Brittany's addiction to eating car seat foam forces her family to intervene; Lauren has put her addiction to bodybuilding behind her but has found a new obsession; Asha's addiction to her long locks remains strong, but her health remains in jeopardy.

Kinah's addiction to eating toilet paper threatens her health, and her relationships are also on the line; Nathaniel has taken his love of cars to the extreme; Lisa eats cat hair -- and she just cannot get enough.

Nick and Aubrey's addiction to drinking urine has Nick's mom extremely concerned; Karmello's life has gained new meaning since her addiction to illegal butt injections; Lori's addiction to sleeping with her blow-dryer might be affecting someone else.

Tyler's addiction to smelling tuna is getting in the way of finding love; Lacey's addiction to plastic surgery and her cup size has grown; after mourning the loss of her record-setting fingernails, Ayanna still has an addiction.

Brittany's addiction to eating car seat foam forces her family to intervene; Lauren has put her addiction to bodybuilding behind her but has found a new obsession; Asha's addiction to her long locks remains strong, but her health remains in jeopardy.

Debbie lost the company of her four children to hoarding; Chip's family of six is forced to live in sixteen hundred square feet of living space.

Patti's extreme hoarding has made it impossible for her daughter to live with her; Jonathan's obsession keeps his three-year-old son from coming in the door.

Lee's anger issues continue to jeopardize his relationship with Rena and threaten to derail both of their weight-loss journeys; a major life event sends Sarah into a depression that she must pull herself out of if she wants to keep losing weight.

Diagnosed with cancer and battling depression, Bettie Jo finds out she's pregnant, and she must find a way to cope with the help of her husband; Susan suffers a major setback after surgery for her excess skin.

Joe made a drastic turn from being suicidal and is now ready for marriage, but the reality of more weight loss could stop him from achieving his dream.

In the fourth year of his weight-loss journey, Sean struggles to get past the loss of his mother and live on his own; Dr. Now intervenes to control Sean's eating for a time.

Liz has gone from being bedbound with lymphedemas on both legs to standing and walking; if Jenn and Marissa can't get along as mother and daughter to lose weight, they'll have to proceed apart; with facts and bonus scenes.

For Milla Clark, after three years and five surgeries, success would mean beating the odds and becoming one of Dr. Nowzaradan's most impressive weight-loss patients, but failure would mean slipping back to the bedbound life.

After a lifelong struggle with obesity, the three Perrio siblings travel to Houston in a last-chance journey to lose weight.

Tammy faces a tough choice when her husband wants her back, but only if she moves away from Houston and Dr. Now's program; Karina's weight loss begins to slow, but she finds happiness dating a guy Dr. Now is surprised to see in his clinic again.

Erica's success on her weight-loss journey is derailed by heartbreak; Benji must reach his goal weight without the support of his brother.

Alicia's relationship with her boyfriend, Tim, comes under the microscope; Pauline must beg her way back onto the program after quitting.

Erica's success on her weight-loss journey is derailed by heartbreak; Benji must reach his goal weight without the support of his brother.

Alicia's relationship with her boyfriend, Tim, comes under the microscope; Pauline must beg her way back onto the program after quitting.

Tammy faces a tough choice when her husband wants her back, but only if she moves away from Houston and Dr. Now's program; Karina's weight loss begins to slow, but she finds happiness dating a guy Dr. Now is surprised to see in his clinic again.

Alicia, all smiles and laughter on the outside, secretly fears that her food addiction will kill her before she can marry her long-time love or watch her nieces grow up.

An overweight woman struggles with flesh-eating bacteria and butterfly shaped fat deposits; unexpected news threatens her weight loss journey.

Laura has used food to cope with her emotions; she is confined to a wheelchair and relies on an oxygen tank to breathe and her husband and mother to survive.

Unable to stand for more than a short period of time, Karina's weight places a burden on her parents and drives a wedge between her and her sister.

Lisa's struggle with her weight begins as a child and significantly worsens after witnessing her brother's murder; now bedridden and unable to care for herself, Lisa must find a way to lose the weight or she will never see her grandchildren grow up.

After years of a tumultuous relationship with her husband, Tamy's eating addiction has caused her weight to balloon to over 500 pounds; she has become a hermit and hopes to restart her life so she can better care for her son, Zachary.

