A lifetime of abuse has left Michael anxious and afraid to leave the house; with the help of his devoted wife, he must follow Dr. Now's program to keep from eating himself to death.

Krystal begins overeating to shield herself with a protective layer of obesity after suffering years of abuse; once a means of protection, her pathological eating now threatens to destroy her life if she doesn't get help.

Twins Kandi and Brandi have a combined weight of over 1,100 pounds and fear losing each other to obesity, so they decide to make a change together.

Penny has been bedridden for four years and moves to Texas to have gastric bypass; her unwillingness to make lifestyle changes could mean failure.

Chuck weighs almost 700 pounds; he has had to downsize his business and his wife feels like a single-parent who is ready to leave him.

At over 700 pounds, Brianne undertakes a weight-loss journey to save her own life; she faces an unexpected challenge to her fragile progress when her husband suffers a heart attack on a birthday she will never forget.

Octavia has been bedbound for nearly a year when she decides to make the trip to Houston to get help from Dr. Now, but when it turns out that her best friend is also her worst enabler, Octavia will have to choose between old habits and a new life.

Robin and her brother Chris are both obese and already lost a sibling to obesity; they plan to visit Dr. Now together when Chris suffers a stroke and can't go; Chris' son Garrett, already 600 pounds at age 20, is game to join the journey.

A college graduate with a once-promising career, Justin has eaten his life away to the point of never leaving the house for anything but food; only the help of Dr. Now's weight-loss program can restore his hopes of living a happy, productive life.

Holly already has one failed weight loss surgery, so to succeed this time, she must do more than change her eating habits, she must address the childhood issues that continue to plague her.

Lacey wants skin removal surgery, but Dr. Now begins to wonder if she even wants to lose weight; in Houston, Mercedes and her kids face destitution.

After a year of isolation due to COVID-19, brothers John and Lonnie return to see Dr. Now with a collective weight loss that makes them some of his most successful patients ever.

Lacey wants skin removal surgery, but Dr. Now begins to wonder if she even wants to lose weight; in Houston, Mercedes and her kids face destitution.

After a year of isolation due to COVID-19, brothers John and Lonnie return to see Dr. Now with a collective weight loss that makes them some of his most successful patients ever.

Holly already has one failed weight loss surgery, so to succeed this time, she must do more than change her eating habits, she must address the childhood issues that continue to plague her.

Pregnant detainees await trial; Jamie, a mother of four struggles for visitation rights; Tanya requests house arrest to prepare for the birth of her son.

Latoya struggles with giving up her baby for adoption; Esther is sent to disciplinary segregation.

A pianist's finger goes missing after getting accidentally sawed off; a man's pacemaker threatens to kill him; a man behaves bizarrely.

A pregnant woman is shot in the abdomen; a doctor is the victim of a car burglary; a storm is preventing a patient's life-saving surgery.

A woman risks losing her finger after trying on an ill-fitting engagement ring; a body builder can't breathe and doctors are shocked to discover why; a gunshot victim.

Trauma surgeon Kris Gebrowski and Dr. Steve Nishida handle a wide variety of cases at Honolulu's Queens Medical Center.

Patients at the University Hospital trauma center in Albuquerque, N.M., often come from great distances.

Louisville's University Hospital sees the results of domestic violence.

The Elvis Presley Trauma Center in Memphis, Tenn.; butcher-knife injury; teen injured in car accident; man breaks hip.

A man seeking redemption from his troubled past longs to reunite with the grown son he only got to hold for a few minutes; 46 years after placing her daughter up for adoption, a woman still carries the feeling of guilt for being an unwed mother.

A couple longs to find the daughter they had as young teens; a woman learns her birth was a secret; taking place live, a bride and groom reveal a momentous surprise to their wedding guests and someone gets reunited with a long-lost family member.

A woman whose daughter perished in a car accident hopes to find comfort in locating her granddaughter, who was placed for adoption 26 years ago; a woman yearning to meet her birth mother is stunned by an unlikely figure in the search.

