Rick tries to salvage his cluttered home that was nearly destroyed in a house fire; Linda must get her house up to code in 60 days or she will be on the streets.

Traci is pregnant and desperate to move back home, but it's filled floor to ceiling with her mother's stuff.

Kathleen discovers a hoard of mice living in her kitchen; spending the night in a hoard might be the end of a marriage before it even begins.

Medical responders were not able to get in Renee's front door after she had fallen unconscious in her home.

Rick tries to salvage his cluttered home that was nearly destroyed in a house fire; Linda must get her house up to code in 60 days or she will be on the streets.

A mother tries to protect her children from their father's hoard; an artist chooses frog, penguins and banana peels over her boyfriend.

Maggie's piles of collections is putting her son's life at risk; Bob's passion for swimming pool parts is pushing his family to the brink.

After losing 275 lbs., Mikki became a fitness fanatic, but the weight loss left her with a lot of sagging skin; Denise's obesity always made her feel invisible, but after losing 200 lbs. the skin still hinders her from fitting in with her family.

Rebecca lost her weight to be more active with her young son, but the plan backfired because she's now trapped in her excess skin; after his dad died, Sal dropped a ton of weight, but with all the excess skin, he fears he will never become a dad.

Autumn wants to make up for lost time with her son, but the excess skin from major weight loss is holding her back; Cody always pretended to be happy when he was 500-lbs, but after losing the weight, he's covered in skin and is sick of pretending.

Ronnie and Michael Robinette are thriving, but their extra skin is getting in the way; at 64, Renee's excess skin inhibits her from enjoying her relationship and expressing her true self in public.

Dr. Dow and J.J. Virgin are called in to save a pizza addict; consuming 80 times more pizza than an average American.

A woman is addicted to ice cream bars, eating up to 40 bars a day.

A 26 year old man is addicted to maple syrup.

A 34 year old woman in obsessed with eating cheesy potatoes; specialists are called in to help with this damaging and compulsive diet.

Mysti consumes as much as 40 gallons of tartar sauce a year.

A 34-year old diabetic is in need of help to save him from his addiction to cheeseburgers.

After a horrific car accident as a child, Heather's ankle was rebuilt from parts of her body; now it's up to Dr. Vincent to help her walk again.

Dr. Vincent tries to save a man's enormous toe; Dr. Schaeffer has his hands full treating a little boy with big demands; a man with incredibly long toes.

Dr. Schaeffer has to straighten a woman's serpentine foot to reset her life, as Dr. Vincent gets a drummer's foot back on the beat.

Dr. Ebonie's skills are tested as she attempts to diagnose a patient with feet covered in huge, wart-like masses; Dr. Brad is confronted with a mystery case that could be related to the elephant man as well as a patient with paper-thin skin.

Nate sees Dr. Brad for help with the raging calluses on his feet; Savannah has a rare condition that made her big toe grow to an enormous size and hopes Dr. Ebonie can help; Dr. Brad is determined to uncover the mystery behind John's foot growth.

A woman undergoes a risky craniotomy; a man searches for answers.

A teenager is rushed to the hospital after taking aspirin to help alleviate altitude sickness; a woman has pain in her arm that mysteriously spreads.

A woman and her husband decide to start a family after numerous negative pregnancy tests; a man appears to suffer an embolism.

A 3-month-old boy has breathing difficulties; a woman has stomach problems; stepping on a crochet hook causes strange problems for a patient.

An infant shows diverse symptoms; an ER nurse gets a diagnosis of lymphoma, before another symptom reveals her true illness.

Twins battle seemingly unrelated illnesses.

A woman and her husband decide to start a family after numerous negative pregnancy tests; a man appears to suffer an embolism.

A 3-month-old boy has breathing difficulties; a woman has stomach problems; stepping on a crochet hook causes strange problems for a patient.

An infant shows diverse symptoms; an ER nurse gets a diagnosis of lymphoma, before another symptom reveals her true illness.

Twins battle seemingly unrelated illnesses.

A woman undergoes a risky craniotomy; a man searches for answers.

A teenager is rushed to the hospital after taking aspirin to help alleviate altitude sickness; a woman has pain in her arm that mysteriously spreads.

