A boy with an extra arm growing out of his back; a woman whose knees bend backwards; a tumor in a woman's eye could soon threaten her life.

A man has a tumor twice the size of his head; a man with a leg that weighs more than 200 pounds seeks a diagnosis; an extremely tall teenage girl seeks help for her condition.

A man with branch like growths covering his hands and feet seeks treatment; a woman's muscles are slowly turning to bone; two brothers with tumors covering their bodies undergo surgery.

A teenage girl sleeps for weeks at a time, a boy with a brain-crushing skull defies the odds and a unique couple faces a big challenge.

A boy with an extra arm growing out of his back; a woman whose knees bend backwards; a tumor in a woman's eye could soon threaten her life.

The level one trauma center at Fresno's University Medical Center treats car crash victims and infant with respiratory problems.

Doctors treat a series of gunshot victims and a woman with vision and mobility problems at Wishard Hospital in Indianapolis.

Kristina tries to help a 19-year-old meth addict who has turned to prostitution to support her drug habit.

A 21-year-old OxyContin addict comes from a family with a devastating history of addiction problems.

After falling in love in a drug recovery program, a couple fall back into their old habits.

Susan aches for a mother-daughter relationship, and searches for both her biological mother and the daughter she placed for adoption as a teen; Tammy is still haunted for never getting to say goodbye to the son she birthed over 30 years ago.

A woman's world was shaken when she discovered she was adopted at 25, and goes onto learn more dramatic revelations; a mother is in a race against time to find her son who she placed for adoption 46 years ago.

A woman searches for her beloved sister who she tried to adopt herself years ago; after a life of longing, a couple is desperate to find the son they placed for adoption fifty years ago when they were teens.

A woman searches for her brother, hoping to fulfill a promise she made to her late mother, and discovers a 40-year-old secret about her parents' past; a woman consumed by a lifelong search for her mom finds hope with a new DNA connection.

A 19-year-old discovers she is pregnant in the middle of the night.

Kaitlyn is home alone in the tub when she suddenly feels her baby's head crowning; Myrna suffers a seizure and collapses into a coma.

Fifteen months after her son's birth, Emily fears her appendix has burst and her mother rushes her to the emergency room.

Dana is having debilitating stomach pains at work; the paramedics arrive just in time to deliver a baby.

A 20-year old woman suffers abdominal pain while at work; while waiting it out she realizes she is delivering a baby.

After a negative pregnancy test, Monique delivers a baby in her bathroom.

A flight attendant has mysterious pains in her stomach; she is stunned to learn she is in labor.

After staying home from class, Katlyn makes a trip to the bathroom, which brings her to her knees in pain, and she realizes that she is in labor.

Nicole has a c-section and Mariah refuses to help; Kim goes through a painful labor and delivery; Lemhele and Shaniyah go back to therapy.

Nicole makes a controversial announcement; Kim deals with her grandmother; Shaniyah gets induced.

Kim's boyfriend is released from rehab; Nicole and AJ get married; Shaniyah and Lemhele struggle with two new babies in the house; Lorna has a difficult birth.

After Thomas Hicks sold over 200 babies illegally in the 1950s and 1960s, Jane Blasio works to reunite the stolen babies with biological families while trying to unearth secrets about Hicks himself.

Jane discovers a suspicious pattern of babies with extremely low birth weights coming out of the clinic; Chris finds out that Dr. Hicks may have hidden birth records in his mausoleum; Diane hopes to meet her biological father.

Jane and Lisa meet the first Hicks baby, Stephen Dilbeck; Chris and Sallie open the mausoleum in search of birth records rumored to be inside as they work on getting approval of an exhumation.

Stephen Dilbeck gets some shocking information about his birth family from Jane and Lisa; Chris and Sallie work on getting approval of an exhumation that will answer questions for hundreds of Hicks babies.

After Thomas Hicks sold over 200 babies illegally in the 1950s and 1960s, Jane Blasio works to reunite the stolen babies with biological families while trying to unearth secrets about Hicks himself.

