Jessica is stricken with chills, fever, and migraines; Jake starts military training and finds painful lumps on his body.

A baby has strange spots all over; a dad's muscle weakness.

A woman suddenly loses a breast; a baby cries and vomits when fed.

After moving houses, and months of strange behavior, 11-year-old Sammy stops walking and only hops. Can doctors bring him out of the bizarre world he is slipping into?

Jessica is stricken with chills, fever, and migraines; Jake starts military training and finds painful lumps on his body.

A baby has strange spots all over; a dad's muscle weakness.

Brain death; life support; organ donation; transplants.

Shooting victim; teen is severely injured.

After a year on a weight loss program, Steven remains completely non-compliant and Justin focuses on a new career instead of his diet, but time is quickly running out for surgery.

A woman struggles to make a positive change to be part of her partner and son's lives and turn her life around.

An overweight woman struggles with flesh-eating bacteria and butterfly shaped fat deposits; unexpected news threatens her weight loss journey.

A college graduate with a once-promising career, Justin has eaten his life away to the point of never leaving the house for anything but food; only the help of Dr. Now's weight-loss program can restore his hopes of living a happy, productive life.

Holly already has one failed weight loss surgery, so to succeed this time, she must do more than change her eating habits, she must address the childhood issues that continue to plague her.

Lacey ballooned up over 600 lbs on pizza and ice cream and knows Dr. Now is her best hope for success; she must now rally her divorced parents around her for support and find a way to modulate her moods that won't include binge-eating.

Brandon is a talented musician with a beautiful voice and a run-away weight problem; he wants to lose weight and embark on a career; he also wants to take the next step with his girlfriend, Taylor, whom he risks losing if he can't make a change.

When Nathan's weight gets in the way of his job as a drama teacher, it's a wake-up call for him; changing his life might mean a falling out with his wife, Amber, who is also overweight, unless she can lose, too.

Lacey is so big from overeating that she can barely leave the house, but that hasn't stopped her from finding love with Ricky; Lacey's weight isn't the only thing between her and a happy husband, however, with Ricky's sister Sharon in the picture.

For Julian and his wife, Irma, it was love at first sight; in order to grow old together, Julian will have to overcome the food addiction that made him more than 800 pounds.

Lacey is so big from overeating that she can barely leave the house, but that hasn't stopped her from finding love with Ricky; Lacey's weight isn't the only thing between her and a happy husband, however, with Ricky's sister Sharon in the picture.

For Julian and his wife, Irma, it was love at first sight; in order to grow old together, Julian will have to overcome the food addiction that made him more than 800 pounds.

When Nathan's weight gets in the way of his job as a drama teacher, it's a wake-up call for him; changing his life might mean a falling out with his wife, Amber, who is also overweight, unless she can lose, too.

Robert is back to see if Dr. Lee and Dr. Umar can remove his recurring head keloid for good; Justice has small lesions all over her body; Mike has hundreds of lipomas that bring him great discomfort.

Debra has a large, brain-like growth on the side of her head that feels like a sponge, has crevices and emits an odor; Dusten is a cowboy looking to remove the painful lump on his knee; Ramiro has a bump on his jaw that has already been removed once.

Eric hopes Dr. Lee is able to remove the giant growth from his behind; Breanna suffers from itchy dry skin she can't help but scratch; Michael makes jokes, but he knows the bump on his head is anything but funny.

Robert has thousands of unique bumps on his arms that Dr. Lee has never seen; Alexis has a painful cheek cyst that oozes and has a pungent odor; Stuart's cluster of back bumps disgusts his wife but thrills Dr. Lee.

Elaine calls the growth on her love handle her third breast; Jessica's cyst is close to her eye and could be dangerous for Dr. Lee to remove; Dwayne wants his nose bumps removed, but he may not be able to make it through the pain of the procedure.

Dr. Lee faces off with iguana-wrangler Madison's head growths; Chanel suffers from painful cyst tunnels beneath her armpit skin that leak and smell like the food she eats; the dark purple birthmark on Eddie's nose has made him a recluse.

Bob suffers from mysterious open-wound sores all over his body; Virginia's stress-ball-sized lump is such a pain in her neck that she can't wait to have it removed; Ted suffers from flaking, itchy, stucco-like skin and has had no luck finding a cure.

