Wess gets off to a great start in Dr. Now's program, but when the cravings continue after surgery, Dr. Now sends him to therapy to confront his demons; Wess must ask himself whether he is ready to live his truth as a gay man in small-town Texas.

As an Italian American, Geno was raised with lots of love, family and food; now, he's still living with his mom and eating himself to death, and it's time to make a change; Geno's cousin, Nico, joins the cause; they pledge to lose weight together.

Doctors treat a gunshot victim who has a life-threatening wound to the head.

Staff treats patient injured while engaging in risky behavior at night.

Medical staff treats a patient who was hit by a train while crossing the tracks.

Medical staff treats patient injured in a car wreck involving multiple vehicles.

A young boy with a life-threatening neck growth seeks treatment; a baby born with eight limbs undergoes groundbreaking surgery.

Two-year-old Indonesian chain smoker; young man with facial tumor may not survive surgery; seven-year-old twins attached at the head.

A teenager who has been hiding a rare condition undergoes surgery, doctors attempt to diagnose a young girl born with dark hair covering her entire body and a man with tree like growths encasing his hands and feet seeks treatment.

Triplets born with a rare condition need surgery or their brains could be crushed; a boy has legs that have become so large he is unable to move; a soccer star who was born without feet.

Young Dominican woman cries blood; world's fattes child has insatiable appetite; young girl trapped behind werewolf's face.

A man passes out from abdominal pain; a woman helps solve the mystery of her estranged father's deadly symptoms; a group of delirious Civil War re-enactment soldiers arrives in the ER.

A wrist fracture turns into a medical mystery; two fishermen get stuck on the same lure; a cheerleader with a sprained finger nearly dies of an unexpected cause; a power outage foils the ER team's effort to get a dying patient to the O.R.

The hospital is locked down when a nurse is shot in the ER; medics rush a bride from her wedding who is in an unexplained altered mental state; a doctor must perform a risky intervention to save the life of a teenage girl.

A teen football player suffers a stroke; a doctor remembers his first major trauma in the 1970s; a doctor tries to figure out what causes a patient's abdominal pain.

A doctor with a severe bee allergy is stung while treating a critical patient who's been stabbed in the eye; a man comes into the ER after slitting his own throat; a paramedic becomes a patient when she's struck by a mysterious illness.

A zombie apocalypse fantasy becomes a nightmare when visitors crash a couple's romp; a housewife's homemade rejuvenation treatment gets her hot and bothered; a pilot has trouble telling the truth after he lands.

A marine mishap befalls a couple on vacation; a 12-hour sex-a-thon ends with a collapse for a Reiki instructor.

A pregnant woman tries anything to induce labor but a trip to the ER brings her a surprise; a superhero can't stay up after a night on patrol.

A date is ruined after a closet quickie causes a catastrophe; a toy won't stop buzzing, but a couple is determined to get to dinner anyway; a prisoner has problems after a conjugal visit.

A zombie apocalypse fantasy becomes a nightmare when visitors crash a couple's romp; a housewife's homemade rejuvenation treatment gets her hot and bothered; a pilot has trouble telling the truth after he lands.

A marine mishap befalls a couple on vacation; a 12-hour sex-a-thon ends with a collapse for a Reiki instructor.

A pregnant woman tries anything to induce labor but a trip to the ER brings her a surprise; a superhero can't stay up after a night on patrol.

A date is ruined after a closet quickie causes a catastrophe; a toy won't stop buzzing, but a couple is determined to get to dinner anyway; a prisoner has problems after a conjugal visit.

A teen football player suffers a stroke; a doctor remembers his first major trauma in the 1970s; a doctor tries to figure out what causes a patient's abdominal pain.

A doctor with a severe bee allergy is stung while treating a critical patient who's been stabbed in the eye; a man comes into the ER after slitting his own throat; a paramedic becomes a patient when she's struck by a mysterious illness.