Two brothers navigate a painful past as they search for the family they've longed for their entire lives, and their journey reopens decades-old family mysteries about their birth mother, twin siblings and a baby who was only rumored to exist.

Lisa meets a woman who was left on a curb by her mother when she was just four years old; Chris uncovers stunning information for a woman searching for her family that leads to an unexpected reunion.

A teacher's aide fails to recognize the signs of pregnancy; a 40-year-old is shocked to learn that she is pregnant.

A mother mistakes labor pains for kidney stones; after losing weight, a woman discovers she is pregnant.

A newlywed couple is moving cross-country when the young wife, not knowing she is pregnant, discovers she is in labor.

Victoria suddenly goes into labor at her mother-in-law's house, never suspecting she was pregnant.

Ressa collapses and goes into a coma after a miscarriage five months earlier; she has an eclamptic seizure caused by her full term baby.

Alicia barely survives a harrowing car accident. Then, just 18 months later, a surprising pregnancy threatens the life of her newborn.

Melissa is rushed to the hospital thinking she might be having a miscarriage; she gives birth to an unexpected baby in the backseat.

Jenna is rushed to the hospital to find out she is in labor and at a hospital that hasn't delivered a baby in 15 years.

A teacher's aide fails to recognize the signs of pregnancy; a 40-year-old is shocked to learn that she is pregnant.

A mother mistakes labor pains for kidney stones; after losing weight, a woman discovers she is pregnant.

A newlywed couple is moving cross-country when the young wife, not knowing she is pregnant, discovers she is in labor.

Victoria suddenly goes into labor at her mother-in-law's house, never suspecting she was pregnant.

Ressa collapses and goes into a coma after a miscarriage five months earlier; she has an eclamptic seizure caused by her full term baby.

Alicia barely survives a harrowing car accident. Then, just 18 months later, a surprising pregnancy threatens the life of her newborn.

Melissa is rushed to the hospital thinking she might be having a miscarriage; she gives birth to an unexpected baby in the backseat.

Jenna is rushed to the hospital to find out she is in labor and at a hospital that hasn't delivered a baby in 15 years.

Two brothers navigate a painful past as they search for the family they've longed for their entire lives, and their journey reopens decades-old family mysteries about their birth mother, twin siblings and a baby who was only rumored to exist.

Lisa meets a woman who was left on a curb by her mother when she was just four years old; Chris uncovers stunning information for a woman searching for her family that leads to an unexpected reunion.

A woman gets a Christmas tree imbedded in her neck; a boy out fishing almost chokes on a barb; a man is filled with enough air to fill 1000 balloons; learn how they survived.

A man gets a wire embedded in his heart; three year old swallows magnets; woman has pencil in her brain; man has a five centimeter splinter removed from eye.

A car accident leaves a pole penetrating a man's mouth and neck, a man accidentally eats a sewing needle, a 75-year-old man finds out he has had a nail in his face.

Melanie wants to feel normal and date, but her layers of skin are dragging her down; Lauren is so uncomfortable in her excess skin that she can't have the normal life she wants with her boyfriend.

After losing 275 lbs., Mikki became a fitness fanatic, but the weight loss left her with a lot of sagging skin; Denise's obesity always made her feel invisible, but after losing 200 lbs. the skin still hinders her from fitting in with her family.

Rebecca lost her weight to be more active with her young son, but the plan backfired because she's now trapped in her excess skin; after his dad died, Sal dropped a ton of weight, but with all the excess skin, he fears he will never become a dad.

Autumn wants to make up for lost time with her son, but the excess skin from major weight loss is holding her back; Cody always pretended to be happy when he was 500-lbs, but after losing the weight, he's covered in skin and is sick of pretending.

A teenager's hair begins to fall out.

An elderly woman cannot walk straight; a baby cries incessantly.

A woman's legs may need amputation; one side of a woman's face is numb.

