Octavia has been bedbound for nearly a year when she decides to make the trip to Houston to get help from Dr. Now, but when it turns out that her best friend is also her worst enabler, Octavia will have to choose between old habits and a new life.

Robin and her brother Chris are both obese and already lost a sibling to obesity; they plan to visit Dr. Now together when Chris suffers a stroke and can't go; Chris' son Garrett, already 600 pounds at age 20, is game to join the journey.

At over 700 pounds, Brianne undertakes a weight-loss journey to save her own life; she faces an unexpected challenge to her fragile progress when her husband suffers a heart attack on a birthday she will never forget.

After a negative pregnancy test, Monique delivers a baby in her bathroom.

Dana is having debilitating stomach pains at work; the paramedics arrive just in time to deliver a baby.

A 20-year old woman suffers abdominal pain while at work; while waiting it out she realizes she is delivering a baby.

A flight attendant has mysterious pains in her stomach; she is stunned to learn she is in labor.

A woman in top shape suddenly has debilitating cramps; at the hospital she is stunned to learn she is pregnant and in labor.

Back pain is typical for Andrea, but when she starts bleeding severely, she must call 911.

Anna cannot believe her eyes when she gives birth to a baby in her kitchen.

Kayla goes to a small-town clinic and gets the news she's in labor; with few supplies and a tornado looming, she must be transferred to another hospital over 100 miles away.

Tiffany and Destiny both live with the rare disease Osteogenesis Imperfecta, which causes brittle bones, and set out on a life changing journey to meet each other.

Getting too hot can be fatal for twins Andrew and Brandon, who meet Josh, a fellow sufferer of Ectodermal Dysplasia.

Tiffany and Yajaira have Jarcho Levin Syndrome, which malformed their ribs and spines during infancy.

A man with half a torso learns if his rare bone-eating disease is back; a young girl undergoes surgery to stop her facial tumor from choking her; a boy is born with half a face.

A man with cold-like symptoms loses his limbs and lips; a young girl has a prematurely fused skull; a boy with brittle bones and a rare skin condition gets life-changing surgery; a woman suffers from a disfiguring birthmark; with bonus content.

A woman suffers from cyclical vomiting syndrome; a man with warts all over his body searches for cures; a girl fights for a surgery that could allow her to speak for the first time; with bonus content.

A man's maimed hand is sewn into his stomach to avoid amputation; a young girl is born with a deformed mouth and jaw; a boy's organs are inverted; a man who can't smile finds love; with bonus content.

A boy tries to get his balloon facial tumor removed; a woman who is allergic to UV light must take precautions; a woman fears her birthmark is still growing; a boy with undeveloped legs walks on all fours; with bonus content.

An ultrasound anomaly worries expectant parents; a biology teacher has a bizarre symptom.

A couple's baby is born without a heartbeat; a woman experiences excruciating headaches.

A baby boy has bouts of vomiting and diarrhea from the day of his birth; a young woman experiences blackouts after she hits puberty.

An overweight girl experiences dizziness and shortness of breath with any physical exertion.

Mysterious symptoms appear for a man who recently underwent minor surgery.

Doctors can't pinpoint the cause of the array of ailments a woman has been suffering from for more than 50 years.

A baby boy has bouts of vomiting and diarrhea from the day of his birth; a young woman experiences blackouts after she hits puberty.

An overweight girl experiences dizziness and shortness of breath with any physical exertion.

Mysterious symptoms appear for a man who recently underwent minor surgery.

Doctors can't pinpoint the cause of the array of ailments a woman has been suffering from for more than 50 years.

An ultrasound anomaly worries expectant parents; a biology teacher has a bizarre symptom.

A couple's baby is born without a heartbeat; a woman experiences excruciating headaches.

Eight women cope with their incarceration in Gwinnett County Jail; one woman prepares for her release.

Nine women try to cope with their incarceration; a woman awaits trial for five years.

A young mother faces the idea of seeing her son through visitation glass; an inmate promises not to return but finds herself back in jail; a desperate inmate only needs a small amount of money to get released.