Jane discovers a suspicious pattern of babies with extremely low birth weights coming out of the clinic; Chris finds out that Dr. Hicks may have hidden birth records in his mausoleum; Diane hopes to meet her biological father.

Jane and Lisa meet the first Hicks baby, Stephen Dilbeck; Chris and Sallie open the mausoleum in search of birth records rumored to be inside as they work on getting approval of an exhumation.

Stephen Dilbeck gets some shocking information about his birth family from Jane and Lisa; Chris and Sallie work on getting approval of an exhumation that will answer questions for hundreds of Hicks babies.

Nicole makes a controversial announcement; Kim deals with her grandmother; Shaniyah gets induced.

Kim's boyfriend is released from rehab; Nicole and AJ get married; Shaniyah and Lemhele struggle with two new babies in the house; Lorna has a difficult birth.

Weighing over 700-lbs, Nicole is on the verge of leaving her two young children motherless; trying to survive a family of addicts, she commits to Dr. Nowzaradan's diet program, but crisis threatens to derail all her hopes for weight-loss.

An 800-pound man who lost his job and is mostly housebound looks to find the strength to face his past and save his own life.

A woman struggles to make a positive change to be part of her partner and son's lives and turn her life around.

Bethany has two daughters who live in fear of losing their mom to her food addiction; once an addiction counselor, Bethany has gotten so big that she can no longer work; now she risks losing her life if Dr Now can't help her curb her own addiction.

JT is almost 900lbs with a 100-lb lymphedema mass on his leg and a food addiction that is bound to kill him if he doesn't change; his girlfriend takes him to Houston, but when his behavior drives her away, JT is left with only Dr. Now to help.

Gina and wife Beth live with Gina's mother, but she and Gina's sister blame Beth for Gina's spiraling weight problem; it will take all Gina's will to leave home for Houston to get Dr Now's help, to save her life and her marriage.

When Travis gets too big to walk down the aisle, he promises to give his wife a proper wedding; he gains more weight, leaving Dr Now as Travis' only hope to lose weight and get the life he and his wife dreamed of having together.

Joyce needs home health care and hasn't left the house in three years; getting to Dr. Now in Houston is just the first step and when he prescribes therapy where Joyce must revisit an unhappy past with her mom; it might be more than she can handle.

Thederick has lost enough weight to get the giant lymphedema mass removed from his leg, in one of Dr. Now's biggest removals ever.

After getting his surgery canceled and living in his van by the beach, surgery may be the break David has been waiting for his whole life; Syreeta suffers a devastating personal tragedy that only strengthens her desire to become a mother.

Thederick has lost enough weight to get the giant lymphedema mass removed from his leg, in one of Dr. Now's biggest removals ever.

After getting his surgery canceled and living in his van by the beach, surgery may be the break David has been waiting for his whole life; Syreeta suffers a devastating personal tragedy that only strengthens her desire to become a mother.

Joyce needs home health care and hasn't left the house in three years; getting to Dr. Now in Houston is just the first step and when he prescribes therapy where Joyce must revisit an unhappy past with her mom; it might be more than she can handle.

Louis is a veteran who is covered in scaly, dry skin that makes him feel like an alligator; Irais's kids are bullied because of the embarrassing growth on her head; Johnny has been living with a stubborn lump on his back for too long.

Patrick's nose is covered by huge bumps, and he can barely breathe; Aziza and Lauren are friends who bonded over their matching wrist lumps; Joe has a mound in the middle of his forehead that looks like a third eye.

April is covered in bumps that disfigure her arms; Genner flies all the way from the Philippines to have Dr. Lee help with his bumpy nose; Chris suffers from psoriasis that nearly covers his body and a bump on his head.

Matt has a skin condition that causes tumors to grow all over his body; Yamileth hasn't pursued her dreams because of the lump on her neck; Pat is covered with dark spots from her neck to her abdomen; Jennifer has a unicorn bump on her forehead.

