Jason lost their confidence and motivation due to the large growth on his neck; Shawnell's multiple mystery bumps on her head destroy her self-esteem; Jim's growth protruding off of his nose makes it hard to breathe.

Roger has a growth on his shoulder that he calls his second head; Jenna is a teenager with a bubble behind her ear; Susan is covered in bumps that effect her everyday life.

Ruben is a personal trainer whose head growth has prevented him from seeing clients; Kaitlin has blue marks and scars up and down her arms due to long-term drug use; Adrian was left with a disfiguring bump on her behind after falling down stairs.

Margarita is a matriarch who has been hiding her armpit lump from her family; Kayla is an aspiring musician with a promising career that her painful eczema has brought to a halt; Bradley has a concerning growth that looks like raw meat on his leg.

A patient fights for his life after a four-story fall; a 12-year-old boy is hit by a car and injures his foot.

A heart attack victim is brought back to life; a mother and her newborn survive a horrific crash; a 65-year-old man falls two floors down an elevator shaft.

A newborn with a potentially life-threatening infection; the victim of a gang-related attack; a patient who has survived a bullet passing through all of his vital organs.

A man falls five stories; a shopkeeper is shot in the head at point-blank range; a woman accidentally drinks a bottle of cleaning fluid.

A man wounded in a drive-by shooting; a patient with flesh-eating bacteria; a woman hit by a car.

Two brothers arrive at the ER after being crushed by a falling building; a victim of a gang-related incident; a patient who fell 40 feet.

A wrist fracture turns into a medical mystery; two fishermen get stuck on the same lure; a cheerleader with a sprained finger nearly dies of an unexpected cause; a power outage foils the ER team's effort to get a dying patient to the O.R.

A teen football player suffers a stroke; a doctor remembers his first major trauma in the 1970s; a doctor tries to figure out what causes a patient's abdominal pain.

A surgical resident puts her training to the test when a mugging survivor arrives with two bullet wounds.

An alligator snapping turtle is clamped to a man's neck; an impending hurricane; impaled by a chainsaw.

A party attendee becomes paralyzed; a boy crushed by an ATV; a girl injects herself with epinephrine accidentally.

A man's mysterious injury; a patient says they've been shot in the head; a woman is brain dead.

Debbie turned to hoarding after a confession ended her marriage; with illness in her family, Julie hoards to ease the pain.

Traci is pregnant and desperate to move back home, but it's filled floor to ceiling with her mother's stuff.

Medical responders were not able to get in Renee's front door after she had fallen unconscious in her home.

Donny has been to jail twice because of his hoard; Joyce finds comfort in her doll collection, while others see it as creepy.

A former ventriloquist turns her career into an obsession; Harold has trouble being a good father when his daughter isn't allowed in his home.

Sherry's hoarding has broken up her marriage and now authorities threaten to take her children and condemn her home.

Medical responders were not able to get in Renee's front door after she had fallen unconscious in her home.

Donny has been to jail twice because of his hoard; Joyce finds comfort in her doll collection, while others see it as creepy.

A former ventriloquist turns her career into an obsession; Harold has trouble being a good father when his daughter isn't allowed in his home.

Sherry's hoarding has broken up her marriage and now authorities threaten to take her children and condemn her home.

Debbie turned to hoarding after a confession ended her marriage; with illness in her family, Julie hoards to ease the pain.

Traci is pregnant and desperate to move back home, but it's filled floor to ceiling with her mother's stuff.

Melissa has isolated herself at home and lost many friends to avoid feeling the shame of what her food addiction has done to her body; now, the only way to get her life back is to leave it behind to start a new one with Dr. Now's help in Houston.

At 24-years-old, Bettie Jo is on her way to reaching 700 pounds and relies on her husband for her basic needs.

An 800-pound man who lost his job and is mostly housebound looks to find the strength to face his past and save his own life.

Kenae' is already big before her weight gain takes off after the death of her beloved mother; refusing to deal with the pain, Kenae' turns to food to fill the void.

Lupe has spent the last 10 years in bed and is totally dependent on her husband, prompting a cross-country move that could save her life or end up backfiring.

Twins Kandi and Brandi have a combined weight of over 1,100 pounds and fear losing each other to obesity, so they decide to make a change together.

At 670 pounds, Ashley, who lives in her parents' home with her husband, decides she must make a drastic change to save her life and her marriage.

Erica regrets not keeping a promise to her mom and hopes her siblings will help, but they're reluctant based on her past failures.

