Tommy wants to lose weight so he can marry his fiancee and have the life he always dreamed of with her, but to break the cycle of pathological eating that left him nearly bed-bound, he'll have to face a piece of his past he has always kept secret.

Dominic's life is falling apart due to his food addiction; over 600 pounds and living in a van with his brother, he decides to leave California for Texas, where only Dr. Now can help him learn to face life's challenges without using food to cope.

At 600 pounds, Ashley has to move home so her mom can help her care for herself and her newborn daughter; Ashley must overcome a lifetime's worth of unfortunate circumstances and get Dr. Now's help in Houston.

Barbara's back lump became more noticeable after she lost 131 pounds; Bob has two painful bumps on his back; Hilda's depression is a result of the multitude of bumps on her eyelids; Art has one big bump on his head that he covers up with hats.

Taylore is a beautiful young woman who has unsightly elf-like bumps on her ears; Jose never goes out because of the baseball-sized lump on his head; Ken is covered in painful bumps that make it difficult to do everyday things.

Angelina has a huge chest lump under her left breast; Delano has a football-sized mass on his back.

Melissa tries to cover a huge lipoma with a sweatshirt for years; Tyler's fear of cancer keep him from having his huge head lumps diagnosed; Tahj is covered in painful boils; Amber has ear keloids that take control of her life.

Ronen's mysterious lump above his knee is one of the largest Dr. Lee has ever seen; Amber suffers from a debilitating skin disease that no one understands; Sandy has a neck lump she calls Tommy; Kristy's eyelid cyst is ruining her life.

Half of Mary's body is a size 18 while the other half is a size 8; Anthony's cyst is in the area called the "Triangle of Death;" Shane wants to get a lump off his back; Brandi is anxious about getting a lump removed from her chest.

Belinda's lump on her neck causes her to basically be immobile; Nicole won't get married until she gets her armpit lump removed; Adela's chest and back are covered in wisdom spots; Nick foolishly removes a lipoma at home and now needs Dr. Lee.

Diane has tumors all over her body that have ruined her life; Will fears his shoulder lump will be ripped open at work; Anthony's daughters force him to get his lump examined; a woman detests her hideous varicose veins.

Taylor has a large bump at the base of her spine that is far more dangerous than she realizes; John jokes about his hip lump, but it's no laughing matter; Noelle had her ears stretched as a teen, but now wants them repaired.

Louis is a veteran who is covered in scaly, dry skin that makes him feel like an alligator; Irais's kids are bullied because of the embarrassing growth on her head; Johnny has been living with a stubborn lump on his back for too long.

Patrick's nose is covered by huge bumps, and he can barely breathe; Aziza and Lauren are friends who bonded over their matching wrist lumps; Joe has a mound in the middle of his forehead that looks like a third eye.

April is covered in bumps that disfigure her arms; Genner flies all the way from the Philippines to have Dr. Lee help with his bumpy nose; Chris suffers from psoriasis that nearly covers his body and a bump on his head.

Matt has a skin condition that causes tumors to grow all over his body; Yamileth hasn't pursued her dreams because of the lump on her neck; Pat is covered with dark spots from her neck to her abdomen; Jennifer has a unicorn bump on her forehead.

Amber has hundreds of tumors on her face; Antonio has a mound on his spine and is afraid it might be impossible to remove; sisters Cheri and Janice both suffer from possibly matching lumps; Tatiana has an embarrassing bump on her butt cheek.

Lisa has a horn growing out of the back of her head and fears that it could be cancer; Victor has a bulbous lump on his chest; Chuck has a Popeye-shaped bump on his arm; Christian and Jonathan are teenage brothers with matching lumps.

Dr. Sandra Lee treats Heather, who has a huge growth on her leg and fears removing it could leave a keloid scar; Paul has a giant hump on his back.

Rhonda has bumps all over her head, including a horned growth that has her deeply concerned; Fred has a mysterious condition on his hands and has not been able to get answers from any doctors; Kevin has a huge lump protruding from his hip.

