Nothing means more to Chris than his relationship with his daughter, Zoey, but now he feels he is failing her as his weight gain begins to limit his mobility.

Patrick's weight has never been a bother, but now he's so big that it's getting in the way of his relationship with his daughter; if he wants to see her graduate high school, he'll have to reverse course.

JT is almost 900lbs with a 100-lb lymphedema mass on his leg and a food addiction that is bound to kill him if he doesn't change; his girlfriend takes him to Houston, but when his behavior drives her away, JT is left with only Dr. Now to help.

Boys Giovanni and Owen share the rare condition Schwartz-Jampel Syndrome, which permanently and painfully contracts their muscles; the two share hardships and triumphs, and strike up a friendship.

Tiffany and Destiny both live with the rare disease Osteogenesis Imperfecta, which causes brittle bones, and set out on a life-changing journey to meet each other.

Bobbi and Kenny have skin that painfully grows in thick scales due to the rare condition Lamellar Ichthyosis.

The CDC, NYPD and FBI team up to deal with anthrax; a mysterious illness targets young girls.

Organ donor recipients share similar symptoms before lapsing into coma; pox outbreak in the Midwest.

A disease that kills 17,000 crows and zoo birds also fills a city's emergency room; an unidentified virus in the Southwest.

A woman starts growing uncontrollably.

A woman suffers crippling sinus pains.

A young man has strange growths; toddler rapidly gains weight.

A baby is born with a series of defects; deadly sore throat.

A doctor treats three gunshot victims who claim be innocent bystanders; a doctor must perform emergency brain surgery on his first day; a bride-to-be suddenly slips into a diabetic coma.

A woman stops eating because she believes she is dead; a runner goes blind in one eye during a marathon; an ER tech's stroke-like symptoms.

A woman believes her neighbors want to kill her; a man is near death after an arrow pierces his chest; two women with swollen abdomens refuse to explain the cause of their pain.

A circus sword-swallower suffers from a persistent case of hiccups; a mother and daughter mysteriously collapse in the ER; a woman loses control of her legs at her daughter's graduation.

Charmaine from Trinidad suffers from one of the most extreme cases of neurofibromatosis ever recorded; tumors cover every inch of her body and obstruct her ability to breathe and swallow; without surgery, these growing tumors threaten her life.

Thirty-year-old Alexandra has a 20-pound, sagging tumor that starts at the back of her neck and now reaches below her waist; as the tumor on Claudia's backside continues to grow, so does the urgency for surgeons to remove it.

Despite his family's pleas, Marlow explores a high-risk surgery to remove a facial tumor; Amy has let the tumor on her back grow for more than 17 years; after finally making the decision to remove it, she learns that now it might be too late.

A massive tumor on Tim's neck continues to grow at an alarming rate, but doctors fear that removing it could leave him paralyzed.

Charmaine from Trinidad suffers from one of the most extreme cases of neurofibromatosis ever recorded; tumors cover every inch of her body and obstruct her ability to breathe and swallow; without surgery, these growing tumors threaten her life.

Thirty-year-old Alexandra has a 20-pound, sagging tumor that starts at the back of her neck and now reaches below her waist; as the tumor on Claudia's backside continues to grow, so does the urgency for surgeons to remove it.

Despite his family's pleas, Marlow explores a high-risk surgery to remove a facial tumor; Amy has let the tumor on her back grow for more than 17 years; after finally making the decision to remove it, she learns that now it might be too late.

A massive tumor on Tim's neck continues to grow at an alarming rate, but doctors fear that removing it could leave him paralyzed.

A woman believes her neighbors want to kill her; a man is near death after an arrow pierces his chest; two women with swollen abdomens refuse to explain the cause of their pain.

A circus sword-swallower suffers from a persistent case of hiccups; a mother and daughter mysteriously collapse in the ER; a woman loses control of her legs at her daughter's graduation.

A drug dealer stages an alligator attack; a desperate man uses a corpse to stand in for him.