A current inmate learns that her son has died in a car crash; an inmate's first Mother's Day behind bars; female inmate almost nine months pregnant.

The Las Vegas University Medical Center is the only Level One Trauma Center in Nevada.

Up-close look in the only Level One Trauma Center in Nevada.

The staff and cases that come through at the Las Vegas University Medical Center.

The staff and cases that come through at the Las Vegas University Medical Center.

A driver wrecks their car into a restaurant patio; medics rescue a 25-year-old man from a burning vehicle; a ventriloquist barely misses getting hit by a car.

The trained medical physicians and staff at the Las Vegas University Medical Center treat patients in the Pediatric Emergency Department.

Police officers bring in a criminal that is comatose; a man found passed out in the snow with no jacket or shoes arrives in the ER and a doctor is faced with a family emergency on her day-off.

A man's itchy rash turns out to be more than just poison oak; a young woman bleeds profusely from the inside of her lip, but there is no obvious cause; a family of three is admitted as car accident victims, but the doctor makes a shocking discovery.

A patient appears to be hallucinating and sends ER staff on a wild goose chase; a new nurse makes a shocking mistake; doctors try to help a former EMT who was found lethargic and slurring his words.

A boa constrictor has wrapped around a man's arm and won't let go; a young woman has a severe laceration, but doctors begin to suspect there may be more to her case than the injury; a young man goes into anaphylactic shock after a dinner out.

A patient gets brought in with a live shark clamped onto his thigh, and he wants to save the shark; complications arise for a woman with a life-threatening condition; a mysterious condition causes a man to pass out.

A fishing lure embedded in a man's face turns out to be the least of his problems; a pair of unconscious teenagers get brought to the ER, where dramatic family secrets come out; an ER technician collapses and refuses traditional medical treatment.

Two separate car crash victims are brought to the ER in their underwear; a woman is acting delusional and refuses to allow the ER staff to touch her; a doctor struggles to diagnose a dehydrated and nauseous 10 year old.

A teenage girl is impaled through the neck on an iron fence; a patient is convinced he's turning into a vampire; a first-year attending physician stands up to a room full of senior specialists to save the life of a critically ill pregnant woman.

A patient gets brought in with a live shark clamped onto his thigh, and he wants to save the shark; complications arise for a woman with a life-threatening condition; a mysterious condition causes a man to pass out.

A fishing lure embedded in a man's face turns out to be the least of his problems; a pair of unconscious teenagers get brought to the ER, where dramatic family secrets come out; an ER technician collapses and refuses traditional medical treatment.

Two separate car crash victims are brought to the ER in their underwear; a woman is acting delusional and refuses to allow the ER staff to touch her; a doctor struggles to diagnose a dehydrated and nauseous 10 year old.

A teenage girl is impaled through the neck on an iron fence; a patient is convinced he's turning into a vampire; a first-year attending physician stands up to a room full of senior specialists to save the life of a critically ill pregnant woman.

A patient appears to be hallucinating and sends ER staff on a wild goose chase; a new nurse makes a shocking mistake; doctors try to help a former EMT who was found lethargic and slurring his words.

A boa constrictor has wrapped around a man's arm and won't let go; a young woman has a severe laceration, but doctors begin to suspect there may be more to her case than the injury; a young man goes into anaphylactic shock after a dinner out.

A college graduate with a once-promising career, Justin has eaten his life away to the point of never leaving the house for anything but food; only the help of Dr. Now's weight-loss program can restore his hopes of living a happy, productive life.

Donald has difficulty walking and relies on his parents to take care of him, so he gets motivated to begin his weight loss journey.

Henry hopes to transform himself for his high school reunion, and gastric bypass is the first step to combating his 715 pounds.

Holly already has one failed weight loss surgery, so to succeed this time, she must do more than change her eating habits, she must address the childhood issues that continue to plague her.

Lacey ballooned up over 600 lbs on pizza and ice cream and knows Dr. Now is her best hope for success; she must now rally her divorced parents around her for support and find a way to modulate her moods that won't include binge-eating.