Jen has substantial growths on her ears that cause her depression, pain and vertigo; Juliet is under emotional distress because of the bumps all over her neck and chest; Gerald has a mysterious, kiwi-size lump on his middle finger.

Lisa has a horn growing out of the back of her head and fears that it could be cancer; Victor has a bulbous lump on his chest; Chuck has a Popeye-shaped bump on his arm; Christian and Jonathan are teenage brothers with matching lumps.

Dr. Sandra Lee treats Heather, who has a huge growth on her leg and fears removing it could leave a keloid scar; Paul has a giant hump on his back.

Rhonda has bumps all over her head, including a horned growth that has her deeply concerned; Fred has a mysterious condition on his hands and has not been able to get answers from any doctors; Kevin has a huge lump protruding from his hip.

Jen has substantial growths on her ears that cause her depression, pain and vertigo; Juliet is under emotional distress because of the bumps all over her neck and chest; Gerald has a mysterious, kiwi-size lump on his middle finger.

Matt has a skin condition that causes tumors to grow all over his body; Yamileth hasn't pursued her dreams because of the lump on her neck; Pat is covered with dark spots from her neck to her abdomen; Jennifer has a unicorn bump on her forehead.

Amber has hundreds of tumors on her face; Antonio has a mound on his spine and is afraid it might be impossible to remove; sisters Cheri and Janice both suffer from possibly matching lumps; Tatiana has an embarrassing bump on her butt cheek.

Follows Maria and Teresa Tapia, conjoined twins from the Dominican Republic, as they travel to Richmond, Virginia to undergo separation surgery.

Stories of three very different sets of twins incorporate their lives since being surgically separated.

Kendra Herrin and her sister, Maliyah, were born attached at the abdomen and pelvis; doctors use a groundbreaking surgical procedure to separate the girls.

A newlywed couple is moving cross-country when the young wife, not knowing she is pregnant, discovers she is in labor.

Victoria suddenly goes into labor at her mother-in-law's house, never suspecting she was pregnant.

Ressa collapses and goes into a coma after a miscarriage five months earlier; she has an eclamptic seizure caused by her full term baby.

Alicia barely survives a harrowing car accident. Then, just 18 months later, a surprising pregnancy threatens the life of her newborn.

Melissa is rushed to the hospital thinking she might be having a miscarriage; she gives birth to an unexpected baby in the backseat.

Jenna is rushed to the hospital to find out she is in labor and at a hospital that hasn't delivered a baby in 15 years.

A student's head is impaled by a trophy deer's antlers; a semi-conscious car crash victim; a woman with an allergic reaction.

A man injured in a medieval role playing battle has a sword impaled in his head; a critically ill patient is so afraid of germs he won't allow doctors to treat him; two patients with the same life-threatening symptoms.

A doctor treats three gunshot victims who claim be innocent bystanders; a doctor must perform emergency brain surgery on his first day; a bride-to-be suddenly slips into a diabetic coma.

A woman stops eating because she believes she is dead; a runner goes blind in one eye during a marathon; an ER tech's stroke-like symptoms.

A woman believes her neighbors want to kill her; a man is near death after an arrow pierces his chest; two women with swollen abdomens refuse to explain the cause of their pain.

A circus sword-swallower suffers from a persistent case of hiccups; a mother and daughter mysteriously collapse in the ER; a woman loses control of her legs at her daughter's graduation.

A woman who slept through the birth of her child, hopes to find a diagnosis for her sleeping condition; a man with giant genitals seeks help; a 2.5ft teenager hopes to find out what stalled his growth.

A boy born with no eyes; a separated conjoined twin adjusts to life after losing his twin brother; two brothers suffer from a very rare bone condition; a boy living with a huge facial growth finally gets a diagnosis.

In India, Hemlata Singh, gave birth to a boy with the head and arms of his dead twin attached to his chest; doctors try to save the newborn and separate him from his sibling's body.

A girl's rare disorder causes her eyes to fall out of her head; a man who grows branches from his hands and feet hopes to return home; a baby with a large face tumor.

The world's tiniest brothers find out if they'll ever be able to grow; conjoined twins seek separation surgery; a boy has a rare brain tumor; a girl living with a face tumor embraces her condition.