Joyce needs home health care and hasn't left the house in three years; getting to Dr. Now in Houston is just the first step and when he prescribes therapy where Joyce must revisit an unhappy past with her mom; it might be more than she can handle.

At over 700 pounds, Teretha's life is confined to a bed, which is a long way from her former job representing Detroit's healthy eating program; a gastric bypass will hopefully save her life.

Milla is bedridden and dependent on her husband and five kids, who can't resist her unending requests for junk food.

Erica must return to California to continue her weight-loss journey, but she fears past emotional trauma will derail her progress.

Erica regrets not keeping a promise to her mom and hopes her siblings will help, but they're reluctant based on her past failures.

Mother of four LaShanta has been bed-bound for two years, and she relies on her kids to keep her cleaned and fed; her last chance to break the cycle of food addiction is to join Dr. Now's program, but it will take a village to get her out the door.

Holly already has one failed weight loss surgery, so to succeed this time, she must do more than change her eating habits, she must address the childhood issues that continue to plague her.

Holly faces a wedding and an operation; Lashanta is not losing weight and when a car crashes through her living room wall her progress is even slower.

Robin and her brother Chris are both obese and already lost a sibling to obesity; they plan to visit Dr. Now together when Chris suffers a stroke and can't go; Chris' son Garrett, already 600 pounds at age 20, is game to join the journey.

Robin and Garrett started their weight-loss journeys together as aunt and nephew; almost four years later, they're like war buddies, striving to reach their target weights through a combination of shedding pounds and skin removal surgeries.

Robin and her brother Chris are both obese and already lost a sibling to obesity; they plan to visit Dr. Now together when Chris suffers a stroke and can't go; Chris' son Garrett, already 600 pounds at age 20, is game to join the journey.

Robin and Garrett started their weight-loss journeys together as aunt and nephew; almost four years later, they're like war buddies, striving to reach their target weights through a combination of shedding pounds and skin removal surgeries.

Holly faces a wedding and an operation; Lashanta is not losing weight and when a car crashes through her living room wall her progress is even slower.

Robert has a small keloid on his ear and a large, snakelike keloid on the back of his head that has been removed and returned three times; Angela has four growths on her head and hides away from those she loves out of embarrassment.

Robert is back to see if Dr. Lee and Dr. Umar can remove his recurring head keloid for good; Justice has small lesions all over her body; Mike has hundreds of lipomas that bring him great discomfort.

Debra has a large, brain-like growth on the side of her head that feels like a sponge, has crevices and emits an odor; Dusten is a cowboy looking to remove the painful lump on his knee; Ramiro has a bump on his jaw that has already been removed once.

Eric hopes Dr. Lee is able to remove the giant growth from his behind; Breanna suffers from itchy dry skin she can't help but scratch; Michael makes jokes, but he knows the bump on his head is anything but funny.

Robert has thousands of unique bumps on his arms that Dr. Lee has never seen; Alexis has a painful cheek cyst that oozes and has a pungent odor; Stuart's cluster of back bumps disgusts his wife but thrills Dr. Lee.

Elaine calls the growth on her love handle her third breast; Jessica's cyst is close to her eye and could be dangerous for Dr. Lee to remove; Dwayne wants his nose bumps removed, but he may not be able to make it through the pain of the procedure.

Dr. Lee faces off with iguana-wrangler Madison's head growths; Chanel suffers from painful cyst tunnels beneath her armpit skin that leak and smell like the food she eats; the dark purple birthmark on Eddie's nose has made him a recluse.

Bob suffers from mysterious open-wound sores all over his body; Virginia's stress-ball-sized lump is such a pain in her neck that she can't wait to have it removed; Ted suffers from flaking, itchy, stucco-like skin and has had no luck finding a cure.

Steven's bump is so large, his daughter thinks he is growing a monster on his back; Catherine's arm lump has grown so big that it's nearly up to her armpit; Ethan suffers from an irritating rash in an uncomfortable and awkward place on his body.

John lost his sight at a young age and soon after began growing lumps on his body. Lynette has hundreds of pebble-sized bumps all over her arms, chest and belly. Gabe cannot imagine going to college with the unsightly mole on the back of his head.