Steven's bump is so large, his daughter thinks he is growing a monster on his back; Catherine's arm lump has grown so big that it's nearly up to her armpit; Ethan suffers from an irritating rash in an uncomfortable and awkward place on his body.

John lost his sight at a young age and soon after began growing lumps on his body. Lynette has hundreds of pebble-sized bumps all over her arms, chest and belly. Gabe cannot imagine going to college with the unsightly mole on the back of his head.

Casey's birthmark covers most of her face, head and neck; James has mysterious massive growths on his inner thigh and lower abdomen; Jerry had to hang up his rock star vocal cords when a lump grew out the side of his throat.

Johnnie's crippling psoriasis keeps him from spending time with his daughter; Aimee has a mohawk of cysts on her head; Edith's face markings and itchy skin condition turn out to be more than she expected.

Elizabeth's head is covered with giant cauliflower-shaped bumps; Jamaal has been growing a strange knob on the left side of his butt since he was just a boy; Donna's cracking, bleeding skin condition has aged her face and kept her from being social.

Kenny was born with a rare condition that causes hundreds of lumps to grow all over his body; Ebonee covers the tiny bumps on her eyes with sunglasses; Paula's painful and swollen feet ooze a substance that emits a foul odor.

Jacqueline's massive shoulder growth makes it difficult for her to do her favorite hobby of fire spinning; the mysterious bump on James' cheek loves to bleed; Mikalia has possessed a bumpy, smelly mass on her head since birth.

After losing his longtime love, Joe wants the large bumps all over his head removed; the itchy, painful rash on Nisa's ears spreads to her face; Jennifer has dark spots all over her face that nobody is allowed to see.

Cedric has a bump on his eye and a painful lump on his neck that have kept him from working; Katherine's large ear cluster puts her neighborhood watch job at risk; Andrea uses makeup to cover the white spots all over her face and body.

Jimmy's flaky, raised alligator skin feels like an itchy hell, and he wants it cured so he can find love; Djuka is a stubborn guy with a stubborn bump; Talina has hundreds of tumors all over her body, causing embarrassment and discomfort.

Brittney has hundreds of tiny bumps over her chest that have destroyed her confidence; John has a nose the size of a plum and leans on his local family clinic for help; Dr. Lee's friend Raquel drops in and brings out her wild side.

After losing his longtime love, Joe wants the large bumps all over his head removed; the itchy, painful rash on Nisa's ears spreads to her face; Jennifer has dark spots all over her face that nobody is allowed to see.

Cedric has a bump on his eye and a painful lump on his neck that have kept him from working; Katherine's large ear cluster puts her neighborhood watch job at risk; Andrea uses makeup to cover the white spots all over her face and body.

Jimmy's flaky, raised alligator skin feels like an itchy hell, and he wants it cured so he can find love; Djuka is a stubborn guy with a stubborn bump; Talina has hundreds of tumors all over her body, causing embarrassment and discomfort.

Brittney has hundreds of tiny bumps over her chest that have destroyed her confidence; John has a nose the size of a plum and leans on his local family clinic for help; Dr. Lee's friend Raquel drops in and brings out her wild side.

Kenny was born with a rare condition that causes hundreds of lumps to grow all over his body; Ebonee covers the tiny bumps on her eyes with sunglasses; Paula's painful and swollen feet ooze a substance that emits a foul odor.

Jacqueline's massive shoulder growth makes it difficult for her to do her favorite hobby of fire spinning; the mysterious bump on James' cheek loves to bleed; Mikalia has possessed a bumpy, smelly mass on her head since birth.

Boys Giovanni and Owen share the rare condition Schwartz Jampel Syndrome, which permanently and painfully contracts their muscles; the two share hardships and triumphs, and strike up a friendship.

Tiffany and Destiny both live with the rare disease Osteogenesis Imperfecta, which causes brittle bones, and set out on a life changing journey to meet each other.

An inebriated husband's idea to get his wife in the mood; using a treat in a new explosive way; a quickie in the car leads one couple to the emergency room.

A clumsy couple loses something while playing in the bedroom; uncontrollable passion and ice cream; a hot time on the Fourth of July.