A 16-year-old's behavioral issues may cause her to be expelled; daycare fees may force another student to leave school.

Florence's first prom; campaign to be prom queen.

A student struggles with self-esteem, weight issues and a son who has behavioral problems; a first time mom-to-be attempts to repair her relationship with her own mother.

A woman gives birth prematurely during Hurricane Sandy; an Army soldier coaches his wife's delivery from Afghanistan; a baby delivered in a shopping mall parking lot.

An emergency birth interrupts a wedding; a woman delivers after crashing her car; a baby with a life-threatening condition is born prematurely.

A baby is born twice; a woman in labor is torn apart by a tornado; a wife gives birth at home.

A woman is impaled on an iron spike; a man spears his friend on a fishing trip; an elderly gardener's shears are lodged in his eye.

A man is impaled on a fence post; a farmer has an object lodged in his brain; a woman is skewered on a hooked pole when she feeds the birds.

A woman gets a Christmas tree imbedded in her neck; a boy out fishing almost chokes on a barb; a man is filled with enough air to fill 1000 balloons; learn how they survived.

A man gets a wire embedded in his heart; three year old swallows magnets; woman has pencil in her brain; man has a five centimeter splinter removed from eye.

A husband and wife try to hide from drug dealers and the law; a man has a cold-blooded plan to cash in on his life insurance.

Stephen Dilbeck gets some shocking information about his birth family from Jane and Lisa; Chris and Sallie work on getting approval of an exhumation that will answer questions for hundreds of Hicks babies.

Jane and Lisa share the news about the exhumation with a group of Hicks babies that have questioned whether Dr. Hicks was in fact their biological father; Sallie and the Hicks babies learn the DNA results.

Wendy and her team encounter unexpected challenges with the exhumation; Sallie struggles emotionally with her decision to exhume; the Hicks babies learn the DNA results; three Hicks babies are connected with biological family.

Chris tries to unravel a legal mystery involving a woman's sister who she last saw across a New York courtroom 30 years ago.

A Vietnam vet hopes Lisa can help him make amends for the past by locating the daughter he lost custody of forty years ago; a woman's struggle to fit in takes a surprising turn when Chris reveals a series of stunning coincidences very close to home.

Lisa hopes that locating a man's biological mother will finally allow him to overcome his lifelong struggle with abandonment; Chris locates a woman's only child and delivers the difficult details of her daughter's birth story.

Identical twins enlist Lisa's help to unlock the mystery of why they were placed for adoption; Chris hopes to fulfill the wishes of a deceased father by tracking down the first-born son he and his wife had placed for adoption.

Chris tries to unravel a legal mystery involving a woman's sister who she last saw across a New York courtroom 30 years ago.

A Vietnam vet hopes Lisa can help him make amends for the past by locating the daughter he lost custody of forty years ago; a woman's struggle to fit in takes a surprising turn when Chris reveals a series of stunning coincidences very close to home.

Lisa hopes that locating a man's biological mother will finally allow him to overcome his lifelong struggle with abandonment; Chris locates a woman's only child and delivers the difficult details of her daughter's birth story.

Identical twins enlist Lisa's help to unlock the mystery of why they were placed for adoption; Chris hopes to fulfill the wishes of a deceased father by tracking down the first-born son he and his wife had placed for adoption.

Jane and Lisa share the news about the exhumation with a group of Hicks babies that have questioned whether Dr. Hicks was in fact their biological father; Sallie and the Hicks babies learn the DNA results.

Wendy and her team encounter unexpected challenges with the exhumation; Sallie struggles emotionally with her decision to exhume; the Hicks babies learn the DNA results; three Hicks babies are connected with biological family.

Lisa's struggle with her weight begins as a child and significantly worsens after witnessing her brother's murder; now bedridden and unable to care for herself, Lisa must find a way to lose the weight or she will never see her grandchildren grow up.