Casey's birthmark covers most of her face, head and neck; James has mysterious massive growths on his inner thigh and lower abdomen; Jerry had to hang up his rock star vocal cords when a lump grew out the side of his throat.

Johnnie's crippling psoriasis keeps him from spending time with his daughter; Aimee has a mohawk of cysts on her head; Edith's face markings and itchy skin condition turn out to be more than she expected.

Elizabeth's head is covered with giant cauliflower-shaped bumps; Jamaal has been growing a strange knob on the left side of his butt since he was just a boy; Donna's cracking, bleeding skin condition has aged her face and kept her from being social.

Kenny was born with a rare condition that causes hundreds of lumps to grow all over his body; Ebonee covers the tiny bumps on her eyes with sunglasses; Paula's painful and swollen feet ooze a substance that emits a foul odor.

Jacqueline's massive shoulder growth makes it difficult for her to do her favorite hobby of fire spinning; the mysterious bump on James' cheek loves to bleed; Mikalia has possessed a bumpy, smelly mass on her head since birth.

After losing his longtime love, Joe wants the large bumps all over his head removed; the itchy, painful rash on Nisa's ears spreads to her face; Jennifer has dark spots all over her face that nobody is allowed to see.

Cedric has a bump on his eye and a painful lump on his neck that have kept him from working; Katherine's large ear cluster puts her neighborhood watch job at risk; Andrea uses makeup to cover the white spots all over her face and body.

Jimmy's flaky, raised alligator skin feels like an itchy hell, and he wants it cured so he can find love; Djuka is a stubborn guy with a stubborn bump; Talina has hundreds of tumors all over her body, causing embarrassment and discomfort.

Jacqueline's massive shoulder growth makes it difficult for her to do her favorite hobby of fire spinning; the mysterious bump on James' cheek loves to bleed; Mikalia has possessed a bumpy, smelly mass on her head since birth.

After losing his longtime love, Joe wants the large bumps all over his head removed; the itchy, painful rash on Nisa's ears spreads to her face; Jennifer has dark spots all over her face that nobody is allowed to see.

Cedric has a bump on his eye and a painful lump on his neck that have kept him from working; Katherine's large ear cluster puts her neighborhood watch job at risk; Andrea uses makeup to cover the white spots all over her face and body.

Jimmy's flaky, raised alligator skin feels like an itchy hell, and he wants it cured so he can find love; Djuka is a stubborn guy with a stubborn bump; Talina has hundreds of tumors all over her body, causing embarrassment and discomfort.

Elizabeth's head is covered with giant cauliflower-shaped bumps; Jamaal has been growing a strange knob on the left side of his butt since he was just a boy; Donna's cracking, bleeding skin condition has aged her face and kept her from being social.

Kenny was born with a rare condition that causes hundreds of lumps to grow all over his body; Ebonee covers the tiny bumps on her eyes with sunglasses; Paula's painful and swollen feet ooze a substance that emits a foul odor.

Gang warfare and a high population of sick patients keep medical center workers on the move in Los Angeles.

The work of the staff at Baylor University Medical Center in Dallas includes a rodeo champion who was trampled by a bull.

Mentally ill son attacks family; horse throws polo-player.

Stuntman has a bike accident; gang-war stabbing; car-crash victims; man gets burned in a camping accident.

The staff of Wishard Memorial Hospital treat accident victims and victims of violence.

Stabbing victim; drunken teen; shooting victim.

A teenager's bulging tummy and stomach pains; a man's own attempted murder; a college coed stops breathing mysteriously.

A man thinks he's constipated; a young woman in cardiac arrest; a patient's family is clueless.

Bizarre fishing injuries; deadly abdominal pains; teenage victims of a car crash.

A student has difficulty breathing; a man impaled by a shovel; a police officer has a heart attack.

A golfer's life-saving surgery; three nearly naked adults in the ER; a patient accidentally shot by his brother.

A elder playboy has a minor injury that turns deadly; a health fanatic's juice diet leaves him in a comatose state; while juggling multiple critical patients, doctors nearly misdiagnose one who has suddenly deteriorated.

A teenage girl sleeps for weeks at a time, a boy with a brain-crushing skull defies the odds and a unique couple faces a big challenge.

A boy with an extra arm growing out of his back; a woman whose knees bend backwards; a tumor in a woman's eye could soon threaten her life.