A couple's video game fantasy has embarrassing results; a young man's itchy crotch; a couples private passion on lover's lane turns to a dangerous accident.

Freeing a man from a painful steel ring down there; a tryst at a construction site turns disastrous; a man blacks out during sex.

A woman experiences severe abdominal cramps while on a boat in the middle of the open water.

A high-school student thinks that her weight gain and fatigue are from eating poorly and working too much.

After failing two pregnancy tests, a woman is shocked to learn the truth about her symptoms; a woman gets a surprise after having gastric bypass surgery.

An unknowing mother goes into labor in her bathroom; a woman's water breaks years after being told that she is unable to get pregnant.

A teenager believes that she is unable to bear children after having an aggressive chemotherapy treatment; a nursing student learns she is pregnant after an emergency appendectomy.

A new mother struggles to lose her baby weight; a mother gets a surprise after having her tubes tied.

Traci is pregnant and desperate to move back home, but it's filled floor to ceiling with her mother's stuff.

Kathleen discovers a hoard of mice living in her kitchen; spending the night in a hoard might be the end of a marriage before it even begins.

Medical responders were not able to get in Renee's front door after she had fallen unconscious in her home.

Rick tries to salvage his cluttered home that was nearly destroyed in a house fire; Linda must get her house up to code in 60 days or she will be on the streets.

After meeting and falling in love at a bariatric rehab center, Lee and Rena are battling health and anger issues while taking a desperate, second attempt to save their relationship and their lives.

Joe made a drastic turn from being suicidal and is now ready for marriage, but the reality of more weight loss could stop him from achieving his dream.

With her weight loss, Laura is much less dependent on her husband Joey, who is now having trouble finding his place in their relationship; challenging patient Marla returns and the fireworks begin once again.

Dr. Nowzaradan is worried Lupe's emotional issues are blocking her weight loss journey since she's shed over 300-lbs but still can't walk; when Ashley is struck with sudden paralysis, her own emotional stability is thrown into peril.

Gastric surgery freed Brittani from her housebound life, but to achieve her ideal body she'll have to endure two more painful surgeries; Sean's super-obesity nearly killed him.

Surgery enables Teretha to return to family in Detroit, but it soon threatens to undo all her progress; Chad is back on the road, but his old diet is a risk.

After losing 250lbs, Nikki is on her way to skin surgery, but when a close friend dies from weight loss surgery, Nikki's progress is derailed by fears.

Bianca is all in for a move to Houston with her boyfriend and two young kids to get Dr. Now's help with a second weight-loss surgery.

Mike was born with a talent for sports and an omnivorous appetite to match; after his football dreams were dashed by multiple concussions, Mike packed on over 700 pounds, now he must find a new purpose in life to avoid succumbing to pain and regret.

James B, grew up eating rich Haitian food and loves it with a passion; James needs Dr. Now's help to diminish that love in order to survive, but a death in the family sends James retreating back to the comforts he knows.

Mike was born with a talent for sports and an omnivorous appetite to match; after his football dreams were dashed by multiple concussions, Mike packed on over 700 pounds, now he must find a new purpose in life to avoid succumbing to pain and regret.

James B, grew up eating rich Haitian food and loves it with a passion; James needs Dr. Now's help to diminish that love in order to survive, but a death in the family sends James retreating back to the comforts he knows.

Bianca is all in for a move to Houston with her boyfriend and two young kids to get Dr. Now's help with a second weight-loss surgery.

A woman whose extreme obesity has left her nearly immobile must overcome both her physical and emotional pain if she is ever to live a normal life again.

Laura has used food to cope with her emotions; she is confined to a wheelchair and relies on an oxygen tank to breathe and her husband and mother to survive.

Bedridden Marla is so heavy she cannot stand up; she must face the hard truth about her condition and understand the toll it takes on her supportive family.

Maja moves to Houston to undertake a difficult weight-loss journey with the support of her boyfriend, Christian; when Christian decides he's had enough and leaves Maja high and dry, she discovers that the only person she can count on is herself.

Despite moving to Houston with the solid support of her boyfriend, Aaron, and her cousin, Jasmine, Tiffany finds it difficult to break the cycle of depressed eating when her two roommates don't join her diet and leave the house every day for work.