A man faces amputation when a mystery disease turns his extremities black; a young woman develops paralyzing fears about ordinary objects.

A beautiful model turns into a raging monster and starts attacking everyone around her; a man's life is nearly destroyed when he can't stop burping.

A woman's life is ruined by extreme sweating day and night; a young teacher prays to stop living when he feels invisible bugs crawling all over him.

Meet three of the tallest teenagers in America who haven't finished growing.

A woman who slept through the birth of her child, hopes to find a diagnosis for her sleeping condition; a man with giant genitals seeks help; a 2.5ft teenager hopes to find out what stalled his growth.

A boy can't stop his giant foot from growing; a woman with bubbly skin and her kids embrace their condition; a dwarf boy who defied the odds has one more challenge to face; a man with a facial tumor must conquer his fear of surgery.

A boy born with no eyes; a separated conjoined twin adjusts to life after losing his twin brother; two brothers suffer from a very rare bone condition; a boy living with a huge facial growth finally gets a diagnosis.

In India, Hemlata Singh, gave birth to a boy with the head and arms of his dead twin attached to his chest; doctors try to save the newborn and separate him from his sibling's body.

A woman who slept through the birth of her child, hopes to find a diagnosis for her sleeping condition; a man with giant genitals seeks help; a 2.5ft teenager hopes to find out what stalled his growth.

A boy can't stop his giant foot from growing; a woman with bubbly skin and her kids embrace their condition; a dwarf boy who defied the odds has one more challenge to face; a man with a facial tumor must conquer his fear of surgery.

A boy born with no eyes; a separated conjoined twin adjusts to life after losing his twin brother; two brothers suffer from a very rare bone condition; a boy living with a huge facial growth finally gets a diagnosis.

In India, Hemlata Singh, gave birth to a boy with the head and arms of his dead twin attached to his chest; doctors try to save the newborn and separate him from his sibling's body.

A woman's life is ruined by extreme sweating day and night; a young teacher prays to stop living when he feels invisible bugs crawling all over him.

Meet three of the tallest teenagers in America who haven't finished growing.

At 670 pounds, Ashley, who lives in her parents' home with her husband, decides she must make a drastic change to save her life and her marriage.

Zsalynn's 360-body lift procedure proves to be more challenging than expected; lonely and depressed since her gastric surgery, Olivia wants skin removal surgery but struggles to lose the weight to qualify.

Diagnosed with cancer and battling depression, Bettie Jo finds out she's pregnant, and she must find a way to cope with the help of her husband; Susan suffers a major setback after surgery for her excess skin.

Doug has lost over 200 pounds and is more involved with his family life. He is now an example of healthy habits, but eating disorders threaten to derail his progress.

Pauline's self-destructive behavior continues to be a problem; Chad strives to be a better father and husband as he continues his journey; June's progress stalls when frequent travel and wedding plans cause her to slip back into bad habits.

After a year on a weight loss program, Steven remains completely non-compliant and Justin focuses on a new career instead of his diet, but time is quickly running out for surgery.

A year since her weight-loss journey began, Janine is still in the 500s and mostly immobile, and now, Dr. Nowzaradan is running out of options for how to treat her if she can't find a way to control her eating habit and start walking again.

Having her daughters help bathe her is not how Chrystal pictured parenting but she is so large that there's no other option; Chrystal wants Dr. Now's help but she didn't know that bringing her childhood trauma to light would be part of the deal.

Ryan moved to Montana to keep himself from going down a dark path of drug addiction but his new path may be no less lethal than the last if he can't find a way to curb his eating habits before they kill him.

Paul weighs in at 700 pounds, and his girlfriend struggles with how this limits their ability to live a normal life; he thinks their relationship won't survive if he moves to work with Dr. Now, but prioritizing his own health is the only option.

Ryan moved to Montana to keep himself from going down a dark path of drug addiction but his new path may be no less lethal than the last if he can't find a way to curb his eating habits before they kill him.