Fearing he'll suffer the same fate as 700-pound brother David, Benji hopes to be able to support both himself and his brother on their life-or-death weight loss journey.

Former plus-size model and advocate Renee realizes the mortal mistakes she has made as her weight swells to 600 pounds and her health crumbles.

Jennifer and her daughter Marissa are stuck in a co-dependent relationship and, with a combined weight of over 900-lbs., both of their lives are in jeopardy; Jennifer must regain control and save both of their lives before it is too late.

Devastated by two miscarriages due to her weight, Schenee is desperate to start a family and stop relying on her husband, Freddie, to take care of her; she hopes weight loss surgery will be able to fix her fertility issues as well as her marriage.

Jennifer and her daughter Marissa are stuck in a co-dependent relationship and, with a combined weight of over 900-lbs., both of their lives are in jeopardy; Jennifer must regain control and save both of their lives before it is too late.

Devastated by two miscarriages due to her weight, Schenee is desperate to start a family and stop relying on her husband, Freddie, to take care of her; she hopes weight loss surgery will be able to fix her fertility issues as well as her marriage.

Former plus-size model and advocate Renee realizes the mortal mistakes she has made as her weight swells to 600 pounds and her health crumbles.

A woman gets a Christmas tree imbedded in her neck; a boy out fishing almost chokes on a barb; a man is filled with enough air to fill 1000 balloons; learn how they survived.

A man gets a wire embedded in his heart; three year old swallows magnets; woman has pencil in her brain; man has a five centimeter splinter removed from eye.

A car accident leaves a pole penetrating a man's mouth and neck, a man accidentally eats a sewing needle, a 75-year-old man finds out he has had a nail in his face.

A couple's long awaited date night leads them to a secluded pasture; a couple with a hidden medical secret; an athletic couple loses their match against the "Kama Sutra."

A couple's alone time at a pool party gets them busted; a man looking to score medicine; a sticky situation that ends in the emergency room.

Alone time at a spa ends up like a crime scene; a nature lover's odd injury; a realtor and his crush go straight from the bedroom to the ER.

Stephen Dilbeck gets some shocking information about his birth family from Jane and Lisa; Chris and Sallie work on getting approval of an exhumation that will answer questions for hundreds of Hicks babies.

Jane and Lisa share the news about the exhumation with a group of Hicks babies that have questioned whether Dr. Hicks was in fact their biological father; Sallie and the Hicks babies learn the DNA results.

Wendy and her team encounter unexpected challenges with the exhumation; Sallie struggles emotionally with her decision to exhume; the Hicks babies learn the DNA results; three Hicks babies are connected with biological family.

Two sisters confront their Puerto Rican birth father after a lifetime of feeling abandoned; an adoptee turns her back on an upsetting past, as the new relationship with her biological mother flourishes.

Newly reunited sisters face a battle that strengthens their bond and uncover another secret held by their mother; two families explore the complicated relationship of sharing a son.

After hearing a shocking story from her biological mother, Kris seeks more answers about the disturbing truth behind her birth father; two strangers come forward with a potential connection to her story.

A surprisingly troubled outcome with her birth mother prompts an adoptee to find her father, leading to life-changing truths; a woman tries to repair relationships with the biological father she just met and the father who raised her.

After a joyful reunion with the daughter he was forced to give up, Jon now struggles to maintain their relationship; high school sweethearts who placed their son up for adoption happily meet his adoptive parents and participate in his wedding.

Ramon's keloids on the back of his head are so large that he may require a skin graft if removed; Lauren has a condition that gives her bumps inside and outside of her body; Tiana has an unknown condition, giving her what looks like four breasts.

Tiana hopes Dr. Mercy can figure out how to get rid of her two extra breasts; Michael wants his giant patches of skin tags removed for his 40th birthday; Chandra's lipoma is weighing her down physically and emotionally.

Dr. Mercy tries to remove Price's lipoma, which is so big that it has gotten in the way of his relationship; Ashley's case of neurofibromatosis is one of the worst in the country; Becca was born with a birthmark that covers the majority of her face.

Jorge's case of rhinophyma is so bad that he has a difficult time breathing; Tracy's body is covered in hundreds of lipomas; Cha comes to Dr. Mercy to help her gain her confidence back due to the bumps on her face.

Ramon's keloids on the back of his head are so large that he may require a skin graft if removed; Lauren has a condition that gives her bumps inside and outside of her body; Tiana has an unknown condition, giving her what looks like four breasts.