Brittani married a man who loves large women, but at 600-lbs, she can barely contribute to their marriage, and gets surgery to try to have a normal relationship.

June copes with the tragic death of her son by eating, and must confront the emotional issues driving her food compulsion after gastric bypass surgery.

John and Lonnie are two brothers from opposite ends of the spectrum; estranged for years, the brothers are now brought together by a common need to lose weight while they still can.

Lindsey has a white picket fence, a loving husband and a great job, but her food addiction threatens to ruin everything; as she embarks on a weight loss journey to save her life, her husband may provide more harm than support.

Bethany has two daughters who live in fear of losing their mom to her food addiction; once an addiction counselor, Bethany has gotten so big that she can no longer work; now she risks losing her life if Dr Now can't help her curb her own addiction.

JT is almost 900lbs with a 100-lb lymphedema mass on his leg and a food addiction that is bound to kill him if he doesn't change; his girlfriend takes him to Houston, but when his behavior drives her away, JT is left with only Dr. Now to help.

Gina and wife Beth live with Gina's mother, but she and Gina's sister blame Beth for Gina's spiraling weight problem; it will take all Gina's will to leave home for Houston to get Dr Now's help, to save her life and her marriage.

Jeanne struggles to care for herself in the aftermath of her dad's death; Brandon strives to get his weight down to feel confident when proposing to his girlfriend, Tayler, and be the man she deserves.

Cillas must face difficulties from his childhood to progress to his goal weight and set an example for his children; Tiffany struggles to lose weight when financial hardships place a strain on her relationship with her boyfriend, Aaron.

Jeanne struggles to care for herself in the aftermath of her dad's death; Brandon strives to get his weight down to feel confident when proposing to his girlfriend, Tayler, and be the man she deserves.

Cillas must face difficulties from his childhood to progress to his goal weight and set an example for his children; Tiffany struggles to lose weight when financial hardships place a strain on her relationship with her boyfriend, Aaron.

Gina and wife Beth live with Gina's mother, but she and Gina's sister blame Beth for Gina's spiraling weight problem; it will take all Gina's will to leave home for Houston to get Dr Now's help, to save her life and her marriage.

Belinda's lump on her neck causes her to basically be immobile; Nicole won't get married until she gets her armpit lump removed; Adela's chest and back are covered in wisdom spots; Nick foolishly removes a lipoma at home and now needs Dr. Lee.

Diane has tumors all over her body that have ruined her life; Will fears his shoulder lump will be ripped open at work; Anthony's daughters force him to get his lump examined; a woman detests her hideous varicose veins.

Taylor has a large bump at the base of her spine that is far more dangerous than she realizes; John jokes about his hip lump, but it's no laughing matter; Noelle had her ears stretched as a teen, but now wants them repaired.

Louis is a veteran who is covered in scaly, dry skin that makes him feel like an alligator; Irais's kids are bullied because of the embarrassing growth on her head; Johnny has been living with a stubborn lump on his back for too long.

Patrick's nose is covered by huge bumps, and he can barely breathe; Aziza and Lauren are friends who bonded over their matching wrist lumps; Joe has a mound in the middle of his forehead that looks like a third eye.

April is covered in bumps that disfigure her arms; Genner flies all the way from the Philippines to have Dr. Lee help with his bumpy nose; Chris suffers from psoriasis that nearly covers his body and a bump on his head.

Matt has a skin condition that causes tumors to grow all over his body; Yamileth hasn't pursued her dreams because of the lump on her neck; Pat is covered with dark spots from her neck to her abdomen; Jennifer has a unicorn bump on her forehead.

Amber has hundreds of tumors on her face; Antonio has a mound on his spine and is afraid it might be impossible to remove; sisters Cheri and Janice both suffer from possibly matching lumps; Tatiana has an embarrassing bump on her butt cheek.

Lisa has a horn growing out of the back of her head and fears that it could be cancer; Victor has a bulbous lump on his chest; Chuck has a Popeye-shaped bump on his arm; Christian and Jonathan are teenage brothers with matching lumps.

