A girl with a paralyzed face tries to find a new smile; a man with a crippling skin condition lives life on his own terms; a man with a form of dwarfism fears his back pain will stop him from running marathons.

Parents of a 44-pound baby seek to understand why their son can't stop eating; a man travels to get his giant neck tumor removed; a young girl lives trapped inside her body; a woman with a severe chemical allergy can't go outside.

A man seeks to get the fatty growths on his chest removed; a boy's eye falls out of his skull; a man with giant facial keloids goes under the knife one last time; a young boy lives with an agonizing skin condition; with bonus content.

A man's body blows up like a balloon after a diving accident; a man seeks to get his giant leg tumor removed; a woman who lost the middle of her face to cancer tries to get her confidence back; a man drinks five gallons of water a day to stay alive.

Lupe has spent the last 10 years in bed and is totally dependent on her husband, prompting a cross-country move that could save her life or end up backfiring.

An overweight woman struggles with flesh-eating bacteria and butterfly shaped fat deposits; unexpected news threatens her weight loss journey.

Laura has used food to cope with her emotions; she is confined to a wheelchair and relies on an oxygen tank to breathe and her husband and mother to survive.

Syreeta thinks that anyone trying to help has an ulterior motive, but she's gotten so big she desperately needs help; she's learning to let down her guard for her husband, but weight-loss surgery will be tough if she can't learn to trust the surgeon.

At 670 pounds, Ashley, who lives in her parents' home with her husband, decides she must make a drastic change to save her life and her marriage.

Cynthia, a single mother focused on raising five kids, comes to realize what her death would mean for their future.

After overcoming a dependence on drugs and alcohol, sneaking food is Doug's last remaining vice; this husband and father must overcome his addictive personality to save his life and marriage.

Tanisha weighs around 600-lbs and she's desperate to survive for her kids and avoid her mother's tragic fate of dying at age 50 from super obesity; now at 32, her future looks grim if she doesn't make a drastic change to save her life.

William was always mobile and fairly athletic -- that is, until he wasn't; it's been years now since a knee injury derailed his sports career, and he's ballooned up over 600 pounds; now, to lose weight he'll have to face up to how bad it's gotten.

Diana, a once thin and active woman, is now a prisoner to her body and trades the comfort of her apartment for a weight loss journey under the strict authority of her niece.

William was always mobile and fairly athletic -- that is, until he wasn't; it's been years now since a knee injury derailed his sports career, and he's ballooned up over 600 pounds; now, to lose weight he'll have to face up to how bad it's gotten.

Diana, a once thin and active woman, is now a prisoner to her body and trades the comfort of her apartment for a weight loss journey under the strict authority of her niece.

Tanisha weighs around 600-lbs and she's desperate to survive for her kids and avoid her mother's tragic fate of dying at age 50 from super obesity; now at 32, her future looks grim if she doesn't make a drastic change to save her life.

After meeting and falling in love at a bariatric rehab center, Lee and Rena are battling health and anger issues while taking a desperate, second attempt to save their relationship and their lives.

Nikki finds her career as a costume designer threatened by immobility, so she undergoes gastric bypass and confronts the emotional causes for her eating.

Ashley confronts medical setbacks and struggles to get past the trauma that ignited her eating disorder.

Liz, completely bed-bound, has severe lymphedema that makes it impossible to walk; utterly isolated, Liz has no friends, battles depression and lives with a mother too ill to take care of her.

Wess gets off to a great start in Dr. Now's program, but when the cravings continue after surgery, Dr. Now sends him to therapy to confront his demons; Wess must ask himself whether he is ready to live his truth as a gay man in small-town Texas.

A woman whose extreme obesity has left her nearly immobile must overcome both her physical and emotional pain if she is ever to live a normal life again.

Unable to stand for more than a short period of time, Karina's weight places a burden on her parents and drives a wedge between her and her sister.

After years of a tumultuous relationship with her husband, Tamy's eating addiction has caused her weight to balloon to over 500 pounds; she has become a hermit and hopes to restart her life so she can better care for her son, Zachary.

Tommy wants to lose weight so he can marry his fiancee and have the life he always dreamed of with her, but to break the cycle of pathological eating that left him nearly bed-bound, he'll have to face a piece of his past he has always kept secret.