Foxy's addiction to having enormous breasts has brought her fame, but her friends feel it is also endangering her health.

Weston loves eating raw meat, but his mom is worried it could lead to major health problems; Rachel breastfeeds her husband, Alexander, but it's upsetting to their family and friends; pillow addict Tamara meets car lover Nathaniel.

Kinah's addiction to eating toilet paper threatens her health, and her relationships are also on the line; Nathaniel has taken his love of cars to the extreme; Lisa eats cat hair -- and she just cannot get enough.

Nick and Aubrey's addiction to drinking urine has Nick's mom extremely concerned; Karmello's life has gained new meaning since her addiction to illegal butt injections; Lori's addiction to sleeping with her blow dryer might be affecting someone else.

Foxy's addiction to having enormous breasts has brought her fame, but her friends feel it is also endangering her health.

Weston loves eating raw meat, but his mom is worried it could lead to major health problems; Rachel breastfeeds her husband, Alexander, but it's upsetting to their family and friends; pillow addict Tamara meets car lover Nathaniel.

Kinah's addiction to eating toilet paper threatens her health, and her relationships are also on the line; Nathaniel has taken his love of cars to the extreme; Lisa eats cat hair -- and she just cannot get enough.

Nick and Aubrey's addiction to drinking urine has Nick's mom extremely concerned; Karmello's life has gained new meaning since her addiction to illegal butt injections; Lori's addiction to sleeping with her blow dryer might be affecting someone else.

A teenage girl sleeps for weeks at a time, a boy with a brain-crushing skull defies the odds and a unique couple faces a big challenge.

A boy with an extra arm growing out of his back; a woman whose knees bend backwards; a tumor in a woman's eye could soon threaten her life.

Krystal S. has finally met the man of her dreams, but she won't let herself marry him until she can be sure that she won't become bedridden and force him into the role of caretaker.

Melissa weighs a shocking 673 pounds, and decides to begin her seven-year weight-loss journey toward a healthier life.

Melissa struggles to get to her ideal weight after starting her weight loss journey from 650 pounds with gastric bypass.

Surgery enabled Laura's independence but the complications nearly killed her and she's terrified about the next skin surgery; Chay revealed to her family she was transgender, but living life as an overweight woman.

Latonya found the man she wants to marry; the only problem is that, at almost 700 pounds, she can't walk down the aisle; Latonya doesn't want to give up the food that she's used to, but she may do it for love.

Mother of four LaShanta has been bed-bound for two years, and she relies on her kids to keep her cleaned and fed; her last chance to break the cycle of food addiction is to join Dr. Now's program, but it will take a village to get her out the door.

Lindsey has a white picket fence, a loving husband and a great job, but her food addiction threatens to ruin everything; as she embarks on a weight loss journey to save her life, her husband may provide more harm than support.

Brandon is a talented musician with a beautiful voice and a run-away weight problem; he wants to lose weight and embark on a career; he also wants to take the next step with his girlfriend, Taylor, whom he risks losing if he can't make a change.

Jeanne lives in an unhygienic household with her mother and schizophrenic father; at well over 600 pounds, Jeanne might never get weight-loss surgery as she runs into several obstacles, especially after an unexpected death in her family.

Jeanne struggles to care for herself in the aftermath of her dad's death; Brandon strives to get his weight down to feel confident when proposing to his girlfriend, Tayler, and be the man she deserves.

Jeanne lives in an unhygienic household with her mother and schizophrenic father; at well over 600 pounds, Jeanne might never get weight-loss surgery as she runs into several obstacles, especially after an unexpected death in her family.

Jeanne struggles to care for herself in the aftermath of her dad's death; Brandon strives to get his weight down to feel confident when proposing to his girlfriend, Tayler, and be the man she deserves.

Brandon is a talented musician with a beautiful voice and a run-away weight problem; he wants to lose weight and embark on a career; he also wants to take the next step with his girlfriend, Taylor, whom he risks losing if he can't make a change.

Mark sets out with a goal for weight-loss surgery, but as weight loss gets easier, he turns down medical advice and decides to do it on his own; Mark thinks he can lose 500 pounds by himself, but Dr. Now sees this as another excuse not to change.