Taylore is a beautiful young woman who has unsightly elf-like bumps on her ears; Jose never goes out because of the baseball-sized lump on his head; Ken is covered in painful bumps that make it difficult to do everyday things.

Josh has a large knot on his head resulting from a car crash from 18 years ago; Brittney is covered in mysterious bumps; TJ has a hard, curious lump protruding from his side; Luis has a bump on his shoulder and his daughters fear it's dangerous.

Barbara's back lump became more noticeable after she lost 131 pounds; Bob has two painful bumps on his back; Hilda's depression is a result of the multitude of bumps on her eyelids; Art has one big bump on his head that he covers up with hats.

Leonard has an alarming bump hanging off of his arm that looks like it's breaking through the skin; Brandon has several lumps on his head that make him fearful for his life; Jess gets a noticeable lump on her butt after falling down the stairs.

Dr. Sandra Lee treats Heather, who has a huge growth on her leg and fears removing it could leave a keloid scar; Paul has a giant hump on his back.

Rhonda has bumps all over her head, including a horned growth that has her deeply concerned; Fred has a mysterious condition on his hands and has not been able to get answers from any doctors; Kevin has a huge lump protruding from his hip.

Jen has substantial growths on her ears that cause her depression, pain and vertigo; Juliet is under emotional distress because of the bumps all over her neck and chest; Gerald has a mysterious, kiwi-size lump on his middle finger.

Gerald is back to see Dr. Lee and a hand specialist about a huge, intrusive bump on his middle finger; Vinnie has a large, embarrassing birthmark on his neck; Leta has a lump on the back of her thigh that she has been hiding from her fiancée.

Tony has large growths on his nose that impair his breathing; Kevin has a bump in his jawline that is a lady deterrent; Marie has an unsightly lump on her forehead that makes her a hermit; Tommy's leg bump makes it difficult for him to work.

Rhonda has bumps all over her head, including a horned growth that has her deeply concerned; Fred has a mysterious condition on his hands and has not been able to get answers from any doctors; Kevin has a huge lump protruding from his hip.

Jen has substantial growths on her ears that cause her depression, pain and vertigo; Juliet is under emotional distress because of the bumps all over her neck and chest; Gerald has a mysterious, kiwi-size lump on his middle finger.

Gerald is back to see Dr. Lee and a hand specialist about a huge, intrusive bump on his middle finger; Vinnie has a large, embarrassing birthmark on his neck; Leta has a lump on the back of her thigh that she has been hiding from her fiancée.

Tony has large growths on his nose that impair his breathing; Kevin has a bump in his jawline that is a lady deterrent; Marie has an unsightly lump on her forehead that makes her a hermit; Tommy's leg bump makes it difficult for him to work.

Leonard has an alarming bump hanging off of his arm that looks like it's breaking through the skin; Brandon has several lumps on his head that make him fearful for his life; Jess gets a noticeable lump on her butt after falling down the stairs.

Dr. Sandra Lee treats Heather, who has a huge growth on her leg and fears removing it could leave a keloid scar; Paul has a giant hump on his back.

Randy's hoarding compulsion affects his living conditions.

Decades of hoarding isolates Benny from his family.

Two brothers help make arrangements for a former owner to buy her house back after a real estate auction, but things do not go as planned.

After being reported to the Board of Health, Val's house was condemned; a massive haul-away had the house clean again, but when the enforcement officer made a recent follow-up visit, the house was cluttered and he warned Val to clean it up.

Going back to see Rhonda's home five years after her family and a team of professionals helped her to clean it up.

Stephanie and her mom Darcy lost a combined weight of 320 lbs.; BJ overcame drug and food addiction to lose 350 lbs. and his body is now covered with excess skin.

