The hospital is locked down when a nurse is shot in the ER; medics rush a bride from her wedding who is in an unexplained altered mental state; a doctor must perform a risky intervention to save the life of a teenage girl.

A teen football player suffers a stroke; a doctor remembers his first major trauma in the 1970s; a doctor tries to figure out what causes a patient's abdominal pain.

Ronnie and Michael Robinette are thriving, but their extra skin is getting in the way; at 64, Renee's excess skin inhibits her from enjoying her relationship and expressing her true self in public.

Tamika finds a partner who makes her feel happy, but she feels uncomfortable due to her excess skin; Emilly blames herself for her son's weight gain, and, now, they both struggle with the pain loose skin has brought into their lives.

After being a victim of a crime, Marranda finds solace in food and her weight balloons; she loses the weight, but her skin is a reminder of her trauma; Jannet's excess skin is keeping her from meeting a life partner.

Rafael loses over 500 pounds through diet and exercise, but his excess skin becomes a huge hindrance on his life and progress; Anna loses 330 pounds but her low self-esteem holds her back from being the mother she wants to be.

A woman surviving blindness and albinism suffers another disease.

A toddler has unexplained bleeding; a college student has intense cramps.

A toddler cannot walk or stand.

A teenager fails to hit puberty; a collapsed lung.

Jessica is a little person with dangerous toppling piles of clutter; along with her mother she has filled her entire home.

After being the target of a school shooting a former principal's life has changed; paralyzed by PTSD and hoarding Wayne has abandoned his family.

A wife has transformed one couple's home into a heap of trash; on the verge of foreclosure.

Frank didn't expect Susan to fill his house with clutter when she moved in; though her home of forty-eight years sits condemned just two blocks away.

Jessica is a little person with dangerous toppling piles of clutter; along with her mother she has filled her entire home.

After being the target of a school shooting a former principal's life has changed; paralyzed by PTSD and hoarding Wayne has abandoned his family.

A wife has transformed one couple's home into a heap of trash; on the verge of foreclosure.

Frank didn't expect Susan to fill his house with clutter when she moved in; though her home of forty-eight years sits condemned just two blocks away.

A toddler cannot walk or stand.

A teenager fails to hit puberty; a collapsed lung.

Erica regrets not keeping a promise to her mom and hopes her siblings will help, but they're reluctant based on her past failures.

Olivia suffers an unexpected loss; James strives to reach his goal of skin surgery and have a fulfilling relationship.

Zsalynn struggles between fighting her weight and fighting for her marriage; Christina releases the negativity in her life and finally begins to live.

Born as "Matthew," Destinee never felt like she fit in; now, having come out as a 600-pound transgender woman, she likes her curves, but she will need to say goodbye to them if she wants to be approved to transition completely.

Jeanne lives in an unhygienic household with her mother and schizophrenic father; at well over 600 pounds, Jeanne might never get weight-loss surgery as she runs into several obstacles, especially after an unexpected death in her family.

Since the death of his mother, Aaron lives at home to care for his aging father, but due to his food addiction, Aaron has to heavily rely on his father for help instead. Aaron must learn to care for himself to avoid eating himself to death.

Kelly is on the verge of immobility when she decides to make the trip to Houston to visit Dr. Now; her journey gets off to a painful start when a long travel-day grows longer as Kelly gets stuck in a cab on her way from the clinic to the hospital.

Syreeta thinks that anyone trying to help has an ulterior motive, but she's gotten so big she desperately needs help; she's learning to let down her guard for her husband, but weight-loss surgery will be tough if she can't learn to trust the surgeon.

Mark sets out with a goal for weight-loss surgery, but as weight loss gets easier, he turns down medical advice and decides to do it on his own; Mark thinks he can lose 500 pounds by himself, but Dr. Now sees this as another excuse not to change.

With her weight spiraling, Stephanie needs her mom's help to care for her three kids; she's at the point where she'll have to lose weight or risk not having the chance to see her kids grow up.

Mark sets out with a goal for weight-loss surgery, but as weight loss gets easier, he turns down medical advice and decides to do it on his own; Mark thinks he can lose 500 pounds by himself, but Dr. Now sees this as another excuse not to change.

With her weight spiraling, Stephanie needs her mom's help to care for her three kids; she's at the point where she'll have to lose weight or risk not having the chance to see her kids grow up.

Syreeta thinks that anyone trying to help has an ulterior motive, but she's gotten so big she desperately needs help; she's learning to let down her guard for her husband, but weight-loss surgery will be tough if she can't learn to trust the surgeon.

