Mark sets out with a goal for weight-loss surgery, but as weight loss gets easier, he turns down medical advice and decides to do it on his own; Mark thinks he can lose 500 pounds by himself, but Dr. Now sees this as another excuse not to change.

With her weight spiraling, Stephanie needs her mom's help to care for her three kids; she's at the point where she'll have to lose weight or risk not having the chance to see her kids grow up.

Lindsey has a white picket fence, a loving husband and a great job, but her food addiction threatens to ruin everything; as she embarks on a weight loss journey to save her life, her husband may provide more harm than support.

Casey's birthmark covers most of her face, head and neck; James has mysterious massive growths on his inner thigh and lower abdomen; Jerry had to hang up his rock star vocal cords when a lump grew out the side of his throat.

Johnnie's crippling psoriasis keeps him from spending time with his daughter; Aimee has a mohawk of cysts on her head; Edith's face markings and itchy skin condition turn out to be more than she expected.

Elizabeth's head is covered with giant cauliflower-shaped bumps; Jamaal has been growing a strange knob on the left side of his butt since he was just a boy; Donna's cracking, bleeding skin condition has aged her face and kept her from being social.

Kenny was born with a rare condition that causes hundreds of lumps to grow all over his body; Ebonee covers the tiny bumps on her eyes with sunglasses; Paula's painful and swollen feet ooze a substance that emits a foul odor.

Jacqueline's massive shoulder growth makes it difficult for her to do her favorite hobby of fire spinning; the mysterious bump on James' cheek loves to bleed; Mikalia has possessed a bumpy, smelly mass on her head since birth.

After losing his longtime love, Joe wants the large bumps all over his head removed; the itchy, painful rash on Nisa's ears spreads to her face; Jennifer has dark spots all over her face that nobody is allowed to see.

Cedric has a bump on his eye and a painful lump on his neck that have kept him from working; Katherine's large ear cluster puts her neighborhood watch job at risk; Andrea uses makeup to cover the white spots all over her face and body.

Jimmy's flaky, raised alligator skin feels like an itchy hell, and he wants it cured so he can find love; Djuka is a stubborn guy with a stubborn bump; Talina has hundreds of tumors all over her body, causing embarrassment and discomfort.

Brittney has hundreds of tiny bumps over her chest that have destroyed her confidence; John has a nose the size of a plum and leans on his local family clinic for help; Dr. Lee's friend Raquel drops in and brings out her wild side.

Mike's religious beliefs have kept him from seeing a doctor about his huge growth; Kylie has come to love her birthmark and is torn about whether to get it removed; Shad's head bump bursts open and smells like death.

Tyler's hands are so dry, cracked and painful that he considers getting them amputated; Ebonee covers the tiny bumps around her eyes with sunglasses; Ralph feels like a cyst factory with painful cysts covering his back.

Kelly has a massive shoulder growth; Erica stabbed her hand with a pencil 45 years ago and believes the lead remains trapped in her palm; Paula's painful and swollen feet ooze a substance that emits the foulest of odors.

Dr. Lee has a surprise for Paula, who has oozing, odoriferous and painful legs; Mike needs to get rid of the bump on his head before two major life events; Amanda feels inadequate for her husband because of the saggy growth on her back.

Alyse has been suffering from a burning rash that feels like it's rubbing away her existence; Terry has become too big for his britches due to a painful butt cheek lipoma; James has demons on his back that are ruining his life.

With new pop-up facts and behind-the-scenes secrets, Dr. Lee assists Ronen with the mysterious lump above his knee. Amber suffers from a debilitating skin disease, Sandy has a neck lump, and Kristy's eyelid cyst is ruining her life.

All new juicy pop-up facts and behind-the-scenes secrets finally revealed; a woman suffers from clusters of face bumps, and a man has a growth that dangles near his genital area; a patient's nose lump makes it difficult for him to breathe.

With pop-up facts and behind-the-scenes secrets; a patient returns to find out if a suspicious eye growth is skin cancer; a woman hopes Dr. Lee can help her with clusters of lumps; a man suffers from a giant forehead lump.