An unknown syndrome ages two boys rapidly; a man with a basketball sized tumor gets surgery; a woman with a giant leg finds love.

In India, Hemlata Singh, gave birth to a boy with the head and arms of his dead twin attached to his chest; doctors try to save the newborn and separate him from his sibling's body.

A girl's rare disorder causes her eyes to fall out of her head; a man who grows branches from his hands and feet hopes to return home; a baby with a large face tumor.

An unknown syndrome ages two boys rapidly; a man with a basketball sized tumor gets surgery; a woman with a giant leg finds love.

A woman who slept through the birth of her child, hopes to find a diagnosis for her sleeping condition; a man with giant genitals seeks help; a 2.5ft teenager hopes to find out what stalled his growth.

A boy born with no eyes; a separated conjoined twin adjusts to life after losing his twin brother; two brothers suffer from a very rare bone condition; a boy living with a huge facial growth finally gets a diagnosis.

Melissa has isolated herself at home and lost many friends to avoid feeling the shame of what her food addiction has done to her body; now, the only way to get her life back is to leave it behind to start a new one with Dr. Now's help in Houston.

Zsaylnn needs to lose weight to be the mother her daughter deserves; her husband loves large women and does not support her goals.

A woman battles severe depression and has not left her Chicago basement in two years; the hope of having a life-changing surgery.

Kenae' is already big before her weight gain takes off after the death of her beloved mother; refusing to deal with the pain, Kenae' turns to food to fill the void.

Krystal begins overeating to shield herself with a protective layer of obesity after suffering years of abuse; once a means of protection, her pathological eating now threatens to destroy her life if she doesn't get help.

Isaac helped raise his siblings after his mom suffered a debilitating stroke when he was 10. While learning to cook for his family, he began comfort-eating. Now to avoid eating himself to death, Isaac must learn to take care of himself for a change.

A lifetime of abuse has left Michael anxious and afraid to leave the house; with the help of his devoted wife, he must follow Dr. Now's program to keep from eating himself to death.

Shannon's husband loves her the way she is, but that may not help because she's 700 pounds and bedridden; Dr. Now knows it's not easy to break a toxic cycle of overfeeding and enabling, but that's what needs to happen if Shannon wants to live.

Irene had to move back in with her son because her weight made it unbearable to live on her own. When Dr. Now can't get through to her, the only thing that might help her break the cycle is a once-in-a-lifetime turn of events.

Through tough times, food has always been Tammy's friend; now she has gotten so big that her daughters and mother have moved home to care for her, and unless Dr. Now can get her to confront her grief, food might be her killer.

Irene had to move back in with her son because her weight made it unbearable to live on her own. When Dr. Now can't get through to her, the only thing that might help her break the cycle is a once-in-a-lifetime turn of events.

Through tough times, food has always been Tammy's friend; now she has gotten so big that her daughters and mother have moved home to care for her, and unless Dr. Now can get her to confront her grief, food might be her killer.

Shannon's husband loves her the way she is, but that may not help because she's 700 pounds and bedridden; Dr. Now knows it's not easy to break a toxic cycle of overfeeding and enabling, but that's what needs to happen if Shannon wants to live.

James B, grew up eating rich Haitian food and loves it with a passion; James needs Dr. Now's help to diminish that love in order to survive, but a death in the family sends James retreating back to the comforts he knows.

Christina has not left her house in two years due to her size; she has eaten herself into a state that will soon kill her if she does not change.

James comes from a long line of family obesity; he is determined not to die as his sister and father did; he hopes to get gastric bypass and even start dating again.

Living with his family, Lucas wants to spread his wings and fly, but at 600 pounds, he can't take off. All he does is eat and game, and if he wants to leave the nest and live a normal life, he needs Dr. Now's help to lose over 400 pounds.

Margaret's life at 700 pounds is in need of a jump-start; at age 35, she is a mama's girl; it's time for Margaret to get out of bed, overcome her food addiction and break away from the comfort of her mother so she can finally live her life.

