John and Lonnie are two brothers from opposite ends of the spectrum; estranged for years, the brothers are now brought together by a common need to lose weight while they still can.

After a year of isolation due to COVID-19, brothers John and Lonnie return to see Dr. Now with a collective weight loss that makes them some of his most successful patients ever.

Irene had to move back in with her son because her weight made it unbearable to live on her own. When Dr. Now can't get through to her, the only thing that might help her break the cycle is a once-in-a-lifetime turn of events.

JT is almost 900lbs with a 100-lb lymphedema mass on his leg and a food addiction that is bound to kill him if he doesn't change; his girlfriend takes him to Houston, but when his behavior drives her away, JT is left with only Dr. Now to help.

June copes with the tragic death of her son by eating, and must confront the emotional issues driving her food compulsion after gastric bypass surgery.

At 650 pounds, Gideon's weight prohibits him from working, making him completely dependent on his exhausted wife.

Devastated by the sudden loss of her son, Dottie's weight loss journey is in danger of going off track; June embarks on a plan to win approval for skin surgery; Melissa, Jessica and Matt prepare for skin removal surgery.

Dottie faces an unexpected challenge to her weight-loss when her husband's drinking problem becomes intolerable for her and her son; Cynthia starts to wonder if being there for her kids at her current weight is more important than losing more.

James becomes bedridden, unable to stand and can barely move his legs; Holly and Mark prepare for skin removal surgery.

Jeanne struggles to care for herself in the aftermath of her dad's death; Brandon strives to get his weight down to feel confident when proposing to his girlfriend, Tayler, and be the man she deserves.

Mercedes, who has severe lymphedema, must overcome trauma to lose weight.

Lacey is so big from overeating that she can barely leave the house, but that hasn't stopped her from finding love with Ricky; Lacey's weight isn't the only thing between her and a happy husband, however, with Ricky's sister Sharon in the picture.

Lacey wants skin removal surgery, but Dr. Now begins to wonder if she even wants to lose weight; in Houston, Mercedes and her kids face destitution.

Lacey is so big from overeating that she can barely leave the house, but that hasn't stopped her from finding love with Ricky; Lacey's weight isn't the only thing between her and a happy husband, however, with Ricky's sister Sharon in the picture.

Lacey wants skin removal surgery, but Dr. Now begins to wonder if she even wants to lose weight; in Houston, Mercedes and her kids face destitution.

Mercedes, who has severe lymphedema, must overcome trauma to lose weight.

Kinah's addiction to eating toilet paper threatens her health, and her relationships are also on the line; Nathaniel has taken his love of cars to the extreme; Lisa eats cat hair - and she just cannot get enough.

Nick and Aubrey's addiction to drinking urine has Nick's mom extremely concerned; Karmello's life has gained new meaning since her addiction to illegal butt injections; Lori's addiction to sleeping with her blow dryer might be affecting someone else.

Tyler's addiction to smelling tuna is getting in the way of finding love; Lacey's addiction to plastic surgery and her cup size has grown; after mourning the loss of her record-setting fingernails, Ayanna still has an addiction.

Brittany's addiction to eating car seat foam forces her family to intervene; Lauren has put her addiction to bodybuilding behind her but has found a new obsession; Asha's addiction to her long locks remains strong, but her health remains in jeopardy.

Foxy's addiction to having enormous breasts has brought her fame, but her friends feel it is also endangering her health.

Weston loves eating raw meat, but his mom is worried it could lead to major health problems; Rachel breastfeeds her husband, Alexander, but it's upsetting to their family and friends; pillow addict Tamara meets car lover Nathaniel.

A woman and her out of control obsession with bikinis, sweaters and dresses.

Tammy is forced to eat her meals in her car; her sick father is unable to return home from the hospital.

Sharon gets caught stealing from her neighbors; Len must choose between his hoarding and his daughter.

Debbie lost the company of her four children to hoarding; Chip's family of six is forced to live in sixteen hundred square feet of living space.