All new pop-up facts and behind-the-scenes secrets; Barbara's back lump becomes more noticeable after she loses 131 pounds; Bob has painful back bumps; Hilda struggles with bumps on her eyelids; Art covers his head bumps with hats.

With new pop-up facts and behind-the-scenes secrets, Dr. Lee assists Ronen with the mysterious lump above his knee. Amber suffers from a debilitating skin disease, Sandy has a neck lump, and Kristy's eyelid cyst is ruining her life.

All new juicy pop-up facts and behind-the-scenes secrets finally revealed; a woman suffers from clusters of face bumps, and a man has a growth that dangles near his genital area; a patient's nose lump makes it difficult for him to breathe.

With pop-up facts and behind-the-scenes secrets; a patient returns to find out if a suspicious eye growth is skin cancer; a woman hopes Dr. Lee can help her with clusters of lumps; a man suffers from a giant forehead lump.

All new pop-up facts and behind-the-scenes secrets; Barbara's back lump becomes more noticeable after she loses 131 pounds; Bob has painful back bumps; Hilda struggles with bumps on her eyelids; Art covers his head bumps with hats.

Dr. Lee has a surprise for Paula, who has oozing, odoriferous and painful legs; Mike needs to get rid of the bump on his head before two major life events; Amanda feels inadequate for her husband because of the saggy growth on her back.

Alyse has been suffering from a burning rash that feels like it's rubbing away her existence; Terry has become too big for his britches due to a painful butt cheek lipoma; James has demons on his back that are ruining his life.

A woman is impaled on an iron spike; a man spears his friend on a fishing trip; an elderly gardener's shears are lodged in his eye.

A man is impaled on a fence post; a farmer has an object lodged in his brain; a woman is skewered on a hooked pole when she feeds the birds.

A woman gets a Christmas tree imbedded in her neck; a boy out fishing almost chokes on a barb; a man is filled with enough air to fill 1000 balloons; learn how they survived.

A woman gives birth prematurely during Hurricane Sandy; an Army soldier coaches his wife's delivery from Afghanistan; a baby delivered in a shopping mall parking lot.

A woman gives birth while trapped in an elevator; two truckers deliver a baby in a diner; a prolapsed umbilical cord threatens a baby's life.

A cop delivers a baby at a gas station; a woman has a baby six days after learning she's pregnant; a singer gives birth during a talent competition.

Jamie's tiredness leads to shocking news; David has joint pain and low stamina.

Bonnie's tingling foot; Shannon's high fever causes her to black out.

Jordan has bleeding gums and bruises; Tannis has headaches and high blood pressure.

Kurt's body lumps; Jessica's cheek numbness and dizziness.

Checking in with Season 2 folks who have undergone agonizing surgeries to remove over 100 pounds of excess skin.

Checking in with season two folks who have undergone agonizing surgeries to remove over 100 pounds of excess skin.

Stephanie and her mom Darcy lost a combined weight of 320 lbs.; BJ overcame drug and food addiction to lose 350 lbs. and his body is now covered with excess skin.

Antonia overcame her food addiction to lose 190lbs, but the extra skin is keeping her from feeling confident and sexy; Natasha lost almost 300lbs after gastric bypass surgery, but now struggles with carrying a lot of saggy excess skin.

Dr. Meegan Gruber specializes in performing surgery while patients are completely awake; Derrick orders lunch while getting his "man boobs" removed; Genny has a request to get rid of both of her chins; Megan needs surgery to fix her "ball sack arms."

Dr. Meegan Gruber faces the most daunting awake surgery of her career: removing a giant hanging stomach; Jason looks for a butt lift to help him scandalize all of Kentucky; a patient calls her psychic mid-surgery.

Mother of eight Rubi stuns Dr. Meegan Gruber when she arrives with a hip condition unlike anything the doctor has ever seen; Ashley asks to have her bat wings clipped; Jim seeks a solution for a giant neck that's swallowing his jawline.

With bonus scenes; Monica returns for a second time in the hope that Dr. Lee can remove some more of her face growths; Ken has several cysts on his head that he has tried to remove on his own; Maranda has a mystery skin sore.