Tiana hopes Dr. Mercy can figure out how to get rid of her two extra breasts; Michael wants his giant patches of skin tags removed for his 40th birthday; Chandra's lipoma is weighing her down physically and emotionally.

Dr. Mercy tries to remove Price's lipoma, which is so big that it has gotten in the way of his relationship; Ashley's case of neurofibromatosis is one of the worst in the country; Becca was born with a birthmark that covers the majority of her face.

Jorge's case of rhinophyma is so bad that he has a difficult time breathing; Tracy's body is covered in hundreds of lipomas; Cha comes to Dr. Mercy to help her gain her confidence back due to the bumps on her face.

A surprisingly troubled outcome with her birth mother prompts an adoptee to find her father, leading to life-changing truths; a woman tries to repair relationships with the biological father she just met and the father who raised her.

After a joyful reunion with the daughter he was forced to give up, Jon now struggles to maintain their relationship; high school sweethearts who placed their son up for adoption happily meet his adoptive parents and participate in his wedding.

A patient fights for his life after a four-story fall; a 12-year-old boy is hit by a car and injures his foot.

A heart attack victim is brought back to life; a mother and her newborn survive a horrific crash; a 65-year-old man falls two floors down an elevator shaft.

A newborn with a potentially life-threatening infection; the victim of a gang-related attack; a patient who has survived a bullet passing through all of his vital organs.

A 16-year-old's behavioral issues may cause her to be expelled; daycare fees may force another student to leave school.

Florence's first prom; campaign to be prom queen.

A student struggles with self-esteem, weight issues and a son who has behavioral problems; a first time mom-to-be attempts to repair her relationship with her own mother.

Richanne is diagnosed with a brain tumor and pregnant; Paola's pregnancy could ruin her career.

Sandra relationship with her daughters; Dannielle risks her relationship with her grandfather.

Charity's sixth child is on the way; Natasha fears her boyfriend will leave her.

Amy's ninth child; Destiny is pregnant with twins at age 20.

The doctors and nurses of Good Samaritan Regional Medical Center pursue diverse goals at the Level One Trauma Center.

The staff at Rocky Mountain Regional Trauma Center in Denver treats victims of accidents, violence and illness.

Victims of car crash, scalding, burn.

Victims of shootings, stabbings, heroin overdose.

A teenage girl is impaled through the neck on an iron fence; a patient is convinced he's turning into a vampire; a first-year attending physician stands up to a room full of senior specialists to save the life of a critically ill pregnant woman.

The ER is a crime scene when a woman's belly pain is caused by smuggled narcotics; a doctor is mystified by heart attacks occurring the same day in the same family; strange markings on the body of a car crash victim lead to the cause of the accident.

Two seemingly unrelated gunshot wounds lead to a bizarre night in the ER; a senior nurse unravels at the sight of a critical patient, and reveals a shocking secret; a patient's grave symptoms mysteriously disappear whenever the doctor touches him.

A woman comes in with a piece of rebar impaling her thigh; a man brings his girlfriend into the ER for an STD workup; an ER doctor confronts a woman's prejudiced colleagues.

A teenage girl is impaled through the neck on an iron fence; a patient is convinced he's turning into a vampire; a first-year attending physician stands up to a room full of senior specialists to save the life of a critically ill pregnant woman.

The ER is a crime scene when a woman's belly pain is caused by smuggled narcotics; a doctor is mystified by heart attacks occurring the same day in the same family; strange markings on the body of a car crash victim lead to the cause of the accident.

Two seemingly unrelated gunshot wounds lead to a bizarre night in the ER; a senior nurse unravels at the sight of a critical patient, and reveals a shocking secret; a patient's grave symptoms mysteriously disappear whenever the doctor touches him.

A woman comes in with a piece of rebar impaling her thigh; a man brings his girlfriend into the ER for an STD workup; an ER doctor confronts a woman's prejudiced colleagues.

Victims of car crash, scalding, burn.

Victims of shootings, stabbings, heroin overdose.

Liz, completely bed-bound, has severe lymphedema that makes it impossible to walk; utterly isolated, Liz has no friends, battles depression and lives with a mother too ill to take care of her.

Bedridden Marla is so heavy she cannot stand up; she must face the hard truth about her condition and understand the toll it takes on her supportive family.