Patti's extreme hoarding has made it impossible for her daughter to live with her; Jonathan's obsession keeps his three-year-old son from coming in the door.

Kay's years of hoarding has put her marriage in jeopardy; Toni's compulsive shopping has made her home unsafe for her granddaughter.

Featuring an eight foot tall teen, a boy from India who possesses his own tail, a man with super sized muscles and a lobster woman.

A teenager in desperate need of surgery to remove a face tumor, a woman whose body is turning to stone, and a man that has found the perfect use for his enormous arm.

A teen who has aged prematurely; a school teacher who cries crystals; a mother with very brittle bones; a boy with butterfly skin.

A girl is born without a proper facial structure; a baby with an alien-shaped head; a 4 year old who weighs 145 pounds; a legless gymnast.

A man has a tumor twice the size of his head; a man with a leg that weighs more than 200 pounds seeks a diagnosis; an extremely tall teenage girl seeks help for her condition.

A man with branch like growths covering his hands and feet seeks treatment; a woman's muscles are slowly turning to bone; two brothers with tumors covering their bodies undergo surgery.

A teen who has aged prematurely; a school teacher who cries crystals; a mother with very brittle bones; a boy with butterfly skin.

A girl is born without a proper facial structure; a baby with an alien-shaped head; a 4 year old who weighs 145 pounds; a legless gymnast.

A man has a tumor twice the size of his head; a man with a leg that weighs more than 200 pounds seeks a diagnosis; an extremely tall teenage girl seeks help for her condition.

A man with branch like growths covering his hands and feet seeks treatment; a woman's muscles are slowly turning to bone; two brothers with tumors covering their bodies undergo surgery.

Featuring an eight foot tall teen, a boy from India who possesses his own tail, a man with super sized muscles and a lobster woman.

A teenager in desperate need of surgery to remove a face tumor, a woman whose body is turning to stone, and a man that has found the perfect use for his enormous arm.

Once 800lbs, housebound and alone, Joe is now engaged and planning a wedding; after losing over 300lbs, Pauline is on the verge of independence if only she can qualify for the skin surgery she needs so badly.

Dottie wants to be a better mom, so she agrees to a drastic new diet, but her child's life-threatening emergency and her own self-sabotage threaten to derail all hopes for weight-loss.

Randy's food addiction dissolved his marriage and keeps him from seeing his daughter, so he endures a rigorous pre-surgery diet surrounded by fast-food temptations to regain control of his life.

Vianey and Allen are locked in a co-dependent relationship based on a shared love of food; as they head to Houston, they will soon find out if their relationship can handle the strain of growing healthy together.

Vianey and Allen have been on a weight-loss journey together; after Allen's surgery is a success and Vianey's is not, the couple struggle to get back on the same page to save their lives.

Liz has gone from being bedbound with lymphedemas on both legs to standing and walking; if Jenn and Marissa can't get along as mother and daughter to lose weight, they'll have to proceed apart; with facts and bonus scenes.

Jennifer and her daughter Marissa are stuck in a co-dependent relationship and, with a combined weight of over 900-lbs., both of their lives are in jeopardy; Jennifer must regain control and save both of their lives before it is too late.

Since the death of his mother, Aaron lives at home to care for his aging father, but due to his food addiction, Aaron has to heavily rely on his father for help instead. Aaron must learn to care for himself to avoid eating himself to death.

Octavia has been bedbound for nearly a year when she decides to make the trip to Houston to get help from Dr. Now, but when it turns out that her best friend is also her worst enabler, Octavia will have to choose between old habits and a new life.

After regaining her mobility, Octavia is determined to never be stuck in the bed again, but difficult life circumstances threaten her ability to eat right and stay on track; Aaron is laid low by the death of his father, but true love saves him.

Octavia has been bedbound for nearly a year when she decides to make the trip to Houston to get help from Dr. Now, but when it turns out that her best friend is also her worst enabler, Octavia will have to choose between old habits and a new life.

After regaining her mobility, Octavia is determined to never be stuck in the bed again, but difficult life circumstances threaten her ability to eat right and stay on track; Aaron is laid low by the death of his father, but true love saves him.