Cynthia, a single mother focused on raising five kids, comes to realize what her death would mean for their future.

After overcoming a dependence on drugs and alcohol, sneaking food is Doug's last remaining vice; this husband and father must overcome his addictive personality to save his life and marriage.

Cynthia, a single mother focused on raising five kids, comes to realize what her death would mean for their future.

After overcoming a dependence on drugs and alcohol, sneaking food is Doug's last remaining vice; this husband and father must overcome his addictive personality to save his life and marriage.

Erica regrets not keeping a promise to her mom and hopes her siblings will help, but they're reluctant based on her past failures.

Diana, a once thin and active woman, is now a prisoner to her body and trades the comfort of her apartment for a weight loss journey under the strict authority of her niece.

A woman struggles to make a positive change to be part of her partner and son's lives and turn her life around.

An overweight woman struggles with flesh-eating bacteria and butterfly shaped fat deposits; unexpected news threatens her weight loss journey.

James becomes bedridden, unable to stand and can barely move his legs; Holly and Mark prepare for skin removal surgery.

Weighing over 700-lbs, Nicole is on the verge of leaving her two young children motherless; trying to survive a family of addicts, she commits to Dr. Nowzaradan's diet program, but crisis threatens to derail all her hopes for weight-loss.

Kirsten is close to losing all her mobility, and while she's trying to control of her obesity, she's also in danger of losing her troubled son.

Michael's massive body has left him dependent upon his family, and he must learn to control his anger issues around food, lose weight and address the root of his issues or risk losing everything.

Tanisha weighs around 600-lbs and she's desperate to survive for her kids and avoid her mother's tragic fate of dying at age 50 from super obesity; now at 32, her future looks grim if she doesn't make a drastic change to save her life.

Most of the extreme weight on Tracey's body resides in her shockingly misshapen legs, which are massive with severe lymphedema, and gastric surgery is her only chance of survival; Brenda and Melissa prepare for skin removal surgery.

After getting his surgery canceled and living in his van by the beach, surgery may be the break David has been waiting for his whole life; Syreeta suffers a devastating personal tragedy that only strengthens her desire to become a mother.

Most of the extreme weight on Tracey's body resides in her shockingly misshapen legs, which are massive with severe lymphedema, and gastric surgery is her only chance of survival; Brenda and Melissa prepare for skin removal surgery.

After getting his surgery canceled and living in his van by the beach, surgery may be the break David has been waiting for his whole life; Syreeta suffers a devastating personal tragedy that only strengthens her desire to become a mother.

Tanisha weighs around 600-lbs and she's desperate to survive for her kids and avoid her mother's tragic fate of dying at age 50 from super obesity; now at 32, her future looks grim if she doesn't make a drastic change to save her life.

A couple longs to find the daughter they had as young teens; a woman learns her birth was a secret; taking place live, a bride and groom reveal a momentous surprise to their wedding guests and someone gets reunited with a long-lost family member.

Two brothers navigate a painful past as they search for the family they've longed for their entire lives, and their journey reopens decades-old family mysteries about their birth mother, twin siblings and a baby who was only rumored to exist.

A man who always longed for a sibling stumbles upon a shocking family murder; Lisa meets a woman eager to find her biological mother, but she also finds information that changes her view of the past.

A young man who received letters from his birth mother longs to know the truth of the words she wrote; a man haunted by the memory of his younger brother being taken from their home seeks to reunite the family.

A woman discovers troubling news about her biological father, but uncovers exciting information about his family; adoptee Leslie and her birth mother Janice seek help after their newfound relationship derails.

Newly reunited sisters face a battle that strengthens their bond and uncover another secret held by their mother; two families explore the complicated relationship of sharing a son.

Chandra is afflicted by a unknown condition that has left his body riddled with hundreds of tumors; in a race against time to find a cure.

Doctors seek to restore the face of a little girl with a giant facial cleft; a pregnant little person and her husband find out if their son will have two forms of dwarfism; a woman's face is slowly being destroyed by a tumor.

Doctors attempt to separate twins who were born joined at the head; a woman with a rare brittle bone disorder doesn't let her disease control her life; a man with a huge facial tumor undergoes major surgery to save his life.

Two-year-old Indonesian chain smoker; young man with facial tumor may not survive surgery; seven-year-old twins attached at the head.

Young Dominican woman cries blood; world's fattes child has insatiable appetite; young girl trapped behind werewolf's face.

A man has an upside-down head; a girl's face tumor; triplets undergo surgery; a man with misshapen tumors and giant-sized limbs; a man who eats but can't gain any weight.

