The bulbous tumor growing from Jennifer's stomach threatens her relationship with her long-time boyfriend; fifteen-year-old Marcelo travels from Angola to Los Angeles to have a massive neck tumor removed, but the operation may be too risky.

Charmaine from Trinidad suffers from one of the most extreme cases of neurofibromatosis ever recorded; tumors cover every inch of her body and obstruct her ability to breathe and swallow; without surgery, these growing tumors threaten her life.

Thirty-year-old Alexandra has a 20-pound, sagging tumor that starts at the back of her neck and now reaches below her waist; as the tumor on Claudia's backside continues to grow, so does the urgency for surgeons to remove it.

Despite his family's pleas, Marlow explores a high-risk surgery to remove a facial tumor; Amy has let the tumor on her back grow for more than 17 years; after finally making the decision to remove it, she learns that now it might be too late.

The bulbous tumor growing from Jennifer's stomach threatens her relationship with her long-time boyfriend; fifteen-year-old Marcelo travels from Angola to Los Angeles to have a massive neck tumor removed, but the operation may be too risky.

Baby Samantha has surgery to remove congenital cataracts that could lead to blindness; as the months pass, Samantha is unable to roll, crawl or talk, and her head is unusually small for her age; her parents seek help.

A baby's gaze is fixed on the ceiling; a woman's bruise will not disappear.

At 670 pounds, Ashley, who lives in her parents' home with her husband, decides she must make a drastic change to save her life and her marriage.

Dottie wants to be a better mom, so she agrees to a drastic new diet, but her child's life-threatening emergency and her own self-sabotage threaten to derail all hopes for weight-loss.

Randy's food addiction dissolved his marriage and keeps him from seeing his daughter, so he endures a rigorous pre-surgery diet surrounded by fast-food temptations to regain control of his life.

Mother of four LaShanta has been bed-bound for two years, and she relies on her kids to keep her cleaned and fed; her last chance to break the cycle of food addiction is to join Dr. Now's program, but it will take a village to get her out the door.

JT is almost 900lbs with a 100-lb lymphedema mass on his leg and a food addiction that is bound to kill him if he doesn't change; his girlfriend takes him to Houston, but when his behavior drives her away, JT is left with only Dr. Now to help.

For 23 years, Leneatha has worked as a pharmacy tech at a local hospital; now, she has a young daughter to support, but she's so big that it's hard to move; if Dr Now can't help her stop eating, losing her job could be the least of her worries.

At nearly 1,000 pounds, Samantha is dangerously close to dying; to make matters worse, she's paid to eat by making videos online; if Samantha doesn't overcome her toxic relationship with food, she worries she will leave her daughter motherless.

For Julian and his wife, Irma, it was love at first sight; in order to grow old together, Julian will have to overcome the food addiction that made him more than 800 pounds.

Bianca is all in for a move to Houston with her boyfriend and two young kids to get Dr. Now's help with a second weight-loss surgery.

Born as "Matthew," Destinee never felt like she fit in; now, having come out as a 600-pound transgender woman, she likes her curves, but she will need to say goodbye to them if she wants to be approved to transition completely.

Bianca is all in for a move to Houston with her boyfriend and two young kids to get Dr. Now's help with a second weight-loss surgery.

Born as "Matthew," Destinee never felt like she fit in; now, having come out as a 600-pound transgender woman, she likes her curves, but she will need to say goodbye to them if she wants to be approved to transition completely.

For Julian and his wife, Irma, it was love at first sight; in order to grow old together, Julian will have to overcome the food addiction that made him more than 800 pounds.

Josh has a large knot on his head resulting from a car crash from 18 years ago; Brittney is covered in mysterious bumps; TJ has a hard, curious lump protruding from his side; Luis has a bump on his shoulder and his daughters fear it's dangerous.

Barbara's back lump became more noticeable after she lost 131 pounds; Bob has two painful bumps on his back; Hilda's depression is a result of the multitude of bumps on her eyelids; Art has one big bump on his head that he covers up with hats.

Leonard has an alarming bump hanging off of his arm that looks like it's breaking through the skin; Brandon has several lumps on his head that make him fearful for his life; Jess gets a noticeable lump on her butt after falling down the stairs.