Chay has eaten his way to 600 pounds to cope with the emotional turmoil of his childhood; he loses his emotional support and searches for new strength to take control of his life.

After a difficult childhood with an abusive stepfather and drug-addicted mother, Sarah is fighting for her life at only 24 years old.

With the support of his fiancé, Kathryn, Robert turns to Dr. Nowzaradan in a final, desperate attempt to save his life; he tries to reverse a lifelong food addiction that has left him bed-bound, saddled with grotesque lymphedema, and nearly 900-lbs.

At over 700 pounds, Brianne undertakes a weight-loss journey to save her own life; she faces an unexpected challenge to her fragile progress when her husband suffers a heart attack on a birthday she will never forget.

Octavia has been bedbound for nearly a year when she decides to make the trip to Houston to get help from Dr. Now, but when it turns out that her best friend is also her worst enabler, Octavia will have to choose between old habits and a new life.

Robin and her brother Chris are both obese and already lost a sibling to obesity; they plan to visit Dr. Now together when Chris suffers a stroke and can't go; Chris' son Garrett, already 600 pounds at age 20, is game to join the journey.

A college graduate with a once-promising career, Justin has eaten his life away to the point of never leaving the house for anything but food; only the help of Dr. Now's weight-loss program can restore his hopes of living a happy, productive life.

Holly already has one failed weight loss surgery, so to succeed this time, she must do more than change her eating habits, she must address the childhood issues that continue to plague her.

A college graduate with a once-promising career, Justin has eaten his life away to the point of never leaving the house for anything but food; only the help of Dr. Now's weight-loss program can restore his hopes of living a happy, productive life.

Holly already has one failed weight loss surgery, so to succeed this time, she must do more than change her eating habits, she must address the childhood issues that continue to plague her.

Robin and her brother Chris are both obese and already lost a sibling to obesity; they plan to visit Dr. Now together when Chris suffers a stroke and can't go; Chris' son Garrett, already 600 pounds at age 20, is game to join the journey.

Kenny was born with a rare condition that causes hundreds of lumps to grow all over his body; Ebonee covers the tiny bumps on her eyes with sunglasses; Paula's painful and swollen feet ooze a substance that emits a foul odor.

Jacqueline's massive shoulder growth makes it difficult for her to do her favorite hobby of fire spinning; the mysterious bump on James' cheek loves to bleed; Mikalia has possessed a bumpy, smelly mass on her head since birth.

After losing his longtime love, Joe wants the large bumps all over his head removed; the itchy, painful rash on Nisa's ears spreads to her face; Jennifer has dark spots all over her face that nobody is allowed to see.

Cedric has a bump on his eye and a painful lump on his neck that have kept him from working; Katherine's large ear cluster puts her neighborhood watch job at risk; Andrea uses makeup to cover the white spots all over her face and body.

Jimmy's flaky, raised alligator skin feels like an itchy hell, and he wants it cured so he can find love; Djuka is a stubborn guy with a stubborn bump; Talina has hundreds of tumors all over her body, causing embarrassment and discomfort.

Brittney has hundreds of tiny bumps over her chest that have destroyed her confidence; John has a nose the size of a plum and leans on his local family clinic for help; Dr. Lee's friend Raquel drops in and brings out her wild side.

Mike's religious beliefs have kept him from seeing a doctor about his huge growth; Kylie has come to love her birthmark and is torn about whether to get it removed; Shad's head bump bursts open and smells like death.

Tyler's hands are so dry, cracked and painful that he considers getting them amputated; Ebonee covers the tiny bumps around her eyes with sunglasses; Ralph feels like a cyst factory with painful cysts covering his back.

Kelly has a massive shoulder growth; Erica stabbed her hand with a pencil 45 years ago and believes the lead remains trapped in her palm; Paula's painful and swollen feet ooze a substance that emits the foulest of odors.

Dr. Lee has a surprise for Paula, who has oozing, odoriferous and painful legs; Mike needs to get rid of the bump on his head before two major life events; Amanda feels inadequate for her husband because of the saggy growth on her back.

Alyse has been suffering from a burning rash that feels like it's rubbing away her existence; Terry has become too big for his britches due to a painful butt cheek lipoma; James has demons on his back that are ruining his life.