Cynthia, a single mother focused on raising five kids, comes to realize what her death would mean for their future.

Ashley wants to achieve her goal of owning a childcare facility, but must lose weight before her dreams can be met.

Penny has been bedridden for four years and moves to Texas to have gastric bypass; her unwillingness to make lifestyle changes could mean failure.

When Annjeanette was nine, a campaign was established to send her to fat camp; she hated that her weight had become a source of public shame and she has struggled to overcome her food addiction; now, she must change her habits to save her life.

When Angela's family is unable to accompany her on her weight-loss journey to Texas she is unsure what to do; at the last minute, she reaches out to an old flame, Eric, who still has love for her and is willing to make the trip.

Mother of four LaShanta has been bed-bound for two years, and she relies on her kids to keep her cleaned and fed; her last chance to break the cycle of food addiction is to join Dr. Now's program, but it will take a village to get her out the door.

Cillas' food addiction is getting in the way of his ability to be there for his fiancée, Jessica, and her three daughters; if he doesn't lose weight soon, he knows he'll lose either his girls or his life.

Mercedes, who has severe lymphedema, must overcome trauma to lose weight.

Thederick has lost enough weight to get the giant lymphedema mass removed from his leg, in one of Dr. Now's biggest removals ever.

After getting his surgery canceled and living in his van by the beach, surgery may be the break David has been waiting for his whole life; Syreeta suffers a devastating personal tragedy that only strengthens her desire to become a mother.

Thederick has lost enough weight to get the giant lymphedema mass removed from his leg, in one of Dr. Now's biggest removals ever.

After getting his surgery canceled and living in his van by the beach, surgery may be the break David has been waiting for his whole life; Syreeta suffers a devastating personal tragedy that only strengthens her desire to become a mother.

Mercedes, who has severe lymphedema, must overcome trauma to lose weight.

A gunman opens fire outside a strip club; a street performer's magic trick goes horribly wrong; BMX superstar T.J. Lavin's routine jump has a shocking outcome.

A maintenance worker falls from an iconic hotel sign; a rat bite has horrifying implications for its trainer and a plane crashes on a residential street.

A shootout leaves a police officer clinging to life; a cowboy and cupid help a she-devil in distress; a zip-line guide falls 80 feet to the canyon floor.

A woman gets a Christmas tree imbedded in her neck; a boy out fishing almost chokes on a barb; a man is filled with enough air to fill 1000 balloons; learn how they survived.

A man gets a wire embedded in his heart; three year old swallows magnets; woman has pencil in her brain; man has a five centimeter splinter removed from eye.

A car accident leaves a pole penetrating a man's mouth and neck, a man accidentally eats a sewing needle, a 75-year-old man finds out he has had a nail in his face.

Jamie's tiredness leads to shocking news; David has joint pain and low stamina.

Bonnie's tingling foot; Shannon's high fever causes her to black out.

Jordan has bleeding gums and bruises; Tannis has headaches and high blood pressure.

Kurt's body lumps; Jessica's cheek numbness and dizziness.

A man's maimed hand is sewn into his stomach to avoid amputation; a young girl is born with a deformed mouth and jaw; a boy's organs are inverted; a man who can't smile finds love; with bonus content.

A boy tries to get his balloon facial tumor removed; a woman who is allergic to UV light must take precautions; a woman fears her birthmark is still growing; a boy with undeveloped legs walks on all fours; with bonus content.

A boy who can't stop eating undergoes a series of operations to save his life; a young man who is more than 7-feet tall learns if he's still growing; a boy is born without eyes; Irish twins' muscles and flesh turn to bone; with bonus content.

A man seeks to get the fatty growths on his chest removed; a boy's eye falls out of his skull; a man with giant facial keloids goes under the knife one last time; a young boy lives with an agonizing skin condition; with bonus content.

Geoffrey lost his home and has 30 days to clear the clutter or he will lose everything left inside.

Ken's girlfriend is giving him one last chance to clear out; Lea could lose her children if she cannot clean her clutter.

A father and son who both hoard; one faces jail time while the other could lose his newborn son.

Tim's inheritance is dwindling and he risks losing his home; twin brothers Lorrin and Orin face a similar predicament.

Geoffrey lost his home and has 30 days to clear the clutter or he will lose everything left inside.

Ken's girlfriend is giving him one last chance to clear out; Lea could lose her children if she cannot clean her clutter.