At 700 pounds, Ontreon has managed to keep going thanks to his faith in God, and he's training to become a minister; Onteon is hopeful but has to believe in himself.

Dolly has pain all over, and the skin apron pulling on her abdomen is miserable, but her mom and others wait on her hand and foot.

Lisa wouldn't have made it this far without the help of her chief enabler, her boyfriend Randy; when Randy falls ill, Lisa finds out if she has the will and determination to turn her life around.

Growing up in foster care, David suffered from a lack of attention and didn't develop a sense of self-worth; now he's relying on his favorite foster mom to support him as he finds the motivation to change and save his own life.

As an Italian American, Geno was raised with lots of love, family and food; now, he's still living with his mom and eating himself to death, and it's time to make a change; Geno's cousin, Nico, joins the cause; they pledge to lose weight together.

Growing up in foster care, David suffered from a lack of attention and didn't develop a sense of self-worth; now he's relying on his favorite foster mom to support him as he finds the motivation to change and save his own life.

As an Italian American, Geno was raised with lots of love, family and food; now, he's still living with his mom and eating himself to death, and it's time to make a change; Geno's cousin, Nico, joins the cause; they pledge to lose weight together.

Lisa wouldn't have made it this far without the help of her chief enabler, her boyfriend Randy; when Randy falls ill, Lisa finds out if she has the will and determination to turn her life around.

Lisa helps a man find his birth mother, hoping to answer why she placed him for adoption, but kept his three brothers; after turning to psychics for answers, a woman seeking details about her birth mom hopes Chris can separate truth from fiction.

A dramatic turn of events takes place as Chris and Lisa investigate two seemingly different cases; a chance discovery raises the tantalizing prospect that the mother and son they are helping may be looking for one another.

Lisa helps a woman locate her son, hoping to heal the broken heart she's had since placing him for adoption decades ago; a tragic beginning of a woman's life with her mother dying in childbirth has Chris searching for her father.

Lisa helps a man locate his birth mother hoping to answer why she chose to marry a man who didn't want to raise him; a woman searches for the biological mother who abandoned her at a babysitter's house when she was three months old.

A 16-year-old's behavioral issues may cause her to be expelled; daycare fees may force another student to leave school.

Florence's first prom; campaign to be prom queen.

A student struggles with self-esteem, weight issues and a son who has behavioral problems; a first time mom-to-be attempts to repair her relationship with her own mother.

Traci is pregnant and desperate to move back home, but it's filled floor to ceiling with her mother's stuff.

Medical responders were not able to get in Renee's front door after she had fallen unconscious in her home.

Donny has been to jail twice because of his hoard; Joyce finds comfort in her doll collection, while others see it as creepy.

It takes less than a week for 16-year old Haley to fill a bedroom with stuff; her parents hope that a visit with an extreme hoarder will scare their daughter straight.

Larina's compulsive hoarding puts her on the verge of losing her 10-year-old daughter.

An ER doctor's friend arrives at the hospital combative and out of control; a cyclist's throat is torn open when a driver opens a car door in her path; a nursing student is found passed out on the hospital floor.

A young girl is mysteriously paralyzed from the waist down; a young man complains of a splitting headache; a bride-to-be has appendicitis on her wedding day.

Doctors use a robot to treat a seizing 7-year-old boy; a chef's tongue is swelling; a woman who crashed her car insists her injured dog be treated first.

A man with a slashed wrist has a startling secret; a woman gives birth unexpectedly, shocking the ER staff; a surgeon requires urgent treatment after falling off a bed while trying to help his patient.

A young boy at a sleepover party mysteriously loses control over his arms and legs; a woman is shot in the leg at her own bachelorette party; bubbles in a woman's arteries are causing a stroke.

A patient suddenly starts seizing; an ER physician is at a restaurant when she is thrown into an emergency situation to save a child; a pregnant woman's heart is racing.

Doctors use a robot to treat a seizing 7-year-old boy; a chef's tongue is swelling; a woman who crashed her car insists her injured dog be treated first.