Dr. Meegan Gruber specializes in performing surgery while patients are completely awake; Derrick orders lunch while getting his "man boobs" removed; Genny has a request to get rid of both of her chins; Megan needs surgery to fix her "ball sack arms."

Dr. Meegan Gruber faces the most daunting awake surgery of her career: removing a giant hanging stomach; Jason looks for a butt lift to help him scandalize all of Kentucky; a patient calls her psychic mid-surgery.

Mother of eight Rubi stuns Dr. Meegan Gruber when she arrives with a hip condition unlike anything the doctor has ever seen; Ashley asks to have her bat wings clipped; Jim seeks a solution for a giant neck that's swallowing his jawline.

With bonus scenes; Monica returns for a second time in the hope that Dr. Lee can remove some more of her face growths; Ken has several cysts on his head that he has tried to remove on his own; Maranda has a mystery skin sore.

Stephanie and her mom Darcy lost a combined weight of 320 lbs.; BJ overcame drug and food addiction to lose 350 lbs. and his body is now covered with excess skin.

Antonia overcame her food addiction to lose 190lbs, but the extra skin is keeping her from feeling confident and sexy; Natasha lost almost 300lbs after gastric bypass surgery, but now struggles with carrying a lot of saggy excess skin.

Brittani has lost over 400 pounds in two years, so she and husband Bill think about expanding their family; Lupe has struggled since surgery, but, having left her husband, may finally start to make the permanent changes she needs.

Joe made a drastic turn from being suicidal and is now ready for marriage, but the reality of more weight loss could stop him from achieving his dream.

With her weight loss, Laura is much less dependent on her husband Joey, who is now having trouble finding his place in their relationship; challenging patient Marla returns and the fireworks begin once again.

Pauline's self-destructive behavior continues to be a problem; Chad strives to be a better father and husband as he continues his journey; June's progress stalls when frequent travel and wedding plans cause her to slip back into bad habits.

After a year on a weight loss program, Steven remains completely non-compliant and Justin focuses on a new career instead of his diet, but time is quickly running out for surgery; Kylie and Anna prepare for skin removal surgery.

Tammy faces a tough choice when her husband wants her back, but only if she moves away from Houston and Dr. Now's program; Karina's weight loss begins to slow, but she finds happiness dating a guy Dr. Now is surprised to see in his clinic again.

Erica's success on her weight-loss journey is derailed by heartbreak; Benji must reach his goal weight without the support of his brother.

Right when Angie is starting to succeed in Dr. Now's program, her marriage falls apart and her life is thrown into chaos, but she tries to move ahead alone despite dire difficulties.

Right when Angie starts to succeed in Dr. Now's program, her marriage falls apart and her life is thrown into chaos; Angie moves ahead despite dire difficulties, but when her body starts to break down, Angie fears the worst and faces it alone.

Lacey wants skin removal surgery, but Dr. Now begins to wonder if she even wants to lose weight; in Houston, Mercedes and her kids face destitution.

Right when Angie starts to succeed in Dr. Now's program, her marriage falls apart and her life is thrown into chaos; Angie moves ahead despite dire difficulties, but when her body starts to break down, Angie fears the worst and faces it alone.

Lacey wants skin removal surgery, but Dr. Now begins to wonder if she even wants to lose weight; in Houston, Mercedes and her kids face destitution.

Right when Angie is starting to succeed in Dr. Now's program, her marriage falls apart and her life is thrown into chaos, but she tries to move ahead alone despite dire difficulties.

Kirsten is close to losing all her mobility, and while she's trying to control of her obesity, she's also in danger of losing her troubled son.

Pauline is 51-years-old and nearly 700 pounds; her addiction to food has taken over the life of her son and primary caretaker.

At 24 years old, Bettie Jo is on her way to reaching 700 pounds and relies on her husband for her basic needs.

Liz, completely bed-bound, has severe lymphedema that makes it impossible to walk; utterly isolated, Liz has no friends, battles depression and lives with a mother too ill to take care of her.

Devastated by two miscarriages due to her weight, Schenee is desperate to start a family and stop relying on her husband, Freddie, to take care of her; she hopes weight loss surgery will be able to fix her fertility issues as well as her marriage.