An innocent man goes underground after refusing to commit a crime; a man who seems to have it all stages a plane crash to escape his life.

A husband and wife try to hide from drug dealers and the law; a man has a cold-blooded plan to cash in on his life insurance.

Stressed out Naomi struggles with her liquid diet and may reach her breaking point; Drew wants to have the weight loss surgery, but when he steps on a scale he's thrown off entirely; bed-bound Chitoka asks Dr. Procter for a house call.

After struggling with her liquid diet, Naomi learns if she is approved for surgery; Drew's new weigh-in leads him down a slippery path; family tragedy motivates Chitoka to try to become more mobile, starting by trying to leave her bedroom.

Chitoka attempts to walk outside for the first time in years; Naomi finds some things remain the same post-surgery; Drew risks getting his surgery canceled entirely if he doesn't fight for it and lose weight.

A look at two women with a history of addiction who are pregnant and struggling to stay clean.

Trisha spends her pregnancy behind bars for dealing and using drugs; up for parole, she discovers that she has chance to prove she can conquer her addiction and be the mother her child needs.

Jenna's life is dominated by fear of contamination OCD; with a second child on the way, Jenna struggles with her condition that worsens with pregnancy; she dictates both her marriage and young son's life.

Lisa helps a man yearning to discover his biological roots, but fearful of rejection from the family he has never met; Chris reveals the truth to a woman who has felt guilty that her birth might have devastated the life of her 14-year-old mom.

A tough Texas lawman seeks Lisa's help to tackle the one investigation he's never been able to solve: the story of his own birth and adoption.

Chris tries to unravel a legal mystery involving a woman's sister who she last saw across a New York courtroom 30 years ago.

A Vietnam vet hopes Lisa can help him make amends for the past by locating the daughter he lost custody of forty years ago; a woman's struggle to fit in takes a surprising turn when Chris reveals a series of stunning coincidences very close to home.

The recent revelation of a 49-year-old man's adoption sends Chris searching for answers to a secret his adoptive parents took to the grave; a biracial woman enlists Lisa's help to find her birth family, revealing some unfortunate tragedies.

After Thomas Hicks sold over 200 babies illegally in the 1950s and 1960s, Jane Blasio works to reunite the stolen babies with biological families while trying to unearth secrets about Hicks himself.

Jane discovers a suspicious pattern of babies with extremely low birth weights coming out of the clinic; Chris finds out that Dr. Hicks may have hidden birth records in his mausoleum; Diane hopes to meet her biological father.

Jane and Lisa meet the first Hicks baby, Stephen Dilbeck; Chris and Sallie open the mausoleum in search of birth records rumored to be inside as they work on getting approval of an exhumation.

Stephen Dilbeck gets some shocking information about his birth family from Jane and Lisa; Chris and Sallie work on getting approval of an exhumation that will answer questions for hundreds of Hicks babies.

After Thomas Hicks sold over 200 babies illegally in the 1950s and 1960s, Jane Blasio works to reunite the stolen babies with biological families while trying to unearth secrets about Hicks himself.

Jane discovers a suspicious pattern of babies with extremely low birth weights coming out of the clinic; Chris finds out that Dr. Hicks may have hidden birth records in his mausoleum; Diane hopes to meet her biological father.

Jane and Lisa meet the first Hicks baby, Stephen Dilbeck; Chris and Sallie open the mausoleum in search of birth records rumored to be inside as they work on getting approval of an exhumation.

Stephen Dilbeck gets some shocking information about his birth family from Jane and Lisa; Chris and Sallie work on getting approval of an exhumation that will answer questions for hundreds of Hicks babies.

A Vietnam vet hopes Lisa can help him make amends for the past by locating the daughter he lost custody of forty years ago; a woman's struggle to fit in takes a surprising turn when Chris reveals a series of stunning coincidences very close to home.