Krystal, a witch, looks to clear a curse of a cyst from her face; Keven wants to get a butt lipoma removed to get his tush back into a regular shape; Raquel, Dr. Lee's esthetician BFF, almost suffocates Dr. Lee with love and a facial.

J-Fab is the life of the party, but her shoulder bump is seriously cramping her style; Dan is a gentle giant with lumps on his head that add a few inches; Teresa's red face and bumpy nose make her feel like a monster.

Fit guy Alonso wants to show off his progress in the gym, but his 70 lipomas are holding him back; Porscha is a comic book enthusiast with two symmetrical lumps on her face; Jeffrey has a leaky lump named Larry on the back of his head.

Diane has thousands of tumors all over her body; Will fears his shoulder lump will be ripped open; Anthony gets his lump examined; Kal Elle detests her hideous varicose veins.

Robert is back to see if Dr. Lee and Dr. Umar can remove his recurring head keloid for good; Justice has small lesions all over her body; Mike has hundreds of lipomas that bring him great discomfort.

Pop-up facts and behind-the-scene secrets are revealed; Belinda's lump on her neck causes her immobility; Nicole needs her armpit lump removed; Adela's chest and back are covered in wisdom spots; Nick foolishly removes a lipoma at home.

April is covered with disfiguring bumps on her arms; Genner, from the Philippines, needs help with his bumpy nose.

Diane has thousands of tumors all over her body; Will fears his shoulder lump will be ripped open; Anthony gets his lump examined; Kal Elle detests her hideous varicose veins.

Pop-up facts and behind-the-scene secrets are revealed; Louis is covered in scaly, dry skin that makes him feel like an alligator; Irais' children are bullied because of the growth on her head; Johnny has a stubborn lump on his back.

Pop-up facts and behind-the-scene secrets are revealed; Belinda's lump on her neck causes her immobility; Nicole needs her armpit lump removed; Adela's chest and back are covered in wisdom spots; Nick foolishly removes a lipoma at home.

April is covered with disfiguring bumps on her arms; Genner, from the Philippines, needs help with his bumpy nose.

J-Fab is the life of the party, but her shoulder bump is seriously cramping her style; Dan is a gentle giant with lumps on his head that add a few inches; Teresa's red face and bumpy nose make her feel like a monster.

Fit guy Alonso wants to show off his progress in the gym, but his 70 lipomas are holding him back; Porscha is a comic book enthusiast with two symmetrical lumps on her face; Jeffrey has a leaky lump named Larry on the back of his head.

Boys Giovanni and Owen share the rare condition Schwartz-Jampel Syndrome, which permanently and painfully contracts their muscles; the two share hardships and triumphs, and strike up a friendship.

Tiffany and Destiny both live with the rare disease Osteogenesis Imperfecta, which causes brittle bones, and set out on a life changing journey to meet each other.

Bobbi and Kenny have skin that painfully grows in thick scales due to the rare condition Lamellar Ichthyosis.

Eight women cope with their incarceration in Gwinnett County Jail; one woman prepares for her release.

A woman is arrested for smuggling drug paraphernalia into court; two heroin addicts turn to each other for support; a life of prostitution supports a woman's drug habit.

A woman turns to drugs to numb the pain of her divorce; a crack addict attempts to head-butt an officer; a dental office assistant is arrested for stealing.

An emergency birth interrupts a wedding; a woman delivers after crashing her car; a baby with a life-threatening condition is born prematurely.

A baby is born twice; a woman in labor is torn apart by a tornado; a wife gives birth at home.

A woman goes into delivery while in a cab; a life-threatening pregnancy; twin sisters have their babies on the same day.

A young boy at a sleepover party mysteriously loses control over his arms and legs; a woman is shot in the leg at her own bachelorette party; bubbles in a woman's arteries are causing a stroke.

A patient suddenly starts seizing; an ER physician is at a restaurant when she is thrown into an emergency situation to save a child; a pregnant woman's heart is racing.

A young pregnant woman in labor begs the ER doctor to keep her pregnancy a secret from her father; twins share confusing symptoms; a man with no pulse or blood pressure is still alive and breathing.

A man is impaled in his abdomen by a stiletto heel; a seemingly healthy outdoorsman has a series of seizures that baffle his doctors; two patients make their doctor suspicious when they both complain about identical headaches that started during sex.