A teenager fails to hit puberty; a collapsed lung.

A woman starts growing uncontrollably.

A young man has strange growths; toddler rapidly gains weight.

Constant respiratory infections and an inability to grow; mysterious spasms and back pain overcome a man's life.

A girl is born with shocking deformities; a college student suffers from fluid around his heart and lungs.

Weak muscles make walking and using hands difficult; bump on the finger could be the first sign of a deadly infection.

A young man has strange growths; toddler rapidly gains weight.

Constant respiratory infections and an inability to grow; mysterious spasms and back pain overcome a man's life.

A girl is born with shocking deformities; a college student suffers from fluid around his heart and lungs.

Weak muscles make walking and using hands difficult; bump on the finger could be the first sign of a deadly infection.

A teenager fails to hit puberty; a collapsed lung.

A woman starts growing uncontrollably.

Louisville's University Hospital sees the results of domestic violence.

The level one trauma center at Fresno's University Medical Center treats car crash victims and infant with respiratory problems.

The doctors and nurses of Good Samaritan Regional Medical Center pursue diverse goals at the Level One Trauma Center.

Victims of shootings, stabbings, heroin overdose.

Gang warfare and a high population of sick patients keep medical center workers on the move in Los Angeles.

Bobbi and Kenny have skin that painfully grows in thick scales due to the rare condition Lamellar Ichthyosis.

Getting too hot can be fatal for twins Andrew and Brandon, who meet Josh, a fellow sufferer of Ectodermal Dysplasia.

Boys Giovanni and Owen share the rare condition Schwartz Jampel Syndrome, which permanently and painfully contracts their muscles; the two share hardships and triumphs, and strike up a friendship.

Tiffany and Destiny both live with the rare disease Osteogenesis Imperfecta, which causes brittle bones, and set out on a life changing journey to meet each other.

Born with Goldenhar Syndrome, Austin and Elena have been bullied for looking different, and feel isolated from other kids.

Tiffany and Yajaira have Jarcho Levin Syndrome, which malformed their ribs and spines during infancy.

A teenager's bulging tummy and stomach pains; a man's own attempted murder; a college coed stops breathing mysteriously.

Bizarre fishing injuries; deadly abdominal pains; teenage victims of a car crash.

A golfer's life-saving surgery; three nearly naked adults in the ER; a patient accidentally shot by his brother.

A man injured by a boat propeller; a deadly chain of events; the ER comes to a standstill.

A man's face and body suddenly double in size; a young woman is burning up from the inside out after a day at the beach; a grumpy old man nearly dies before revealing an emotional secret.

A pregnant woman is shot in the abdomen; a doctor is the victim of a car burglary; a storm is preventing a patient's life-saving surgery.

A Halloween zombie with a problem below the belt mystifies doctors; two unconscious men are involved in an accident, a doctor makes a mistake that amazingly explains a patient's condition.

A man injured by a boat propeller; a deadly chain of events; the ER comes to a standstill.

A man's face and body suddenly double in size; a young woman is burning up from the inside out after a day at the beach; a grumpy old man nearly dies before revealing an emotional secret.

A pregnant woman is shot in the abdomen; a doctor is the victim of a car burglary; a storm is preventing a patient's life-saving surgery.

A Halloween zombie with a problem below the belt mystifies doctors; two unconscious men are involved in an accident, a doctor makes a mistake that amazingly explains a patient's condition.

Bizarre fishing injuries; deadly abdominal pains; teenage victims of a car crash.

A golfer's life-saving surgery; three nearly naked adults in the ER; a patient accidentally shot by his brother.

Seana's mind is ready for surgery, but her body still has a conflict with the scale; once almost 900 pounds, J.T. Clark is finally ready to have his massive leg surgically downsized.

Laura has used food to cope with her emotions; she is confined to a wheelchair and relies on an oxygen tank to breathe and her husband and mother to survive.

Bedridden Marla is so heavy she cannot stand up; she must face the hard truth about her condition and understand the toll it takes on her supportive family.

Margaret succeeds in getting surgery, but Dr. Now is dismayed when a few months later she and her mom revert to their old ways; Megan grows impatient with her slow weight loss, and if Dr. Now doesn't approve her for surgery soon, she might quit.

Siblings Carlton and Shantel have always been close, but with their eating habits enabling each other, they need to make a change; Shantel is sad to grow apart from her little brother, but it might be the one thing they both need the most.

Ontreon hopes that surgery can make him a better husband to his wife Musa, but he struggles to move past the grief that's blocked him for years; Wess is doing great post-surgery, but his next goal is crucial to his success.