Dr. Sandra Lee treats Heather, who has a huge growth on her leg and fears removing it could leave a keloid scar; Paul has a giant hump on his back.

Rhonda has bumps all over her head, including a horned growth that has her deeply concerned; Fred has a mysterious condition on his hands and has not been able to get answers from any doctors; Kevin has a huge lump protruding from his hip.

Jen has substantial growths on her ears that cause her depression, pain and vertigo; Juliet is under emotional distress because of the bumps all over her neck and chest; Gerald has a mysterious, kiwi-size lump on his middle finger.

Gerald is back to see Dr. Lee and a hand specialist about a huge, intrusive bump on his middle finger; Vinnie has a large, embarrassing birthmark on his neck; Leta has a lump on the back of her thigh that she has been hiding from her fiancée.

Tony has large growths on his nose that impair his breathing; Kevin has a bump in his jawline that is a lady deterrent; Marie has an unsightly lump on her forehead that makes her a hermit; Tommy's leg bump makes it difficult for him to work.

Gerard has nearly a hundred lumps varying in size all over his body; Gina has bloody lesions all over; Eric has a large bump on his head that he calls his on and off button.

Traci's confidence has been destroyed after years of bullying from the bumps on her face; Ravon has a unique dangling growth on his leg; David has a large lump.

David is back to see Dr. Lee after she spots a suspicious growth under his eye; Nicole is depressed because of the bumps all over her neck; Steve has a noticeable lump on his forehead; Allen has a growth on his biceps but is terrified of doctors.

Tim has a massive growth on his back that affects his ability to work and socialize; Daniel has debilitating psoriasis that covers most of his body; Gloriana and Yolanda are a mother and daughter duo who have bonded over their bumps.

Inoke has a huge, possibly life-threatening bulge on his shoulder; Delano returns with his back lump after Dr. Lee removed a liter of fluid from it; Reed has hundreds of bumps on his chest that burst and leave nasty scars.

With pandemic safety protocols in place, Dr. Lee reopens her office; Monica has a large birthmark growing on the side of her face; Jackie has a melon-sized lump on the back of her shoulder; Reginald has large, rare growths on the back of his head.

Dr. Lee tries to provide the help Reginald needs to remove the large, rare growths on the back of his head; Che're has a prominent bump on her face that has put her in a dark place; Juan has several painful boils on the back of his neck.

Dennis has several giant growths on the back of his head; Juan has a rare condition he hopes Dr. Lee will understand; Natalie searches for answers as to why her body is covered in hundreds of mysterious dark bumps.

Audrey pops the painful bumps that cover her body so she can feel relief; Felicia has a peculiar-looking dark growth on her forehead; Krista's excessive sweating is so severe that on any given day she could fill up an entire milk jug with her sweat.

John fears the large lump on his neck could become so big that it may eventually suffocate him; Shoshana is depressed because of the big growth on her forehead; Ashley hopes Dr. Lee can provide some relief from her three painful skin conditions.

Dr. Lee tries to provide the help Reginald needs to remove the large, rare growths on the back of his head; Che're has a prominent bump on her face that has put her in a dark place; Juan has several painful boils on the back of his neck.

Dennis has several giant growths on the back of his head; Juan has a rare condition he hopes Dr. Lee will understand; Natalie searches for answers as to why her body is covered in hundreds of mysterious dark bumps.

Audrey pops the painful bumps that cover her body so she can feel relief; Felicia has a peculiar-looking dark growth on her forehead; Krista's excessive sweating is so severe that on any given day she could fill up an entire milk jug with her sweat.

John fears the large lump on his neck could become so big that it may eventually suffocate him; Shoshana is depressed because of the big growth on her forehead; Ashley hopes Dr. Lee can provide some relief from her three painful skin conditions.

Inoke has a huge, possibly life-threatening bulge on his shoulder; Delano returns with his back lump after Dr. Lee removed a liter of fluid from it; Reed has hundreds of bumps on his chest that burst and leave nasty scars.

With pandemic safety protocols in place, Dr. Lee reopens her office; Monica has a large birthmark growing on the side of her face; Jackie has a melon-sized lump on the back of her shoulder; Reginald has large, rare growths on the back of his head.