Devastated by two miscarriages due to her weight, Schenee is desperate to start a family and stop relying on her husband, Freddie, to take care of her; she hopes weight loss surgery will be able to fix her fertility issues as well as her marriage.

Tommy wants to lose weight so he can marry his fiancee and have the life he always dreamed of with her, but to break the cycle of pathological eating that left him nearly bed-bound, he'll have to face a piece of his past he has always kept secret.

Devastated by two miscarriages due to her weight, Schenee is desperate to start a family and stop relying on her husband, Freddie, to take care of her; she hopes weight loss surgery will be able to fix her fertility issues as well as her marriage.

After years of a tumultuous relationship with her husband, Tamy's eating addiction has caused her weight to balloon to over 500 pounds; she has become a hermit and hopes to restart her life so she can better care for her son, Zachary.

Siblings searching for their sperm donor father have their worlds turned upside down when Lisa reveals shocking news; Chris embarks on a journey to find the family of a woman abandoned as a baby on an Amish family's porch.

A young man who received letters from his birth mother longs to know the truth of the words she wrote; a man haunted by the memory of his younger brother being taken from their home seeks to reunite the family.

A woman discovers troubling news about her biological father, but uncovers exciting information about his family; adoptee Leslie and her birth mother Janice seek help after their newfound relationship derails.

Getting too hot can be fatal for twins Andrew and Brandon, who meet Josh, a fellow sufferer of Ectodermal Dysplasia.

Tiffany and Yajaira have Jarcho Levin Syndrome, which malformed their ribs and spines during infancy.

Born with Goldenhar Syndrome, Austin and Elena have been bullied for looking different, and feel isolated from other kids.

Troy's extra toe causes him pain, and he hopes Dr. Ebonie can provide him with relief; Dr. Brad does his best to untangle a ballet dancer's twisted feet; Ramon turns to Dr. Ebonie for help with the sacks of fluid hanging from his leg and ankle.

Despite having the longest big toes Dr. Brad has ever seen, Anna hopes for the feet she's always wanted; Russell visits Dr. Ebonie with feet that look like hooves; Patty lost most of her foot in an extreme amputation, and she needs Dr. Sarah's help.

Michael visits Dr. Sarah to see if she can help with his twisted toes. Robyn has corns on her feet and hopes Dr. Brad can cut them out so she'll be able to walk pain free once again. Richard sees Dr. Ebonie for issues related to his missing big toe.

Stacy's life-threatening scar on her foot has left her hopeless; David has the worst case of foot fungus Dr. Schaeffer has seen; Morgan, an erotic paranormal romance novelist, is hoping to get her sixth toe amputated.

A woman with a 2-pound mass in her foot; a man with pasta-shaped toenails; a woman with heels like rocks has the doctors scratching their heads and holding their noses.

Miranda's toddlers have no room to play; Hsi-Ming's daughter is concerned for her mother's health and safety.

A psychologist can't solve her own hoarding problem; millions of roaches are infesting her home.

Vickie and Jeff's marriage is at its breaking point; Vicki reveals secrets she's been keeping.

The city has threatened to demolish Caryn's home if the conditions do not change.

Janet and Herv have kept their hoarding a secret from everyone, but as they confront the clutter, shocking secrets concerning their relationship and sex lives are coming to light, leaving them in a fight to save their house and their marriage.

Two women's compulsive hoarding is crowding out their loved ones.

Vickie and Jeff's marriage is at its breaking point; Vicki reveals secrets she's been keeping.

The city has threatened to demolish Caryn's home if the conditions do not change.

Janet and Herv have kept their hoarding a secret from everyone, but as they confront the clutter, shocking secrets concerning their relationship and sex lives are coming to light, leaving them in a fight to save their house and their marriage.

Two women's compulsive hoarding is crowding out their loved ones.

Miranda's toddlers have no room to play; Hsi-Ming's daughter is concerned for her mother's health and safety.

A psychologist can't solve her own hoarding problem; millions of roaches are infesting her home.

A man undergoes surgery to remove his record-breaking face tumor; a young girl lives with huge hands; a mathematician born with severely deformed legs and a spine walks on all fours.

A woman's arm burns from the inside out; a girl undergoes life-changing surgery to stop her neck from dislocating; a boy has a large facial tumor removed; with bonus content.