Ashley wants to achieve her goal of owning a childcare facility, but must lose weight before her dreams can be met.

Zsaylnn needs to lose weight to be the mother her daughter deserves; her husband loves large women and does not support her goals.

At 24 years old and over 600 lbs, Megan lives at home with her mom, who cooks for her since Megan can't do much on her own; Megan must travel to Houston to meet Dr Now and change her eating habit or her life may end before it ever begins.

Lupe has spent the last 10 years in bed and is totally dependent on her husband, prompting a cross-country move that could save her life or end up backfiring.

When Annjeanette was nine, a campaign was established to send her to fat camp; she hated that her weight had become a source of public shame and she has struggled to overcome her food addiction; now, she must change her habits to save her life.

At over 700 pounds, Brianne undertakes a weight-loss journey to save her own life; she faces an unexpected challenge to her fragile progress when her husband suffers a heart attack on a birthday she will never forget.

There is much to be gained and lost for Brianne in year two of her journey, in which she both loses weight and gains independence; getting back with Erica becomes the top priority for Annjeanette, who chooses love over even her own health.

Doug has lost over 200 pounds and is more involved with his family life. He is now an example of healthy habits, but eating disorders threaten to derail his progress.

After overcoming a dependence on drugs and alcohol, sneaking food is Doug's last remaining vice; this husband and father must overcome his addictive personality to save his life and marriage.

Doug has lost over 200 pounds and is more involved with his family life. He is now an example of healthy habits, but eating disorders threaten to derail his progress.

After overcoming a dependence on drugs and alcohol, sneaking food is Doug's last remaining vice; this husband and father must overcome his addictive personality to save his life and marriage.

There is much to be gained and lost for Brianne in year two of her journey, in which she both loses weight and gains independence; getting back with Erica becomes the top priority for Annjeanette, who chooses love over even her own health.

Weeding through rumors for 15 years, a woman is determined to uncover the truth of her biological mother, only to reveal more unexpected family secrets; identical twin sisters search for their biological mother, unsure if she's even alive.

A woman's world was shaken when she discovered she was adopted at 25, and goes onto learn more dramatic revelations; a mother is in a race against time to find her son who she placed for adoption 46 years ago.

A woman searches for her beloved sister who she tried to adopt herself years ago; after a life of longing, a couple is desperate to find the son they placed for adoption fifty years ago when they were teens.

A man searches for his birth mother, whose disappearance when he was 5 years old has haunted him for his entire life; a woman hoping to meet a member of her biological family faces certain realities about her true past.

Nicky Freeman is 40 years old with the body of a 10-year-old, and Gabby Williams is a 6-year-old who is like a newborn, but doctors do not understand why.

Gabby isn't aging and no one knows why; she is eight years old but looks like a three-month old baby; two new cases have emerged that could reveal the mystery.

A woman gives birth prematurely during Hurricane Sandy; an Army soldier coaches his wife's delivery from Afghanistan; a baby delivered in a shopping mall parking lot.

An emergency birth interrupts a wedding; a woman delivers after crashing her car; a baby with a life-threatening condition is born prematurely.

A baby is born twice; a woman in labor is torn apart by a tornado; a wife gives birth at home.

A woman goes into delivery while in a cab; a life-threatening pregnancy; twin sisters have their babies on the same day.

A best friend's offer to be a surrogate results in a life-threatening pregnancy; a woman is bitten by a deadly snake three weeks before her due date; a cupcake famed for inducing labor.

A woman gives birth while trapped in an elevator; two truckers deliver a baby in a diner; a prolapsed umbilical cord threatens a baby's life.

A man injured by a boat propeller; a deadly chain of events; the ER comes to a standstill.

Two gunshot victims; a jogger goes into a coma; the ER staff becomes detectives.

A newlywed's hand gets stuck in a kitchen appliance; a student with an injury down under; a heavy drinker has complications.

A college student's face covered in a plaster mask; a stroke patient's heart keeps stopping and restarting without intervention.

A patient's violent outbursts; a man's heart fails; a patient with severe burns prays for a miracle.

A patient gets drunk to save his life; a patient is stiff after a fall; a patient tasered by the police; a boy impaled by a bottle rocket in the neck.