Born as "Matthew," Destinee never felt like she fit in; now, having come out as a 600-pound transgender woman, she likes her curves, but she will need to say goodbye to them if she wants to be approved to transition completely.

Jeanne lives in an unhygienic household with her mother and schizophrenic father; at well over 600 pounds, Jeanne might never get weight-loss surgery as she runs into several obstacles, especially after an unexpected death in her family.

Living with his family, Lucas wants to spread his wings and fly, but at 600 pounds, he can't take off. All he does is eat and game, and if he wants to leave the nest and live a normal life, he needs Dr. Now's help to lose over 400 pounds.

Margaret's life at 700 pounds is in need of a jump-start; at age 35, she is a mama's girl; it's time for Margaret to get out of bed, overcome her food addiction and break away from the comfort of her mother so she can finally live her life.

At 700 pounds, Ontreon has managed to keep going thanks to his faith in God, and he's training to become a minister; Onteon is hopeful but has to believe in himself.

Margaret's life at 700 pounds is in need of a jump-start; at age 35, she is a mama's girl; it's time for Margaret to get out of bed, overcome her food addiction and break away from the comfort of her mother so she can finally live her life.

At 700 pounds, Ontreon has managed to keep going thanks to his faith in God, and he's training to become a minister; Onteon is hopeful but has to believe in himself.

Living with his family, Lucas wants to spread his wings and fly, but at 600 pounds, he can't take off. All he does is eat and game, and if he wants to leave the nest and live a normal life, he needs Dr. Now's help to lose over 400 pounds.

A man falls five stories; a shopkeeper is shot in the head at point-blank range; a woman accidentally drinks a bottle of cleaning fluid.

A man wounded in a drive-by shooting; a patient with flesh-eating bacteria; a woman hit by a car.

A woman whose parents kicked her out after learning she was pregnant tries to find the son she hasn't seen in fifty years; a man desperate to find his biological brother tries to heal his mother's broken heart.

Tammy searches for her two younger brothers who vanished after they were taken by social services 20 years ago; Tineke hopes that finding and meeting her biological mother will unlock a true understanding of her own racial identity.

Musician Mark has been eager to find his biological mother since he learned she was an award-winning cellist, and uncovers heartbreaking details and life-affirming surprises.

Susan aches for a mother-daughter relationship, and searches for both her biological mother and the daughter she placed for adoption as a teen; Tammy is still haunted for never getting to say goodbye to the son she birthed over 30 years ago.

Fifteen months after her son's birth, Emily fears her appendix has burst and her mother rushes her to the emergency room.

Dana is having debilitating stomach pains at work; the paramedics arrive just in time to deliver a baby.

A 20-year old woman suffers abdominal pain while at work; while waiting it out she realizes she is delivering a baby.

After a negative pregnancy test, Monique delivers a baby in her bathroom.

A flight attendant has mysterious pains in her stomach; she is stunned to learn she is in labor.

After staying home from class, Katlyn makes a trip to the bathroom, which brings her to her knees in pain, and she realizes that she is in labor.

A woman in top shape suddenly has debilitating cramps; at the hospital she is stunned to learn she is pregnant and in labor.

Back pain is typical for Andrea, but when she starts bleeding severely, she must call 911.

Mothers and their teenage daughters unexpectedly find themselves pregnant at the same time.

Four mothers and four daughters who are all pregnant at the same time.

Tensions run high at Lorna and Chae's baby shower; Kim's boyfriend violates probation; Nicole is newly single; Lemhele races to the hospital to give birth.

Two families welcome a new child; two defiant boyfriends return while another slips away.

A man's face and body suddenly double in size; a young woman is burning up from the inside out after a day at the beach; a grumpy old man nearly dies before revealing an emotional secret.

A pianist's finger goes missing after getting accidentally sawed off; a man's pacemaker threatens to kill him; a man behaves bizarrely.

A pregnant woman is shot in the abdomen; a doctor is the victim of a car burglary; a storm is preventing a patient's life-saving surgery.

A woman risks losing her finger after trying on an ill-fitting engagement ring; a body builder can't breathe and doctors are shocked to discover why; a gunshot victim.