Paul weighs in at 700 pounds, and his girlfriend struggles with how this limits their ability to live a normal life; he thinks their relationship won't survive if he moves to work with Dr. Now, but prioritizing his own health is the only option.

Having her daughters help bathe her is not how Chrystal pictured parenting but she is so large that there's no other option; Chrystal wants Dr. Now's help but she didn't know that bringing her childhood trauma to light would be part of the deal.

Robert has thousands of unique bumps on his arms that Dr. Lee has never seen; Alexis has a painful cheek cyst that oozes and has a pungent odor; Stuart's cluster of back bumps disgusts his wife but thrills Dr. Lee.

Elaine calls the growth on her love handle her third breast; Jessica's cyst is close to her eye and could be dangerous for Dr. Lee to remove; Dwayne wants his nose bumps removed, but he may not be able to make it through the pain of the procedure.

Dr. Lee faces off with iguana-wrangler Madison's head growths; Chanel suffers from painful cyst tunnels beneath her armpit skin that leak and smell like the food she eats; the dark purple birthmark on Eddie's nose has made him a recluse.

Bob suffers from mysterious open-wound sores all over his body; Virginia's stress-ball-sized lump is such a pain in her neck that she can't wait to have it removed; Ted suffers from flaking, itchy, stucco-like skin and has had no luck finding a cure.

Steven's bump is so large, his daughter thinks he is growing a monster on his back; Catherine's arm lump has grown so big that it's nearly up to her armpit; Ethan suffers from an irritating rash in an uncomfortable and awkward place on his body.

John lost his sight at a young age and soon after began growing lumps on his body. Lynette has hundreds of pebble-sized bumps all over her arms, chest and belly. Gabe cannot imagine going to college with the unsightly mole on the back of his head.

Casey's birthmark covers most of her face, head and neck; James has mysterious massive growths on his inner thigh and lower abdomen; Jerry had to hang up his rock star vocal cords when a lump grew out the side of his throat.

Johnnie's crippling psoriasis keeps him from spending time with his daughter; Aimee has a mohawk of cysts on her head; Edith's face markings and itchy skin condition turn out to be more than she expected.

Elizabeth's head is covered with giant cauliflower-shaped bumps; Jamaal has been growing a strange knob on the left side of his butt since he was just a boy; Donna's cracking, bleeding skin condition has aged her face and kept her from being social.

Kenny was born with a rare condition that causes hundreds of lumps to grow all over his body; Ebonee covers the tiny bumps on her eyes with sunglasses; Paula's painful and swollen feet ooze a substance that emits a foul odor.

Jacqueline's massive shoulder growth makes it difficult for her to do her favorite hobby of fire spinning; the mysterious bump on James' cheek loves to bleed; Mikalia has possessed a bumpy, smelly mass on her head since birth.

After losing his longtime love, Joe wants the large bumps all over his head removed; the itchy, painful rash on Nisa's ears spreads to her face; Jennifer has dark spots all over her face that nobody is allowed to see.

Cedric has a bump on his eye and a painful lump on his neck that have kept him from working; Katherine's large ear cluster puts her neighborhood watch job at risk; Andrea uses makeup to cover the white spots all over her face and body.

Jimmy's flaky, raised alligator skin feels like an itchy hell, and he wants it cured so he can find love; Djuka is a stubborn guy with a stubborn bump; Talina has hundreds of tumors all over her body, causing embarrassment and discomfort.

Brittney has hundreds of tiny bumps over her chest that have destroyed her confidence; John has a nose the size of a plum and leans on his local family clinic for help; Dr. Lee's friend Raquel drops in and brings out her wild side.

Mike's religious beliefs have kept him from seeing a doctor about his huge growth; Kylie has come to love her birthmark and is torn about whether or not to get it removed; Shad's head bump bursts open and smells like death.