A father and son who both hoard; one faces jail time while the other could lose his newborn son.

Tim's inheritance is dwindling and he risks losing his home; twin brothers Lorrin and Orin face a similar predicament.

A boy who can't stop eating undergoes a series of operations to save his life; a young man who is more than 7-feet tall learns if he's still growing; a boy is born without eyes; Irish twins' muscles and flesh turn to bone; with bonus content.

A man seeks to get the fatty growths on his chest removed; a boy's eye falls out of his skull; a man with giant facial keloids goes under the knife one last time; a young boy lives with an agonizing skin condition; with bonus content.

Pregnant detainees await trial; Jamie, a mother of four struggles for visitation rights; Tanya requests house arrest to prepare for the birth of her son.

Latoya struggles with giving up her baby for adoption; Esther is sent to disciplinary segregation.

On the day before Halloween, Abbigale gives birth when she didn't know she was pregnant.

While attempting to recover from the stress of getting mugged and a bad fall, Nikki finds out she is pregnant and full term.

Paramedics rush Anna to a hospital on Christmas Eve for what she thinks is food poisoning only to discover she's 41 weeks pregnant, in labor and didn't know it.

A woman who has accepted that she may never have a child is rushed to a hospital with cramps attributed to work stress and is shocked to find out she's pregnant and in labor.

Stabbing pains in the pelvis send a woman to an ER, where she discovers she has given birth, without realizing she was pregnant.

Tiffany thinks the abdominal pain she is having is from a rupturing cyst, but it's actually a child she didn't know she was carrying.

A woman misses her period but a home pregnancy test is negative, so she thinks it must be the stress of her upcoming wedding until a few months later when she is shocked to find herself delivering a baby girl while on the toilet.

After spending a day with her family riding roller coasters at a theme park, a woman suddenly feels exhausted and nauseous, begins having cramps, heads to the bathroom, and gives birth to a baby boy on the floor.

A young child does not respond to pain; a woman experiences unexplained seizures.

A teenager's hair begins to fall out.

Baby Samantha has surgery to remove congenital cataracts that could lead to blindness; as the months pass, Samantha is unable to roll, crawl or talk, and her head is unusually small for her age; her parents seek help.

A baby's gaze is fixed on the ceiling; a woman's bruise will not disappear.

A woman gives birth prematurely during Hurricane Sandy; an Army soldier coaches his wife's delivery from Afghanistan; a baby delivered in a shopping mall parking lot.

An emergency birth interrupts a wedding; a woman delivers after crashing her car; a baby with a life-threatening condition is born prematurely.

A baby is born twice; a woman in labor is torn apart by a tornado; a wife gives birth at home.

A woman goes into delivery while in a cab; a life-threatening pregnancy; twin sisters have their babies on the same day.

After Thomas Hicks sold over 200 babies illegally in the 1950s and 1960s, Jane Blasio works to reunite the stolen babies with biological families while trying to unearth secrets about Hicks himself.

Jane discovers a suspicious pattern of babies with extremely low birth weights coming out of the clinic; Chris finds out that Dr. Hicks may have hidden birth records in his mausoleum; Diane hopes to meet her biological father.

Jane and Lisa meet the first Hicks baby, Stephen Dilbeck; Chris and Sallie open the mausoleum in search of birth records rumored to be inside as they work on getting approval of an exhumation.

Stephen Dilbeck gets some shocking information about his birth family from Jane and Lisa; Chris and Sallie work on getting approval of an exhumation that will answer questions for hundreds of Hicks babies.

After Thomas Hicks sold over 200 babies illegally in the 1950s and 1960s, Jane Blasio works to reunite the stolen babies with biological families while trying to unearth secrets about Hicks himself.

Jane discovers a suspicious pattern of babies with extremely low birth weights coming out of the clinic; Chris finds out that Dr. Hicks may have hidden birth records in his mausoleum; Diane hopes to meet her biological father.

Jane and Lisa meet the first Hicks baby, Stephen Dilbeck; Chris and Sallie open the mausoleum in search of birth records rumored to be inside as they work on getting approval of an exhumation.

Stephen Dilbeck gets some shocking information about his birth family from Jane and Lisa; Chris and Sallie work on getting approval of an exhumation that will answer questions for hundreds of Hicks babies.

A baby is born twice; a woman in labor is torn apart by a tornado; a wife gives birth at home.

A woman goes into delivery while in a cab; a life-threatening pregnancy; twin sisters have their babies on the same day.