Brandon is a talented musician with a beautiful voice and a run-away weight problem; he wants to lose weight and embark on a career; he also wants to take the next step with his girlfriend, Taylor, whom he risks losing if he can't make a change.

Maja moves to Houston to undertake a difficult weight-loss journey with the support of her boyfriend, Christian; when Christian decides he's had enough and leaves Maja high and dry, she discovers that the only person she can count on is herself.

Despite moving to Houston with the solid support of her boyfriend, Aaron, and her cousin, Jasmine, Tiffany finds it difficult to break the cycle of depressed eating when her two roommates don't join her diet and leave the house every day for work.

Born as "Matthew," Destinee never felt like she fit in; now, having come out as a 600-pound transgender woman, she likes her curves, but she will need to say goodbye to them if she wants to be approved to transition completely.

Jeanne lives in an unhygienic household with her mother and schizophrenic father; at well over 600 pounds, Jeanne might never get weight-loss surgery as she runs into several obstacles, especially after an unexpected death in her family.

Born as "Matthew," Destinee never felt like she fit in; now, having come out as a 600-pound transgender woman, she likes her curves, but she will need to say goodbye to them if she wants to be approved to transition completely.

Jeanne lives in an unhygienic household with her mother and schizophrenic father; at well over 600 pounds, Jeanne might never get weight-loss surgery as she runs into several obstacles, especially after an unexpected death in her family.

Despite moving to Houston with the solid support of her boyfriend, Aaron, and her cousin, Jasmine, Tiffany finds it difficult to break the cycle of depressed eating when her two roommates don't join her diet and leave the house every day for work.

Angelina has a huge chest lump under her left breast; Delano has a football-sized mass on his back.

Melissa tries to cover a huge lipoma with a sweatshirt for years; Tyler's fear of cancer keep him from having his huge head lumps diagnosed; Tahj is covered in painful boils; Amber has ear keloids that take control of her life.

Ronen's mysterious lump above his knee is one of the largest Dr. Lee has ever seen; Amber suffers from a debilitating skin disease that no one understands; Sandy has a neck lump she calls Tommy; Kristy's eyelid cyst is ruining her life.

Half of Mary's body is a size 18 while the other half is a size 8; Anthony's cyst is in the area called the "Triangle of Death;" Shane wants to get a lump off his back; Brandi is anxious about getting a lump removed from her chest.

Belinda's lump on her neck causes her to basically be immobile; Nicole won't get married until she gets her armpit lump removed; Adela's chest and back are covered in wisdom spots; Nick foolishly removes a lipoma at home and now needs Dr. Lee.

Diane has tumors all over her body that have ruined her life; Will fears his shoulder lump will be ripped open at work; Anthony's daughters force him to get his lump examined; a woman detests her hideous varicose veins.

Taylor has a large bump at the base of her spine that is far more dangerous than she realizes; John jokes about his hip lump, but it's no laughing matter; Noelle had her ears stretched as a teen, but now wants them repaired.

Louis is a veteran who is covered in scaly, dry skin that makes him feel like an alligator; Irais's kids are bullied because of the embarrassing growth on her head; Johnny has been living with a stubborn lump on his back for too long.

Patrick's nose is covered by huge bumps, and he can barely breathe; Aziza and Lauren are friends who bonded over their matching wrist lumps; Joe has a mound in the middle of his forehead that looks like a third eye.

April is covered in bumps that disfigure her arms; Genner flies all the way from the Philippines to have Dr. Lee help with his bumpy nose; Chris suffers from psoriasis that nearly covers his body and a bump on his head.

Matt has a skin condition that causes tumors to grow all over his body; Yamileth hasn't pursued her dreams because of the lump on her neck; Pat is covered with dark spots from her neck to her abdomen; Jennifer has a unicorn bump on her forehead.

Amber has hundreds of tumors on her face; Antonio has a mound on his spine and is afraid it might be impossible to remove; sisters Cheri and Janice both suffer from possibly matching lumps; Tatiana has an embarrassing bump on her butt cheek.

Lisa has a horn growing out of the back of her head and fears that it could be cancer; Victor has a bulbous lump on his chest; Chuck has a Popeye-shaped bump on his arm; Christian and Jonathan are teenage brothers with matching lumps.