Tyler's hands are so dry, cracked and painful that he considers getting them amputated; Ebonee covers the tiny bumps around her eyes with sunglasses; Ralph feels like a cyst factory with painful cysts covering his back.

Kelly has a massive shoulder growth; Erica stabbed her hand with a pencil 45 years ago and believes the lead remains trapped in her palm; Paula's painful and swollen feet ooze a substance that emits the foulest of odors.

Brittney has hundreds of tiny bumps over her chest that have destroyed her confidence; John has a nose the size of a plum and leans on his local family clinic for help; Dr. Lee's friend Raquel drops in and brings out her wild side.

Mike's religious beliefs have kept him from seeing a doctor about his huge growth; Kylie has come to love her birthmark and is torn about whether or not to get it removed; Shad's head bump bursts open and smells like death.

Tyler's hands are so dry, cracked and painful that he considers getting them amputated; Ebonee covers the tiny bumps around her eyes with sunglasses; Ralph feels like a cyst factory with painful cysts covering his back.

Kelly has a massive shoulder growth; Erica stabbed her hand with a pencil 45 years ago and believes the lead remains trapped in her palm; Paula's painful and swollen feet ooze a substance that emits the foulest of odors.

Cedric has a bump on his eye and a painful lump on his neck that have kept him from working; Katherine's large ear cluster puts her neighborhood watch job at risk; Andrea uses makeup to cover the white spots all over her face and body.

Jimmy's flaky, raised alligator skin feels like an itchy hell, and he wants it cured so he can find love; Djuka is a stubborn guy with a stubborn bump; Talina has hundreds of tumors all over her body, causing embarrassment and discomfort.

Intervention expert Kristina Wandzilak works with individuals struggling with addiction problems.

A diabetic and alcoholic man, 26, alienates his family and friends with his downward spiral of drinking.

A heroin addict who is supported financially by her 70-year-old father turns to Kristina for help to get out of her drug-induced haze.

Kristina tries to help a 19-year-old meth addict who has turned to prostitution to support her drug habit.

Linda's family is on the edge of collapse because of her hoarding; Norski has overcome addiction but can she kick the hoarding habit.

Michael has six weeks to clean his house or he will go to jail; a motivational speaker can not manage her own life.

Joyce's compulsive collecting almost cost her husband his life; Norine's hoarding forced her teenage daughter out of the house.

Debbie turned to hoarding after a confession ended her marriage; with illness in her family, Julie hoards to ease the pain.

Jahn is an extreme hoarder trying to clear her two houses before they are both condemned.

A patient suddenly starts seizing; an ER physician is at a restaurant when she is thrown into an emergency situation to save a child; a pregnant woman's heart is racing.

A young pregnant woman in labor begs the ER doctor to keep her pregnancy a secret from her father; twins share confusing symptoms; a man with no pulse or blood pressure is still alive and breathing.

A man is impaled in his abdomen by a stiletto heel; a seemingly healthy outdoorsman has a series of seizures that baffle his doctors; two patients make their doctor suspicious when they both complain about identical headaches that started during sex.

A patient's pet causes pandemonium; a man experiences paralysis that climbs up his legs to his chest until he can no longer breathe; a war veteran suffers from phantom pain in his amputated hand.

A patient appears to be hallucinating and sends ER staff on a wild goose chase; a new nurse makes a shocking mistake; doctors try to help a former EMT who was found lethargic and slurring his words.

John fears the large lump on his neck could become so big that it may eventually suffocate him; Shoshana is depressed because of the big growth on her forehead; Ashley hopes Dr. Lee can provide some relief from her three painful skin conditions.

Yaellie, 9, has itchy psoriasis on over 90 percent of her body; former U.S. Marine Matt has a large recurring lump in his armpit; twins Tracie and Stacie have numerous matching bumps on their heads that sometimes leak.

Joanne has been held back from success because of her forehead growth; Shakisaha split her left earlobe after stretching it with gauges; Mike is a tough guy with a soft bump on his head; Dania's rhinophyma has kept her from enjoying her life.