Maja moves to Houston to undertake a difficult weight-loss journey with the support of her boyfriend, Christian; when Christian decides he's had enough and leaves Maja high and dry, she discovers that the only person she can count on is herself.

Despite moving to Houston with the solid support of her boyfriend, Aaron, and her cousin, Jasmine, Tiffany finds it difficult to break the cycle of depressed eating when her two roommates don't join her diet and leave the house every day for work.

JT is almost 900lbs with a 100-lb lymphedema mass on his leg and a food addiction that is bound to kill him if he doesn't change; his girlfriend takes him to Houston, but when his behavior drives her away, JT is left with only Dr. Now to help.

Nothing means more to Chris than his relationship with his daughter, Zoey, but now he feels he is failing her as his weight gain begins to limit his mobility.

Patrick's weight has never been a bother, but now he's so big that it's getting in the way of his relationship with his daughter; if he wants to see her graduate high school, he'll have to reverse course.

Nothing means more to Chris than his relationship with his daughter, Zoey, but now he feels he is failing her as his weight gain begins to limit his mobility.

Patrick's weight has never been a bother, but now he's so big that it's getting in the way of his relationship with his daughter; if he wants to see her graduate high school, he'll have to reverse course.

JT is almost 900lbs with a 100-lb lymphedema mass on his leg and a food addiction that is bound to kill him if he doesn't change; his girlfriend takes him to Houston, but when his behavior drives her away, JT is left with only Dr. Now to help.

Boys Giovanni and Owen share the rare condition Schwartz-Jampel Syndrome, which permanently and painfully contracts their muscles; the two share hardships and triumphs, and strike up a friendship.

Tiffany and Destiny both live with the rare disease Osteogenesis Imperfecta, which causes brittle bones, and set out on a life-changing journey to meet each other.

Bobbi and Kenny have skin that painfully grows in thick scales due to the rare condition Lamellar Ichthyosis.

The CDC, NYPD and FBI team up to deal with anthrax; a mysterious illness targets young girls.

Organ donor recipients share similar symptoms before lapsing into coma; pox outbreak in the Midwest.

A disease that kills 17,000 crows and zoo birds also fills a city's emergency room; an unidentified virus in the Southwest.

A woman starts growing uncontrollably.

A woman suffers crippling sinus pains.

A young man has strange growths; toddler rapidly gains weight.

A baby is born with a series of defects; deadly sore throat.

A doctor treats three gunshot victims who claim be innocent bystanders; a doctor must perform emergency brain surgery on his first day; a bride-to-be suddenly slips into a diabetic coma.

A woman stops eating because she believes she is dead; a runner goes blind in one eye during a marathon; an ER tech's stroke-like symptoms.

A woman believes her neighbors want to kill her; a man is near death after an arrow pierces his chest; two women with swollen abdomens refuse to explain the cause of their pain.

A circus sword-swallower suffers from a persistent case of hiccups; a mother and daughter mysteriously collapse in the ER; a woman loses control of her legs at her daughter's graduation.

Charmaine from Trinidad suffers from one of the most extreme cases of neurofibromatosis ever recorded; tumors cover every inch of her body and obstruct her ability to breathe and swallow; without surgery, these growing tumors threaten her life.

Thirty-year-old Alexandra has a 20-pound, sagging tumor that starts at the back of her neck and now reaches below her waist; as the tumor on Claudia's backside continues to grow, so does the urgency for surgeons to remove it.

Despite his family's pleas, Marlow explores a high-risk surgery to remove a facial tumor; Amy has let the tumor on her back grow for more than 17 years; after finally making the decision to remove it, she learns that now it might be too late.

A massive tumor on Tim's neck continues to grow at an alarming rate, but doctors fear that removing it could leave him paralyzed.

Charmaine from Trinidad suffers from one of the most extreme cases of neurofibromatosis ever recorded; tumors cover every inch of her body and obstruct her ability to breathe and swallow; without surgery, these growing tumors threaten her life.

Thirty-year-old Alexandra has a 20-pound, sagging tumor that starts at the back of her neck and now reaches below her waist; as the tumor on Claudia's backside continues to grow, so does the urgency for surgeons to remove it.