A man falls five stories; a shopkeeper is shot in the head at point-blank range; a woman accidentally drinks a bottle of cleaning fluid.

A man wounded in a drive-by shooting; a patient with flesh-eating bacteria; a woman hit by a car.

Two brothers arrive at the ER after being crushed by a falling building; a victim of a gang-related incident; a patient who fell 40 feet.

Police officers bring in a criminal that is comatose; a man found passed out in the snow with no jacket or shoes arrives in the ER; a doctor is faced with a family emergency on her day off.

A fishing lure embedded in a man's face turns out to be the least of his problems; a pair of unconscious teenagers get brought to the ER, where dramatic family secrets come out; an ER technician collapses and refuses traditional medical treatment.

A man's itchy rash turns out to be more than just poison oak; a young woman bleeds profusely from the inside of her lip, but there is no obvious cause; a family of three is admitted as car accident victims, but the doctor makes a shocking discovery.

Two separate car crash victims are brought to the ER in their underwear; a woman is acting delusional and refuses to allow the ER staff to touch her; a doctor struggles to diagnose a dehydrated and nauseous 10-year-old.

A teenage girl is impaled through the neck on an iron fence; a patient is convinced he's turning into a vampire; a first-year attending physician stands up to a room full of senior specialists to save the life of a critically ill pregnant woman.

A date is ruined after a closet quickie causes a catastrophe; a toy won't stop buzzing, but a couple is determined to get to dinner anyway; a prisoner has problems after a conjugal visit.

Sexy salsa dancers get a little too frisky and must sashay their way to the hospital; a woman is in pain after experiencing never-ending arousal.

A man and his wife get a vacuum stuck where it shouldn't be; an ice rink quickie leaves a skater with a bizarre injury and a lifetime of embarrassment; a threesome gives a man an unusual problem.

A boyfriend turns a door knob installation into a sexy chore that ends poorly; a couples' game night ends with a woman in severe pain and extreme worry; a paramedic rescues a young couple that fell into a well.

Pregnant detainees await trial; Jamie, a mother of four struggles for visitation rights; Tanya requests house arrest to prepare for the birth of her son.

Latoya struggles with giving up her baby for adoption; Esther is sent to disciplinary segregation.

Chris and Lisa join forces in an attempt to solve the childhood mystery of why a woman was separated from her birth family at the age of two.

A woman enlists Lisa's help to find her birth mother, but unearths a 40-year-old secret in the process.

Chris tries to solve the 50-year-old mystery of why a woman was abandoned at a laundromat days after being born; a family enlists Lisa's help to track down the firstborn son that was placed for adoption, hoping to fulfill a father's dying wish.

Lisa tackles the challenging mystery of why a woman was abandoned in a trash can as a baby; unexpected DNA results throw a woman's entire identity into question.

Chris and Lisa join forces in an attempt to solve the childhood mystery of why a woman was separated from her birth family at the age of two.

A woman enlists Lisa's help to find her birth mother, but unearths a 40-year-old secret in the process.

Chris tries to solve the 50-year-old mystery of why a woman was abandoned at a laundromat days after being born; a family enlists Lisa's help to track down the firstborn son that was placed for adoption, hoping to fulfill a father's dying wish.

Lisa tackles the challenging mystery of why a woman was abandoned in a trash can as a baby; unexpected DNA results throw a woman's entire identity into question.

Pregnant detainees await trial; Jamie, a mother of four struggles for visitation rights; Tanya requests house arrest to prepare for the birth of her son.

Latoya struggles with giving up her baby for adoption; Esther is sent to disciplinary segregation.

Holly faces a wedding and an operation; Lashanta is not losing weight and when a car crashes through her living room wall her progress is even slower.

Chuck's second year of weight loss and a new relationship; Paula struggles with juggling many responsibilities along with her weight-loss.

Penny returns to Maryland believing she can lose weight; Tara continues to lose weight and is dating for the first time.

After getting his surgery canceled and living in his van by the beach, surgery may be the break David has been waiting for his whole life; Syreeta suffers a devastating personal tragedy that only strengthens her desire to become a mother.

Seana's mind is ready for surgery, but her body still has a conflict with the scale; once almost 900 pounds, J.T. Clark is finally ready to have his massive leg surgically downsized.