Amber has hundreds of tumors on her face; Antonio has a mound on his spine and is afraid it might be impossible to remove; sisters Cheri and Janice both suffer from possibly matching lumps; Tatiana has an embarrassing bump on her butt cheek.

Lisa has a horn growing out of the back of her head and fears that it could be cancer; Victor has a bulbous lump on his chest; Chuck has a Popeye-shaped bump on his arm; Christian and Jonathan are teenage brothers with matching lumps.

Taylore is a beautiful young woman who has unsightly elf-like bumps on her ears; Jose never goes out because of the baseball-sized lump on his head; Ken is covered in painful bumps that make it difficult to do everyday things.

Josh has a large knot on his head resulting from a car crash from 18 years ago; Brittney is covered in mysterious bumps; TJ has a hard, curious lump protruding from his side; Luis has a bump on his shoulder and his daughters fear it's dangerous.

Barbara's back lump became more noticeable after she lost 131 pounds; Bob has two painful bumps on his back; Hilda's depression is a result of the multitude of bumps on her eyelids; Art has one big bump on his head that he covers up with hats.

Leonard has an alarming bump hanging off of his arm that looks like it's breaking through the skin; Brandon has several lumps on his head that make him fearful for his life; Jess gets a noticeable lump on her butt after falling down the stairs.

Dr. Sandra Lee treats Heather, who has a huge growth on her leg and fears removing it could leave a keloid scar; Paul has a giant hump on his back.

Rhonda has bumps all over her head, including a horned growth that has her deeply concerned; Fred has a mysterious condition on his hands and has not been able to get answers from any doctors; Kevin has a huge lump protruding from his hip.

Jen has substantial growths on her ears that cause her depression, pain and vertigo; Juliet is under emotional distress because of the bumps all over her neck and chest; Gerald has a mysterious, kiwi-size lump on his middle finger.

Gerald is back to see Dr. Lee and a hand specialist about a huge, intrusive bump on his middle finger; Vinnie has a large, embarrassing birthmark on his neck; Leta has a lump on the back of her thigh that she has been hiding from her fiancée.

Tony has large growths on his nose that impair his breathing; Kevin has a bump in his jawline that is a lady deterrent; Marie has an unsightly lump on her forehead that makes her a hermit; Tommy's leg bump makes it difficult for him to work.

Gerard has nearly a hundred lumps varying in size all over his body; Gina has bloody lesions all over; Eric has a large bump on his head that he calls his on and off button.

Traci's confidence has been destroyed after years of bullying from the bumps on her face; Ravon has a unique dangling growth on his leg; David has a large lump.

David is back to see Dr. Lee after she spots a suspicious growth under his eye; Nicole is depressed because of the bumps all over her neck; Steve has a noticeable lump on his forehead; Allen has a growth on his biceps but is terrified of doctors.

Tony has large growths on his nose that impair his breathing; Kevin has a bump in his jawline that is a lady deterrent; Marie has an unsightly lump on her forehead that makes her a hermit; Tommy's leg bump makes it difficult for him to work.

Gerard has nearly a hundred lumps varying in size all over his body; Gina has bloody lesions all over; Eric has a large bump on his head that he calls his on and off button.

Traci's confidence has been destroyed after years of bullying from the bumps on her face; Ravon has a unique dangling growth on his leg; David has a large lump.

David is back to see Dr. Lee after she spots a suspicious growth under his eye; Nicole is depressed because of the bumps all over her neck; Steve has a noticeable lump on his forehead; Allen has a growth on his biceps but is terrified of doctors.

Jen has substantial growths on her ears that cause her depression, pain and vertigo; Juliet is under emotional distress because of the bumps all over her neck and chest; Gerald has a mysterious, kiwi-size lump on his middle finger.

Gerald is back to see Dr. Lee and a hand specialist about a huge, intrusive bump on his middle finger; Vinnie has a large, embarrassing birthmark on his neck; Leta has a lump on the back of her thigh that she has been hiding from her fiancée.