Antonia overcame her food addiction to lose 190lbs, but the extra skin is keeping her from feeling confident and sexy; Natasha lost almost 300lbs after gastric bypass surgery, but now struggles with carrying a lot of saggy excess skin.

Linda is hoping skin removal surgery will give her the self-esteem she needs to be an amazing role model to her daughters; Angel hates her extra skin because it's turning her into an introvert around her family.

Shantel needs to get rid of her excess skin to gain the confidence she needs to set a positive example for her daughter; Hope has an obsession with weight loss that could make her too unhealthy to have skin removal surgery.

An ER doctor's friend arrives at the hospital combative and out of control; a cyclist's throat is torn open when a driver opens a car door in her path; a nursing student is found passed out on the hospital floor.

A young girl is mysteriously paralyzed from the waist down; a young man complains of a splitting headache; a bride-to-be has appendicitis on her wedding day.

Doctors use a robot to treat a seizing 7-year-old boy; a chef's tongue is swelling; a woman who crashed her car insists her injured dog be treated first.

A man with a slashed wrist has a startling secret; a woman gives birth unexpectedly, shocking the ER staff; a surgeon requires urgent treatment after falling off a bed while trying to help his patient.

A young boy at a sleepover party mysteriously loses control over his arms and legs; a woman is shot in the leg at her own bachelorette party; bubbles in a woman's arteries are causing a stroke.

With pandemic safety protocols in place, Dr. Lee reopens her office; Monica has a large birthmark growing on the side of her face; Jackie has a melon-sized lump on the back of her shoulder; Reginald has large, rare growths on the back of his head.

Dr. Lee tries to provide the help Reginald needs to remove the large, rare growths on the back of his head; Che'Re has a prominent bump on her face that has put her in a dark place; Juan has several painful boils on the back of his neck.

Dennis has several giant growths on the back of his head; Juan has a rare condition he hopes Dr. Lee will understand; Natalie searches for answers as to why her body is covered in hundreds of mysterious dark bumps.

Audrey pops the painful bumps that cover her body so she can feel relief; Felicia has a peculiar-looking dark growth on her forehead; Krista's excessive sweating is so severe that on any given day she could fill up an entire milk jug with her sweat.

With pandemic safety protocols in place, Dr. Lee reopens her office; Monica has a large birthmark growing on the side of her face; Jackie has a melon-sized lump on the back of her shoulder; Reginald has large, rare growths on the back of his head.

Dr. Lee tries to provide the help Reginald needs to remove the large, rare growths on the back of his head; Che'Re has a prominent bump on her face that has put her in a dark place; Juan has several painful boils on the back of his neck.

Dennis has several giant growths on the back of his head; Juan has a rare condition he hopes Dr. Lee will understand; Natalie searches for answers as to why her body is covered in hundreds of mysterious dark bumps.

Audrey pops the painful bumps that cover her body so she can feel relief; Felicia has a peculiar-looking dark growth on her forehead; Krista's excessive sweating is so severe that on any given day she could fill up an entire milk jug with her sweat.

A man with a slashed wrist has a startling secret; a woman gives birth unexpectedly, shocking the ER staff; a surgeon requires urgent treatment after falling off a bed while trying to help his patient.

A young boy at a sleepover party mysteriously loses control over his arms and legs; a woman is shot in the leg at her own bachelorette party; bubbles in a woman's arteries are causing a stroke.

After years of a tumultuous relationship with her husband, Tamy's eating addiction has caused her weight to balloon to over 500 pounds; she has become a hermit and hopes to restart her life so she can better care for her son, Zachary.

Zsalynn struggles between fighting her weight and fighting for her marriage; Christina releases the negativity in her life and finally begins to live.

Chuck's second year of weight loss and a new relationship; Paula struggles with juggling many responsibilities along with her weight-loss.

A number of challenges seem to have cornered Betti Jo and her husband; Susan encounters a serious problem that can throw everything off track.