Since the death of his mother, Aaron lives at home to care for his aging father, but due to his food addiction, Aaron has to heavily rely on his father for help instead. Aaron must learn to care for himself to avoid eating himself to death.

Robert has a small keloid on his ear and a large, snakelike keloid on the back of his head that has been removed and returned three times; Angela has four growths on her head and hides away from those she loves out of embarrassment.

Robert is back to see if Dr. Lee and Dr. Umar can remove his recurring head keloid for good; Justice has small lesions all over her body; Mike has hundreds of lipomas that bring him great discomfort.

Debra has a large, brain-like growth on the side of her head that feels like a sponge, has crevices and emits an odor; Dusten is a cowboy looking to remove the painful lump on his knee; Ramiro has a bump on his jaw that has already been removed once.

Eric hopes Dr. Lee is able to remove the giant growth from his behind; Breanna suffers from itchy dry skin she can't help but scratch; Michael makes jokes, but he knows the bump on his head is anything but funny.

Robert has thousands of unique bumps on his arms that Dr. Lee has never seen; Alexis has a painful cheek cyst that oozes and has a pungent odor; Stuart's cluster of back bumps disgusts his wife but thrills Dr. Lee.

Elaine calls the growth on her love handle her third breast; Jessica's cyst is close to her eye and could be dangerous for Dr. Lee to remove; Dwayne wants his nose bumps removed, but he may not be able to make it through the pain of the procedure.

Dr. Lee faces off with iguana-wrangler Madison's head growths; Chanel suffers from painful cyst tunnels beneath her armpit skin that leak and smell like the food she eats; the dark purple birthmark on Eddie's nose has made him a recluse.

Bob suffers from mysterious open-wound sores all over his body; Virginia's stress-ball-sized lump is such a pain in her neck that she can't wait to have it removed; Ted suffers from flaking, itchy, stucco-like skin and has had no luck finding a cure.

Steven's bump is so large, his daughter thinks he is growing a monster on his back; Catherine's arm lump has grown so big that it's nearly up to her armpit; Ethan suffers from an irritating rash in an uncomfortable and awkward place on his body.

John lost his sight at a young age and soon after began growing lumps on his body. Lynette has hundreds of pebble-sized bumps all over her arms, chest and belly. Gabe cannot imagine going to college with the unsightly mole on the back of his head.

Casey's birthmark covers most of her face, head and neck; James has mysterious massive growths on his inner thigh and lower abdomen; Jerry had to hang up his rock star vocal cords when a lump grew out the side of his throat.

Johnnie's crippling psoriasis keeps him from spending time with his daughter; Aimee has a mohawk of cysts on her head; Edith's face markings and itchy skin condition turn out to be more than she expected.

Elizabeth's head is covered with giant cauliflower-shaped bumps; Jamaal has been growing a strange knob on the left side of his butt since he was just a boy; Donna's cracking, bleeding skin condition has aged her face and kept her from being social.

Kenny was born with a rare condition that causes hundreds of lumps to grow all over his body; Ebonee covers the tiny bumps on her eyes with sunglasses; Paula's painful and swollen feet ooze a substance that emits a foul odor.

Jacqueline's massive shoulder growth makes it difficult for her to do her favorite hobby of fire spinning; the mysterious bump on James' cheek loves to bleed; Mikalia has possessed a bumpy, smelly mass on her head since birth.

After losing his longtime love, Joe wants the large bumps all over his head removed; the itchy, painful rash on Nisa's ears spreads to her face; Jennifer has dark spots all over her face that nobody is allowed to see.

Cedric has a bump on his eye and a painful lump on his neck that have kept him from working; Katherine's large ear cluster puts her neighborhood watch job at risk; Andrea uses makeup to cover the white spots all over her face and body.

Jimmy's flaky, raised alligator skin feels like an itchy hell, and he wants it cured so he can find love; Djuka is a stubborn guy with a stubborn bump; Talina has hundreds of tumors all over her body, causing embarrassment and discomfort.