A doctor treats three gunshot victims who claim be innocent bystanders; a doctor must perform emergency brain surgery on his first day; a bride-to-be suddenly slips into a diabetic coma.

A Halloween zombie with a problem below the belt mystifies doctors; two unconscious men are involved in an accident, a doctor makes a mistake that amazingly explains a patient's condition.

A woman's face-lift goes terribly wrong; a hospital chaplain's sudden personality change; a pregnant woman's life-threatening symptoms need urgent treatment.

A student's head is impaled by a trophy deer's antlers; a semi-conscious car crash victim; a woman with an allergic reaction.

A man injured in a medieval role playing battle has a sword impaled in his head; a critically ill patient is so afraid of germs he won't allow doctors to treat him; two patients with the same life-threatening symptoms.

Brian once weighed over 600 pounds and now has lots of sagging skin; Tanya lost nearly 200 pounds and her excess skin drapes over her new frame.

Ariel is 23 and has already lost 260 pounds, but finds the excess skin less feminine than being obese; spirited Chantae is desperate to enjoy life again after losing 222 pounds.

Julie's globs of excess skin cause her to recoil from the touch of her children; Andrew shed 300-lbs. by spending every spare moment in the gym, but is now engulfed in empty skin that's killing his dream of body-building.

Megan lost weight after being bullied in high school but is still constantly tormented when she sees her dramatic loose skin in the mirror; Ashley lost 220-lbs. but her excess skin that leaves her in pain.

Constant respiratory infections and an inability to grow; mysterious spasms and back pain overcome a man's life.

Harry is born healthy but his body starts transforming; Sadie is on the brink of starvation.

A girl is born with shocking deformities; a college student suffers from fluid around his heart and lungs.

A 25-year-old woman becomes paralyzed from the chest down; an unknown condition steals a woman's eyesight.

Weak muscles make walking and using hands difficult; bump on the finger could be the first sign of a deadly infection.

A woman is stuck in bed after a night at a cheap hotel; a woman cools down during a Fourth of July photo shoot; a couple initiate their tree house, and something gets cut off.

An addiction to hot sauce causes an inferno; hickeys from a secret lover may be the cause of a medical crisis; getting lucky at a bowling alley leads to the ER.

A man's chastity belt injury; a sneaky vacation treat becomes a deadly headache; a couple's romp while decorating for their wedding reception leaves them questioning their future.

A man cannot believe he is getting busy with his girlfriend in his sleep; a steamy first date cooking class; a retirement hobby gets a man in trouble.

A woman is stuck in bed after a night at a cheap hotel; a woman cools down during a Fourth of July photo shoot; a couple initiate their tree house, and something gets cut off.

An addiction to hot sauce causes an inferno; hickeys from a secret lover may be the cause of a medical crisis; getting lucky at a bowling alley leads to the ER.

A man's chastity belt injury; a sneaky vacation treat becomes a deadly headache; a couple's romp while decorating for their wedding reception leaves them questioning their future.

A man cannot believe he is getting busy with his girlfriend in his sleep; a steamy first date cooking class; a retirement hobby gets a man in trouble.

A 25-year-old woman becomes paralyzed from the chest down; an unknown condition steals a woman's eyesight.

Weak muscles make walking and using hands difficult; bump on the finger could be the first sign of a deadly infection.

Kirsten is close to losing all her mobility, and while she's trying to control of her obesity, she's also in danger of losing her troubled son.

Despite having lost 378 pounds, Angel's crippling knee pain and history of extreme obesity threatens everything for which she's worked; Charity finds the strength to return to a normal life after post surgery complications.

Olivia suffers an unexpected loss; James strives to reach his goal of skin surgery and have a fulfilling relationship.

After a lifelong struggle with obesity, the three Perrio siblings travel to Houston in a last-chance journey to lose weight.