Over 11 years, Melissa has lost 500 pounds and saw her weight drop to 137 pounds; now facing marital problems, three pregnancies, and life as a single mom, Melissa is struggling with a 150-pound weight gain and finds herself at a crossroads.

Steven Assanti weighs nearly 800 pounds and his brother Justin almost 600 pounds, and although they can't stand each other, their father packs up the family to travel across the country and seek help.

After successful sleeve gastrectomy procedures, the Dreier twins collectively lose more than 400 pounds and work toward skin surgeries when a major life event disrupts their world and threatens their progress.

Syreeta thinks that anyone trying to help has an ulterior motive, but she's gotten so big she desperately needs help; she's learning to let down her guard for her husband, but weight-loss surgery will be tough if she can't learn to trust the surgeon.

Mark sets out with a goal for weight-loss surgery, but as weight loss gets easier, he turns down medical advice and decides to do it on his own; Mark thinks he can lose 500 pounds by himself, but Dr. Now sees this as another excuse not to change.

With her weight spiraling, Stephanie needs her mom's help to care for her three kids; she's at the point where she'll have to lose weight or risk not having the chance to see her kids grow up.

Mark sets out with a goal for weight-loss surgery, but as weight loss gets easier, he turns down medical advice and decides to do it on his own; Mark thinks he can lose 500 pounds by himself, but Dr. Now sees this as another excuse not to change.

With her weight spiraling, Stephanie needs her mom's help to care for her three kids; she's at the point where she'll have to lose weight or risk not having the chance to see her kids grow up.

Syreeta thinks that anyone trying to help has an ulterior motive, but she's gotten so big she desperately needs help; she's learning to let down her guard for her husband, but weight-loss surgery will be tough if she can't learn to trust the surgeon.

Fearing he'll suffer the same fate as 700-pound brother David, Benji hopes to be able to support both himself and his brother on their life-or-death weight loss journey.

At 650 pounds, Gideon's weight prohibits him from working, making him completely dependent on his exhausted wife.

Dottie wants to be a better mom, so she agrees to a drastic new diet, but her child's life-threatening emergency and her own self-sabotage threaten to derail all hopes for weight-loss.

When Travis gets too big to walk down the aisle, he promises to give his wife a proper wedding; he gains more weight, leaving Dr Now as Travis' only hope to lose weight and get the life he and his wife dreamed of having together.

Joyce needs home health care and hasn't left the house in three years; getting to Dr. Now in Houston is just the first step and when he prescribes therapy where Joyce must revisit an unhappy past with her mom; it might be more than she can handle.

Shantel's brother Carlton lives downstairs but she hardly ever sees him because at 600 lbs each, neither can do the stairs safely; to break free from a death spiral of codependent eating they need Dr. Now's help to reforge their sibling relationship.

Seana is 23 and nearly 700 lbs, living at her mom's house, depressed and anxious, her weight-gain threatening to take her last breath; Dr. Now can give her the tools she needs to live, but until she chooses life, no one can save Seana but herself.

Nothing means more to Chris than his relationship with his daughter, Zoey, but now he feels he is failing her as his weight gain begins to limit his mobility.

Patrick's weight has never been a bother, but now he's so big that it's getting in the way of his relationship with his daughter; if he wants to see her graduate high school, he'll have to reverse course.

Krystal S. has finally met the man of her dreams, but she won't let herself marry him until she can be sure that she won't become bedridden and force him into the role of caretaker.

Patrick's weight has never been a bother, but now he's so big that it's getting in the way of his relationship with his daughter; if he wants to see her graduate high school, he'll have to reverse course.

Krystal S. has finally met the man of her dreams, but she won't let herself marry him until she can be sure that she won't become bedridden and force him into the role of caretaker.

Nothing means more to Chris than his relationship with his daughter, Zoey, but now he feels he is failing her as his weight gain begins to limit his mobility.

A 20-year meth addict's addiction worsens after the sudden death of his father.