Despite his family's pleas, Marlow explores a high-risk surgery to remove a facial tumor; Amy has let the tumor on her back grow for more than 17 years; after finally making the decision to remove it, she learns that now it might be too late.

A massive tumor on Tim's neck continues to grow at an alarming rate, but doctors fear that removing it could leave him paralyzed.

A woman believes her neighbors want to kill her; a man is near death after an arrow pierces his chest; two women with swollen abdomens refuse to explain the cause of their pain.

A circus sword-swallower suffers from a persistent case of hiccups; a mother and daughter mysteriously collapse in the ER; a woman loses control of her legs at her daughter's graduation.

A drug dealer stages an alligator attack; a desperate man uses a corpse to stand in for him.

An innocent man goes underground after refusing to commit a crime; a man who seems to have it all stages a plane crash to escape his life.

A husband and wife try to hide from drug dealers and the law; a man has a cold-blooded plan to cash in on his life insurance.

Stressed out Naomi struggles with her liquid diet and may reach her breaking point; Drew wants to have the weight loss surgery, but when he steps on a scale he's thrown off entirely; bed-bound Chitoka asks Dr. Procter for a house call.

After struggling with her liquid diet, Naomi learns if she is approved for surgery; Drew's new weigh-in leads him down a slippery path; family tragedy motivates Chitoka to try to become more mobile, starting by trying to leave her bedroom.

Chitoka attempts to walk outside for the first time in years; Naomi finds some things remain the same post-surgery; Drew risks getting his surgery canceled entirely if he doesn't fight for it and lose weight.

A look at two women with a history of addiction who are pregnant and struggling to stay clean.

Trisha spends her pregnancy behind bars for dealing and using drugs; up for parole, she discovers that she has chance to prove she can conquer her addiction and be the mother her child needs.

Jenna's life is dominated by fear of contamination OCD; with a second child on the way, Jenna struggles with her condition that worsens with pregnancy; she dictates both her marriage and young son's life.

Lisa helps a man yearning to discover his biological roots, but fearful of rejection from the family he has never met; Chris reveals the truth to a woman who has felt guilty that her birth might have devastated the life of her 14-year-old mom.

A tough Texas lawman seeks Lisa's help to tackle the one investigation he's never been able to solve: the story of his own birth and adoption.

Chris tries to unravel a legal mystery involving a woman's sister who she last saw across a New York courtroom 30 years ago.

A Vietnam vet hopes Lisa can help him make amends for the past by locating the daughter he lost custody of forty years ago; a woman's struggle to fit in takes a surprising turn when Chris reveals a series of stunning coincidences very close to home.

The recent revelation of a 49-year-old man's adoption sends Chris searching for answers to a secret his adoptive parents took to the grave; a biracial woman enlists Lisa's help to find her birth family, revealing some unfortunate tragedies.

After Thomas Hicks sold over 200 babies illegally in the 1950s and 1960s, Jane Blasio works to reunite the stolen babies with biological families while trying to unearth secrets about Hicks himself.

Jane discovers a suspicious pattern of babies with extremely low birth weights coming out of the clinic; Chris finds out that Dr. Hicks may have hidden birth records in his mausoleum; Diane hopes to meet her biological father.

Jane and Lisa meet the first Hicks baby, Stephen Dilbeck; Chris and Sallie open the mausoleum in search of birth records rumored to be inside as they work on getting approval of an exhumation.

Stephen Dilbeck gets some shocking information about his birth family from Jane and Lisa; Chris and Sallie work on getting approval of an exhumation that will answer questions for hundreds of Hicks babies.

After Thomas Hicks sold over 200 babies illegally in the 1950s and 1960s, Jane Blasio works to reunite the stolen babies with biological families while trying to unearth secrets about Hicks himself.

Jane discovers a suspicious pattern of babies with extremely low birth weights coming out of the clinic; Chris finds out that Dr. Hicks may have hidden birth records in his mausoleum; Diane hopes to meet her biological father.

Jane and Lisa meet the first Hicks baby, Stephen Dilbeck; Chris and Sallie open the mausoleum in search of birth records rumored to be inside as they work on getting approval of an exhumation.