Tamy faces a tough choice when her husband wants her back, but only if she moves away from Houston and Dr. Now's program; Karina's weight loss begins to slow, but she finds happiness dating a guy Dr. Now is surprised to see in his clinic again.

Erica's success on her weight-loss journey is derailed by heartbreak; Benji must reach his goal weight without the support of his brother.

Alicia's relationship with her boyfriend, Tim, comes under the microscope; Pauline must beg her way back onto the program after quitting.

As an Italian American, Geno was raised with lots of love, family and food; now, he's still living with his mom and eating himself to death, and it's time to make a change; Geno's cousin, Nico, joins the cause; they pledge to lose weight together.

Latonya found the man she wants to marry; the only problem is that, at almost 700 pounds, she can't walk down the aisle; Latonya doesn't want to give up the food that she's used to, but she may do it for love.

Wess gets off to a great start in Dr. Now's program, but when the cravings continue after surgery, Dr. Now sends him to therapy to confront his demons; Wess must ask himself whether he is ready to live his truth as a gay man in small-town Texas.

Latonya found the man she wants to marry; the only problem is that, at almost 700 pounds, she can't walk down the aisle; Latonya doesn't want to give up the food that she's used to, but she may do it for love.

Wess gets off to a great start in Dr. Now's program, but when the cravings continue after surgery, Dr. Now sends him to therapy to confront his demons; Wess must ask himself whether he is ready to live his truth as a gay man in small-town Texas.

As an Italian American, Geno was raised with lots of love, family and food; now, he's still living with his mom and eating himself to death, and it's time to make a change; Geno's cousin, Nico, joins the cause; they pledge to lose weight together.

Michael's massive body has left him dependent upon his family, and he must learn to control his anger issues around food, lose weight and address the root of his issues or risk losing everything.

An overweight woman struggles with flesh-eating bacteria and butterfly shaped fat deposits; unexpected news threatens her weight loss journey.

Laura has used food to cope with her emotions; she is confined to a wheelchair and relies on an oxygen tank to breathe and her husband and mother to survive.

Shantel's brother Carlton lives downstairs but she hardly ever sees him because at 600 lbs each, neither can do the stairs safely; to break free from a death spiral of codependent eating they need Dr. Now's help to reforge their sibling relationship.

Seana is 23 and nearly 700 lbs, living at her mom's house, depressed and anxious, her weight-gain threatening to take her last breath; Dr. Now can give her the tools she needs to live, but until she chooses life, no one can save Seana but herself.

At 600 pounds, Ashley has to move home so her mom can help her care for herself and her newborn daughter; Ashley must overcome a lifetime's worth of unfortunate circumstances and get Dr. Now's help in Houston.

Tommy wants to lose weight so he can marry his fiancee and have the life he always dreamed of with her, but to break the cycle of pathological eating that left him nearly bed-bound, he'll have to face a piece of his past he has always kept secret.

Dominic's life is falling apart due to his food addiction; over 600 pounds and living in a van with his brother, he decides to leave California for Texas, where only Dr. Now can help him learn to face life's challenges without using food to cope.

Siblings Carlton and Shantel have always been close, but with their eating habits enabling each other, they need to make a change; Shantel is sad to grow apart from her little brother, but it might be the one thing they both need the most.

Ontreon hopes that surgery can make him a better husband to his wife Musa, but he struggles to move past the grief that's blocked him for years; Wess is doing great post-surgery, but his next goal is crucial to his success.

Siblings Carlton and Shantel have always been close, but with their eating habits enabling each other, they need to make a change; Shantel is sad to grow apart from her little brother, but it might be the one thing they both need the most.

Ontreon hopes that surgery can make him a better husband to his wife Musa, but he struggles to move past the grief that's blocked him for years; Wess is doing great post-surgery, but his next goal is crucial to his success.

Dominic's life is falling apart due to his food addiction; over 600 pounds and living in a van with his brother, he decides to leave California for Texas, where only Dr. Now can help him learn to face life's challenges without using food to cope.