Jacqueline's massive shoulder growth makes it difficult for her to do her favorite hobby of fire spinning; the mysterious bump on James' cheek loves to bleed; Mikalia has possessed a bumpy, smelly mass on her head since birth.

After losing his longtime love, Joe wants the large bumps all over his head removed; the itchy, painful rash on Nisa's ears spreads to her face; Jennifer has dark spots all over her face that nobody is allowed to see.

Cedric has a bump on his eye and a painful lump on his neck that have kept him from working; Katherine's large ear cluster puts her neighborhood watch job at risk; Andrea uses makeup to cover the white spots all over her face and body.

Jimmy's flaky, raised alligator skin feels like an itchy hell, and he wants it cured so he can find love; Djuka is a stubborn guy with a stubborn bump; Talina has hundreds of tumors all over her body, causing embarrassment and discomfort.

Elizabeth's head is covered with giant cauliflower-shaped bumps; Jamaal has been growing a strange knob on the left side of his butt since he was just a boy; Donna's cracking, bleeding skin condition has aged her face and kept her from being social.

Kenny was born with a rare condition that causes hundreds of lumps to grow all over his body; Ebonee covers the tiny bumps on her eyes with sunglasses; Paula's painful and swollen feet ooze a substance that emits a foul odor.

A brain ailment strikes a 22-year-old woman.

Eight-year-old Joshua Wooten is rushed to the ER after his mother finds him collapsed on the bedroom floor. When it is found that Joshua is struggling to breathe and his health continues to decline, doctors are left baffled at what is the cause.

A single mother finds she can no longer walk.

A military wife suffers a sudden paralysis in her leg that defies explanation; doctors discover it may have something to do with her husband's top secret work.

When a young woman goes to the ER with severe abdominal pains, the doctors find a rare and virulent type of cancer that gives her ten years to live.

After moving to a new apartment, the mother of a little girl notices her child is suffering from a burning rash; doctors work to solve what caused it.

A swimmer gets attacks of near-paralytic exhaustion, after which his urine becomes strangely dark; when he has a heart attack, a doctor suspects something sinister.

A college student comes down with a purple rash that literally spreads before his eyes; as his health deteriorates, the doctor must race to find the cause.

A young child blisters after exposure to a few minutes of sun; Doctors make a discovery that the child's inability to sweat is one symptom of a mysterious disorder.

After a young man blows his nose, he becomes violently ill and passes out; his condition progressively worsens while doctors try to diagnose what's wrong before one more sneeze kills him.

A healthy pastor feels like he has had a heart attack every day for years; a friend gives advice and doctors try to solve the mystery.

Decades after a car accident, a woman loses the ability to speak; when her speech returns, she speaks with a foreign accent; one doctor thinks he knows why.

A mother tries to protect her children from their father's hoard; an artist chooses frog, penguins and banana peels over her boyfriend.

Maggie's piles of collections is putting her son's life at risk; Bob's passion for swimming pool parts is pushing his family to the brink.

Traci is pregnant and desperate to move back home, but it's filled floor to ceiling with her mother's stuff.

Kathleen discovers a hoard of mice living in her kitchen; spending the night in a hoard might be the end of a marriage before it even begins.

Medical responders were not able to get in Renee's front door after she had fallen unconscious in her home.

Rick tries to salvage his cluttered home that was nearly destroyed in a house fire; Linda must get her house up to code in 60 days or she will be on the streets.

Traci is pregnant and desperate to move back home, but it's filled floor to ceiling with her mother's stuff.

Kathleen discovers a hoard of mice living in her kitchen; spending the night in a hoard might be the end of a marriage before it even begins.

Medical responders were not able to get in Renee's front door after she had fallen unconscious in her home.

Rick tries to salvage his cluttered home that was nearly destroyed in a house fire; Linda must get her house up to code in 60 days or she will be on the streets.

A mother tries to protect her children from their father's hoard; an artist chooses frog, penguins and banana peels over her boyfriend.

Maggie's piles of collections is putting her son's life at risk; Bob's passion for swimming pool parts is pushing his family to the brink.