Stephen Dilbeck gets some shocking information about his birth family from Jane and Lisa; Chris and Sallie work on getting approval of an exhumation that will answer questions for hundreds of Hicks babies.

A Vietnam vet hopes Lisa can help him make amends for the past by locating the daughter he lost custody of forty years ago; a woman's struggle to fit in takes a surprising turn when Chris reveals a series of stunning coincidences very close to home.

The recent revelation of a 49-year-old man's adoption sends Chris searching for answers to a secret his adoptive parents took to the grave; a biracial woman enlists Lisa's help to find her birth family, revealing some unfortunate tragedies.

Michael's massive body has left him dependent upon his family, and he must learn to control his anger issues around food, lose weight and address the root of his issues or risk losing everything.

An 800-pound man who lost his job and is mostly housebound looks to find the strength to face his past and save his own life.

A woman struggles to make a positive change to be part of her partner and son's lives and turn her life around.

Unable to stand for more than a short period of time, Karina's weight places a burden on her parents and drives a wedge between her and her sister.

After a difficult childhood with an abusive stepfather and drug-addicted mother, Sarah is fighting for her life at only 24 years old.

Born as "Matthew," Destinee never felt like she fit in; now, having come out as a 600-pound transgender woman, she likes her curves, but she will need to say goodbye to them if she wants to be approved to transition completely.

Jeanne lives in an unhygienic household with her mother and schizophrenic father; at well over 600 pounds, Jeanne might never get weight-loss surgery as she runs into several obstacles, especially after an unexpected death in her family.

When Travis gets too big to walk down the aisle, he promises to give his wife a proper wedding; he gains more weight, leaving Dr Now as Travis' only hope to lose weight and get the life he and his wife dreamed of having together.

Krystal S. has finally met the man of her dreams, but she won't let herself marry him until she can be sure that she won't become bedridden and force him into the role of caretaker.

Abi was struggling with his weight before a fluke accident left him mostly paralyzed; bedbound for seven years since then and topping 700 pounds, Abi's only hope for a future with his wife is to get Dr. Now's help to lose weight.

Krystal S. has finally met the man of her dreams, but she won't let herself marry him until she can be sure that she won't become bedridden and force him into the role of caretaker.

Abi was struggling with his weight before a fluke accident left him mostly paralyzed; bedbound for seven years since then and topping 700 pounds, Abi's only hope for a future with his wife is to get Dr. Now's help to lose weight.

When Travis gets too big to walk down the aisle, he promises to give his wife a proper wedding; he gains more weight, leaving Dr Now as Travis' only hope to lose weight and get the life he and his wife dreamed of having together.

Krystal, a witch, looks to clear a curse of a cyst from her face; Keven wants to get a butt lipoma removed to get his tush back into a regular shape; Raquel, Dr. Lee's esthetician BFF, almost suffocates Dr. Lee with love and a facial.

J-Fab is the life of the party, but her shoulder bump is seriously cramping her style; Dan is a gentle giant with lumps on his head that add a few inches; Teresa's red face and bumpy nose make her feel like a monster.

Fit guy Alonso wants to show off his progress in the gym, but his 70 lipomas are holding him back; Porscha is a comic book enthusiast with two symmetrical lumps on her face; Jeffrey has a leaky lump named Larry on the back of his head.

Robert carries the weight of providing for his family and the weight of the huge lump on his head; Christina has liquid-filled growths next to her eyes; Felipe, a photographer with a dry skin condition so severe he risks losing his career.

Natasha has ambitions of becoming a model, but her massive ear keloids are keeping her off the runway; eight-year-old Wynter wants her scaly mermaid skin cured; Dr. Lee's bestie, Raquel, needs help with a new product for a private area.

Nhan has an extreme, red birthmark that covers half his face; Debbie worries that her shoulder lump will prematurely age her; Justin is a dude rockin' a man bun, but he's having no fun due to the bumps poking through his scalp.

Jess is a widower looking for love who is stuck with a giant bump on his neck; Cherish developed a leopard-print face during pregnancy; former NFL defensive tackle Marcell Dareus hopes Dr. Lee can tackle his forehead lipoma.