Deadly parasites attack a 9-year-old hockey player, a computer programmer and a marathon runner.

A mass of decaying worms is discovered in a dance instructor's colon; a vacationer suffers headaches and a seizure; parasites get under a scientist's skin.

Parents of a 44-pound baby seek to understand why their son can't stop eating; a man travels to get his giant neck tumor removed; a young girl lives trapped inside her body; a woman with a severe chemical allergy can't go outside.

A man who had a full-face transplant faces another life-threatening challenge; a boy with a talent for singing is prematurely aging; in a Peruvian village, boys and men go blind by the age of 50.

A man undergoes surgery to remove his record-breaking face tumor; a young girl lives with huge hands; a mathematician born with severely deformed legs and a spine walks on all fours.

A woman hopes the tooth transplanted in her eye will stop her from going blind; conjoined twins share a single body; a boy with gigantism in his legs turns to doctors for a cure; a mother has surgery to remove the massive fatty tumors in her neck.

A teen sleeps for 10 days.

A tumor hides another malady; a marathon runner experiences chronic fatigue.

A woman undergoes a risky craniotomy; a man searches for answers.

A teenager is rushed to the hospital after taking aspirin to help alleviate altitude sickness; a woman has pain in her arm that mysteriously spreads.

Two rockers join the mile-high club and cause an emergency landing; a woman's new look; a recent college grad helps his elderly neighbor.

A man becomes paralyzed after sex; a couple's birth plan leads to shocking symptoms; a man gives his girlfriend a special gift.

A woman discovers that some moves from her pole dancing class should not be tried at home; a man is being treated for a painful injury when his wife and mistress show up; one man is left speechless after a night of tantric magic.

College sweethearts get busted and have to go to the ER and the dentist; a fetish feast leaves a woman without hearing; a man is stuck in his zipper.

A man passes out from abdominal pain; a woman helps solve the mystery of her estranged father's deadly symptoms; a group of delirious Civil War re-enactment soldiers arrives in the ER.

A wrist fracture turns into a medical mystery; two fishermen get stuck on the same lure; a cheerleader with a sprained finger nearly dies of an unexpected cause; a power outage foils the ER team's effort to get a dying patient to the O.R.

The hospital is locked down when a nurse is shot in the ER; medics rush a bride from her wedding who is in an unexplained altered mental state; a doctor must perform a risky intervention to save the life of a teenage girl.

A teen football player suffers a stroke; a doctor remembers his first major trauma in the 1970s; a doctor tries to figure out what causes a patient's abdominal pain.

A man passes out from abdominal pain; a woman helps solve the mystery of her estranged father's deadly symptoms; a group of delirious Civil War re-enactment soldiers arrives in the ER.

A wrist fracture turns into a medical mystery; two fishermen get stuck on the same lure; a cheerleader with a sprained finger nearly dies of an unexpected cause; a power outage foils the ER team's effort to get a dying patient to the O.R.

The hospital is locked down when a nurse is shot in the ER; medics rush a bride from her wedding who is in an unexplained altered mental state; a doctor must perform a risky intervention to save the life of a teenage girl.

A teen football player suffers a stroke; a doctor remembers his first major trauma in the 1970s; a doctor tries to figure out what causes a patient's abdominal pain.

A woman discovers that some moves from her pole dancing class should not be tried at home; a man is being treated for a painful injury when his wife and mistress show up; one man is left speechless after a night of tantric magic.

College sweethearts get busted and have to go to the ER and the dentist; a fetish feast leaves a woman without hearing; a man is stuck in his zipper.

A military wife suffers a sudden paralysis in her leg that defies explanation; doctors discover it may have something to do with her husband's top secret work.

When a young woman goes to the ER with severe abdominal pains, the doctors find a rare and virulent type of cancer that gives her ten years to live.

A healthy pastor feels like he has had a heart attack every day for years; a friend gives advice and doctors try to solve the mystery.

Getting too hot can be fatal for twins Andrew and Brandon, who meet Josh, a fellow sufferer of Ectodermal Dysplasia.