Taylore is a beautiful young woman who has unsightly elf-like bumps on her ears; Jose never goes out because of the baseball-sized lump on his head; Ken is covered in painful bumps that make it difficult to do everyday things.

Josh has a large knot on his head resulting from a car crash from 18 years ago; Brittney is covered in mysterious bumps; TJ has a hard, curious lump protruding from his side; Luis has a bump on his shoulder and his daughters fear it's dangerous.

Barbara's back lump became more noticeable after she lost 131 pounds; Bob has two painful bumps on his back; Hilda's depression is a result of the multitude of bumps on her eyelids; Art has one big bump on his head that he covers up with hats.

Leonard has an alarming bump hanging off of his arm that looks like it's breaking through the skin; Brandon has several lumps on his head that make him fearful for his life; Jess gets a noticeable lump on her butt after falling down the stairs.

Dr. Sandra Lee treats Heather, who has a huge growth on her leg and fears removing it could leave a keloid scar; Paul has a giant hump on his back.

Josh has a large knot on his head resulting from a car crash from 18 years ago; Brittney is covered in mysterious bumps; TJ has a hard, curious lump protruding from his side; Luis has a bump on his shoulder and his daughters fear it's dangerous.

Barbara's back lump became more noticeable after she lost 131 pounds; Bob has two painful bumps on his back; Hilda's depression is a result of the multitude of bumps on her eyelids; Art has one big bump on his head that he covers up with hats.

Leonard has an alarming bump hanging off of his arm that looks like it's breaking through the skin; Brandon has several lumps on his head that make him fearful for his life; Jess gets a noticeable lump on her butt after falling down the stairs.

Dr. Sandra Lee treats Heather, who has a huge growth on her leg and fears removing it could leave a keloid scar; Paul has a giant hump on his back.

Lisa has a horn growing out of the back of her head and fears that it could be cancer; Victor has a bulbous lump on his chest; Chuck has a Popeye-shaped bump on his arm; Christian and Jonathan are teenage brothers with matching lumps.

Taylore is a beautiful young woman who has unsightly elf-like bumps on her ears; Jose never goes out because of the baseball-sized lump on his head; Ken is covered in painful bumps that make it difficult to do everyday things.

Dr. Vincent uses a cadaver bone to fix a woman's foot who's deathly afraid of infection; surgery to correct a woman's webbed toes becomes a crisis for Dr. Schaeffer when she develops a dangerous complication that could cost the patient her toes.

A man with an enormous lump on his foot creates a mystery for Dr. Vincent; Dr. Schaeffer faces a case of a wart cluster that is all over a man's foot; patient Kiara has the first double big toe the doctor has ever come face-to-face with.

After a horrific car accident as a child, Heather's ankle was rebuilt from parts of her body; now it's up to Dr. Vincent to help her walk again.

Dr. Schaeffer has to straighten a woman's serpentine foot to reset her life, as Dr. Vincent gets a drummer's foot back on the beat.

Nate sees Dr. Brad for help with the raging calluses on his feet; Savannah has a rare condition that made her big toe grow to an enormous size and hopes Dr. Ebonie can help; Dr. Brad is determined to uncover the mystery behind John's foot growth.

Despite having the longest big toes Dr. Brad has ever seen, Anna hopes for the feet she's always wanted; Russell visits Dr. Ebonie with feet that look like hooves; Patty lost most of her foot in an extreme amputation, and she needs Dr. Sarah's help.

Brittany's addiction to eating car seat foam forces her family to intervene; Lauren has put her addiction to bodybuilding behind her but has found a new obsession; Asha's addiction to her long locks remains strong, but her health remains in jeopardy.

Nick and Aubrey's addiction to drinking urine has Nick's mom extremely concerned; Karmello's life has gained new meaning since her addiction to illegal butt injections; Lori's addiction to sleeping with her blow dryer might be affecting someone else.

Weston loves eating raw meat, but his mom is worried it could lead to major health problems; Rachel breastfeeds her husband, Alexander, but it's upsetting to their family and friends; pillow addict Tamara meets car lover Nathaniel.