Brent has a tricep bump potentially intertwined in his muscle; Jeb loves the beach but refuses to go because of the massive number of blackheads, pimples, and cysts all over his body; Wanda's mysterious mark that caves in her side.

Don's psoriasis has completely taken over his body; Jeff has a large growth on his spine; Sara has an extra set of breasts and nipples.

Angelina has a huge chest lump under her left breast; Delano has a football-sized mass on his back.

Melissa tries to cover a huge lipoma with a sweatshirt for years; Tyler's fear of cancer keeps him from having his huge head lumps diagnosed; Tahj is covered in painful boils; Amber has ear keloids that take control of her life.

Ronen's mysterious lump above his knee is one of the largest Dr. Lee has ever seen; Amber suffers from a debilitating skin disease that no one understands; Sandy has a neck lump she calls Tommy; Kristy's eyelid cyst is ruining her life.

Half of Mary's body is a size 18 while the other half is a size 8; Anthony's cyst is in the area called the "Triangle of Death;" Shane wants to get a lump off his back; Brandi is anxious about getting a lump removed from her chest.

Belinda's lump on her neck causes her to basically be immobile; Nicole won't get married until she gets her armpit lump removed; Adela's chest and back are covered in wisdom spots; Nick foolishly removes a lipoma at home and now needs Dr. Lee.

Diane has tumors all over her body that have ruined her life; Will fears his shoulder lump will be ripped open at work; Anthony's daughters force him to get his lump examined; a woman detests her hideous varicose veins.

Taylor has a large bump at the base of her spine that is far more dangerous than she realizes; John jokes about his hip lump, but it's no laughing matter; Noelle had her ears stretched as a teen, but now wants them repaired.

Louis is a veteran who is covered in scaly, dry skin that makes him feel like an alligator; Irais's kids are bullied because of the embarrassing growth on her head; Johnny has been living with a stubborn lump on his back for too long.

Patrick's nose is covered by huge bumps, and he can barely breathe; Aziza and Lauren are friends who bonded over their matching wrist lumps; Joe has a mound in the middle of his forehead that looks like a third eye.

Diane has tumors all over her body that have ruined her life; Will fears his shoulder lump will be ripped open at work; Anthony's daughters force him to get his lump examined; a woman detests her hideous varicose veins.

Taylor has a large bump at the base of her spine that is far more dangerous than she realizes; John jokes about his hip lump, but it's no laughing matter; Noelle had her ears stretched as a teen, but now wants them repaired.

Louis is a veteran who is covered in scaly, dry skin that makes him feel like an alligator; Irais's kids are bullied because of the embarrassing growth on her head; Johnny has been living with a stubborn lump on his back for too long.

Patrick's nose is covered by huge bumps, and he can barely breathe; Aziza and Lauren are friends who bonded over their matching wrist lumps; Joe has a mound in the middle of his forehead that looks like a third eye.

Half of Mary's body is a size 18 while the other half is a size 8; Anthony's cyst is in the area called the "Triangle of Death;" Shane wants to get a lump off his back; Brandi is anxious about getting a lump removed from her chest.

Belinda's lump on her neck causes her to basically be immobile; Nicole won't get married until she gets her armpit lump removed; Adela's chest and back are covered in wisdom spots; Nick foolishly removes a lipoma at home and now needs Dr. Lee.

A maintenance worker falls from an iconic hotel sign; a rat bite has horrifying implications for its trainer and a plane crashes on a residential street.

Doctors retrieve a stolen Rolex from a very private spot; a pick-up turns deadly when a cabbie is shot multiple times; a dirt-bike accident in the desert leaves a 52-year-old thrill-seeker clinging to life.

Phil is a 58-year-old meth user whose addiction spans over three decades.

Theresa is a homeless alcoholic whose addiction puts her life at risk.

Heroin addicts that live in a tent.

Traci is pregnant and desperate to move back home, but it's filled floor to ceiling with her mother's stuff.

Kathleen discovers a hoard of mice living in her kitchen; spending the night in a hoard might be the end of a marriage before it even begins.