Megan is a 33-year-old alcoholic with social anxiety and a troubled past.

Phil is a 58-year-old meth user whose addiction spans over three decades.

Bennie and Rhonda have lived decades of compulsive hoarding that have driven their loved ones away.

Laura and Margaret are both mothers and extreme hoarders; their parallel obsessions have made them prisoners in their own homes while tearing their families apart.

Deborah and Mary both start hoarding in the wake of personal tragedies; ever since Deborah killed her drug-addicted boyfriend in self-defense, she and her son have lived amid growing piles of trash and unused possessions.

9/11 trauma was the trigger for one woman; the lasting effects of a brain hemorrhage.

A man thinks he's constipated; a young woman in cardiac arrest; a patient's family is clueless.

Bizarre fishing injuries; deadly abdominal pains; teenage victims of a car crash.

A student has difficulty breathing; a man impaled by a shovel; a police officer has a heart attack.

A golfer's life-saving surgery; three nearly naked adults in the ER; a patient accidentally shot by his brother.

Chiropractor Dr. Colón treats Liana, a cane-bound woman suffering from involuntary tremors; Sarah's obsession with corsets causes her migraines; Amy, a little person, can no longer walk on her own; Brenda has uncontrollable gas.

Dr. Colón helps a woman who cannot keep her joints in place; a new mother suffers from a tragic boat accident; a bodybuilding leukemia survivor; a constipated baby.

Dr. ColÃ3n faces more chiropractic challenges when she treats a woman with CMT who hopes to stand at her daughter's wedding, a big breasted woman with extreme neck pain, and the show's sound man, who was born with cerebral palsy and an uneven body.

Tamika finds a partner who makes her feel happy, but she feels uncomfortable due to her excess skin; Emilly blames herself for her son's weight gain, and, now, they both struggle with the pain loose skin has brought into their lives.

After being a victim of a crime, Marranda finds solace in food and her weight balloons; she loses the weight, but her skin is a reminder of her trauma; Jannet's excess skin is keeping her from meeting a life partner.

Rafael loses over 500 pounds through diet and exercise, but his excess skin becomes a huge hindrance on his life and progress; Anna loses 330 pounds but her low self-esteem holds her back from being the mother she wants to be.

Carlynda needs two full knee replacements but doctors won't perform surgery until the skin is gone; after extreme weight loss and marrying the love of her life, Karen wants to start a family, but her excess skin gets in her way.

Tamika finds a partner who makes her feel happy, but she feels uncomfortable due to her excess skin; Emilly blames herself for her son's weight gain, and, now, they both struggle with the pain loose skin has brought into their lives.

After being a victim of a crime, Marranda finds solace in food and her weight balloons; she loses the weight, but her skin is a reminder of her trauma; Jannet's excess skin is keeping her from meeting a life partner.

Rafael loses over 500 pounds through diet and exercise, but his excess skin becomes a huge hindrance on his life and progress; Anna loses 330 pounds but her low self-esteem holds her back from being the mother she wants to be.

Carlynda needs two full knee replacements but doctors won't perform surgery until the skin is gone; after extreme weight loss and marrying the love of her life, Karen wants to start a family, but her excess skin gets in her way.

Dr. Colón helps a woman who cannot keep her joints in place; a new mother suffers from a tragic boat accident; a bodybuilding leukemia survivor; a constipated baby.

Dr. ColÃ3n faces more chiropractic challenges when she treats a woman with CMT who hopes to stand at her daughter's wedding, a big breasted woman with extreme neck pain, and the show's sound man, who was born with cerebral palsy and an uneven body.

Weeding through rumors for 15 years, a woman is determined to uncover the truth of her biological mother, only to reveal more unexpected family secrets; identical twin sisters search for their biological mother, unsure if she's even alive.

A woman's world was shaken when she discovered she was adopted at 25, and goes onto learn more dramatic revelations; a mother is in a race against time to find her son who she placed for adoption 46 years ago.