A man's face and body suddenly double in size; a young woman is burning up from the inside out after a day at the beach; a grumpy old man nearly dies before revealing an emotional secret.

A pianist's finger goes missing after getting accidentally sawed off; a man's pacemaker threatens to kill him; a man behaves bizarrely.

A pregnant woman is shot in the abdomen; a doctor is the victim of a car burglary; a storm is preventing a patient's life-saving surgery.

A woman risks losing her finger after trying on an ill-fitting engagement ring; a body builder can't breathe and doctors are shocked to discover why; a gunshot victim.

Tensions run high at Lorna and Chae's baby shower; Kim's boyfriend violates probation; Nicole is newly single; Lemhele races to the hospital to give birth.

Two families welcome a new child; two defiant boyfriends return while another slips away.

A woman with twisted toes; a man with Frankenstein feet; a mother with extreme calluses.

Dr. Brad and Dr. Sarah have their hands full when they are faced with twins who have identical toe problems; a boy with extremely itchy feet and a woman born with a massively large toe are desperate for Dr. Ebonie's help.

A man with horns on his feet, a woman whose foot went through a windshield, and a guy who has dead man's feet create mysterious challenges for Dr. Brad and Dr. Ebonie.

Staff members of the University Medical Center in Newark, N.J., explain what led them to where they are.

Doctors from King Drew Medical Center in South Central Los Angeles represent a number of races and creeds.

New Orleans Charity Hospital spends an Easter weekend trying to save children hit by cars, gunshot victims and stabbed teens.

Nashville, Tenn.; man exposes himself to a fatal virus; an attempted suicide; prom night; teen tumbles out of speeding car.

At MetroHealth Hospital, 60 percent of traumas are alcohol-related and more than half are from car crashes.

Jamie's tiredness leads to shocking news; David has joint pain and low stamina.

Bonnie's tingling foot; Shannon's high fever causes her to black out.

Jordan has bleeding gums and bruises; Tannis has headaches and high blood pressure.

Kurt's body lumps; Jessica's cheek numbness and dizziness.

Follows Maria and Teresa Tapia, conjoined twins from the Dominican Republic, as they travel to Richmond, Virginia to undergo separation surgery.

Stories of three very different sets of twins incorporate their lives since being surgically separated.

A man seeks to repair his face after being mauled by a tiger; an 11-year-old undergoes fire treatment to lose weight; a boy living with tissue paper skin; a man with a hole in his face search for cures; a model embraces her hairy birthmarks.

A girl lives with ants in her head; a man undergoes surgery to remove his 132-lb tumor; a woman with a large facial tumor contemplates a life-changing surgery.

A man is slowly choking to death because of his overgrown face; a boy is born with three arms; family members embrace being born with six fingers on each hand; an obese man strives to lose enough weight to have life-saving surgery.

The world's tallest child can't stop growing; a man learns how to use a dead man's hand; a teenager discovers he has a parasitic twin and it's been growing inside him; a limbless girl gets fitted for prosthetic limbs.

A man seeks to repair his face after being mauled by a tiger; an 11-year-old undergoes fire treatment to lose weight; a boy living with tissue paper skin; a man with a hole in his face search for cures; a model embraces her hairy birthmarks.

A girl lives with ants in her head; a man undergoes surgery to remove his 132-lb tumor; a woman with a large facial tumor contemplates a life-changing surgery.

A man is slowly choking to death because of his overgrown face; a boy is born with three arms; family members embrace being born with six fingers on each hand; an obese man strives to lose enough weight to have life-saving surgery.

The world's tallest child can't stop growing; a man learns how to use a dead man's hand; a teenager discovers he has a parasitic twin and it's been growing inside him; a limbless girl gets fitted for prosthetic limbs.

Follows Maria and Teresa Tapia, conjoined twins from the Dominican Republic, as they travel to Richmond, Virginia to undergo separation surgery.

Stories of three very different sets of twins incorporate their lives since being surgically separated.

Alicia, all smiles and laughter on the outside, secretly fears that her food addiction will kill her before she can marry her long-time love or watch her nieces grow up.

Despite having lost 378 pounds, Angel's crippling knee pain and history of extreme obesity threatens everything for which she's worked; Charity finds the strength to return to a normal life after post surgery complications.