Tiffany and Yajaira have Jarcho Levin Syndrome, which malformed their ribs and spines during infancy.

Born with Goldenhar Syndrome, Austin and Elena have been bullied for looking different, and feel isolated from other kids.

Pat and Joe has an extreme collection of infamous kid dolls; Kitty Kay Sera is obsessed with the color pink.

A woman collects Mickey Mouse memorabilia; a collection of more than 2,000 wigs.

Bob and Lizzie love to flaunt their collection of love dolls around town; Everything about Doris is from 1950.

Frances and Bob have transformed their entire home into a feline fantasy land; Ron has built a replica of the oval office in his home.

Stanley has been obsessed with being an adult baby for the past 18 years;.

Over 300 mannequins have taken over Chad Michael's house; Zizi is obsessed with carrots, from tattoos to decorating every room in her house with them.

Geoffrey lost his home and has 30 days to clear the clutter or he will lose everything left inside.

Jessica is a little person with dangerous toppling piles of clutter; along with her mother she has filled her entire home.

After being the target of a school shooting a former principal's life has changed; paralyzed by PTSD and hoarding Wayne has abandoned his family.

A wife has transformed one couple's home into a heap of trash; on the verge of foreclosure.

Frank didn't expect Susan to fill his house with clutter when she moved in; though her home of forty-eight years sits condemned just two blocks away.

Lisa helps a man find answers about his adoption; a breast cancer survivor searches for her birth mother.

Chris unwraps the mystery of a woman's origins, which at a Korean orphanage; Lisa desperately searches for a woman's only child, hoping it will heal her.

Lisa hopes that locating a man's biological mother will finally allow him to overcome his lifelong struggle with abandonment; Chris locates a woman's only child and delivers the difficult details of her daughter's birth story.

Identical twins enlist Lisa's help to unlock the mystery of why they were placed for adoption; Chris hopes to fulfill the wishes of a deceased father by tracking down the first-born son he and his wife had placed for adoption.

Lisa helps a man find answers about his adoption; a breast cancer survivor searches for her birth mother.

Chris unwraps the mystery of a woman's origins, which at a Korean orphanage; Lisa desperately searches for a woman's only child, hoping it will heal her.

Lisa hopes that locating a man's biological mother will finally allow him to overcome his lifelong struggle with abandonment; Chris locates a woman's only child and delivers the difficult details of her daughter's birth story.

Identical twins enlist Lisa's help to unlock the mystery of why they were placed for adoption; Chris hopes to fulfill the wishes of a deceased father by tracking down the first-born son he and his wife had placed for adoption.

A wife has transformed one couple's home into a heap of trash; on the verge of foreclosure.

Frank didn't expect Susan to fill his house with clutter when she moved in; though her home of forty-eight years sits condemned just two blocks away.

Tanisha weighs around 600-lbs and she's desperate to survive for her kids and avoid her mother's tragic fate of dying at age 50 from super obesity; now at 32, her future looks grim if she doesn't make a drastic change to save her life.

Zsalynn struggles between fighting her weight and fighting for her marriage; Christina releases the negativity in her life and finally begins to live.

Chuck's second year of weight loss and a new relationship; Paula struggles with juggling many responsibilities along with her weight-loss.

Dottie faces an unexpected challenge to her weight-loss when her husband's drinking problem becomes intolerable for her and her son; Cynthia starts to wonder if being there for her kids at her current weight is more important than losing more.

In order to keep pace with her daughter Charly's impressive weight loss, Charity must do something she's never done and find a way to go it alone.

Steven's dysfunction escalates, pushing his relationship with Dr. Nowzaradan; his brother Justin takes the leap to go to Houston to finally accept help.

Dr. Nowzaradan is worried Lupe's emotional issues are blocking her weight loss journey since she's shed over 300-lbs but still can't walk; when Ashley is struck with sudden paralysis, her own emotional stability is thrown into peril.