After losing 275 lbs., Mikki became a fitness fanatic, but the weight loss left her with a lot of sagging skin; Denise's obesity always made her feel invisible, but after losing 200 lbs. the skin still hinders her from fitting in with her family.

Rebecca lost her weight to be more active with her young son, but the plan backfired because she's now trapped in her excess skin; after his dad died, Sal dropped a ton of weight, but with all the excess skin, he fears he will never become a dad.

Autumn wants to make up for lost time with her son, but the excess skin from major weight loss is holding her back; Cody always pretended to be happy when he was 500-lbs, but after losing the weight, he's covered in skin and is sick of pretending.

Ronnie and Michael Robinette are thriving, but their extra skin is getting in the way; at 64, Renee's excess skin inhibits her from enjoying her relationship and expressing her true self in public.

Dr. Dow and J.J. Virgin are called in to save a pizza addict; consuming 80 times more pizza than an average American.

A woman is addicted to ice cream bars, eating up to 40 bars a day.

A 26 year old man is addicted to maple syrup.

A 34 year old woman in obsessed with eating cheesy potatoes; specialists are called in to help with this damaging and compulsive diet.

Mysti consumes as much as 40 gallons of tartar sauce a year.

A 34-year old diabetic is in need of help to save him from his addiction to cheeseburgers.

After a horrific car accident as a child, Heather's ankle was rebuilt from parts of her body; now it's up to Dr. Vincent to help her walk again.

Dr. Vincent tries to save a man's enormous toe; Dr. Schaeffer has his hands full treating a little boy with big demands; a man with incredibly long toes.

Dr. Schaeffer has to straighten a woman's serpentine foot to reset her life, as Dr. Vincent gets a drummer's foot back on the beat.

Dr. Ebonie's skills are tested as she attempts to diagnose a patient with feet covered in huge, wart-like masses; Dr. Brad is confronted with a mystery case that could be related to the elephant man as well as a patient with paper-thin skin.

Nate sees Dr. Brad for help with the raging calluses on his feet; Savannah has a rare condition that made her big toe grow to an enormous size and hopes Dr. Ebonie can help; Dr. Brad is determined to uncover the mystery behind John's foot growth.

A woman undergoes a risky craniotomy; a man searches for answers.

A teenager is rushed to the hospital after taking aspirin to help alleviate altitude sickness; a woman has pain in her arm that mysteriously spreads.

A woman and her husband decide to start a family after numerous negative pregnancy tests; a man appears to suffer an embolism.

A 3-month-old boy has breathing difficulties; a woman has stomach problems; stepping on a crochet hook causes strange problems for a patient.

An infant shows diverse symptoms; an ER nurse gets a diagnosis of lymphoma, before another symptom reveals her true illness.

Twins battle seemingly unrelated illnesses.

A woman and her husband decide to start a family after numerous negative pregnancy tests; a man appears to suffer an embolism.

A 3-month-old boy has breathing difficulties; a woman has stomach problems; stepping on a crochet hook causes strange problems for a patient.

An infant shows diverse symptoms; an ER nurse gets a diagnosis of lymphoma, before another symptom reveals her true illness.

Twins battle seemingly unrelated illnesses.

A woman undergoes a risky craniotomy; a man searches for answers.

A teenager is rushed to the hospital after taking aspirin to help alleviate altitude sickness; a woman has pain in her arm that mysteriously spreads.

Joyce needs home health care and hasn't left the house in three years; getting to Dr. Now in Houston is just the first step and when he prescribes therapy where Joyce must revisit an unhappy past with her mom; it might be more than she can handle.

At over 700 pounds, Teretha's life is confined to a bed, which is a long way from her former job representing Detroit's healthy eating program; a gastric bypass will hopefully save her life.

Milla is bedridden and dependent on her husband and five kids, who can't resist her unending requests for junk food.

Erica must return to California to continue her weight-loss journey, but she fears past emotional trauma will derail her progress.