A man with a slashed wrist has a startling secret; a woman gives birth unexpectedly, shocking the ER staff; a surgeon requires urgent treatment after falling off a bed while trying to help his patient.

A young boy at a sleepover party mysteriously loses control over his arms and legs; a woman is shot in the leg at her own bachelorette party; bubbles in a woman's arteries are causing a stroke.

A patient suddenly starts seizing; an ER physician is at a restaurant when she is thrown into an emergency situation to save a child; a pregnant woman's heart is racing.

An ER doctor's friend arrives at the hospital combative and out of control; a cyclist's throat is torn open when a driver opens a car door in her path; a nursing student is found passed out on the hospital floor.

A young girl is mysteriously paralyzed from the waist down; a young man complains of a splitting headache; a bride-to-be has appendicitis on her wedding day.

Season 1 skin removal patients try to cope with life one year after undergoing near total body transformations.

Checking in with Season 2 folks who have undergone agonizing surgeries to remove over 100 pounds of excess skin.

Checking in with season two folks who have undergone agonizing surgeries to remove over 100 pounds of excess skin.

Stephanie and her mom Darcy lost a combined weight of 320 lbs.; BJ overcame drug and food addiction to lose 350 lbs. and his body is now covered with excess skin.

A year after the Anderson family started their weight loss journey, they find that the honeymoon period is over as they begin to struggle; their 600-pound cousin Shavonne wants to follow in their footsteps.

Shavonne calls out the family for not losing weight; Naomi gets devastating news that might derail her goals for good; Drew attempts to re-enter the dating world for the first time in a decade; Chitoka tries to get back on track.

The members of the Anderson family work through their issues in group therapy; Chitoka and Shavonne face the painful memories that have kept them from losing more weight.

Shavonne undergoes high-risk bariatric surgery; Chitoka struggles to lose enough weight to be approved for skin tightening surgery; Drew works up the courage to go on another date; the family throws a party for Shavonne to reveal her weight loss.

Fall from a ladder; young car-crash victims.

Gunshot victims; homeless children with colds; seizure; stroke victim.

A family of three and the drunk driver who hit them; burn victim; crash victim; baby with sickle-cell anemia.

Car-crash victims; smoker fights for breath; uncooperative patient.

Baby Samantha has surgery to remove congenital cataracts that could lead to blindness; as the months pass, Samantha is unable to roll, crawl or talk, and her head is unusually small for her age; her parents seek help.

A baby's gaze is fixed on the ceiling; a woman's bruise will not disappear.

An elderly woman cannot walk straight; a baby cries incessantly.

A woman's legs may need amputation; one side of a woman's face is numb.

A man gains 100 pounds of water weight.

A woman has pain with her menstrual cycle; growths on body.

An elderly woman cannot walk straight; a baby cries incessantly.

A woman's legs may need amputation; one side of a woman's face is numb.

A man gains 100 pounds of water weight.

A woman has pain with her menstrual cycle; growths on body.

Baby Samantha has surgery to remove congenital cataracts that could lead to blindness; as the months pass, Samantha is unable to roll, crawl or talk, and her head is unusually small for her age; her parents seek help.

A baby's gaze is fixed on the ceiling; a woman's bruise will not disappear.

Having her daughters help bathe her is not how Chrystal pictured parenting but she is so large that there's no other option; Chrystal wants Dr. Now's help but she didn't know that bringing her childhood trauma to light would be part of the deal.

Penny has been bedridden for four years and moves to Texas to have gastric bypass; her unwillingness to make lifestyle changes could mean failure.

Chuck weighs almost 700 pounds; he has had to downsize his business and his wife feels like a single-parent who is ready to leave him.

Ryan moved to Montana to keep himself from going down a dark path of drug addiction but his new path may be no less lethal than the last if he can't find a way to curb his eating habits before they kill him.

Paul weighs in at 700 pounds, and his girlfriend struggles with how this limits their ability to live a normal life; he thinks their relationship won't survive if he moves to work with Dr. Now, but prioritizing his own health is the only option.

When Nathan's weight gets in the way of his job as a drama teacher, it's a wake-up call for him; changing his life might mean a falling out with his wife, Amber, who is also overweight, unless she can lose, too.