Kinah's addiction to eating toilet paper threatens her health, and her relationships are also on the line; Nathaniel has taken his love of cars to the extreme; Lisa eats cat hair - and she just cannot get enough.

Tyler's addiction to smelling tuna is getting in the way of finding love; Lacey's addiction to plastic surgery and her cup size has grown; after mourning the loss of her record-setting fingernails, Ayanna still has an addiction.

Foxy's addiction to having enormous breasts has brought her fame, but her friends feel it is also endangering her health.

Tammy is forced to eat her meals in her car; her sick father is unable to return home from the hospital.

Sharon gets caught stealing from her neighbors; Len must choose between his hoarding and his daughter.

Debbie lost the company of her four children to hoarding; Chip's family of six is forced to live in sixteen hundred square feet of living space.

Patti's extreme hoarding has made it impossible for her daughter to live with her; Jonathan's obsession keeps his three-year-old son from coming in the door.

Kay's years of hoarding has put her marriage in jeopardy; Toni's compulsive shopping has made her home unsafe for her granddaughter.

A mother tries to protect her children from their father's hoard; an artist chooses frog, penguins and banana peels over her boyfriend.

Debbie lost the company of her four children to hoarding; Chip's family of six is forced to live in sixteen hundred square feet of living space.

Patti's extreme hoarding has made it impossible for her daughter to live with her; Jonathan's obsession keeps his three-year-old son from coming in the door.

Kay's years of hoarding has put her marriage in jeopardy; Toni's compulsive shopping has made her home unsafe for her granddaughter.

A mother tries to protect her children from their father's hoard; an artist chooses frog, penguins and banana peels over her boyfriend.

Tammy is forced to eat her meals in her car; her sick father is unable to return home from the hospital.

Sharon gets caught stealing from her neighbors; Len must choose between his hoarding and his daughter.

Since the death of his mother, Aaron lives at home to care for his aging father, but due to his food addiction, Aaron has to heavily rely on his father for help instead. Aaron must learn to care for himself to avoid eating himself to death.

Ashley wants to achieve her goal of owning a childcare facility, but must lose weight before her dreams can be met.

Zsaylnn needs to lose weight to be the mother her daughter deserves; her husband loves large women and does not support her goals.

When Annjeanette was nine, a campaign was established to send her to fat camp; she hated that her weight had become a source of public shame and she has struggled to overcome her food addiction; now, she must change her habits to save her life.

When Angela's family is unable to accompany her on her weight-loss journey to Texas she is unsure what to do; at the last minute, she reaches out to an old flame, Eric, who still has love for her and is willing to make the trip.

Mother of four LaShanta has been bed-bound for two years, and she relies on her kids to keep her cleaned and fed; her last chance to break the cycle of food addiction is to join Dr. Now's program, but it will take a village to get her out the door.

Cillas' food addiction is getting in the way of his ability to be there for his fiancée, Jessica, and her three daughters; if he doesn't lose weight soon, he knows he'll lose either his girls or his life.

Mercedes, who has severe lymphedema, must overcome trauma to lose weight.

At over 600 pounds, Angie is trying to get to Houston to see Dr. Nowzaradan, in hope of getting weight loss surgery to save her life; family conflict and disagreements may stop her from being able to do what she needs before she even gets the chance.

Vianey and Allen are locked in a co-dependent relationship based on a shared love of food; as they head to Houston, they will soon find out if their relationship can handle the strain of growing healthy together.

At over 600 pounds, Angie is trying to get to Houston to see Dr. Nowzaradan, in hope of getting weight loss surgery to save her life; family conflict and disagreements may stop her from being able to do what she needs before she even gets the chance.

Vianey and Allen are locked in a co-dependent relationship based on a shared love of food; as they head to Houston, they will soon find out if their relationship can handle the strain of growing healthy together.

Mercedes, who has severe lymphedema, must overcome trauma to lose weight.

Krystal begins overeating to shield herself with a protective layer of obesity after suffering years of abuse; once a means of protection, her pathological eating now threatens to destroy her life if she doesn't get help.