After overcoming a dependence on drugs and alcohol, sneaking food is Doug's last remaining vice; this husband and father must overcome his addictive personality to save his life and marriage.

Zsaylnn needs to lose weight to be the mother her daughter deserves; her husband loves large women and does not support her goals.

A woman battles severe depression and has not left her Chicago basement in two years; the hope of having a life-changing surgery.

At over 600 pounds, Angie is trying to get to Houston to see Dr. Nowzaradan, in hope of getting weight loss surgery to save her life; family conflict and disagreements may stop her from being able to do what she needs before she even gets the chance.

Vianey and Allen are locked in a co-dependent relationship based on a shared love of food; as they head to Houston, they will soon find out if their relationship can handle the strain of growing healthy together.

John and Lonnie are two brothers from opposite ends of the spectrum; estranged for years, the brothers are now brought together by a common need to lose weight while they still can.

Lindsey has a white picket fence, a loving husband and a great job, but her food addiction threatens to ruin everything; as she embarks on a weight loss journey to save her life, her husband may provide more harm than support.

Nothing means more to Chris than his relationship with his daughter, Zoey, but now he feels he is failing her as his weight gain begins to limit his mobility.

Patrick's weight has never been a bother, but now he's so big that it's getting in the way of his relationship with his daughter; if he wants to see her graduate high school, he'll have to reverse course.

Krystal S. has finally met the man of her dreams, but she won't let herself marry him until she can be sure that she won't become bedridden and force him into the role of caretaker.

Patrick's weight has never been a bother, but now he's so big that it's getting in the way of his relationship with his daughter; if he wants to see her graduate high school, he'll have to reverse course.

Krystal S. has finally met the man of her dreams, but she won't let herself marry him until she can be sure that she won't become bedridden and force him into the role of caretaker.

Nothing means more to Chris than his relationship with his daughter, Zoey, but now he feels he is failing her as his weight gain begins to limit his mobility.

Melissa tries to cover a huge lipoma with a sweatshirt for years; Tyler's fear of cancer keep him from having his huge head lumps diagnosed; Tahj is covered in painful boils; Amber has ear keloids that take control of her life.

Ronen's mysterious lump above his knee is one of the largest Dr. Lee has ever seen; Amber suffers from a debilitating skin disease that no one understands; Sandy has a neck lump she calls Tommy; Kristy's eyelid cyst is ruining her life.

Half of Mary's body is a size 18 while the other half is a size 8; Anthony's cyst is in the area called the "Triangle of Death;" Shane wants to get a lump off his back; Brandi is anxious about getting a lump removed from her chest.

Belinda's lump on her neck causes her to basically be immobile; Nicole won't get married until she gets her armpit lump removed; Adela's chest and back are covered in wisdom spots; Nick foolishly removes a lipoma at home and now needs Dr. Lee.

Diane has tumors all over her body that have ruined her life; Will fears his shoulder lump will be ripped open at work; Anthony's daughters force him to get his lump examined; a woman detests her hideous varicose veins.

Taylor has a large bump at the base of her spine that is far more dangerous than she realizes; John jokes about his hip lump, but it's no laughing matter; Noelle had her ears stretched as a teen, but now wants them repaired.

Louis is a veteran who is covered in scaly, dry skin that makes him feel like an alligator; Irais's kids are bullied because of the embarrassing growth on her head; Johnny has been living with a stubborn lump on his back for too long.

Patrick's nose is covered by huge bumps, and he can barely breathe; Aziza and Lauren are friends who bonded over their matching wrist lumps; Joe has a mound in the middle of his forehead that looks like a third eye.

April is covered in bumps that disfigure her arms; Genner flies all the way from the Philippines to have Dr. Lee help with his bumpy nose; Chris suffers from psoriasis that nearly covers his body and a bump on his head.

Matt has a skin condition that causes tumors to grow all over his body; Yamileth hasn't pursued her dreams because of the lump on her neck; Pat is covered with dark spots from her neck to her abdomen; Jennifer has a unicorn bump on her forehead.

Amber has hundreds of tumors on her face; Antonio has a mound on his spine and is afraid it might be impossible to remove; sisters Cheri and Janice both suffer from possibly matching lumps; Tatiana has an embarrassing bump on her butt cheek.

Lisa has a horn growing out of the back of her head and fears that it could be cancer; Victor has a bulbous lump on his chest; Chuck has a Popeye-shaped bump on his arm; Christian and Jonathan are teenage brothers with matching lumps.