James has a large, squishy lump on his forehead; Tanisha has a growth on her arm and itchy scars all over her body; Ed wants his stomach lump removed before his girlfriend gets out of prison; Justin has painful mystery bumps all over his head.

John fears the large lump on his neck could become so big that it may eventually suffocate him; Shoshana is depressed because of the big growth on her forehead; Ashley hopes Dr. Lee can provide some relief from her three painful skin conditions.

Yaellie, 9, has itchy psoriasis on over 90 percent of her body; former U.S. Marine Matt has a large recurring lump in his armpit; twins Tracie and Stacie have numerous matching bumps on their heads that sometimes leak.

Joanne has been held back from success because of her forehead growth; Shakisaha split her left earlobe after stretching it with gauges; Mike is a tough guy with a soft bump on his head; Dania's rhinophyma has kept her from enjoying her life.

James has a large, squishy lump on his forehead; Tanisha has a growth on her arm and itchy scars all over her body; Ed wants his stomach lump removed before his girlfriend gets out of prison; Justin has painful mystery bumps all over his head.

A patient's pet causes pandemonium; a man experiences paralysis that climbs up his legs to his chest until he can no longer breathe; a war veteran suffers from phantom pain in his amputated hand.

A patient appears to be hallucinating and sends ER staff on a wild goose chase; a new nurse makes a shocking mistake; doctors try to help a former EMT who was found lethargic and slurring his words.

Erica regrets not keeping a promise to her mom and hopes her siblings will help, but they're reluctant based on her past failures.

Christina has not left her house in two years due to her size; she has eaten herself into a state that will soon kill her if she does not change.

Paula has built a wall around herself to push people away; when she suddenly loses a loved one she can no longer ignore the threat of losing her own life.

Lacey ballooned up over 600 lbs on pizza and ice cream and knows Dr. Now is her best hope for success; she must now rally her divorced parents around her for support and find a way to modulate her moods that won't include binge-eating.

Brandon is a talented musician with a beautiful voice and a run-away weight problem; he wants to lose weight and embark on a career; he also wants to take the next step with his girlfriend, Taylor, whom he risks losing if he can't make a change.

Maja moves to Houston to undertake a difficult weight-loss journey with the support of her boyfriend, Christian; when Christian decides he's had enough and leaves Maja high and dry, she discovers that the only person she can count on is herself.

Despite moving to Houston with the solid support of her boyfriend, Aaron, and her cousin, Jasmine, Tiffany finds it difficult to break the cycle of depressed eating when her two roommates don't join her diet and leave the house every day for work.

When Nathan's weight gets in the way of his job as a drama teacher, it's a wake-up call for him; changing his life might mean a falling out with his wife, Amber, who is also overweight, unless she can lose, too.

Lacey is so big from overeating that she can barely leave the house, but that hasn't stopped her from finding love with Ricky; Lacey's weight isn't the only thing between her and a happy husband, however, with Ricky's sister Sharon in the picture.

For Julian and his wife, Irma, it was love at first sight; in order to grow old together, Julian will have to overcome the food addiction that made him more than 800 pounds.

Lacey is so big from overeating that she can barely leave the house, but that hasn't stopped her from finding love with Ricky; Lacey's weight isn't the only thing between her and a happy husband, however, with Ricky's sister Sharon in the picture.

For Julian and his wife, Irma, it was love at first sight; in order to grow old together, Julian will have to overcome the food addiction that made him more than 800 pounds.

When Nathan's weight gets in the way of his job as a drama teacher, it's a wake-up call for him; changing his life might mean a falling out with his wife, Amber, who is also overweight, unless she can lose, too.

Cynthia, a single mother focused on raising five kids, comes to realize what her death would mean for their future.

James comes from a long line of family obesity; he is determined not to die as his sister and father did; he hopes to get gastric bypass and even start dating again.