Erica regrets not keeping a promise to her mom and hopes her siblings will help, but they're reluctant based on her past failures.

Mother of four LaShanta has been bed-bound for two years, and she relies on her kids to keep her cleaned and fed; her last chance to break the cycle of food addiction is to join Dr. Now's program, but it will take a village to get her out the door.

Holly already has one failed weight loss surgery, so to succeed this time, she must do more than change her eating habits, she must address the childhood issues that continue to plague her.

Holly faces a wedding and an operation; Lashanta is not losing weight and when a car crashes through her living room wall her progress is even slower.

Robin and her brother Chris are both obese and already lost a sibling to obesity; they plan to visit Dr. Now together when Chris suffers a stroke and can't go; Chris' son Garrett, already 600 pounds at age 20, is game to join the journey.

Robin and Garrett started their weight-loss journeys together as aunt and nephew; almost four years later, they're like war buddies, striving to reach their target weights through a combination of shedding pounds and skin removal surgeries.

Robin and her brother Chris are both obese and already lost a sibling to obesity; they plan to visit Dr. Now together when Chris suffers a stroke and can't go; Chris' son Garrett, already 600 pounds at age 20, is game to join the journey.

Robin and Garrett started their weight-loss journeys together as aunt and nephew; almost four years later, they're like war buddies, striving to reach their target weights through a combination of shedding pounds and skin removal surgeries.

Holly faces a wedding and an operation; Lashanta is not losing weight and when a car crashes through her living room wall her progress is even slower.

Pauline's self-destructive behavior continues to be a problem; Chad strives to be a better father and husband as he continues his journey; June's progress stalls when frequent travel and wedding plans cause her to slip back into bad habits.

Sean has a massive growth protruding from his side and skin so stretched it's tearing apart, forcing his mother to change both of their lifestyles before he can be approved for surgery.

Amber is 23, over 600-lbs, and relies on her family and boyfriend for even simple needs; her fear of dying young is so overwhelming that she decides to relocate 2,000 miles in hopes that weight loss surgery will give her life back.

A college graduate with a once-promising career, Justin has eaten his life away to the point of never leaving the house for anything but food; only the help of Dr. Now's weight-loss program can restore his hopes of living a happy, productive life.

After successful sleeve gastrectomy procedures, the Dreier twins collectively lose more than 400 pounds and work toward skin surgeries when a major life event disrupts their world and threatens their progress.

Unable to stand for more than a short period of time, Karina's weight places a burden on her parents and drives a wedge between her and her sister.

Kenae' is already big before her weight gain takes off after the death of her beloved mother; refusing to deal with the pain, Kenae' turns to food to fill the void.

Despite moving to Houston with the solid support of her boyfriend, Aaron, and her cousin, Jasmine, Tiffany finds it difficult to break the cycle of depressed eating when her two roommates don't join her diet and leave the house every day for work.

Cillas' food addiction is getting in the way of his ability to be there for his fiancée, Jessica, and her three daughters; if he doesn't lose weight soon, he knows he'll lose either his girls or his life.

Cillas must face difficulties from his childhood to progress to his goal weight and set an example for his children; Tiffany struggles to lose weight when financial hardships place a strain on her relationship with her boyfriend, Aaron.

Cillas' food addiction is getting in the way of his ability to be there for his fiancée, Jessica, and her three daughters; if he doesn't lose weight soon, he knows he'll lose either his girls or his life.

Cillas must face difficulties from his childhood to progress to his goal weight and set an example for his children; Tiffany struggles to lose weight when financial hardships place a strain on her relationship with her boyfriend, Aaron.

Despite moving to Houston with the solid support of her boyfriend, Aaron, and her cousin, Jasmine, Tiffany finds it difficult to break the cycle of depressed eating when her two roommates don't join her diet and leave the house every day for work.

Gang warfare and a high population of sick patients keep medical center workers on the move in Los Angeles.

The work of the staff at Baylor University Medical Center in Dallas includes a rodeo champion who was trampled by a bull.

Mentally ill son attacks family; horse throws polo-player.