Cillas must face difficulties from his childhood to progress to his goal weight and set an example for his children; Tiffany struggles to lose weight when financial hardships place a strain on her relationship with her boyfriend, Aaron.

Holly faces a wedding and an operation; Lashanta is not losing weight and when a car crashes through her living room wall her progress is even slower.

Robin and Garrett started their weight-loss journeys together as aunt and nephew; almost four years later, they're like war buddies, striving to reach their target weights through a combination of shedding pounds and skin removal surgeries.

Vianey and Allen have been on a weight-loss journey together; after Allen's surgery is a success and Vianey's is not, the couple struggle to get back on the same page to save their lives.

Robin and Garrett started their weight-loss journeys together as aunt and nephew; almost four years later, they're like war buddies, striving to reach their target weights through a combination of shedding pounds and skin removal surgeries.

Vianey and Allen have been on a weight-loss journey together; after Allen's surgery is a success and Vianey's is not, the couple struggle to get back on the same page to save their lives.

Holly faces a wedding and an operation; Lashanta is not losing weight and when a car crashes through her living room wall her progress is even slower.

Robert has a small keloid on his ear and a large, snakelike keloid on the back of his head that has been removed and returned three times; Angela has four growths on her head and hides away from those she loves out of embarrassment.

Robert is back to see if Dr. Lee and Dr. Umar can remove his recurring head keloid for good; Justice has small lesions all over her body; Mike has hundreds of lipomas that bring him great discomfort.

Debra has a large, brain-like growth on the side of her head that feels like a sponge, has crevices and emits an odor; Dusten is a cowboy looking to remove the painful lump on his knee; Ramiro has a bump on his jaw that has already been removed once.

Eric hopes Dr. Lee is able to remove the giant growth from his behind; Breanna suffers from itchy dry skin she can't help but scratch; Michael makes jokes, but he knows the bump on his head is anything but funny.

Robert has thousands of unique bumps on his arms that Dr. Lee has never seen; Alexis has a painful cheek cyst that oozes and has a pungent odor; Stuart's cluster of back bumps disgusts his wife but thrills Dr. Lee.

Elaine calls the growth on her love handle her third breast; Jessica's cyst is close to her eye and could be dangerous for Dr. Lee to remove; Dwayne wants his nose bumps removed, but he may not be able to make it through the pain of the procedure.

Dr. Lee faces off with iguana-wrangler Madison's head growths; Chanel suffers from painful cyst tunnels beneath her armpit skin that leak and smell like the food she eats; the dark purple birthmark on Eddie's nose has made him a recluse.

Bob suffers from mysterious open-wound sores all over his body; Virginia's stress-ball-sized lump is such a pain in her neck that she can't wait to have it removed; Ted suffers from flaking, itchy, stucco-like skin and has had no luck finding a cure.

Steven's bump is so large, his daughter thinks he is growing a monster on his back; Catherine's arm lump has grown so big that it's nearly up to her armpit; Ethan suffers from an irritating rash in an uncomfortable and awkward place on his body.

John lost his sight at a young age and soon after began growing lumps on his body. Lynette has hundreds of pebble-sized bumps all over her arms, chest and belly. Gabe cannot imagine going to college with the unsightly mole on the back of his head.

Casey's birthmark covers most of her face, head and neck; James has mysterious massive growths on his inner thigh and lower abdomen; Jerry had to hang up his rock star vocal cords when a lump grew out the side of his throat.

Johnnie's crippling psoriasis keeps him from spending time with his daughter; Aimee has a mohawk of cysts on her head; Edith's face markings and itchy skin condition turn out to be more than she expected.

Elizabeth's head is covered with giant cauliflower-shaped bumps; Jamaal has been growing a strange knob on the left side of his butt since he was just a boy; Donna's cracking, bleeding skin condition has aged her face and kept her from being social.

Kenny was born with a rare condition that causes hundreds of lumps to grow all over his body; Ebonee covers the tiny bumps on her eyes with sunglasses; Paula's painful and swollen feet ooze a substance that emits a foul odor.

Jacqueline's massive shoulder growth makes it difficult for her to do her favorite hobby of fire spinning; the mysterious bump on James' cheek loves to bleed; Mikalia has possessed a bumpy, smelly mass on her head since birth.

After losing his longtime love, Joe wants the large bumps all over his head removed; the itchy, painful rash on Nisa's ears spreads to her face; Jennifer has dark spots all over her face that nobody is allowed to see.