Margaret succeeds in getting surgery, but Dr. Now is dismayed when a few months later she and her mom revert to their old ways; Megan grows impatient with her slow weight loss, and if Dr. Now doesn't approve her for surgery soon, she might quit.

Siblings Carlton and Shantel have always been close, but with their eating habits enabling each other, they need to make a change; Shantel is sad to grow apart from her little brother, but it might be the one thing they both need the most.

Ontreon hopes that surgery can make him a better husband to his wife Musa, but he struggles to move past the grief that's blocked him for years; Wess is doing great post-surgery, but his next goal is crucial to his success.

Gastric surgery freed Brittani from her housebound life, but to achieve her ideal body she'll have to endure two more painful surgeries; Sean's super-obesity nearly killed him.

Surgery enables Teretha to return to family in Detroit, but it soon threatens to undo all her progress; Chad is back on the road, but his old diet is a risk.

Gastric surgery freed Brittani from her housebound life, but to achieve her ideal body she'll have to endure two more painful surgeries; Sean's super-obesity nearly killed him.

Surgery enables Teretha to return to family in Detroit, but it soon threatens to undo all her progress; Chad is back on the road, but his old diet is a risk.

Ontreon hopes that surgery can make him a better husband to his wife Musa, but he struggles to move past the grief that's blocked him for years; Wess is doing great post-surgery, but his next goal is crucial to his success.

Erica regrets not keeping a promise to her mom and hopes her siblings will help, but they're reluctant based on her past failures.

At over 700 pounds, Teretha's life is confined to a bed, which is a long way from her former job representing Detroit's healthy eating program; a gastric bypass will hopefully save her life.

Milla is bedridden and dependent on her husband and five kids, who can't resist her unending requests for junk food.

Cillas' food addiction is getting in the way of his ability to be there for his fiancée, Jessica, and her three daughters; if he doesn't lose weight soon, he knows he'll lose either his girls or his life.

Gina and wife Beth live with Gina's mother, but she and Gina's sister blame Beth for Gina's spiraling weight problem; it will take all Gina's will to leave home for Houston to get Dr Now's help, to save her life and her marriage.

Twenty years after her father died as the result of a botched weight-loss surgery, Carrie is on the brink of eating herself to death; she must face the fear and grief of losing her father and end a cycle of toxic behavior with her husband, Chris.

Thederick has become housebound from eating and only goes outside to greet the ice cream man; after a recent hospital scare, it's finally clicked that if Dr. Now's program doesn't work for him, then nothing will.

Mike was born with a talent for sports and an omnivorous appetite to match; after his football dreams were dashed by multiple concussions, Mike packed on over 700 pounds, now he must find a new purpose in life to avoid succumbing to pain and regret.

James B, grew up eating rich Haitian food and loves it with a passion; James needs Dr. Now's help to diminish that love in order to survive, but a death in the family sends James retreating back to the comforts he knows.

Jeanne lives in an unhygienic household with her mother and schizophrenic father; at well over 600 pounds, Jeanne might never get weight-loss surgery as she runs into several obstacles, especially after an unexpected death in her family.

James B, grew up eating rich Haitian food and loves it with a passion; James needs Dr. Now's help to diminish that love in order to survive, but a death in the family sends James retreating back to the comforts he knows.

Jeanne lives in an unhygienic household with her mother and schizophrenic father; at well over 600 pounds, Jeanne might never get weight-loss surgery as she runs into several obstacles, especially after an unexpected death in her family.

Mike was born with a talent for sports and an omnivorous appetite to match; after his football dreams were dashed by multiple concussions, Mike packed on over 700 pounds, now he must find a new purpose in life to avoid succumbing to pain and regret.

Las Vegas paramedics Calvin Griffin, an 11-year veteran, and Walt West and Melanie Isom, two rookies with less than a year's experience.

Washington, D.C., emergency medical technicians often work on the front lines of some of the United States' most dangerous streets.

Paramedics work the streets of Tampa, Fla., by truck or helicopter, and confront everything from a bull goring to a minor concussion.

A shootout leaves a police officer clinging to life; a cowboy and cupid help a she-devil in distress; a zip-line guide falls 80 feet to the canyon floor.