A man with cold-like symptoms loses his limbs and lips; a young girl has a prematurely fused skull; a boy with brittle bones and a rare skin condition gets life-changing surgery; a woman suffers from a disfiguring birthmark; with bonus content.

A boy tries to get his balloon facial tumor removed; a woman who is allergic to UV light must take precautions; a woman fears her birthmark is still growing; a boy with undeveloped legs walks on all fours; with bonus content.

A young girl with a crippling leg defect undergoes life-changing surgery; a man is born with his heart outside his rib cage; a karate champion battles a rare skin disorder.

A girl with a paralyzed face tries to find a new smile; a man with a crippling skin condition lives life on his own terms; a man with a form of dwarfism fears his back pain will stop him from running marathons.

Parents of a 44-pound baby seek to understand why their son can't stop eating; a man travels to get his giant neck tumor removed; a young girl lives trapped inside her body; a woman with a severe chemical allergy can't go outside.

A pregnant woman suffers strokes and a heart attack.

A woman experiences severe abdominal cramps while on a boat in the middle of the open water.

A high-school student thinks that her weight gain and fatigue are from eating poorly and working too much.

After failing two pregnancy tests, a woman is shocked to learn the truth about her symptoms; a woman gets a surprise after having gastric bypass surgery.

An unknowing mother goes into labor in her bathroom; a woman's water breaks years after being told that she is unable to get pregnant.

A teenager believes that she is unable to bear children after having an aggressive chemotherapy treatment; a nursing student learns she is pregnant after an emergency appendectomy.

A new mother struggles to lose her baby weight; a mother gets a surprise after having her tubes tied.

A teacher's aide fails to recognize the signs of pregnancy; a 40-year-old is shocked to learn that she is pregnant.

A young mother with a reputation for being a hypochondriac shocks her family when she goes into labor; a couple learns that they are having a baby while at a dinner party.

A mother mistakes labor pains for kidney stones; after losing weight, a woman discovers she is pregnant.

A young woman experiences fainting spells after a car accident; an 11-year-old suffers a terrible headache.

A woman experiences dizzy spells after a vacation; a woman suffers stomach pain and bizarre swelling.

Student experiences crippling pain in his lower back; an adopted child has a lump on her shoulder.

An infant screams in the pool; a mother is struck by a series of headaches.

An infant has an eye problem; a young girl is unusually sweaty.

Parents notice their 7-month-old son has troubling physical impairments; a woman traveling the world starts experiencing unusual back pain and tingling in her feet.

Student experiences crippling pain in his lower back; an adopted child has a lump on her shoulder.

An infant screams in the pool; a mother is struck by a series of headaches.

An infant has an eye problem; a young girl is unusually sweaty.

Parents notice their 7-month-old son has troubling physical impairments; a woman traveling the world starts experiencing unusual back pain and tingling in her feet.

A young woman experiences fainting spells after a car accident; an 11-year-old suffers a terrible headache.

A woman experiences dizzy spells after a vacation; a woman suffers stomach pain and bizarre swelling.

After a lifelong struggle with obesity, the three Perrio siblings travel to Houston in a last-chance journey to lose weight.

Bedridden Marla is so heavy she cannot stand up; she must face the hard truth about her condition and understand the toll it takes on her supportive family.

Chay has eaten his way to 600 pounds to cope with the emotional turmoil of his childhood; he loses his emotional support and searches for new strength to take control of his life.

Weighing over 700-lbs, Nicole is on the verge of leaving her two young children motherless; trying to survive a family of addicts, she commits to Dr. Nowzaradan's diet program, but crisis threatens to derail all her hopes for weight-loss.

Sean must overcome recent tragedies in his life before he loses all the progress he made over the last two years; Dottie struggles to stay on track while maintaining her family life.

Vianey and Allen are locked in a co-dependent relationship based on a shared love of food; as they head to Houston, they will soon find out if their relationship can handle the strain of growing healthy together.

Vianey and Allen have been on a weight-loss journey together; after Allen's surgery is a success and Vianey's is not, the couple struggle to get back on the same page to save their lives.

Kirsten is close to losing all her mobility, and while she's trying to control of her obesity, she's also in danger of losing her troubled son.

Amy and Becky are addicted to being identical; Jennifer addicted to eating mattresses.

Robert consumes up to 16 plastic bags every week; 48-year-old Catherine can't part from her plastic doll.