The recent revelation of a 49-year-old man's adoption sends Chris searching for answers to a secret his adoptive parents took to the grave; a biracial woman enlists Lisa's help to find her birth family, revealing some unfortunate tragedies.

Michael's massive body has left him dependent upon his family, and he must learn to control his anger issues around food, lose weight and address the root of his issues or risk losing everything.

An 800-pound man who lost his job and is mostly housebound looks to find the strength to face his past and save his own life.

A woman struggles to make a positive change to be part of her partner and son's lives and turn her life around.

Unable to stand for more than a short period of time, Karina's weight places a burden on her parents and drives a wedge between her and her sister.

After a difficult childhood with an abusive stepfather and drug-addicted mother, Sarah is fighting for her life at only 24 years old.

Born as "Matthew," Destinee never felt like she fit in; now, having come out as a 600-pound transgender woman, she likes her curves, but she will need to say goodbye to them if she wants to be approved to transition completely.

Jeanne lives in an unhygienic household with her mother and schizophrenic father; at well over 600 pounds, Jeanne might never get weight-loss surgery as she runs into several obstacles, especially after an unexpected death in her family.

When Travis gets too big to walk down the aisle, he promises to give his wife a proper wedding; he gains more weight, leaving Dr Now as Travis' only hope to lose weight and get the life he and his wife dreamed of having together.

Krystal S. has finally met the man of her dreams, but she won't let herself marry him until she can be sure that she won't become bedridden and force him into the role of caretaker.

Abi was struggling with his weight before a fluke accident left him mostly paralyzed; bedbound for seven years since then and topping 700 pounds, Abi's only hope for a future with his wife is to get Dr. Now's help to lose weight.

Krystal S. has finally met the man of her dreams, but she won't let herself marry him until she can be sure that she won't become bedridden and force him into the role of caretaker.

Abi was struggling with his weight before a fluke accident left him mostly paralyzed; bedbound for seven years since then and topping 700 pounds, Abi's only hope for a future with his wife is to get Dr. Now's help to lose weight.

When Travis gets too big to walk down the aisle, he promises to give his wife a proper wedding; he gains more weight, leaving Dr Now as Travis' only hope to lose weight and get the life he and his wife dreamed of having together.

Krystal, a witch, looks to clear a curse of a cyst from her face; Keven wants to get a butt lipoma removed to get his tush back into a regular shape; Raquel, Dr. Lee's esthetician BFF, almost suffocates Dr. Lee with love and a facial.

J-Fab is the life of the party, but her shoulder bump is seriously cramping her style; Dan is a gentle giant with lumps on his head that add a few inches; Teresa's red face and bumpy nose make her feel like a monster.

Fit guy Alonso wants to show off his progress in the gym, but his 70 lipomas are holding him back; Porscha is a comic book enthusiast with two symmetrical lumps on her face; Jeffrey has a leaky lump named Larry on the back of his head.

Robert carries the weight of providing for his family and the weight of the huge lump on his head; Christina has liquid-filled growths next to her eyes; Felipe, a photographer with a dry skin condition so severe he risks losing his career.

Natasha has ambitions of becoming a model, but her massive ear keloids are keeping her off the runway; eight-year-old Wynter wants her scaly mermaid skin cured; Dr. Lee's bestie, Raquel, needs help with a new product for a private area.

Nhan has an extreme, red birthmark that covers half his face; Debbie worries that her shoulder lump will prematurely age her; Justin is a dude rockin' a man bun, but he's having no fun due to the bumps poking through his scalp.

Jess is a widower looking for love who is stuck with a giant bump on his neck; Cherish developed a leopard-print face during pregnancy; former NFL defensive tackle Marcell Dareus hopes Dr. Lee can tackle his forehead lipoma.

Brent has a tricep bump potentially intertwined in his muscle; Jeb loves the beach but refuses to go because of the massive number of blackheads, pimples, and cysts all over his body; Wanda's mysterious mark that caves in her side.

Don's psoriasis has completely taken over his body; Jeff has a large growth on his spine; Sara has an extra set of breasts and nipples.