Stuntman has a bike accident; gang-war stabbing; car-crash victims; man gets burned in a camping accident.

The staff of Wishard Memorial Hospital treat accident victims and victims of violence.

Stabbing victim; drunken teen; shooting victim.

A teenager's bulging tummy and stomach pains; a man's own attempted murder; a college coed stops breathing mysteriously.

A man thinks he's constipated; a young woman in cardiac arrest; a patient's family is clueless.

Bizarre fishing injuries; deadly abdominal pains; teenage victims of a car crash.

A student has difficulty breathing; a man impaled by a shovel; a police officer has a heart attack.

A golfer's life-saving surgery; three nearly naked adults in the ER; a patient accidentally shot by his brother.

A elder playboy has a minor injury that turns deadly; a health fanatic's juice diet leaves him in a comatose state; while juggling multiple critical patients, doctors nearly misdiagnose one who has suddenly deteriorated.

A teenage girl sleeps for weeks at a time, a boy with a brain-crushing skull defies the odds and a unique couple faces a big challenge.

A boy with an extra arm growing out of his back; a woman whose knees bend backwards; a tumor in a woman's eye could soon threaten her life.

A teenager whose body is aging ten times faster than normal, a girl with a massive tumor in the middle of her face needs emergency care and a woman battling a rare disorder can't stop eating.

A man born with an extra set of legs finds out whether they can be surgically removed, doctors attempt to recreate a jaw for a young boy who was mauled by a hyena and a woman living with not one, but two rare conditions.

A teenager with a debilitating skin condition is desperate for relief; a woman struggles to cope with a tumor spreading across her head; a five year old with a rare condition defies the odds.

Three young siblings can't stop eating; a man with a life-threatening face tumor must conquer his fear of surgery; a ground breaking operation to separate conjoined twins; two women born with different disabilities excel in sports and life.

A teenager whose body is aging ten times faster than normal, a girl with a massive tumor in the middle of her face needs emergency care and a woman battling a rare disorder can't stop eating.

A man born with an extra set of legs finds out whether they can be surgically removed, doctors attempt to recreate a jaw for a young boy who was mauled by a hyena and a woman living with not one, but two rare conditions.

A teenager with a debilitating skin condition is desperate for relief; a woman struggles to cope with a tumor spreading across her head; a five year old with a rare condition defies the odds.

Three young siblings can't stop eating; a man with a life-threatening face tumor must conquer his fear of surgery; a ground breaking operation to separate conjoined twins; two women born with different disabilities excel in sports and life.

A teenage girl sleeps for weeks at a time, a boy with a brain-crushing skull defies the odds and a unique couple faces a big challenge.

A boy with an extra arm growing out of his back; a woman whose knees bend backwards; a tumor in a woman's eye could soon threaten her life.

Krystal S. has finally met the man of her dreams, but she won't let herself marry him until she can be sure that she won't become bedridden and force him into the role of caretaker.

Melissa weighs a shocking 673 pounds, and decides to begin her seven-year weight-loss journey toward a healthier life.

Melissa struggles to get to her ideal weight after starting her weight loss journey from 650 pounds with gastric bypass.

Surgery enabled Laura's independence but the complications nearly killed her and she's terrified about the next skin surgery; Chay revealed to her family she was transgender, but living life as an overweight woman.

Latonya found the man she wants to marry; the only problem is that, at almost 700 pounds, she can't walk down the aisle; Latonya doesn't want to give up the food that she's used to, but she may do it for love.

Mother of four LaShanta has been bed-bound for two years, and she relies on her kids to keep her cleaned and fed; her last chance to break the cycle of food addiction is to join Dr. Now's program, but it will take a village to get her out the door.

Lindsey has a white picket fence, a loving husband and a great job, but her food addiction threatens to ruin everything; as she embarks on a weight loss journey to save her life, her husband may provide more harm than support.

Brandon is a talented musician with a beautiful voice and a run-away weight problem; he wants to lose weight and embark on a career; he also wants to take the next step with his girlfriend, Taylor, whom he risks losing if he can't make a change.