Syreeta thinks that anyone trying to help has an ulterior motive, but she's gotten so big she desperately needs help; she's learning to let down her guard for her husband, but weight-loss surgery will be tough if she can't learn to trust the surgeon.

Mark sets out with a goal for weight-loss surgery, but as weight loss gets easier, he turns down medical advice and decides to do it on his own; Mark thinks he can lose 500 pounds by himself, but Dr. Now sees this as another excuse not to change.

With her weight spiraling, Stephanie needs her mom's help to care for her three kids; she's at the point where she'll have to lose weight or risk not having the chance to see her kids grow up.

Mark sets out with a goal for weight-loss surgery, but as weight loss gets easier, he turns down medical advice and decides to do it on his own; Mark thinks he can lose 500 pounds by himself, but Dr. Now sees this as another excuse not to change.

With her weight spiraling, Stephanie needs her mom's help to care for her three kids; she's at the point where she'll have to lose weight or risk not having the chance to see her kids grow up.

Syreeta thinks that anyone trying to help has an ulterior motive, but she's gotten so big she desperately needs help; she's learning to let down her guard for her husband, but weight-loss surgery will be tough if she can't learn to trust the surgeon.

Tim has a massive growth on his back that affects his ability to work and socialize; Daniel has debilitating psoriasis that covers most of his body; Gloriana and Yolanda are a mother and daughter duo who have bonded over their bumps.

Inoke has a huge, possibly life-threatening bulge on his shoulder; Delano returns with his back lump after Dr. Lee removed a liter of fluid from it; Reed has hundreds of bumps on his chest that burst and leave nasty scars.

With pandemic safety protocols in place, Dr. Lee reopens her office; Monica has a large birthmark growing on the side of her face; Jackie has a melon-sized lump on the back of her shoulder; Reginald has large, rare growths on the back of his head.

Dr. Lee tries to provide the help Reginald needs to remove the large, rare growths on the back of his head; Che'Re has a prominent bump on her face that has put her in a dark place; Juan has several painful boils on the back of his neck.

Dennis has several giant growths on the back of his head; Juan has a rare condition he hopes Dr. Lee will understand; Natalie searches for answers as to why her body is covered in hundreds of mysterious dark bumps.

Audrey pops the painful bumps that cover her body so she can feel relief; Felicia has a peculiar-looking dark growth on her forehead; Krista's excessive sweating is so severe that on any given day she could fill up an entire milk jug with her sweat.

John fears the large lump on his neck could become so big that it may eventually suffocate him; Shoshana is depressed because of the big growth on her forehead; Ashley hopes Dr. Lee can provide some relief from her three painful skin conditions.

Yaellie, 9, has itchy psoriasis on over 90 percent of her body; former U.S. Marine Matt has a large recurring lump in his armpit; twins Tracie and Stacie have numerous matching bumps on their heads that sometimes leak.

Joanne has been held back from success because of her forehead growth; Shakisaha split her left earlobe after stretching it with gauges; Mike is a tough guy with a soft bump on his head; Dania's rhinophyma has kept her from enjoying her life.

James has a large, squishy lump on his forehead; Tanisha has a growth on her arm and itchy scars all over her body; Ed wants his stomach lump removed before his girlfriend gets out of prison; Justin has painful mystery bumps all over his head.

JD is a gentle giant with a pear-shaped mass hanging off of his ear; David has two bumps on his neck and one on his finger that give him pain; Julie hopes Dr. Lee can remove her large back growth so she can return to the sea.

Stephen's large, bulbous nose gets him unwanted attention, and he hopes Dr. Lee can help; Veronica wants to be free of secrets, including the bump on her butt; Marty has a large, 30-year-old growth on his shoulder that he is ready to remove.

Brittany has been called a monster due to her genetic condition that causes head-to-toe bumps; Leonardo has a fist-size growth on his head, but he is terrified of doctors; Tamyra has skin so thick that she shaves the bottom of her feet for relief.