A mother of two who is too ashamed of her size to be seen with her children; she is committed to regaining her confidence and being a proud mother.

Born as "Matthew," Destinee never felt like she fit in; now, having come out as a 600-pound transgender woman, she likes her curves, but she will need to say goodbye to them if she wants to be approved to transition completely.

Jeanne lives in an unhygienic household with her mother and schizophrenic father; at well over 600 pounds, Jeanne might never get weight-loss surgery as she runs into several obstacles, especially after an unexpected death in her family.

Since the death of his mother, Aaron lives at home to care for his aging father, but due to his food addiction, Aaron has to heavily rely on his father for help instead. Aaron must learn to care for himself to avoid eating himself to death.

Kelly is on the verge of immobility when she decides to make the trip to Houston to visit Dr. Now; her journey gets off to a painful start when a long travel-day grows longer as Kelly gets stuck in a cab on her way from the clinic to the hospital.

Bianca is all in for a move to Houston with her boyfriend and two young kids to get Dr. Now's help with a second weight-loss surgery.

Mike was born with a talent for sports and an omnivorous appetite to match; after his football dreams were dashed by multiple concussions, Mike packed on over 700 pounds, now he must find a new purpose in life to avoid succumbing to pain and regret.

James B, grew up eating rich Haitian food and loves it with a passion; James needs Dr. Now's help to diminish that love in order to survive, but a death in the family sends James retreating back to the comforts he knows.

Mike was born with a talent for sports and an omnivorous appetite to match; after his football dreams were dashed by multiple concussions, Mike packed on over 700 pounds, now he must find a new purpose in life to avoid succumbing to pain and regret.

James B, grew up eating rich Haitian food and loves it with a passion; James needs Dr. Now's help to diminish that love in order to survive, but a death in the family sends James retreating back to the comforts he knows.

Bianca is all in for a move to Houston with her boyfriend and two young kids to get Dr. Now's help with a second weight-loss surgery.

Stacy's life-threatening scar on her foot has left her hopeless; David has the worst case of foot fungus Dr. Schaeffer has seen; Morgan, an erotic paranormal romance novelist, is hoping to get her sixth toe amputated.

A woman with giant springs on her shoes enters Dr. Vincent's office; a man with a rare disease has the largest feet Dr. Schaeffer has ever seen; an athlete with two different-sized feet becomes a difficult surgery.

Dr. Vincent uses a cadaver bone to fix a woman's foot who's deathly afraid of infection; surgery to correct a woman's webbed toes becomes a crisis for Dr. Schaeffer when she develops a dangerous complication that could cost the patient her toes.

Lauana lost 170-lbs to find her tiny frame swamped by excess skin; after losing over 200-lbs, Tim's skin gets in the way of being a great dad.

Megan feels physically and mentally trapped with excess skin under her clothes; Yalena's extreme weight loss counts for nothing unless she sheds her excess skin.

Melissa lost 235 pounds, but her confidence is still low because of her excess skin; Jeff has lost 300 pounds, but continues to hide himself from the world.

Lindsey lost 140 pounds, but her sagging skin keeps her athletic dreams out of reach; Derek wants to pass the Police Academy physical but his excess skin prevents him from training.

A man's face and body suddenly double in size; a young woman is burning up from the inside out after a day at the beach; a grumpy old man nearly dies before revealing an emotional secret.

A pianist's finger goes missing after getting accidentally sawed off; a man's pacemaker threatens to kill him; a man behaves bizarrely.

A pregnant woman is shot in the abdomen; a doctor is the victim of a car burglary; a storm is preventing a patient's life-saving surgery.

A woman risks losing her finger after trying on an ill-fitting engagement ring; a body builder can't breathe and doctors are shocked to discover why; a gunshot victim.

Nicole's addiction to Pony Play; Heather's addicted to drinking paint.

Amy and Becky are addicted to being identical; Jennifer addicted to eating mattresses.