Angelina has a huge chest lump under her left breast; Delano has a football-sized mass on his back.

Melissa tries to cover a huge lipoma with a sweatshirt for years; Tyler's fear of cancer keeps him from having his huge head lumps diagnosed; Tahj is covered in painful boils; Amber has ear keloids that take control of her life.

Ronen's mysterious lump above his knee is one of the largest Dr. Lee has ever seen; Amber suffers from a debilitating skin disease that no one understands; Sandy has a neck lump she calls Tommy; Kristy's eyelid cyst is ruining her life.

Half of Mary's body is a size 18 while the other half is a size 8; Anthony's cyst is in the area called the "Triangle of Death;" Shane wants to get a lump off his back; Brandi is anxious about getting a lump removed from her chest.

Belinda's lump on her neck causes her to basically be immobile; Nicole won't get married until she gets her armpit lump removed; Adela's chest and back are covered in wisdom spots; Nick foolishly removes a lipoma at home and now needs Dr. Lee.

Diane has tumors all over her body that have ruined her life; Will fears his shoulder lump will be ripped open at work; Anthony's daughters force him to get his lump examined; a woman detests her hideous varicose veins.

Taylor has a large bump at the base of her spine that is far more dangerous than she realizes; John jokes about his hip lump, but it's no laughing matter; Noelle had her ears stretched as a teen, but now wants them repaired.

Louis is a veteran who is covered in scaly, dry skin that makes him feel like an alligator; Irais's kids are bullied because of the embarrassing growth on her head; Johnny has been living with a stubborn lump on his back for too long.

Patrick's nose is covered by huge bumps, and he can barely breathe; Aziza and Lauren are friends who bonded over their matching wrist lumps; Joe has a mound in the middle of his forehead that looks like a third eye.

Diane has tumors all over her body that have ruined her life; Will fears his shoulder lump will be ripped open at work; Anthony's daughters force him to get his lump examined; a woman detests her hideous varicose veins.

Taylor has a large bump at the base of her spine that is far more dangerous than she realizes; John jokes about his hip lump, but it's no laughing matter; Noelle had her ears stretched as a teen, but now wants them repaired.

Louis is a veteran who is covered in scaly, dry skin that makes him feel like an alligator; Irais's kids are bullied because of the embarrassing growth on her head; Johnny has been living with a stubborn lump on his back for too long.

Patrick's nose is covered by huge bumps, and he can barely breathe; Aziza and Lauren are friends who bonded over their matching wrist lumps; Joe has a mound in the middle of his forehead that looks like a third eye.

Half of Mary's body is a size 18 while the other half is a size 8; Anthony's cyst is in the area called the "Triangle of Death;" Shane wants to get a lump off his back; Brandi is anxious about getting a lump removed from her chest.

Belinda's lump on her neck causes her to basically be immobile; Nicole won't get married until she gets her armpit lump removed; Adela's chest and back are covered in wisdom spots; Nick foolishly removes a lipoma at home and now needs Dr. Lee.

A maintenance worker falls from an iconic hotel sign; a rat bite has horrifying implications for its trainer and a plane crashes on a residential street.

Doctors retrieve a stolen Rolex from a very private spot; a pick-up turns deadly when a cabbie is shot multiple times; a dirt-bike accident in the desert leaves a 52-year-old thrill-seeker clinging to life.

Phil is a 58-year-old meth user whose addiction spans over three decades.

Theresa is a homeless alcoholic whose addiction puts her life at risk.

Heroin addicts that live in a tent.

Traci is pregnant and desperate to move back home, but it's filled floor to ceiling with her mother's stuff.

Kathleen discovers a hoard of mice living in her kitchen; spending the night in a hoard might be the end of a marriage before it even begins.

Medical responders were not able to get in Renee's front door after she had fallen unconscious in her home.

Rick tries to salvage his cluttered home that was nearly destroyed in a house fire; Linda must get her house up to code in 60 days, or she will be on the streets.