Cedric has a bump on his eye and a painful lump on his neck that have kept him from working; Katherine's large ear cluster puts her neighborhood watch job at risk; Andrea uses makeup to cover the white spots all over her face and body.

Jimmy's flaky, raised alligator skin feels like an itchy hell, and he wants it cured so he can find love; Djuka is a stubborn guy with a stubborn bump; Talina has hundreds of tumors all over her body, causing embarrassment and discomfort.

Jacqueline's massive shoulder growth makes it difficult for her to do her favorite hobby of fire spinning; the mysterious bump on James' cheek loves to bleed; Mikalia has possessed a bumpy, smelly mass on her head since birth.

After losing his longtime love, Joe wants the large bumps all over his head removed; the itchy, painful rash on Nisa's ears spreads to her face; Jennifer has dark spots all over her face that nobody is allowed to see.

Cedric has a bump on his eye and a painful lump on his neck that have kept him from working; Katherine's large ear cluster puts her neighborhood watch job at risk; Andrea uses makeup to cover the white spots all over her face and body.

Jimmy's flaky, raised alligator skin feels like an itchy hell, and he wants it cured so he can find love; Djuka is a stubborn guy with a stubborn bump; Talina has hundreds of tumors all over her body, causing embarrassment and discomfort.

Elizabeth's head is covered with giant cauliflower-shaped bumps; Jamaal has been growing a strange knob on the left side of his butt since he was just a boy; Donna's cracking, bleeding skin condition has aged her face and kept her from being social.

Kenny was born with a rare condition that causes hundreds of lumps to grow all over his body; Ebonee covers the tiny bumps on her eyes with sunglasses; Paula's painful and swollen feet ooze a substance that emits a foul odor.

A student's head is impaled by a trophy deer's antlers; a semi-conscious car crash victim; a woman with an allergic reaction.

A doctor treats three gunshot victims who claim be innocent bystanders; a doctor must perform emergency brain surgery on his first day; a bride-to-be suddenly slips into a diabetic coma.

Two skydivers are impaled by a fence post; multiple patrons stop breathing; a bride's finger gets stuck in a make-up jar.

A hospital worker feels like she is dying; a physician's young son is her patient; wild mushroom picking.

Featuring a man with blue skin; abdominal pains for a girl; the only survivor of a plane crash.

A man thinks he's constipated; a young woman in cardiac arrest; a patient's family is clueless.

A student has difficulty breathing; a man impaled by a shovel; a police officer has a heart attack.

A college student finds out she is pregnant when she is rushed to the emergency room.

A woman goes into labor in her bathtub.

After failing two pregnancy tests, a woman is shocked to learn the truth about her symptoms; a woman gets a surprise after having gastric bypass surgery.

A teenager believes that she is unable to bear children after having an aggressive chemotherapy treatment; a nursing student learns she is pregnant after an emergency appendectomy.

While attempting to recover from the stress of getting mugged and a bad fall, Nikki finds out she is pregnant and full term.

After spending a day with her family riding roller coasters at a theme park, a woman suddenly feels exhausted and nauseous, begins having cramps, heads to the bathroom, and gives birth to a baby boy on the floor.

A teacher's aide fails to recognize the signs of pregnancy; a 40-year-old is shocked to learn that she is pregnant.

A woman who has accepted that she may never have a child is rushed to a hospital with cramps attributed to work stress and is shocked to find out she's pregnant and in labor.

Tiffany thinks the abdominal pain she is having is from a rupturing cyst, but it's actually a child she didn't know she was carrying.

A woman unknowingly conceives just two months after giving birth, suffers horrible cramps one night and delivers a baby girl into her own hands, never aware she was pregnant.

A woman becomes a first time mother in a cab returning home from a club only to be surprised once again at a friend's BBQ years later; another woman goes into labor after believing she has kidney stones and has another unexpected baby a year later.

After one unexpected birth, a woman who thinks she has food poisoning is shocked when she nearly delivers surprise baby number two in a store parking lot; a student thinks she has a tumor but it's a baby; woman with endometriosis.

A backstage quickie at a body building competition; a soldier's welcome home; a sneaky couple has fun where they were told not to.

A couple tries to get intimate in the den but a party crasher lands them in the ER; a bizarrely decorated politician and his wife; aroma therapy causes stress below.

An addiction to hot sauce causes an inferno; hickeys from a secret lover may be the cause of a medical crisis; getting lucky at a bowling alley leads to the ER.