A woman searches for her beloved sister who she tried to adopt herself years ago; after a life of longing, a couple is desperate to find the son they placed for adoption fifty years ago when they were teens.

A man searches for his birth mother, whose disappearance when he was 5 years old has haunted him for his entire life; a woman hoping to meet a member of her biological family faces certain realities about her true past.

A woman searches for her brother, hoping to fulfill a promise she made to her late mother, and discovers a 40-year-old secret about her parents' past; a woman consumed by a lifelong search for her mom finds hope with a new DNA connection.

Cardiac arrest after a DWI crash; ATV accident; drug overdose.

Emergency room doctors deal with mayhem on a daily basis at the University of California at Davis Medical Center.

Doctors and nurses treat patients at Charity Hospital in New Orleans, a city that leads the nation in homicide, cancer, asthma and obesity.

Brain death; life support; organ donation; transplants.

A woman has seizures whenever she hears her favorite pop tunes; a young athlete loses all his body fat and almost starves to death.

A successful businesswoman suddenly seems to become possessed by demons; a young college student battles monstrous pain when she grows fingernails out of her hair follicles.

A mother becomes a recluse when every sound becomes deafeningly loud; a man's career is in jeopardy when he gets drunk without touching a drop of alcohol.

A dad is accused of child abuse when doctors discover his baby has broken bones; a vibrant teenage girl is unable to eat and is wasting away before her mother's eyes.

Jamie's tiredness leads to shocking news; David has joint pain and low stamina.

A young child blisters after exposure to a few minutes of sun; Doctors make a discovery that the child's inability to sweat is one symptom of a mysterious disorder.

After a young man blows his nose, he becomes violently ill and passes out; his condition progressively worsens while doctors try to diagnose what's wrong before one more sneeze kills him.

A healthy pastor feels like he has had a heart attack every day for years; a friend gives advice and doctors try to solve the mystery.

Decades after a car accident, a woman loses the ability to speak; when her speech returns, she speaks with a foreign accent; one doctor thinks he knows why.

A young child blisters after exposure to a few minutes of sun; Doctors make a discovery that the child's inability to sweat is one symptom of a mysterious disorder.

After a young man blows his nose, he becomes violently ill and passes out; his condition progressively worsens while doctors try to diagnose what's wrong before one more sneeze kills him.

A healthy pastor feels like he has had a heart attack every day for years; a friend gives advice and doctors try to solve the mystery.

Decades after a car accident, a woman loses the ability to speak; when her speech returns, she speaks with a foreign accent; one doctor thinks he knows why.

A dad is accused of child abuse when doctors discover his baby has broken bones; a vibrant teenage girl is unable to eat and is wasting away before her mother's eyes.

Jamie's tiredness leads to shocking news; David has joint pain and low stamina.

Former plus-size model and advocate Renee realizes the mortal mistakes she has made as her weight swells to 600 pounds and her health crumbles.

Chuck's second year of weight loss and a new relationship; Paula struggles with juggling many responsibilities along with her weight-loss.

Penny returns to Maryland believing she can lose weight; Tara continues to lose weight and is dating for the first time.

Erica must return to California to continue her weight-loss journey, but she fears past emotional trauma will derail her progress.

Ashley lost over 200 lbs. in Houston, but a family of enablers threatens her progress; Diana has shed 300 lbs., but knee damage may cause her to regain weight.

Kirsten must gain independence to get a full gastric bypass; Michael struggles to lose and battles anger issues; Michael's wife, Roni, wants surgery too.

Ashley hits an emotional wall and is desperate for skin surgery, but she's not losing any weight; after being evicted, Nicole is forced to move back to Ohio, which could impact her weight loss journey.

Abi was struggling with his weight before a fluke accident left him mostly paralyzed; bedbound for seven years since then and topping 700 pounds, Abi's only hope for a future with his wife is to get Dr. Now's help to lose weight.