Extreme hoarder Floyd must clear his hoard or risk losing his three-year-old son.

Tyler's addiction to smelling tuna is getting in the way of finding love; Lacey's addiction to plastic surgery and her cup size has grown; after mourning the loss of her record-setting fingernails, Ayanna still has an addiction.

Brittany's addiction to eating car seat foam forces her family to intervene; Lauren has put her addiction to bodybuilding behind her but has found a new obsession; Asha's addiction to her long locks remains strong, but her health remains in jeopardy.

Foxy's addiction to having enormous breasts has brought her fame, but her friends feel it is also endangering her health.

Weston loves eating raw meat, but his mom is worried it could lead to major health problems; Rachel breastfeeds her husband, Alexander, but it's upsetting to their family and friends; pillow addict Tamara meets car lover Nathaniel.

A man undergoes surgery to remove his record-breaking face tumor; a young girl lives with huge hands; a mathematician born with severely deformed legs and a spine walks on all fours.

A woman hopes the tooth transplanted in her eye will stop her from going blind; conjoined twins share a single body; a boy with gigantism in his legs turns to doctors for a cure; a mother has surgery to remove the massive fatty tumors in her neck.

Doctors seek to restore the face of a little girl with a giant facial cleft; a pregnant little person and her husband find out if their son will have two forms of dwarfism; a woman's face is slowly being destroyed by a tumor.

Doctors attempt to separate twins who were born joined at the head; a woman with a rare brittle bone disorder doesn't let her disease control her life; a man with a huge facial tumor undergoes major surgery to save his life.

A man undergoes surgery to remove his record-breaking face tumor; a young girl lives with huge hands; a mathematician born with severely deformed legs and a spine walks on all fours.

A woman hopes the tooth transplanted in her eye will stop her from going blind; conjoined twins share a single body; a boy with gigantism in his legs turns to doctors for a cure; a mother has surgery to remove the massive fatty tumors in her neck.

Doctors seek to restore the face of a little girl with a giant facial cleft; a pregnant little person and her husband find out if their son will have two forms of dwarfism; a woman's face is slowly being destroyed by a tumor.

Doctors attempt to separate twins who were born joined at the head; a woman with a rare brittle bone disorder doesn't let her disease control her life; a man with a huge facial tumor undergoes major surgery to save his life.

Foxy's addiction to having enormous breasts has brought her fame, but her friends feel it is also endangering her health.

Weston loves eating raw meat, but his mom is worried it could lead to major health problems; Rachel breastfeeds her husband, Alexander, but it's upsetting to their family and friends; pillow addict Tamara meets car lover Nathaniel.

Sean must overcome recent tragedies in his life before he loses all the progress he made over the last two years; Dottie struggles to stay on track while maintaining her family life.

Despite having lost 378 pounds, Angel's crippling knee pain and history of extreme obesity threatens everything for which she's worked; Charity finds the strength to return to a normal life after post surgery complications.

Follows the struggles of overweight people as they try to shed the pounds, and how they feel about their weight loss progress.

A year since her weight-loss journey began, Janine is still in the 500s and mostly immobile, and now, Dr. Nowzaradan is running out of options for how to treat her if she can't find a way to control her eating habit and start walking again.

Lee's anger issues continue to jeopardize his relationship with Rena and threaten to derail both of their weight-loss journeys; a major life event sends Sarah into a depression that she must pull herself out of if she wants to keep losing weight.

Alicia's relationship with her boyfriend, Tim, comes under the microscope; Pauline must beg her way back onto the program after quitting.

Dottie faces an unexpected challenge to her weight-loss when her husband's drinking problem becomes intolerable for her and her son; Cynthia starts to wonder if being there for her kids at her current weight is more important than losing more.

Jeanne struggles to care for herself in the aftermath of her dad's death; Brandon strives to get his weight down to feel confident when proposing to his girlfriend, Tayler, and be the man she deserves.