Doctors retrieve a stolen Rolex from a very private spot; a pick-up turns deadly when a cabbie is shot multiple times; a dirt-bike accident in the desert leaves a 52-year-old thrill-seeker clinging to life.

A brutal assault could end a star athlete's career, a 28-year-old man is hit in the head by a flying baseball bat; and a Vegas chef falls asleep with a loaded gun.

Charmaine from Trinidad suffers from one of the most extreme cases of neurofibromatosis ever recorded; tumors cover every inch of her body and obstruct her ability to breathe and swallow; without surgery, these growing tumors threaten her life.

Thirty-year-old Alexandra has a 20-pound, sagging tumor that starts at the back of her neck and now reaches below her waist; as the tumor on Claudia's backside continues to grow, so does the urgency for surgeons to remove it.

Despite his family's pleas, Marlow explores a high-risk surgery to remove a facial tumor; Amy has let the tumor on her back grow for more than 17 years; after finally making the decision to remove it, she learns that now it might be too late.

Kylie has weight loss surgery that leaves her with a life-threatening infection; Anna fears her extra skin makes her look unprofessional.

Sarah turned to food for comfort during her damaging childhood, but her weight loss left her with sagging skin; Roger overcame a challenging life to raise his children, but his weight loss gave him restricting excess skin.

Annette lost over half of her body weight, but her excess skin is a painful reminder of years of overeating; Callisto lost 250 pounds and became a model, but the shame of her loose skin put her passion and marriage on hold.

Mary hopes skin removal surgery will rid her of the painful memories of her obese life; after a car accident, Lora goes through recovery, obesity and gastric bypass surgery, but gets left with stretched skin and terrible scars.

Sisters Jessica and Melissa are left with massive excess hanging skin after growing up morbidly obese; Matt lost everything he cherished, but after losing weight, his excess skin keeps him from returning to life.

Sean's nightmare keeps coming true, he can't stop pooping himself on stage; Tired of dealing with explosive bowels, Sean asks Dr. Hodges for help; Latoya wants to spend time with her kids again which means the 10 pound mass between her legs needs to go.

AliceJean's botched lap band removal left her with six belly buttons that form a golf course on her stomach; Simone seeks help for her uncontrollable vomiting.

After a botched lap band surgery, Christina has been blending her meals for over a decade; Dr. Caplin assists a patient whose tummy tuck has left her with a butt crack for a stomach.

Lattyse was born with a mysterious growth above her eyebrow that gives her headaches; Robert has a tomato-sized growth on his butt cheek that causes him pain; Sharon has an embarrassing, stinky, leaking cyst under her breast.

Sean's nightmare keeps coming true, he can't stop pooping himself on stage; Tired of dealing with explosive bowels, Sean asks Dr. Hodges for help; Latoya wants to spend time with her kids again which means the 10 pound mass between her legs needs to go.

AliceJean's botched lap band removal left her with six belly buttons that form a golf course on her stomach; Simone seeks help for her uncontrollable vomiting.

After a botched lap band surgery, Christina has been blending her meals for over a decade; Dr. Caplin assists a patient whose tummy tuck has left her with a butt crack for a stomach.

Lattyse was born with a mysterious growth above her eyebrow that gives her headaches; Robert has a tomato-sized growth on his butt cheek that causes him pain; Sharon has an embarrassing, stinky, leaking cyst under her breast.

Mary hopes skin removal surgery will rid her of the painful memories of her obese life; after a car accident, Lora goes through recovery, obesity and gastric bypass surgery, but gets left with stretched skin and terrible scars.

Sisters Jessica and Melissa are left with massive excess hanging skin after growing up morbidly obese; Matt lost everything he cherished, but after losing weight, his excess skin keeps him from returning to life.

A woman with twisted toes; a man with Frankenstein feet; a mother with extreme calluses.

Dr. Brad and Dr. Sarah have their hands full when they are faced with twins who have identical toe problems; a boy with extremely itchy feet and a woman born with a massively large toe are desperate for Dr. Ebonie's help.

A man with horns on his feet, a woman whose foot went through a windshield, and a guy who has dead man's feet create mysterious challenges for Dr. Brad and Dr. Ebonie.