A newlywed's hand gets stuck in a kitchen appliance; a student with an injury down under; a heavy drinker has complications.

A college student's face covered in a plaster mask; a stroke patient's heart keeps stopping and restarting without intervention.

A patient's violent outbursts; a man's heart fails; a patient with severe burns prays for a miracle.

A patient gets drunk to save his life; a patient is stiff after a fall; a patient tasered by the police; a boy impaled by a bottle rocket in the neck.

A man injured by a boat propeller; a deadly chain of events; the ER comes to a standstill.

Two gunshot victims; a jogger goes into a coma; the ER staff becomes detectives.

An Arizona teenager slips when he tries to jump a fence; a Louisiana bull rider has a run-in with a bull and barely survives.

A fireworks enthusiast buys illegal explosives that backfire; a father falls asleep at the wheel; a pilot ground tests his gyrocopter.

A man's arm is stuck in the basement furnace; a dirt bike rider takes a deadly blow to the neck; a man crawling under his truck to start it makes a nearly fatal mistake.

A father of nine falls deep into an abandoned mine shaft; a Florida teenager comes face-to-face with an 11-foot alligator; a Michigan woman rides a snowmobile for the first time and loses control.

Horseback-riding accident; broken wrist; crash victims.

Cardiac arrest after a DWI crash; ATV accident; drug overdose.

Brain death; life support; organ donation; transplants.

Shooting victim; teen is severely injured.

A woman suffers crippling sinus pains.

Constant respiratory infections and an inability to grow; mysterious spasms and back pain overcome a man's life.

A woman starts growing uncontrollably.

A baby is born with a series of defects; deadly sore throat.

A woman becomes violently ill after a lifetime of good health.

A woman experiences perpetual stomach pain; another faces extreme fatigue and night sweating while pregnant.

A man is slowly choking to death because of his overgrown face; a boy is born with three arms; family members embrace being born with six fingers on each hand; an obese man strives to lose enough weight to have life-saving surgery.

The world's tallest child can't stop growing; a man learns how to use a dead man's hand; a teenager discovers he has a parasitic twin and it's been growing inside him; a limbless girl gets fitted for prosthetic limbs.

A boy can't stop his giant foot from growing; a woman with bubbly skin and her kids embrace their condition; a dwarf boy who defied the odds has one more challenge to face; a man with a facial tumor must conquer his fear of surgery.

A woman's arm burns from the inside out; a girl undergoes life-changing surgery to stop her neck from dislocating; a boy has a large facial tumor removed; with bonus content.

A man is slowly choking to death because of his overgrown face; a boy is born with three arms; family members embrace being born with six fingers on each hand; an obese man strives to lose enough weight to have life-saving surgery.

The world's tallest child can't stop growing; a man learns how to use a dead man's hand; a teenager discovers he has a parasitic twin and it's been growing inside him; a limbless girl gets fitted for prosthetic limbs.

A boy can't stop his giant foot from growing; a woman with bubbly skin and her kids embrace their condition; a dwarf boy who defied the odds has one more challenge to face; a man with a facial tumor must conquer his fear of surgery.

A woman's arm burns from the inside out; a girl undergoes life-changing surgery to stop her neck from dislocating; a boy has a large facial tumor removed; with bonus content.

A woman becomes violently ill after a lifetime of good health.

A woman experiences perpetual stomach pain; another faces extreme fatigue and night sweating while pregnant.

Lee's anger issues continue to jeopardize his relationship with Rena and threaten to derail both of their weight-loss journeys; a major life event sends Sarah into a depression that she must pull herself out of if she wants to keep losing weight.

Donald has difficulty walking and relies on his parents to take care of him, so he gets motivated to begin his weight loss journey.

Henry hopes to transform himself for his high school reunion, and gastric bypass is the first step to combating his 715 pounds.

For 23 years, Leneatha has worked as a pharmacy tech at a local hospital; now, she has a young daughter to support, but she's so big that it's hard to move; if Dr Now can't help her stop eating, losing her job could be the least of her worries.

Lisa wouldn't have made it this far without the help of her chief enabler, her boyfriend Randy; when Randy falls ill, Lisa finds out if she has the will and determination to turn her life around.