Cillas must face difficulties from his childhood to progress to his goal weight and set an example for his children; Tiffany struggles to lose weight when financial hardships place a strain on her relationship with her boyfriend, Aaron.

After a year of isolation due to COVID-19, brothers John and Lonnie return to see Dr. Now with a collective weight loss that makes them some of his most successful patients ever.

Cillas must face difficulties from his childhood to progress to his goal weight and set an example for his children; Tiffany struggles to lose weight when financial hardships place a strain on her relationship with her boyfriend, Aaron.

After a year of isolation due to COVID-19, brothers John and Lonnie return to see Dr. Now with a collective weight loss that makes them some of his most successful patients ever.

Jeanne struggles to care for herself in the aftermath of her dad's death; Brandon strives to get his weight down to feel confident when proposing to his girlfriend, Tayler, and be the man she deserves.

Tanisha weighs around 600-lbs, and she's desperate to survive for her kids and avoid her mother's tragic fate of dying at age 50 from super obesity; now at 32, her future looks grim if she doesn't make a drastic change to save her life.

An overweight woman struggles with flesh-eating bacteria and butterfly shaped fat deposits; unexpected news threatens her weight loss journey.

Laura has used food to cope with her emotions; she is confined to a wheelchair and relies on an oxygen tank to breathe and her husband and mother to survive.

Lisa's struggle with her weight begins as a child and significantly worsens after witnessing her brother's murder; now bedridden and unable to care for herself, Lisa must find a way to lose the weight, or she will never see her grandchildren grow up.

With the support of his fiancée, Kathryn, Robert turns to Dr. Nowzaradan in a final, desperate attempt to save his life; he tries to reverse a lifelong food addiction that has left him bed-bound, saddled with grotesque lymphedema, and nearly 900-lbs.

Since the death of his mother, Aaron lives at home to care for his aging father, but due to his food addiction, Aaron has to heavily rely on his father for help instead. Aaron must learn to care for himself to avoid eating himself to death.

Kelly is on the verge of immobility when she decides to make the trip to Houston to visit Dr. Now; her journey gets off to a painful start when a long travel-day grows longer as Kelly gets stuck in a cab on her way from the clinic to the hospital.

Shantel's brother Carlton lives downstairs but she hardly ever sees him because at 600 lbs each, neither can do the stairs safely; to break free from a death spiral of codependent eating they need Dr. Now's help to reforge their sibling relationship.

When a regular trip to the grocery store turns into an emergency for the EMTs, Delana must admit how badly she needs Dr. Now's help to lose weight; hopefully her road to recovery will lead her to reconcile with the daughter she's grown apart from.

William was always mobile and fairly athletic -- that is, until he wasn't; it's been years now since a knee injury derailed his sports career, and he's ballooned up over 600 pounds; now, to lose weight he'll have to face up to how bad it's gotten.

When a regular trip to the grocery store turns into an emergency for the EMTs, Delana must admit how badly she needs Dr. Now's help to lose weight; hopefully her road to recovery will lead her to reconcile with the daughter she's grown apart from.

William was always mobile and fairly athletic -- that is, until he wasn't; it's been years now since a knee injury derailed his sports career, and he's ballooned up over 600 pounds; now, to lose weight he'll have to face up to how bad it's gotten.

Shantel's brother Carlton lives downstairs but she hardly ever sees him because at 600 lbs each, neither can do the stairs safely; to break free from a death spiral of codependent eating they need Dr. Now's help to reforge their sibling relationship.

Eight women cope with their incarceration in Gwinnett County Jail; one woman prepares for her release.

Nine women try to cope with their incarceration; a woman awaits trial for five years.

A young mother faces the idea of seeing her son through visitation glass; an inmate promises not to return but finds herself back in jail; a desperate inmate only needs a small amount of money to get released.

A current inmate learns that her son has died in a car crash; an inmate's first Mother's Day behind bars; female inmate almost nine months pregnant.