A man is addicted to covering his body in orthopedic plaster casts; a woman who speaks with psychics at least three times a day to avoid loneliness.

Carrie drinks about 80 ounces of her own urine a day with the belief it has helped treat her cancer despite no medical proof.

Michelle has been addicted to drinking human and pig blood for 15 years; her mother struggles to accept her addiction and her doctor pushes her to give it up.

Nicole's addiction to Pony Play; Heather's addicted to drinking paint.

Julius has been sexually attracted to balloons for decades and keeps more than fifty thousand in his home at all times; Natasha eats entire jars of clay face masks every day.

For the last six years, 20-year-old Mark has been addicted to his 15 inflatable pool toys as he eats with them, sleeps with them and even bathes them; Karmello has been getting black market butt injections for the last three years.

Amy and Becky are addicted to being identical; Jennifer addicted to eating mattresses.

Robert consumes up to 16 plastic bags every week; 48-year-old Catherine can't part from her plastic doll.

A man is addicted to covering his body in orthopedic plaster casts; a woman who speaks with psychics at least three times a day to avoid loneliness.

Carrie drinks about 80 ounces of her own urine a day with the belief it has helped treat her cancer despite no medical proof.

Michelle has been addicted to drinking human and pig blood for 15 years; her mother struggles to accept her addiction and her doctor pushes her to give it up.

Nicole's addiction to Pony Play; Heather's addicted to drinking paint.

Julius has been sexually attracted to balloons for decades and keeps more than fifty thousand in his home at all times; Natasha eats entire jars of clay face masks every day.

For the last six years, 20-year-old Mark has been addicted to his 15 inflatable pool toys as he eats with them, sleeps with them and even bathes them; Karmello has been getting black market butt injections for the last three years.

Kirsten is close to losing all her mobility, and while she's trying to control of her obesity, she's also in danger of losing her troubled son.

Stacey's shoulder growth prevents her from being the playful teacher she once was; Matthew worries that his mysterious shin rash may be dangerous.

Lattyse was born with a mysterious growth above her eyebrow that gives her headaches. Robert has a tomato-sized growth on his butt cheek that causes him pain and discomfort. Sharon has an embarrassing, stinky, squirting cyst under her breast.

Keke is covered in bumps that make her embarrassed to be intimate with her husband; Jim is a widower with two lumps who wants them removed for himself and his late wife; Corey has been labeled a devil worshipper because of his forehead growth.

Monica returns for a second time in hopes that Dr. Lee can remove some more of her face growths; Ken has several large cysts on his head that he has tried to remove on his own; Maranda has a mystery skin sore that causes discomfort.

Corey is a drag queen and has a bump dangling from his booty; Adam has a semi-circle of about a dozen cysts on his head that he covers with a hat; Virginia has large growths on both of her upper arms that make it difficult to travel in her RV.

Terry's nose growth has prevented him from meeting his grandkids; Remi has alligator-like skin and is not used to taking care of herself; Austin has an embarrassing birthmark right next to his eyelid; Mary Jo has a throbbing bump on her neck.

Roger has enormous growths on his nose that drip pus, attract flies, and are so large that he can barely breathe; Sandra and Jessie are sisters who bonded over their many undiagnosed face bumps.

Gabriel has a huge growth on his clavicle but is terrified of surgery; Karen has dealt with painful, scaly feet for 22 years with no diagnosis; Lorne has embarrassing tumors on his face and body and believes this is why he hasn't met the one yet.

Ruben is a personal trainer whose head growth has prevented him from seeing clients; Kaitlin has blue marks and scars up and down her arms due to long-term drug use; Adrian was left with a disfiguring bump on her behind after falling down stairs.

Margarita is a matriarch who has been hiding her armpit lump from her family; Kayla is an aspiring musician with a promising career that her painful eczema has brought to a halt; Bradley has a concerning growth that looks like raw meat on his leg.

Jeremy is a pastor with a hanging growth in an embarrassing location; Evelyn has recurring keloids that have been removed three times and come back bigger each time; Todd has a bump protruding from his forehead.

Tameru is a drag queen, but he has a myriad of cysts that are the real drag; Devon has uneven skin she thinks may be the result of a hysterectomy a decade ago; Amy has large growths all over her head that make her look like a "hot mess."