A man cannot believe he is getting busy with his girlfriend in his sleep; a steamy first date cooking class; a retirement hobby gets a man in trouble.

A backstage quickie at a body building competition; a soldier's welcome home; a sneaky couple has fun where they were told not to.

A couple tries to get intimate in the den but a party crasher lands them in the ER; a bizarrely decorated politician and his wife; aroma therapy causes stress below.

An addiction to hot sauce causes an inferno; hickeys from a secret lover may be the cause of a medical crisis; getting lucky at a bowling alley leads to the ER.

A man cannot believe he is getting busy with his girlfriend in his sleep; a steamy first date cooking class; a retirement hobby gets a man in trouble.

A woman becomes a first time mother in a cab returning home from a club only to be surprised once again at a friend's BBQ years later; another woman goes into labor after believing she has kidney stones and has another unexpected baby a year later.

After one unexpected birth, a woman who thinks she has food poisoning is shocked when she nearly delivers surprise baby number two in a store parking lot; a student thinks she has a tumor but it's a baby; woman with endometriosis.

After regaining her mobility, Octavia is determined to never be stuck in the bed again, but difficult life circumstances threaten her ability to eat right and stay on track; Aaron is laid low by the death of his father, but true love saves him.

Chay has eaten his way to 600 pounds to cope with the emotional turmoil of his childhood; he loses his emotional support and searches for new strength to take control of his life.

Nikki finds her career as a costume designer threatened by immobility, so she undergoes gastric bypass and confronts the emotional causes for her eating.

Lacey wants skin removal surgery, but Dr. Now begins to wonder if she even wants to lose weight; in Houston, Mercedes and her kids face destitution.

After a year of isolation due to COVID-19, brothers John and Lonnie return to see Dr. Now with a collective weight loss that makes them some of his most successful patients ever.

Maja cannot be allowed to undergo bariatric surgery unless she quits emotional eating. However, it seems like Justin may end up making Dr. Now proud.

There is much to be gained and lost for Brianne in year two of her journey, in which she both loses weight and gains independence; getting back with Erica becomes the top priority for Annjeanette, who chooses love over even her own health.

Jeanne struggles to care for herself in the aftermath of her dad's death; Brandon strives to get his weight down to feel confident when proposing to his girlfriend, Tayler, and be the man she deserves.

Right when Angie is starting to succeed in Dr. Now's program, her marriage falls apart and her life is thrown into chaos, but she tries to move ahead alone despite dire difficulties.

Right when Angie starts to succeed in Dr. Now's program, her marriage falls apart and her life is thrown into chaos; Angie moves ahead despite dire difficulties, but when her body starts to break down, Angie fears the worst and faces it alone.

Right when Angie is starting to succeed in Dr. Now's program, her marriage falls apart and her life is thrown into chaos, but she tries to move ahead alone despite dire difficulties.

Right when Angie starts to succeed in Dr. Now's program, her marriage falls apart and her life is thrown into chaos; Angie moves ahead despite dire difficulties, but when her body starts to break down, Angie fears the worst and faces it alone.

Jeanne struggles to care for herself in the aftermath of her dad's death; Brandon strives to get his weight down to feel confident when proposing to his girlfriend, Tayler, and be the man she deserves.

Twins Kandi and Brandi have a combined weight of over 1,100 pounds and fear losing each other to obesity, so they decide to make a change together.

Melissa weighs a shocking 673 pounds, and decides to begin her seven-year weight-loss journey toward a healthier life.

Melissa struggles to get to her ideal weight after starting her weight loss journey from 650 pounds with gastric bypass.

At over 700 pounds, Brianne undertakes a weight-loss journey to save her own life; she faces an unexpected challenge to her fragile progress when her husband suffers a heart attack on a birthday she will never forget.

Octavia has been bedbound for nearly a year when she decides to make the trip to Houston to get help from Dr. Now, but when it turns out that her best friend is also her worst enabler, Octavia will have to choose between old habits and a new life.

Robin and her brother Chris are both obese and already lost a sibling to obesity; they plan to visit Dr. Now together when Chris suffers a stroke and can't go; Chris' son Garrett, already 600 pounds at age 20, is game to join the journey.

A college graduate with a once-promising career, Justin has eaten his life away to the point of never leaving the house for anything but food; only the help of Dr. Now's weight-loss program can restore his hopes of living a happy, productive life.

As an Italian American, Geno was raised with lots of love, family and food; now, he's still living with his mom and eating himself to death, and it's time to make a change; Geno's cousin, Nico, joins the cause; they pledge to lose weight together.