On the day before Halloween, Abbigale gives birth when she didn't know she was pregnant.

While attempting to recover from the stress of getting mugged and a bad fall, Nikki finds out she is pregnant and full term.

Paramedics rush Anna to a hospital on Christmas Eve for what she thinks is food poisoning only to discover she's 41 weeks pregnant, in labor and didn't know it.

A woman who has accepted that she may never have a child is rushed to a hospital with cramps attributed to work stress and is shocked to find out she's pregnant and in labor.

Stabbing pains in the pelvis send a woman to an ER, where she discovers she has given birth, without realizing she was pregnant.

Tiffany thinks the abdominal pain she is having is from a rupturing cyst, but it's actually a child she didn't know she was carrying.

A woman goes into delivery while in a cab; a life-threatening pregnancy; twin sisters have their babies on the same day.

A best friend's offer to be a surrogate results in a life-threatening pregnancy; a woman is bitten by a deadly snake three weeks before her due date; a cupcake famed for inducing labor.

A woman gives birth while trapped in an elevator; two truckers deliver a baby in a diner; a prolapsed umbilical cord threatens a baby's life.

A grandma-to-be acts as surrogate for her daughter's baby; a very premature baby arrives at a playground; a woman gives birth at home.

A woman's arm burns from the inside out; a girl undergoes life-changing surgery to stop her neck from dislocating; a boy has a large facial tumor removed; with bonus content.

A man with half a torso learns if his rare bone-eating disease is back; a young girl undergoes surgery to stop her facial tumor from choking her; a boy is born with half a face.

A man with cold-like symptoms loses his limbs and lips; a young girl has a prematurely fused skull; a boy with brittle bones and a rare skin condition gets life-changing surgery; a woman suffers from a disfiguring birthmark; with bonus content.

A woman suffers from cyclical vomiting syndrome; a man with warts all over his body searches for cures; a girl fights for a surgery that could allow her to speak for the first time; with bonus content.

A man passes out from abdominal pain; a woman helps solve the mystery of her estranged father's deadly symptoms; a group of delirious Civil War re-enactment soldiers arrives in the ER.

A wrist fracture turns into a medical mystery; two fishermen get stuck on the same lure; a cheerleader with a sprained finger nearly dies of an unexpected cause; a power outage foils the ER team's effort to get a dying patient to the OR.

The hospital is locked down when a nurse is shot in the ER; medics rush a bride from her wedding who is in an unexplained altered mental state; a doctor must perform a risky intervention to save the life of a teenage girl.

A teen football player suffers a stroke; a doctor remembers his first major trauma in the 1970s; a doctor tries to figure out what causes a patient's abdominal pain; a man who is run over twice by his wife.

A man passes out from abdominal pain; a woman helps solve the mystery of her estranged father's deadly symptoms; a group of delirious Civil War re-enactment soldiers arrives in the ER.

A wrist fracture turns into a medical mystery; two fishermen get stuck on the same lure; a cheerleader with a sprained finger nearly dies of an unexpected cause; a power outage foils the ER team's effort to get a dying patient to the OR.

The hospital is locked down when a nurse is shot in the ER; medics rush a bride from her wedding who is in an unexplained altered mental state; a doctor must perform a risky intervention to save the life of a teenage girl.

A teen football player suffers a stroke; a doctor remembers his first major trauma in the 1970s; a doctor tries to figure out what causes a patient's abdominal pain; a man who is run over twice by his wife.

A man with cold-like symptoms loses his limbs and lips; a young girl has a prematurely fused skull; a boy with brittle bones and a rare skin condition gets life-changing surgery; a woman suffers from a disfiguring birthmark; with bonus content.

A woman suffers from cyclical vomiting syndrome; a man with warts all over his body searches for cures; a girl fights for a surgery that could allow her to speak for the first time; with bonus content.

Cynthia, a single mother focused on raising five kids, comes to realize what her death would mean for their future.

Zsaylnn needs to lose weight to be the mother her daughter deserves; her husband loves large women and does not support her goals.

A woman battles severe depression and has not left her Chicago basement in two years; the hope of having a life-changing surgery.

Mercedes, who has severe lymphedema, must overcome trauma to lose weight.