Jason lost their confidence and motivation due to the large growth on his neck; Shawnell's multiple mystery bumps on her head destroy her self-esteem; Jim's growth protruding off of his nose makes it hard to breathe.

Roger has a growth on his shoulder that he calls his second head; Jenna is a teenager with a bubble behind her ear; Susan is covered in bumps that effect her everyday life.

Robert has a small keloid on his ear and a large, snakelike keloid on the back of his head that has been removed and returned three times; Angela has four growths on her head and hides away from those she loves out of embarrassment.

Robert is back to see if Dr. Lee and Dr. Umar can remove his recurring head keloid for good; Justice has small lesions all over her body; Mike has hundreds of lipomas that bring him great discomfort.

Debra has a large, brain-like growth on the side of her head that feels like a sponge, has crevices and emits an odor; Dusten is a cowboy looking to remove the painful lump on his knee; Ramiro has a bump on his jaw that has already been removed once.

Eric hopes Dr. Lee is able to remove the giant growth from his behind; Breanna suffers from itchy dry skin she can't help but scratch; Michael makes jokes, but he knows the bump on his head is anything but funny.

Robert has a small keloid on his ear and a large, snakelike keloid on the back of his head that has been removed and returned three times; Angela has four growths on her head and hides away from those she loves out of embarrassment.

Robert is back to see if Dr. Lee and Dr. Umar can remove his recurring head keloid for good; Justice has small lesions all over her body; Mike has hundreds of lipomas that bring him great discomfort.

Debra has a large, brain-like growth on the side of her head that feels like a sponge, has crevices and emits an odor; Dusten is a cowboy looking to remove the painful lump on his knee; Ramiro has a bump on his jaw that has already been removed once.

Eric hopes Dr. Lee is able to remove the giant growth from his behind; Breanna suffers from itchy dry skin she can't help but scratch; Michael makes jokes, but he knows the bump on his head is anything but funny.

Jason lost their confidence and motivation due to the large growth on his neck; Shawnell's multiple mystery bumps on her head destroy her self-esteem; Jim's growth protruding off of his nose makes it hard to breathe.

Roger has a growth on his shoulder that he calls his second head; Jenna is a teenager with a bubble behind her ear; Susan is covered in bumps that effect her everyday life.

A couple living in a tent hope to find permanent housing before their baby is born.

A woman who entered prison three months pregnant will raise her baby in prison through the duration of her sentence.

Jolene and her boyfriend Correy are expecting a baby girl; Jolene has to choose between taking the psychiatric drugs that control her bi-polar disorder and safeguarding the health of her unborn child.

Colette and Aaron have a long history of heroin addiction, which they've been able to kick with methadone; Colette is pregnant and she is finding that it's possibly riskier to go off the methadone during pregnancy.

A woman is impaled on an iron spike; a man spears his friend on a fishing trip; an elderly gardener's shears are lodged in his eye.

A man is impaled on a fence post; a farmer has an object lodged in his brain; a woman is skewered on a hooked pole when she feeds the birds.

A woman gets a Christmas tree imbedded in her neck; a boy out fishing almost chokes on a barb; a man is filled with enough air to fill 1000 balloons; learn how they survived.

A man gets a wire embedded in his heart; three year old swallows magnets; woman has pencil in her brain; man has a five centimeter splinter removed from eye.

A man's face and body suddenly double in size; a young woman is burning up from the inside out after a day at the beach; a grumpy old man nearly dies before revealing an emotional secret.

A pianist's finger goes missing after getting accidentally sawed off; a man's pacemaker threatens to kill him; a man behaves bizarrely.

A pregnant woman is shot in the abdomen; a doctor is the victim of a car burglary; a storm is preventing a patient's life-saving surgery.

A woman risks losing her finger after trying on an ill-fitting engagement ring; a body builder can't breathe and doctors are shocked to discover why; a gunshot victim.

A Halloween zombie with a problem below the belt mystifies doctors; two unconscious men are involved in an accident, a doctor makes a mistake that amazingly explains a patient's condition.

A woman's face-lift goes terribly wrong; a hospital chaplain's sudden personality change; a pregnant woman's life-threatening symptoms need urgent treatment.

A young boy with a life-threatening neck growth seeks treatment; a baby born with eight limbs undergoes groundbreaking surgery.

Two-year-old Indonesian chain smoker; young man with facial tumor may not survive surgery; seven-year-old twins attached at the head.