Maja moves to Houston to undertake a difficult weight-loss journey with the support of her boyfriend, Christian; when Christian decides he's had enough and leaves Maja high and dry, she discovers that the only person she can count on is herself.

Maja cannot be allowed to undergo bariatric surgery unless she quits emotional eating. However, it seems like Justin may end up making Dr. Now proud.

At over 600 pounds, Angie is trying to get to Houston to see Dr. Nowzaradan, in hope of getting weight loss surgery to save her life; family conflict and disagreements may stop her from being able to do what she needs before she even gets the chance.

Right when Angie is starting to succeed in Dr. Now's program, her marriage falls apart and her life is thrown into chaos, but she tries to move ahead alone despite dire difficulties.

Right when Angie starts to succeed in Dr. Now's program, her marriage falls apart and her life is thrown into chaos; Angie moves ahead despite dire difficulties, but when her body starts to break down, Angie fears the worst and faces it alone.

Right when Angie is starting to succeed in Dr. Now's program, her marriage falls apart and her life is thrown into chaos, but she tries to move ahead alone despite dire difficulties.

Right when Angie starts to succeed in Dr. Now's program, her marriage falls apart and her life is thrown into chaos; Angie moves ahead despite dire difficulties, but when her body starts to break down, Angie fears the worst and faces it alone.

At over 600 pounds, Angie is trying to get to Houston to see Dr. Nowzaradan, in hope of getting weight loss surgery to save her life; family conflict and disagreements may stop her from being able to do what she needs before she even gets the chance.

Brittney has hundreds of tiny bumps over her chest that have destroyed her confidence; John has a nose the size of a plum and leans on his local family clinic for help; Dr. Lee's friend Raquel drops in and brings out her wild side.

Mike's religious beliefs have kept him from seeing a doctor about his huge growth; Kylie has come to love her birthmark and is torn about whether or not to get it removed; Shad's head bump bursts open and smells like death.

Tyler's hands are so dry, cracked and painful that he considers getting them amputated; Ebonee covers the tiny bumps around her eyes with sunglasses; Ralph feels like a cyst factory with painful cysts covering his back.

Kelly has a massive shoulder growth; Erica stabbed her hand with a pencil 45 years ago and believes the lead remains trapped in her palm; Paula's painful and swollen feet ooze a substance that emits the foulest of odors.

Dr. Lee has a surprise for Paula, who has oozing, odoriferous and painful legs; Mike needs to get rid of the bump on his head before two major life events; Amanda feels inadequate for her husband because of the saggy growth on her back.

Alyse has been suffering from a burning rash that feels like it's rubbing away her existence; Terry has become too big for his britches due to a painful butt cheek lipoma; James has demons on his back that are ruining his life.

Krystal, a witch, looks to clear a curse of a cyst from her face; Keven wants to get a butt lipoma removed to get his tush back into a regular shape; Raquel, Dr. Lee's esthetician BFF, almost suffocates Dr. Lee with love and a facial.

J-Fab is the life of the party, but her shoulder bump is seriously cramping her style; Dan is a gentle giant with lumps on his head that add a few inches; Teresa's red face and bumpy nose make her feel like a monster.

Fit guy Alonso wants to show off his progress in the gym, but his 70 lipomas are holding him back; Porscha is a comic book enthusiast with two symmetrical lumps on her face; Jeffrey has a leaky lump named Larry on the back of his head.

Robert carries the weight of providing for his family and the weight of the huge lump on his head; Christina has liquid-filled growths next to her eyes; Felipe, a photographer with a dry skin condition so severe he risks losing his career.

Natasha has ambitions of becoming a model, but her massive ear keloids are keeping her off the runway; eight-year-old Wynter wants her scaly mermaid skin cured; Dr. Lee's bestie, Raquel, needs help with a new product for a private area.

Nhan has an extreme, red birthmark that covers half his face; Debbie worries that her shoulder lump will prematurely age her; Justin is a dude rockin' a man bun, but he's having no fun due to the bumps poking through his scalp.

Jess is a widower looking for love who is stuck with a giant bump on his neck; Cherish developed a leopard-print face during pregnancy; former NFL defensive tackle Marcell Dareus hopes Dr. Lee can tackle his forehead lipoma.