A patient's pet causes pandemonium; a man experiences paralysis that climbs up his legs to his chest until he can no longer breathe; a war veteran suffers from phantom pain in his amputated hand.

Sean's nightmare keeps coming true, he can't stop pooping himself on stage; Tired of dealing with explosive bowels, Sean asks Dr. Hodges for help; Latoya wants to spend time with her kids again which means the 10 pound mass between her legs needs to go.

AliceJean's botched lap band removal left her with six belly buttons that form a golf course on her stomach; Simone seeks help for her uncontrollable vomiting.

After a botched lap band surgery, Christina has been blending her meals for over a decade; Dr. Caplin assists a patient whose tummy tuck has left her with a butt crack for a stomach.

With bonus scenes; Brittany has been called a monster due to her genetic condition; Leonardo has a fist-size growth on his head, but he is terrified of doctors; Tamyra has skin so thick that she shaves the bottom of her feet for relief.

Sean's nightmare keeps coming true, he can't stop pooping himself on stage; Tired of dealing with explosive bowels, Sean asks Dr. Hodges for help; Latoya wants to spend time with her kids again which means the 10 pound mass between her legs needs to go.

AliceJean's botched lap band removal left her with six belly buttons that form a golf course on her stomach; Simone seeks help for her uncontrollable vomiting.

After a botched lap band surgery, Christina has been blending her meals for over a decade; Dr. Caplin assists a patient whose tummy tuck has left her with a butt crack for a stomach.

With bonus scenes; Brittany has been called a monster due to her genetic condition; Leonardo has a fist-size growth on his head, but he is terrified of doctors; Tamyra has skin so thick that she shaves the bottom of her feet for relief.

A man is impaled in his abdomen by a stiletto heel; a seemingly healthy outdoorsman has a series of seizures that baffle his doctors; two patients make their doctor suspicious when they both complain about identical headaches that started during sex.

A patient's pet causes pandemonium; a man experiences paralysis that climbs up his legs to his chest until he can no longer breathe; a war veteran suffers from phantom pain in his amputated hand.

Dottie faces an unexpected challenge to her weight-loss when her husband's drinking problem becomes intolerable for her and her son; Cynthia starts to wonder if being there for her kids at her current weight is more important than losing more.

With her weight loss, Laura is much less dependent on her husband Joey, who is now having trouble finding his place in their relationship; challenging patient Marla returns and the fireworks begin once again.

Despite having lost 378 pounds, Angel's crippling knee pain and history of extreme obesity threatens everything for which she's worked; Charity finds the strength to return to a normal life after post surgery complications.

In order to keep pace with her daughter Charly's impressive weight loss, Charity must do something she's never done and find a way to go it alone.

Steven's dysfunction escalates, pushing his relationship with Dr. Nowzaradan; his brother Justin takes the leap to go to Houston to finally accept help.

Maja cannot be allowed to undergo bariatric surgery unless she quits emotional eating. However, it seems like Justin may end up making Dr. Now proud.

There is much to be gained and lost for Brianne in year two of her journey, in which she both loses weight and gains independence; getting back with Erica becomes the top priority for Annjeanette, who chooses love over even her own health.

Right when Angie is starting to succeed in Dr. Now's program, her marriage falls apart and her life is thrown into chaos, but she tries to move ahead alone despite dire difficulties.

Right when Angie starts to succeed in Dr. Now's program, her marriage falls apart and her life is thrown into chaos; Angie moves ahead despite dire difficulties, but when her body starts to break down, Angie fears the worst and faces it alone.

Jeanne struggles to care for herself in the aftermath of her dad's death; Brandon strives to get his weight down to feel confident when proposing to his girlfriend, Tayler, and be the man she deserves.

Right when Angie starts to succeed in Dr. Now's program, her marriage falls apart and her life is thrown into chaos; Angie moves ahead despite dire difficulties, but when her body starts to break down, Angie fears the worst and faces it alone.

Jeanne struggles to care for herself in the aftermath of her dad's death; Brandon strives to get his weight down to feel confident when proposing to his girlfriend, Tayler, and be the man she deserves.

Right when Angie is starting to succeed in Dr. Now's program, her marriage falls apart and her life is thrown into chaos, but she tries to move ahead alone despite dire difficulties.

Holly already has one failed weight loss surgery, so to succeed this time, she must do more than change her eating habits, she must address the childhood issues that continue to plague her.