Olivia suffers an unexpected loss; James strives to reach his goal of skin surgery and have a fulfilling relationship.

Devastated by the sudden loss of her son, Dottie's weight loss journey is in danger of going off track; June embarks on a plan to win approval for skin surgery; Melissa, Jessica and Matt prepare for skin removal surgery.

Charity's daughter is becoming dangerously obese; devastated by the death of her husband Elroy, Milla must find a way to finally qualify for gastric bypass; check-in with individuals who have undergone skin removal surgery.

Once 800lbs, housebound and alone, Joe is now engaged and planning a wedding; after losing over 300lbs, Pauline is on the verge of independence if only she can qualify for the skin surgery she needs so badly.

Surgery enabled Laura's independence but the complications nearly killed her and she's terrified about the next skin surgery; Chay revealed to her family she was transgender, but living life as an overweight woman.

Dolly has pain all over, and the skin apron pulling on her abdomen is miserable, but her mom and others wait on her hand and foot.

Lisa wouldn't have made it this far without the help of her chief enabler, her boyfriend Randy; when Randy falls ill, Lisa finds out if she has the will and determination to turn her life around.

Growing up in foster care, David suffered from a lack of attention and didn't develop a sense of self-worth; now he's relying on his favorite foster mom to support him as he finds the motivation to change and save his own life.

Lisa wouldn't have made it this far without the help of her chief enabler, her boyfriend Randy; when Randy falls ill, Lisa finds out if she has the will and determination to turn her life around.

Growing up in foster care, David suffered from a lack of attention and didn't develop a sense of self-worth; now he's relying on his favorite foster mom to support him as he finds the motivation to change and save his own life.

Dolly has pain all over, and the skin apron pulling on her abdomen is miserable, but her mom and others wait on her hand and foot.

Mike's religious beliefs have kept him from seeing a doctor about his huge growth; Kylie has come to love her birthmark and is torn about whether or not to get it removed; Shad's head bump bursts open and smells like death.

Tyler's hands are so dry, cracked and painful that he considers getting them amputated; Ebonee covers the tiny bumps around her eyes with sunglasses; Ralph feels like a cyst factory with painful cysts covering his back.

Kelly has a massive shoulder growth; Erica stabbed her hand with a pencil 45 years ago and believes the lead remains trapped in her palm; Paula's painful and swollen feet ooze a substance that emits the foulest of odors.

Dr. Lee has a surprise for Paula, who has oozing, odoriferous and painful legs; Mike needs to get rid of the bump on his head before two major life events; Amanda feels inadequate for her husband because of the saggy growth on her back.

Alyse has been suffering from a burning rash that feels like it's rubbing away her existence; Terry has become too big for his britches due to a painful butt cheek lipoma; James has demons on his back that are ruining his life.

Krystal, a witch, looks to clear a curse of a cyst from her face; Keven wants to get a butt lipoma removed to get his tush back into a regular shape; Raquel, Dr. Lee's esthetician BFF, almost suffocates Dr. Lee with love and a facial.

J-Fab is the life of the party, but her shoulder bump is seriously cramping her style; Dan is a gentle giant with lumps on his head that add a few inches; Teresa's red face and bumpy nose make her feel like a monster.

Fit guy Alonso wants to show off his progress in the gym, but his 70 lipomas are holding him back; Porscha is a comic book enthusiast with two symmetrical lumps on her face; Jeffrey has a leaky lump named Larry on the back of his head.

Robert carries the weight of providing for his family and the weight of the huge lump on his head; Christina has liquid-filled growths next to her eyes; Felipe, a photographer with a dry skin condition so severe he risks losing his career.

Natasha has ambitions of becoming a model, but her massive ear keloids are keeping her off the runway; eight-year-old Wynter wants her scaly mermaid skin cured; Dr. Lee's bestie, Raquel, needs help with a new product for a private area.

Nhan has an extreme, red birthmark that covers half his face; Debbie worries that her shoulder lump will prematurely age her; Justin is a dude rockin' a man bun, but he's having no fun due to the bumps poking through his scalp.