Lacey is so big from overeating that she can barely leave the house, but that hasn't stopped her from finding love with Ricky; Lacey's weight isn't the only thing between her and a happy husband, however, with Ricky's sister Sharon in the picture.

For Julian and his wife, Irma, it was love at first sight; in order to grow old together, Julian will have to overcome the food addiction that made him more than 800 pounds.

Bianca is all in for a move to Houston with her boyfriend and two young kids to get Dr. Now's help with a second weight-loss surgery.

Mike was born with a talent for sports and an omnivorous appetite to match; after his football dreams were dashed by multiple concussions, Mike packed on over 700 pounds, now he must find a new purpose in life to avoid succumbing to pain and regret.

Bianca is all in for a move to Houston with her boyfriend and two young kids to get Dr. Now's help with a second weight-loss surgery.

Mike was born with a talent for sports and an omnivorous appetite to match; after his football dreams were dashed by multiple concussions, Mike packed on over 700 pounds, now he must find a new purpose in life to avoid succumbing to pain and regret.

For Julian and his wife, Irma, it was love at first sight; in order to grow old together, Julian will have to overcome the food addiction that made him more than 800 pounds.

Gerald is back to see Dr. Lee and a hand specialist about a huge, intrusive bump on his middle finger; Vinnie has a large, embarrassing birthmark on his neck; Leta has a lump on the back of her thigh that she has been hiding from her fiancée.

Tony has large growths on his nose that impair his breathing; Kevin has a bump in his jawline that is a lady deterrent; Marie has an unsightly lump on her forehead that makes her a hermit; Tommy's leg bump makes it difficult for him to work.

Gerard has nearly a hundred lumps varying in size all over his body; Gina has bloody lesions all over; Eric has a large bump on his head that he calls his on and off button.

Traci's confidence has been destroyed after years of bullying from the bumps on her face; Ravon has a unique dangling growth on his leg; David has a large lump.

David is back to see Dr. Lee after she spots a suspicious growth under his eye; Nicole is depressed because of the bumps all over her neck; Steve has a noticeable lump on his forehead; Allen has a growth on his biceps but is terrified of doctors.

Tim has a massive growth on his back that affects his ability to work and socialize; Daniel has debilitating psoriasis that covers most of his body; Gloriana and Yolanda are a mother and daughter duo who have bonded over their bumps.

Inoke has a huge, possibly life-threatening bulge on his shoulder; Delano returns with his back lump after Dr. Lee removed a liter of fluid from it; Reed has hundreds of bumps on his chest that burst and leave nasty scars.

With pandemic safety protocols in place, Dr. Lee reopens her office; Monica has a large birthmark growing on the side of her face; Jackie has a melon-sized lump on the back of her shoulder; Reginald has large, rare growths on the back of his head.

Dr. Lee tries to provide the help Reginald needs to remove the large, rare growths on the back of his head; Che'Re has a prominent bump on her face that has put her in a dark place; Juan has several painful boils on the back of his neck.

Dennis has several giant growths on the back of his head; Juan has a rare condition he hopes Dr. Lee will understand; Natalie searches for answers as to why her body is covered in hundreds of mysterious dark bumps.

Audrey pops the painful bumps that cover her body so she can feel relief; Felicia has a peculiar-looking dark growth on her forehead; Krista's excessive sweating is so severe that on any given day she could fill up an entire milk jug with her sweat.

John fears the large lump on his neck could become so big that it may eventually suffocate him; Shoshana is depressed because of the big growth on her forehead; Ashley hopes Dr. Lee can provide some relief from her three painful skin conditions.

Yaellie, 9, has itchy psoriasis on over 90 percent of her body; former U.S. Marine Matt has a large recurring lump in his armpit; twins Tracie and Stacie have numerous matching bumps on their heads that sometimes leak.

Joanne has been held back from success because of her forehead growth; Shakisaha split her left earlobe after stretching it with gauges; Mike is a tough guy with a soft bump on his head; Dania's rhinophyma has kept her from enjoying her life.