Medical responders were not able to get in Renee's front door after she had fallen unconscious in her home.

Rick tries to salvage his cluttered home that was nearly destroyed in a house fire; Linda must get her house up to code in 60 days, or she will be on the streets.

Extreme hoarder Floyd must clear his hoard or risk losing his three-year-old son.

Tyler's addiction to smelling tuna is getting in the way of finding love; Lacey's addiction to plastic surgery and her cup size has grown; after mourning the loss of her record-setting fingernails, Ayanna still has an addiction.

Brittany's addiction to eating car seat foam forces her family to intervene; Lauren has put her addiction to bodybuilding behind her but has found a new obsession; Asha's addiction to her long locks remains strong, but her health remains in jeopardy.

Foxy's addiction to having enormous breasts has brought her fame, but her friends feel it is also endangering her health.

Weston loves eating raw meat, but his mom is worried it could lead to major health problems; Rachel breastfeeds her husband, Alexander, but it's upsetting to their family and friends; pillow addict Tamara meets car lover Nathaniel.

A man undergoes surgery to remove his record-breaking face tumor; a young girl lives with huge hands; a mathematician born with severely deformed legs and a spine walks on all fours.

A woman hopes the tooth transplanted in her eye will stop her from going blind; conjoined twins share a single body; a boy with gigantism in his legs turns to doctors for a cure; a mother has surgery to remove the massive fatty tumors in her neck.

Doctors seek to restore the face of a little girl with a giant facial cleft; a pregnant little person and her husband find out if their son will have two forms of dwarfism; a woman's face is slowly being destroyed by a tumor.

Doctors attempt to separate twins who were born joined at the head; a woman with a rare brittle bone disorder doesn't let her disease control her life; a man with a huge facial tumor undergoes major surgery to save his life.

A man undergoes surgery to remove his record-breaking face tumor; a young girl lives with huge hands; a mathematician born with severely deformed legs and a spine walks on all fours.

A woman hopes the tooth transplanted in her eye will stop her from going blind; conjoined twins share a single body; a boy with gigantism in his legs turns to doctors for a cure; a mother has surgery to remove the massive fatty tumors in her neck.

Doctors seek to restore the face of a little girl with a giant facial cleft; a pregnant little person and her husband find out if their son will have two forms of dwarfism; a woman's face is slowly being destroyed by a tumor.

Doctors attempt to separate twins who were born joined at the head; a woman with a rare brittle bone disorder doesn't let her disease control her life; a man with a huge facial tumor undergoes major surgery to save his life.

Foxy's addiction to having enormous breasts has brought her fame, but her friends feel it is also endangering her health.

Weston loves eating raw meat, but his mom is worried it could lead to major health problems; Rachel breastfeeds her husband, Alexander, but it's upsetting to their family and friends; pillow addict Tamara meets car lover Nathaniel.

Sean must overcome recent tragedies in his life before he loses all the progress he made over the last two years; Dottie struggles to stay on track while maintaining her family life.

Despite having lost 378 pounds, Angel's crippling knee pain and history of extreme obesity threatens everything for which she's worked; Charity finds the strength to return to a normal life after post surgery complications.

Follows the struggles of overweight people as they try to shed the pounds, and how they feel about their weight loss progress.

A year since her weight-loss journey began, Janine is still in the 500s and mostly immobile, and now, Dr. Nowzaradan is running out of options for how to treat her if she can't find a way to control her eating habit and start walking again.

Lee's anger issues continue to jeopardize his relationship with Rena and threaten to derail both of their weight-loss journeys; a major life event sends Sarah into a depression that she must pull herself out of if she wants to keep losing weight.

Alicia's relationship with her boyfriend, Tim, comes under the microscope; Pauline must beg her way back onto the program after quitting.

Dottie faces an unexpected challenge to her weight-loss when her husband's drinking problem becomes intolerable for her and her son; Cynthia starts to wonder if being there for her kids at her current weight is more important than losing more.

Jeanne struggles to care for herself in the aftermath of her dad's death; Brandon strives to get his weight down to feel confident when proposing to his girlfriend, Tayler, and be the man she deserves.