A teenager who has been hiding a rare condition undergoes surgery, doctors attempt to diagnose a young girl born with dark hair covering her entire body and a man with tree like growths encasing his hands and feet seeks treatment.

Triplets born with a rare condition need surgery or their brains could be crushed; a boy has legs that have become so large he is unable to move; a soccer star who was born without feet.

Young Dominican woman cries blood; world's fattes child has insatiable appetite; young girl trapped behind werewolf's face.

Two feet tall woman; real-life Sleeping Beauty; isolated bubble man.

A teenager who has been hiding a rare condition undergoes surgery, doctors attempt to diagnose a young girl born with dark hair covering her entire body and a man with tree like growths encasing his hands and feet seeks treatment.

Triplets born with a rare condition need surgery or their brains could be crushed; a boy has legs that have become so large he is unable to move; a soccer star who was born without feet.

Young Dominican woman cries blood; world's fattes child has insatiable appetite; young girl trapped behind werewolf's face.

Two feet tall woman; real-life Sleeping Beauty; isolated bubble man.

A young boy with a life-threatening neck growth seeks treatment; a baby born with eight limbs undergoes groundbreaking surgery.

Two-year-old Indonesian chain smoker; young man with facial tumor may not survive surgery; seven-year-old twins attached at the head.

Former plus-size model and advocate Renee realizes the mortal mistakes she has made as her weight swells to 600 pounds and her health crumbles.

After gastric bypass surgery, Chad quickly sheds his dangerous weight but faces a medical crisis when he does not follow the doctor's orders.

Brittani married a man who loves large women, but at 600-lbs, she can barely contribute to their marriage, and gets surgery to try to have a normal relationship.

Fearing he'll suffer the same fate as 700-pound brother David, Benji hopes to be able to support both himself and his brother on their life-or-death weight loss journey.

Lisa's struggle with her weight begins as a child and significantly worsens after witnessing her brother's murder; now bedridden and unable to care for herself, Lisa must find a way to lose the weight or she will never see her grandchildren grow up.

After a difficult childhood with an abusive stepfather and drug-addicted mother, Sarah is fighting for her life at only 24 years old.

Octavia has been bedbound for nearly a year when she decides to make the trip to Houston to get help from Dr. Now, but when it turns out that her best friend is also her worst enabler, Octavia will have to choose between old habits and a new life.

Robin and her brother Chris are both obese and already lost a sibling to obesity; they plan to visit Dr. Now together when Chris suffers a stroke and can't go; Chris' son Garrett, already 600 pounds at age 20, is game to join the journey.

Jennifer and her daughter Marissa are stuck in a co-dependent relationship and, with a combined weight of over 900-lbs., both of their lives are in jeopardy; Jennifer must regain control and save both of their lives before it is too late.

Most of the extreme weight on Tracey's body resides in her shockingly misshapen legs, which are massive with severe lymphedema, and gastric surgery is her only chance of survival; Brenda and Melissa prepare for skin removal surgery.

Jennifer and her daughter Marissa are stuck in a co-dependent relationship and, with a combined weight of over 900-lbs., both of their lives are in jeopardy; Jennifer must regain control and save both of their lives before it is too late.

Most of the extreme weight on Tracey's body resides in her shockingly misshapen legs, which are massive with severe lymphedema, and gastric surgery is her only chance of survival; Brenda and Melissa prepare for skin removal surgery.

Robin and her brother Chris are both obese and already lost a sibling to obesity; they plan to visit Dr. Now together when Chris suffers a stroke and can't go; Chris' son Garrett, already 600 pounds at age 20, is game to join the journey.

Maja moves to Houston to undertake a difficult weight-loss journey with the support of her boyfriend, Christian; when Christian decides he's had enough and leaves Maja high and dry, she discovers that the only person she can count on is herself.

Dottie wants to be a better mom, so she agrees to a drastic new diet, but her child's life-threatening emergency and her own self-sabotage threaten to derail all hopes for weight-loss.

Randy's food addiction dissolved his marriage and keeps him from seeing his daughter, so he endures a rigorous pre-surgery diet surrounded by fast-food temptations to regain control of his life.

Despite moving to Houston with the solid support of her boyfriend, Aaron, and her cousin, Jasmine, Tiffany finds it difficult to break the cycle of depressed eating when her two roommates don't join her diet and leave the house every day for work.