James has a large, squishy lump on his forehead; Tanisha has a growth on her arm and itchy scars all over her body; Ed wants his stomach lump removed before his girlfriend gets out of prison; Justin has painful mystery bumps all over his head.

JD is a gentle giant with a pear-shaped mass hanging off of his ear; David has two bumps on his neck and one on his finger that give him pain; Julie hopes Dr. Lee can remove her large back growth so she can return to the sea.

Stephen's large, bulbous nose gets him unwanted attention, and he hopes Dr. Lee can help; Veronica wants to be free of secrets, including the bump on her butt; Marty has a large, 30-year-old growth on his shoulder that he is ready to remove.

Brittany has been called a monster due to her genetic condition that causes head-to-toe bumps; Leonardo has a fist-size growth on his head, but he is terrified of doctors; Tamyra has skin so thick that she shaves the bottom of her feet for relief.

James has a large, squishy lump on his forehead; Tanisha has a growth on her arm and itchy scars all over her body; Ed wants his stomach lump removed before his girlfriend gets out of prison; Justin has painful mystery bumps all over his head.

JD is a gentle giant with a pear-shaped mass hanging off of his ear; David has two bumps on his neck and one on his finger that give him pain; Julie hopes Dr. Lee can remove her large back growth so she can return to the sea.

Stephen's large, bulbous nose gets him unwanted attention, and he hopes Dr. Lee can help; Veronica wants to be free of secrets, including the bump on her butt; Marty has a large, 30-year-old growth on his shoulder that he is ready to remove.

Brittany has been called a monster due to her genetic condition that causes head-to-toe bumps; Leonardo has a fist-size growth on his head, but he is terrified of doctors; Tamyra has skin so thick that she shaves the bottom of her feet for relief.

Yaellie, 9, has itchy psoriasis on over 90 percent of her body; former U.S. Marine Matt has a large recurring lump in his armpit; twins Tracie and Stacie have numerous matching bumps on their heads that sometimes leak.

Joanne has been held back from success because of her forehead growth; Shakisaha split her left earlobe after stretching it with gauges; Mike is a tough guy with a soft bump on his head; Dania's rhinophyma has kept her from enjoying her life.

Riah has been addicted to baby wipes since she was 15 and goes through 500 a day, using them instead of showering; Brea has been addicted to eating sand for the past five years.

Danielle has been addicted to vapor rub for more than 20 years, going through more than 30 jars, inhalers and patches every week; 19-year-old Allison has been eating tires for the past six years, consuming 14 pounds every month.

Keisha is addicted to chewing on urine-soaked diapers; 50-year-old Vladimir is obsessed with using leeches.

Tom spends at least six hours a day cycling; Divya spends her time searching for dead animals on the side of the road and stuffing them.

Theresa has been eating rocks for more than 20 years and cannot stop; Tamara carries around her childhood pillow Boo everywhere she goes.

Meet Kailyn has been eating plastic every day for more than eleven years; meet Gloria who has taken her addiction to bleach to the extreme by bathing in it daily.

Caryn eats over 900 cat treats and several cans of wet food every day; Alicia is addicted to smelling mothballs for 15 years, keeping them all over her house and in her purse.

Bertha's addition to nail polish has her drinking up to five bottles everyday for five years; Jamie can't stop digging in her ears.

Kirstie's addiction to dirt has her eating it everyday for the past 30 years; Ayanna can't stop growing her toenails.

Jillian has been addicted to smelling pine cleaner for two years and can't go more than 15 minutes without a smell; Scott is obsessed with picking up dead animals from the road.

Trina and her husband Mike have done nearly 7,000 coffee enemas over the last two and a half years; Lisa has been addicted to licking her cat and eating clumps of hair for three years.

Asha hasn't cut her 21-foot long hair for nearly 25 years and spends up to 6 hours a day grooming her ten-pound locks; Margaret has stung herself over 50,000 times with bees.

A family of four is on the brink of collapse under the weight of the parents' hoarding; a man denies he's addicted to auctions and garage sales.

Two women seek help for their compulsive hoarding problems.