Jess is a widower looking for love who is stuck with a giant bump on his neck; Cherish developed a leopard-print face during pregnancy; former NFL defensive tackle Marcell Dareus hopes Dr. Lee can tackle his forehead lipoma.

Brent has a tricep bump potentially intertwined in his muscle; Jeb loves the beach but refuses to go because of the massive number of blackheads, pimples, and cysts all over his body; Wanda's mysterious mark that caves in her side.

Don's psoriasis has completely taken over his body; Jeff has a large growth on his spine; Sara has an extra set of breasts and nipples.

Angelina has a huge chest lump under her left breast; Delano has a football-sized mass on his back.

Melissa tries to cover a huge lipoma with a sweatshirt for years; Tyler's fear of cancer keep him from having his huge head lumps diagnosed; Tahj is covered in painful boils; Amber has ear keloids that take control of her life.

Ronen's mysterious lump above his knee is one of the largest Dr. Lee has ever seen; Amber suffers from a debilitating skin disease that no one understands; Sandy has a neck lump she calls Tommy; Kristy's eyelid cyst is ruining her life.

Half of Mary's body is a size 18 while the other half is a size 8; Anthony's cyst is in the area called the "Triangle of Death;" Shane wants to get a lump off his back; Brandi is anxious about getting a lump removed from her chest.

Angelina has a huge chest lump under her left breast; Delano has a football-sized mass on his back.

Melissa tries to cover a huge lipoma with a sweatshirt for years; Tyler's fear of cancer keep him from having his huge head lumps diagnosed; Tahj is covered in painful boils; Amber has ear keloids that take control of her life.

Ronen's mysterious lump above his knee is one of the largest Dr. Lee has ever seen; Amber suffers from a debilitating skin disease that no one understands; Sandy has a neck lump she calls Tommy; Kristy's eyelid cyst is ruining her life.

Half of Mary's body is a size 18 while the other half is a size 8; Anthony's cyst is in the area called the "Triangle of Death;" Shane wants to get a lump off his back; Brandi is anxious about getting a lump removed from her chest.

Brent has a tricep bump potentially intertwined in his muscle; Jeb loves the beach but refuses to go because of the massive number of blackheads, pimples, and cysts all over his body; Wanda's mysterious mark that caves in her side.

Don's psoriasis has completely taken over his body; Jeff has a large growth on his spine; Sara has an extra set of breasts and nipples.

A gunman opens fire outside a strip club; a street performer's magic trick goes horribly wrong; BMX superstar T.J. Lavin's routine jump has a shocking outcome.

A maintenance worker falls from an iconic hotel sign; a rat bite has horrifying implications for its trainer and a plane crashes on a residential street.

A shootout leaves a police officer clinging to life; a cowboy and cupid help a she-devil in distress; a zip-line guide falls 80 feet to the canyon floor.

A teenage girl is impaled through the neck on an iron fence; a patient is convinced he's turning into a vampire; a first-year attending physician stands up to a room full of senior specialists to save the life of a critically ill pregnant woman.

The ER is a crime scene when a woman's belly pain is caused by smuggled narcotics; a doctor is mystified by heart attacks occurring the same day in the same family; strange markings on the body of a car crash victim lead to the cause of the accident.

Two seemingly unrelated gunshot wounds lead to a bizarre night in the ER; a senior nurse unravels at the sight of a critical patient, and reveals a shocking secret; a patient's grave symptoms mysteriously disappear whenever the doctor touches him.

A young boy's body does not produce the correct antibodies; a woman loses the ability to walk.

A young girl has trigeminal neuralgia; a woman seeks a reason for her rapid weight gain and other bodily changes.

Abdominal pains and headaches plague a girl until a diagnosis of retroflex odontoid and Chiari type 1 malformation; a paramedic has AIDS.

Sisters Jessica and Melissa are left with massive excess hanging skin after growing up morbidly obese; Matt lost everything he cherished, but after losing weight, his excess skin keeps him from returning to life.

Season 1 skin removal patients try to cope with life one year after undergoing near total body transformations.

Checking in with Season 2 folks who have undergone agonizing surgeries to remove over 100 pounds of excess skin.

Checking in with season two folks who have undergone agonizing surgeries to remove over 100 pounds of excess skin.