When Travis gets too big to walk down the aisle, he promises to give his wife a proper wedding; he gains more weight, leaving Dr Now as Travis' only hope to lose weight and get the life he and his wife dreamed of having together.

Cindy is resistant to change and spends years creating a world that makes her feel safe; when her friend notices Cindy's health declining rapidly due to her size, she pushes Cindy to move to Houston and see Dr. Now.

Melissa has isolated herself at home and lost many friends to avoid feeling the shame of what her food addiction has done to her body; now, the only way to get her life back is to leave it behind to start a new one with Dr. Now's help in Houston.

Living with his family, Lucas wants to spread his wings and fly, but at 600 pounds, he can't take off. All he does is eat and game, and if he wants to leave the nest and live a normal life, he needs Dr. Now's help to lose over 400 pounds.

Margaret's life at 700 pounds is in need of a jump-start; at age 35, she is a mama's girl; it's time for Margaret to get out of bed, overcome her food addiction and break away from the comfort of her mother so she can finally live her life.

Since the death of his mother, Aaron lives at home to care for his aging father, but due to his food addiction, Aaron has to heavily rely on his father for help instead. Aaron must learn to care for himself to avoid eating himself to death.

Margaret's life at 700 pounds is in need of a jump-start; at age 35, she is a mama's girl; it's time for Margaret to get out of bed, overcome her food addiction and break away from the comfort of her mother so she can finally live her life.

Since the death of his mother, Aaron lives at home to care for his aging father, but due to his food addiction, Aaron has to heavily rely on his father for help instead. Aaron must learn to care for himself to avoid eating himself to death.

Living with his family, Lucas wants to spread his wings and fly, but at 600 pounds, he can't take off. All he does is eat and game, and if he wants to leave the nest and live a normal life, he needs Dr. Now's help to lose over 400 pounds.

Yaellie, 9, has itchy psoriasis on over 90 percent of her body; former U.S. Marine Matt has a large recurring lump in his armpit; twins Tracie and Stacie have numerous matching bumps on their heads that sometimes leak.

Joanne has been held back from success because of her forehead growth; Shakisha split her left earlobe after stretching it with gauges; Mike is a tough guy with a soft bump on his head; Dania's rhinophyma has kept her from enjoying her life.

James has a large, squishy lump on his forehead; Tanisha has a growth on her arm and itchy scars all over her body; Ed wants his stomach lump removed before his girlfriend gets out of prison; Justin has painful mystery bumps all over his head.

JD is a gentle giant with a pear-shaped mass hanging off of his ear; David has two bumps on his neck and one on his finger that give him pain; Julie hopes Dr. Lee can remove her large back growth so she can return to the sea.

Stephen's large, bulbous nose gets him unwanted attention, and he hopes Dr. Lee can help; Veronica wants to be free of secrets, including the bump on her butt; Marty has a large, 30-year-old growth on his shoulder that he is ready to remove.

Brittany has been called a monster due to her genetic condition that causes head-to-toe bumps; Leonardo has a fist-size growth on his head, but he is terrified of doctors; Tamyra has skin so thick that she shaves the bottom of her feet for relief.

Jaclyn has a lump on the back of her head that causes her emotional distress; Shane has a growth between his eyes that could put him in danger at his electrician job; Brittany has seen multiple doctors about the sores on her body with no answers.

Stacey's shoulder growth prevents her from being the playful teacher she once was; Matthew worries that his mysterious shin rash may be dangerous.

Lattyse was born with a mysterious growth above her eyebrow that gives her headaches. Robert has a tomato-sized growth on his butt cheek that causes him pain and discomfort. Sharon has an embarrassing, stinky, squirting cyst under her breast.

Keke is covered in bumps that make her embarrassed to be intimate with her husband; Jim is a widower with two lumps who wants them removed for himself and his late wife; Corey has been labeled a devil worshiper because of his forehead growth.

Monica returns for a second time in hopes that Dr. Lee can remove some more of her face growths; Ken has several large cysts on his head that he has tried to remove on his own; Maranda has a mystery skin sore that causes discomfort.

Corey is a drag queen and has a bump dangling from his booty; Adam has a semicircle of about a dozen cysts on his head that he covers with a hat; Virginia has large growths on both of her upper arms that make it difficult to travel in her RV.