Pregnant detainees await trial; Jamie, a mother of four struggles for visitation rights; Tanya requests house arrest to prepare for the birth of her son.

Latoya struggles with giving up her baby for adoption; Esther is sent to disciplinary segregation.

Bethany is pregnant by her unemployed boyfriend; Cecily fears her pregnancy.

Ashley struggles with three children, one with cerebral palsy and a stepson, and she is afraid to reveal that she is pregnant; Amatulla is embarrassed to be pregnant again.

Kelly's history of miscarriages; Lauren fears her father.

Kanchana fears having a baby; Susannah's third child with a jobless husband.

A mother becomes a recluse when every sound becomes deafeningly loud; a man's career is in jeopardy when he gets drunk without touching a drop of alcohol.

A dad is accused of child abuse when doctors discover his baby has broken bones; a vibrant teenage girl is unable to eat and is wasting away before her mother's eyes.

A woman has seizures whenever she hears her favorite pop tunes; a young athlete loses all his body fat and almost starves to death.

A man faces amputation when a mystery disease turns his extremities black; a young woman develops paralyzing fears about ordinary objects.

The hospital is locked down when a nurse is shot in the ER; medics rush a bride from her wedding who is in an unexplained altered mental state; a doctor must perform a risky intervention to save the life of a teenage girl.

A teen football player suffers a stroke; a doctor remembers his first major trauma in the 1970s; a doctor tries to figure out what causes a patient's abdominal pain; a man who is run over twice by his wife.

A doctor with a severe bee allergy is stung while treating a critical patient who's been stabbed in the eye; a man comes into the ER after slitting his own throat; a paramedic becomes a patient when she's struck by a mysterious illness.

A surgical resident puts her training to the test when a mugging survivor arrives with two bullet wounds.

The hospital is locked down when a nurse is shot in the ER; medics rush a bride from her wedding who is in an unexplained altered mental state; a doctor must perform a risky intervention to save the life of a teenage girl.

A teen football player suffers a stroke; a doctor remembers his first major trauma in the 1970s; a doctor tries to figure out what causes a patient's abdominal pain; a man who is run over twice by his wife.

A doctor with a severe bee allergy is stung while treating a critical patient who's been stabbed in the eye; a man comes into the ER after slitting his own throat; a paramedic becomes a patient when she's struck by a mysterious illness.

A surgical resident puts her training to the test when a mugging survivor arrives with two bullet wounds.

A woman has seizures whenever she hears her favorite pop tunes; a young athlete loses all his body fat and almost starves to death.

A man faces amputation when a mystery disease turns his extremities black; a young woman develops paralyzing fears about ordinary objects.

Staff treats patient injured while engaging in risky behavior at night.

Medical staff treats patient injured in a car wreck involving multiple vehicles.

A child has celiac disease and an intolerance to gluten; a woman's seizures stop after her left frontal lobe is removed.

A child with Hurler's Disease undergoes a stem cell transplant procedure; a woman is diagnosed with Myasthenia Gravis; a pacemaker regulates a man's cardiac arrhythmia.

A young boy's body does not produce the correct antibodies; a woman loses the ability to walk.

A young girl has trigeminal neuralgia; a woman seeks a reason for her rapid weight gain and other bodily changes.

A couple's Halloween cemetery adventures go wrong; two musicians get busy after band rehearsal and land in the ER; baffling symptoms lead a nurse to believe one male model's gift could be his curse.

A couple lands in the ER after making love while skydiving; a quickie at a wake goes terribly wrong; an early morning romp for two nurses.

A backstage quickie at a body building competition; a soldier's welcome home; a sneaky couple has fun where they were told not to.

A boyfriend is forced to spill a secret when a couple's first time encounters failure; a man's balance problem; a firefighter has a ball and ends up speechless.

After losing 275 lbs., Mikki became a fitness fanatic, but the weight loss left her with a lot of sagging skin; Denise's obesity always made her feel invisible, but after losing 200 lbs. the skin still hinders her from fitting in with her family.