Nikki finds her career as a costume designer threatened by immobility, so she undergoes gastric bypass and confronts the emotional causes for her eating.

Ashley confronts medical setbacks and struggles to get past the trauma that ignited her eating disorder.

Kelly is on the verge of immobility when she decides to make the trip to Houston to visit Dr. Now; her journey gets off to a painful start when a long travel-day grows longer as Kelly gets stuck in a cab on her way from the clinic to the hospital.

John and Lonnie are two brothers from opposite ends of the spectrum; estranged for years, the brothers are now brought together by a common need to lose weight while they still can.

Seana is 23 and nearly 700 lbs, living at her mom's house, depressed and anxious, her weight-gain threatening to take her last breath; Dr. Now can give her the tools she needs to live, but until she chooses life, no one can save Seana but herself.

At 600 pounds, Ashley has to move home so her mom can help her care for herself and her newborn daughter; Ashley must overcome a lifetime's worth of unfortunate circumstances and get Dr. Now's help in Houston.

Shannon's husband loves her the way she is, but that may not help because she's 700 pounds and bedridden; Dr. Now knows it's not easy to break a toxic cycle of overfeeding and enabling, but that's what needs to happen if Shannon wants to live.

Irene had to move back in with her son because her weight made it unbearable to live on her own. When Dr. Now can't get through to her, the only thing that might help her break the cycle is a once-in-a-lifetime turn of events.

Through tough times, food has always been Tammy's friend; now she has gotten so big that her daughters and mother have moved home to care for her, and unless Dr. Now can get her to confront her grief, food might be her killer.

Irene had to move back in with her son because her weight made it unbearable to live on her own. When Dr. Now can't get through to her, the only thing that might help her break the cycle is a once-in-a-lifetime turn of events.

Through tough times, food has always been Tammy's friend; now she has gotten so big that her daughters and mother have moved home to care for her, and unless Dr. Now can get her to confront her grief, food might be her killer.

Shannon's husband loves her the way she is, but that may not help because she's 700 pounds and bedridden; Dr. Now knows it's not easy to break a toxic cycle of overfeeding and enabling, but that's what needs to happen if Shannon wants to live.

Dr. Schaeffer, Dr. Haller and Dr. Vincent deck the halls and hang the mistletoes while spreading holiday cheer and treating shocking new cases.

A woman with a 2-pound mass in her foot; a man with pasta-shaped toenails; a woman with heels like rocks has the doctors scratching their heads and holding their noses.

Cindy is desperate to have Dr. Brad fix her stumpy foot; Gregory has open wounds on both feet and hopes Dr. Ebonie can heal them; Glen's feet are split down the middle, and Dr. Brad is determined to find a solution to ease his pain.

A shootout leaves a police officer clinging to life; a cowboy and cupid help a she-devil in distress; a zip-line guide falls 80 feet to the canyon floor.

Doctors retrieve a stolen Rolex from a very private spot; a pick-up turns deadly when a cabbie is shot multiple times; a dirt-bike accident in the desert leaves a 52-year-old thrill-seeker clinging to life.

A brutal assault could end a star athlete's career, a 28-year-old man is hit in the head by a flying baseball bat; and a Vegas chef falls asleep with a loaded gun.

A patient appears to be hallucinating and sends ER staff on a wild goose chase; a new nurse makes a shocking mistake; doctors try to help a former EMT who is found lethargic and slurring his words.

A surfer is impaled between the legs; a football player's severe leg pain leads to an unexpected diagnosis; a woman is given a clot-busting drug to cure her stroke, but she has another condition that could cause that same drug to kill her.

A boa constrictor has wrapped around a man's arm and won't let go; a young woman has a severe laceration, but doctors begin to suspect there may be more to her case than the injury; a young man goes into anaphylactic shock after a dinner out.

An urgent care physician must think outside the box to care for two emergencies at once; a woman with abdominal pain receives an unexpected diagnosis; a yoga instructor has a dangerously high temperature for no obvious reason.

A patient gets brought in with a live shark clamped onto his thigh, and he wants to save the shark; complications arise for a woman with a life-threatening condition; a mysterious condition causes a man to pass out.

Staff treats patient injured while engaging in risky behavior at night.

Medical staff treats a patient who was hit by a train while crossing the tracks.

Medical staff treats patient injured in a car wreck involving multiple vehicles.