Bennie and Rhonda have lived decades of compulsive hoarding that have driven their loved ones away.

Laura and Margaret are both mothers and extreme hoarders; their parallel obsessions have made them prisoners in their own homes while tearing their families apart.

Deborah and Mary both start hoarding in the wake of personal tragedies; ever since Deborah killed her drug-addicted boyfriend in self-defense, she and her son have lived amid growing piles of trash and unused possessions.

9/11 trauma was the trigger for one woman; the lasting effects of a brain hemorrhage.

A man whose body is eating itself hopes surgery can cure him and save his life; a gymnast who lost her leg to cancer hopes her new prosthetic will keep her performing; the shortest living man in the world looks for a diagnosis.

A man who had a full-face transplant faces another life-threatening challenge; a boy with a talent for singing is prematurely aging; in a Peruvian village, boys and men go blind by the age of 50.

A man undergoes surgery to remove his record-breaking face tumor; a young girl lives with huge hands; a mathematician born with severely deformed legs and a spine walks on all fours.

A woman hopes the tooth transplanted in her eye will stop her from going blind; conjoined twins share a single body; a boy with gigantism in his legs turns to doctors for a cure; a mother has surgery to remove the massive fatty tumors in her neck.

Doctors seek to restore the face of a little girl with a giant facial cleft; a pregnant little person and her husband find out if their son will have two forms of dwarfism; a woman's face is slowly being destroyed by a tumor.

Doctors attempt to separate twins who were born joined at the head; a woman with a rare brittle bone disorder doesn't let her disease control her life; a man with a huge facial tumor undergoes major surgery to save his life.

A man undergoes surgery to remove his record-breaking face tumor; a young girl lives with huge hands; a mathematician born with severely deformed legs and a spine walks on all fours.

A woman hopes the tooth transplanted in her eye will stop her from going blind; conjoined twins share a single body; a boy with gigantism in his legs turns to doctors for a cure; a mother has surgery to remove the massive fatty tumors in her neck.

Doctors seek to restore the face of a little girl with a giant facial cleft; a pregnant little person and her husband find out if their son will have two forms of dwarfism; a woman's face is slowly being destroyed by a tumor.

Doctors attempt to separate twins who were born joined at the head; a woman with a rare brittle bone disorder doesn't let her disease control her life; a man with a huge facial tumor undergoes major surgery to save his life.

A man whose body is eating itself hopes surgery can cure him and save his life; a gymnast who lost her leg to cancer hopes her new prosthetic will keep her performing; the shortest living man in the world looks for a diagnosis.

A man who had a full-face transplant faces another life-threatening challenge; a boy with a talent for singing is prematurely aging; in a Peruvian village, boys and men go blind by the age of 50.

Latonya found the man she wants to marry; the only problem is that, at almost 700 pounds, she can't walk down the aisle; Latonya doesn't want to give up the food that she's used to, but she may do it for love.

Paula has built a wall around herself to push people away; when she suddenly loses a loved one she can no longer ignore the threat of losing her own life.

A mother of two who is too ashamed of her size to be seen with her children; she is committed to regaining her confidence and being a proud mother.

Wess gets off to a great start in Dr. Now's program, but when the cravings continue after surgery, Dr. Now sends him to therapy to confront his demons; Wess must ask himself whether he is ready to live his truth as a gay man in small-town Texas.

Syreeta thinks that anyone trying to help has an ulterior motive, but she's gotten so big she desperately needs help; she's learning to let down her guard for her husband, but weight-loss surgery will be tough if she can't learn to trust the surgeon.

Mark sets out with a goal for weight-loss surgery, but as weight loss gets easier, he turns down medical advice and decides to do it on his own; Mark thinks he can lose 500 pounds by himself, but Dr. Now sees this as another excuse not to change.

With her weight spiraling, Stephanie needs her mom's help to care for her three kids; she's at the point where she'll have to lose weight or risk not having the chance to see her kids grow up.

Nothing means more to Chris than his relationship with his daughter, Zoey, but now he feels he is failing her as his weight gain begins to limit his mobility.