Rebecca lost her weight to be more active with her young son, but the plan backfired because she's now trapped in her excess skin; after his dad died, Sal dropped a ton of weight, but with all the excess skin, he fears he will never become a dad.

Autumn wants to make up for lost time with her son, but the excess skin from major weight loss is holding her back; Cody always pretended to be happy when he was 500-lbs, but after losing the weight, he's covered in skin and is sick of pretending.

Ronnie and Michael Robinette are thriving, but their extra skin is getting in the way; at 64, Renee's excess skin inhibits her from enjoying her relationship and expressing her true self in public.

Sean's nightmare keeps coming true, he can't stop pooping himself on stage; tired of dealing with explosive bowels, Sean asks Dr. Hodges for help; Latoya wants to spend time with her kids again which means the 10 pound mass between her legs needs to go.

Alice Jean's botched lap band removal left her with six belly buttons that form a golf course on her stomach; Simone seeks help for her uncontrollable vomiting.

After a botched lap band surgery, Christina has been blending her meals for over a decade; Dr. Caplin assists a patient whose tummy tuck has left her with a butt crack for a stomach.

With pop-up facts and behind-the-scenes secrets; Brittany's genetic condition causes head-to-toe bumps; Leonardo has a fist-size growth on his head; Tamyra has skin so thick that she shaves the bottom of her feet for relief.

Sean's nightmare keeps coming true, he can't stop pooping himself on stage; tired of dealing with explosive bowels, Sean asks Dr. Hodges for help; Latoya wants to spend time with her kids again which means the 10 pound mass between her legs needs to go.

Alice Jean's botched lap band removal left her with six belly buttons that form a golf course on her stomach; Simone seeks help for her uncontrollable vomiting.

After a botched lap band surgery, Christina has been blending her meals for over a decade; Dr. Caplin assists a patient whose tummy tuck has left her with a butt crack for a stomach.

With pop-up facts and behind-the-scenes secrets; Brittany's genetic condition causes head-to-toe bumps; Leonardo has a fist-size growth on his head; Tamyra has skin so thick that she shaves the bottom of her feet for relief.

Autumn wants to make up for lost time with her son, but the excess skin from major weight loss is holding her back; Cody always pretended to be happy when he was 500-lbs, but after losing the weight, he's covered in skin and is sick of pretending.

Ronnie and Michael Robinette are thriving, but their extra skin is getting in the way; at 64, Renee's excess skin inhibits her from enjoying her relationship and expressing her true self in public.

Most of the extreme weight on Tracey's body resides in her shockingly misshapen legs, which are massive with severe lymphedema, and gastric surgery is her only chance of survival; Brenda and Melissa prepare for skin removal surgery.

Bedridden Marla is so heavy she cannot stand up; she must face the hard truth about her condition and understand the toll it takes on her supportive family.

Chay has eaten his way to 600 pounds to cope with the emotional turmoil of his childhood; he loses his emotional support and searches for new strength to take control of his life.

After years of a tumultuous relationship with her husband, Tamy's eating addiction has caused her weight to balloon to over 500 pounds; she has become a hermit and hopes to restart her life so she can better care for her son, Zachary.

At over 700 pounds, Brianne undertakes a weight-loss journey to save her own life; she faces an unexpected challenge to her fragile progress when her husband suffers a heart attack on a birthday she will never forget.

When Annjeanette was nine, a campaign was established to send her to fat camp; she hated that her weight had become a source of public shame, and she has struggled to overcome her food addiction; now, she must change her habits to save her life.

When Angela's family is unable to accompany her on her weight-loss journey to Texas she is unsure what to do; at the last minute, she reaches out to an old flame, Eric, who still has love for her and is willing to make the trip.

At 600 pounds, Ashley has to move home, so her mom can help her care for herself and her newborn daughter; Ashley must overcome a lifetime's worth of unfortunate circumstances and get Dr. Now's help in Houston.