful but has to believe in himself.

Dolly has pain all over, and the skin apron pulling on her abdomen is miserable, but her mom and others wait on her hand and foot.