Terry's nose growth has prevented him from meeting his grandkids; Remi has alligator-like skin and is not used to taking care of herself; Austin has an embarrassing birthmark right next to his eyelid; Mary Jo has a throbbing bump on her neck.

Roger has enormous growths on his nose that drip pus, attract flies, and are so large that he can barely breathe; Sandra and Jessie are sisters who bonded over their many undiagnosed face bumps.

Leonard has a bump on his arm that looks like it's breaking through the skin; Brandon has lumps on his head; Jess gets a lump on her butt after falling down the stairs.

Pop-up facts and behind-the-scenes secrets are revealed; Dr. Sandra Lee assists Matt with the tumors growing all over his body; Yamileth hasn't pursued her dreams because of her neck lump; Jennifer has a unicorn bump on her forehead.

Facts and behind-the-scenes secrets; Melissa tries to cover a lipoma with a sweatshirt; Tyler's fear of cancer keeps him from having his head lumps diagnosed; Amber's ear keloids have taken control of her life.

Gerard has nearly 100 lumps, varying in size, all over his body; no one has been able to help Gina with her bloody lesions; Eric calls the large bump on his head his on-off button.

Leonard has a bump on his arm that looks like it's breaking through the skin; Brandon has lumps on his head; Jess gets a lump on her butt after falling down the stairs.

Pop-up facts and behind-the-scenes secrets are revealed; Dr. Sandra Lee assists Matt with the tumors growing all over his body; Yamileth hasn't pursued her dreams because of her neck lump; Jennifer has a unicorn bump on her forehead.

Facts and behind-the-scenes secrets; Melissa tries to cover a lipoma with a sweatshirt; Tyler's fear of cancer keeps him from having his head lumps diagnosed; Amber's ear keloids have taken control of her life.

Gerard has nearly 100 lumps, varying in size, all over his body; no one has been able to help Gina with her bloody lesions; Eric calls the large bump on his head his on-off button.

Terry's nose growth has prevented him from meeting his grandkids; Remi has alligator-like skin and is not used to taking care of herself; Austin has an embarrassing birthmark right next to his eyelid; Mary Jo has a throbbing bump on her neck.

Roger has enormous growths on his nose that drip pus, attract flies, and are so large that he can barely breathe; Sandra and Jessie are sisters who bonded over their many undiagnosed face bumps.

After learning of her own adoption at a late age, Chris aids a woman determined to unlock the mystery behind her birth story; a desperate mother enlists Lisa's help to locate her firstborn son, hoping to reunite him with his full-blooded siblings.

Lisa faces many challenges when she helps a woman locate her father -- starting with his identity; a woman seeks Chris' help to find her mother, hoping the similarities she read in her adoption paperwork are not just a fantasy.

Chris aids a woman's search for her father after being shuffled through 28 foster homes; two radically different sisters, adopted into the same family, seek Lisa's help to search for their biological mother.

Lisa helps a man find his birth mother, hoping to answer why she placed him for adoption, but kept his three brothers; after turning to psychics for answers, a woman seeking details about her birth mom hopes Chris can separate truth from fiction.

A dramatic turn of events takes place as Chris and Lisa investigate two seemingly different cases; a chance discovery raises the tantalizing prospect that the mother and son they are helping may be looking for one another.

Krystal is keeping the baby a secret; Danie fears her dad will reject her baby.

Carmen is a struggling single mother; Jerline and her husband are unemployed.

Jen is pregnant again after a stillbirth; Chanda is afraid to tell her parents of her pregnancy.

Richanne is diagnosed with a brain tumor and pregnant; Paola's pregnancy could ruin her career.

Sandra relationship with her daughters; Dannielle risks her relationship with her grandfather.

Doctors treat a series of gunshot victims and a woman with vision and mobility problems at Wishard Hospital in Indianapolis.

Gang warfare and a high population of sick patients keep medical center workers on the move in Los Angeles.

Trauma patients flood the Tampa General Hospital during Gasparilla Day -- the city's version of Mardi Gras.

The work of the staff at Baylor University Medical Center in Dallas includes a rodeo champion who was trampled by a bull.