A woman battles severe depression and has not left her Chicago basement in two years; the hope of having a life-changing surgery.

Penny has been bedridden for four years and moves to Texas to have gastric bypass; her unwillingness to make lifestyle changes could mean failure.

Isaac helped raise his siblings after his mom suffered a debilitating stroke when he was 10. While learning to cook for his family, he began comfort-eating. Now to avoid eating himself to death, Isaac must learn to take care of himself for a change.

A lifetime of abuse has left Michael anxious and afraid to leave the house; with the help of his devoted wife, he must follow Dr. Now's program to keep from eating himself to death.

Shannon's husband loves her the way she is, but that may not help because she's 700 pounds and bedridden; Dr. Now knows it's not easy to break a toxic cycle of overfeeding and enabling, but that's what needs to happen if Shannon wants to live.

Irene had to move back in with her son because her weight made it unbearable to live on her own. When Dr. Now can't get through to her, the only thing that might help her break the cycle is a once-in-a-lifetime turn of events.

Through tough times, food has always been Tammy's friend; now she has gotten so big that her daughters and mother have moved home to care for her, and unless Dr. Now can get her to confront her grief, food might be her killer.

Having her daughters help bathe her is not how Chrystal pictured parenting but she is so large that there's no other option; Chrystal wants Dr. Now's help but she didn't know that bringing her childhood trauma to light would be part of the deal.

Ryan moved to Montana to keep himself from going down a dark path of drug addiction but his new path may be no less lethal than the last if he can't find a way to curb his eating habits before they kill him.

Having her daughters help bathe her is not how Chrystal pictured parenting but she is so large that there's no other option; Chrystal wants Dr. Now's help but she didn't know that bringing her childhood trauma to light would be part of the deal.

Ryan moved to Montana to keep himself from going down a dark path of drug addiction but his new path may be no less lethal than the last if he can't find a way to curb his eating habits before they kill him.

Through tough times, food has always been Tammy's friend; now she has gotten so big that her daughters and mother have moved home to care for her, and unless Dr. Now can get her to confront her grief, food might be her killer.

Musician Mark has been eager to find his biological mother since he learned she was an award-winning cellist, and uncovers heartbreaking details and life-affirming surprises.

Weeding through rumors for 15 years, a woman is determined to uncover the truth of her biological mother, only to reveal more unexpected family secrets; identical twin sisters search for their biological mother, unsure if she's even alive.

A woman searches for her beloved sister who she tried to adopt herself years ago; after a life of longing, a couple is desperate to find the son they placed for adoption fifty years ago when they were teens.

A woman searches for her brother, hoping to fulfill a promise she made to her late mother, and discovers a 40-year-old secret about her parents' past; a woman consumed by a lifelong search for her mom finds hope with a new DNA connection.

A man faces amputation when a mystery disease turns his extremities black; a young woman develops paralyzing fears about ordinary objects.

A beautiful model turns into a raging monster and starts attacking everyone around her; a man's life is nearly destroyed when he can't stop burping.

A woman's life is ruined by extreme sweating day and night; a young teacher prays to stop living when he feels invisible bugs crawling all over him.

A boy who can't stop eating undergoes a series of operations to save his life; a young man who is more than 7-feet tall learns if he's still growing; a boy is born without eyes; Irish twins' muscles and flesh turn to bone; with bonus content.

A man seeks to get the fatty growths on his chest removed; a boy's eye falls out of his skull; a man with giant facial keloids goes under the knife one last time; a young boy lives with an agonizing skin condition; with bonus content.

A man's body blows up like a balloon after a diving accident; a man seeks to get his giant leg tumor removed; a woman who lost the middle of her face to cancer tries to get her confidence back; a man drinks five gallons of water a day to stay alive.

The world's fattest man undergoes weight loss surgery; a woman learns why she can't feel physical pain; twins joined at the head learn if they can be separated; a young boy born without limbs relies on constant transfusions; with bonus content.

A young girl with a crippling leg defect undergoes life-changing surgery; a man is born with his heart outside his rib cage; a karate champion battles a rare skin disorder.