Born as "Matthew," Destinee never felt like she fit in; now, having come out as a 600-pound transgender woman, she likes her curves, but she will need to say goodbye to them if she wants to be approved to transition completely.

Jeanne lives in an unhygienic household with her mother and schizophrenic father; at well over 600 pounds, Jeanne might never get weight-loss surgery as she runs into several obstacles, especially after an unexpected death in her family.

Since the death of his mother, Aaron lives at home to care for his aging father, but due to his food addiction, Aaron has to heavily rely on his father for help instead. Aaron must learn to care for himself to avoid eating himself to death.

When Annjeanette was nine, a campaign was established to send her to fat camp; she hated that her weight had become a source of public shame and she has struggled to overcome her food addiction; now, she must change her habits to save her life.

When Angela's family is unable to accompany her on her weight-loss journey to Texas she is unsure what to do; at the last minute, she reaches out to an old flame, Eric, who still has love for her and is willing to make the trip.

Mother of four LaShanta has been bed-bound for two years, and she relies on her kids to keep her cleaned and fed; her last chance to break the cycle of food addiction is to join Dr. Now's program, but it will take a village to get her out the door.

When Angela's family is unable to accompany her on her weight-loss journey to Texas she is unsure what to do; at the last minute, she reaches out to an old flame, Eric, who still has love for her and is willing to make the trip.

Mother of four LaShanta has been bed-bound for two years, and she relies on her kids to keep her cleaned and fed; her last chance to break the cycle of food addiction is to join Dr. Now's program, but it will take a village to get her out the door.

When Annjeanette was nine, a campaign was established to send her to fat camp; she hated that her weight had become a source of public shame and she has struggled to overcome her food addiction; now, she must change her habits to save her life.

Lisa helps a man yearning to discover his biological roots, but fearful of rejection from the family he has never met; Chris reveals the truth to a woman who has felt guilty that her birth might have devastated the life of her 14-year-old mom.

A tough Texas lawman seeks Lisa's help to tackle the one investigation he's never been able to solve: the story of his own birth and adoption.

Chris tries to unravel a legal mystery involving a woman's sister who she last saw across a New York courtroom 30 years ago.

A Vietnam vet hopes Lisa can help him make amends for the past by locating the daughter he lost custody of forty years ago; a woman's struggle to fit in takes a surprising turn when Chris reveals a series of stunning coincidences very close to home.

Charmissa spends up to 10 hours of her day chewing dryer sheets; 25-year-old Riley chooses to live as an adult baby, wearing diapers 24/7 and drinking from a bottle.

Theresa has more than 60 hairless rats that are taking over her studio apartment; Jazz has been growing her fingernails for 22 years.

For more than 30 years, Theresa has been addicted to smelling gasoline and she cannot stop; former drug-addict Krista has 12 'children', all of which are teddy bears.

Evan is addicted to collecting shower drain hair; Nicole has spent the last seven years secretly breaking apart walls to feed her addiction, eating dry wall.

Kinah's addiction to eating toilet paper threatens her health, and her relationships are also on the line; Nathaniel has taken his love of cars to the extreme; Lisa eats cat hair -- and she just cannot get enough.

Nick and Aubrey's addiction to drinking urine has Nick's mom extremely concerned; Karmello's life has gained new meaning since her addiction to illegal butt injections; Lori's addiction to sleeping with her blow dryer might be affecting someone else.

Tyler's addiction to smelling tuna is getting in the way of finding love; Lacey's addiction to plastic surgery and her cup size has grown; after mourning the loss of her record-setting fingernails, Ayanna still has an addiction.

Brittany's addiction to eating car seat foam forces her family to intervene; Lauren has put her addiction to bodybuilding behind her but has found a new obsession; Asha's addiction to her long locks remains strong, but her health remains in jeopardy.

Foxy's addiction to having enormous breasts has brought her fame, but her friends feel it is also endangering her health.

Weston loves eating raw meat, but his mom is worried it could lead to major health problems; Rachel breastfeeds her husband, Alexander, but it's upsetting to their family and friends; pillow addict Tamara meets car lover Nathaniel.

A student's head is impaled by a trophy deer's antlers; a semi-conscious car crash victim; a woman with an allergic reaction.