Taylore is a beautiful young woman who has unsightly elf-like bumps on her ears; Jose never goes out because of the baseball-sized lump on his head; Ken is covered in painful bumps that make it difficult to do everyday things.

Josh has a large knot on his head resulting from a car crash from 18 years ago; Brittney is covered in mysterious bumps; TJ has a hard, curious lump protruding from his side; Luis has a bump on his shoulder and his daughters fear it's dangerous.

Barbara's back lump became more noticeable after she lost 131 pounds; Bob has two painful bumps on his back; Hilda's depression is a result of the multitude of bumps on her eyelids; Art has one big bump on his head that he covers up with hats.

Leonard has an alarming bump hanging off of his arm that looks like it's breaking through the skin; Brandon has several lumps on his head that make him fearful for his life; Jess gets a noticeable lump on her butt after falling down the stairs.

Dr. Sandra Lee treats Heather, who has a huge growth on her leg and fears removing it could leave a keloid scar; Paul has a giant hump on his back.

Rhonda has bumps all over her head, including a horned growth that has her deeply concerned; Fred has a mysterious condition on his hands and has not been able to get answers from any doctors; Kevin has a huge lump protruding from his hip.

Barbara's back lump became more noticeable after she lost 131 pounds; Bob has two painful bumps on his back; Hilda's depression is a result of the multitude of bumps on her eyelids; Art has one big bump on his head that he covers up with hats.

Leonard has an alarming bump hanging off of his arm that looks like it's breaking through the skin; Brandon has several lumps on his head that make him fearful for his life; Jess gets a noticeable lump on her butt after falling down the stairs.

Dr. Sandra Lee treats Heather, who has a huge growth on her leg and fears removing it could leave a keloid scar; Paul has a giant hump on his back.

Rhonda has bumps all over her head, including a horned growth that has her deeply concerned; Fred has a mysterious condition on his hands and has not been able to get answers from any doctors; Kevin has a huge lump protruding from his hip.

Taylore is a beautiful young woman who has unsightly elf-like bumps on her ears; Jose never goes out because of the baseball-sized lump on his head; Ken is covered in painful bumps that make it difficult to do everyday things.

Josh has a large knot on his head resulting from a car crash from 18 years ago; Brittney is covered in mysterious bumps; TJ has a hard, curious lump protruding from his side; Luis has a bump on his shoulder and his daughters fear it's dangerous.

A student's problems at school; a 17-year-old mom is separated from her son; teenage pregnancy.

A woman juggles the demands of finals and raising her blind daughter; a 16-year-old prepares to give birth alone.

When a man who urinates on his feet, a patient who has twisted toes, and a woman who says she walks like a clodhopper visit the doctors, they are faced with shock.

Dr. Ebonie and Dr. Brad have their hands full treating a woman with fluid dripping out of her foot; a man born with seven toes on each foot; a barber that dropped a steel door on his big toe 20 years ago has a nail that is completely deformed.

A woman with horribly dislocated toes, a man who walks on his toenails, and a woman who needs fatter feet are all curious cases for Dr. Brad and Dr. Ebonie.

An urgent care physician must think outside the box to care for two emergencies at once; a woman with abdominal pain receives an unexpected diagnosis; a yoga instructor has a dangerously high temperature for no obvious reason.

A patient gets brought in with a live shark clamped onto his thigh, and he wants to save the shark; complications arise for a woman with a life-threatening condition; a mysterious condition causes a man to pass out.

Police officers bring in a criminal that is comatose; a man found passed out in the snow with no jacket or shoes arrives in the ER and a doctor is faced with a family emergency on her day-off.

A fishing lure embedded in a man's face turns out to be the least of his problems; a pair of unconscious teenagers get brought to the ER, where dramatic family secrets come out; an ER technician collapses and refuses traditional medical treatment.

Three hoarders live in the same apartment complex; their hoarding has gone unchecked for years, but a new management is about to change everything.

Doug stands to lose two houses filled with clutter if he doesn't control his compulsion to collect.

Mike is about to undergo surgery to save his life; the biohazards in his home threaten his recovery.

A mother's battling with hoarding discovers her own daughters compulsion; a family's unity at risk.

Seymour needs to conquer the roach infestation and clear out the hoard in his house, or the city will condemn the home and leave him homeless.

Lisa helps a man find answers about his adoption; a breast cancer survivor searches for her birth mother.

Chris unwraps the mystery of a woman's origins, which at a Korean orphanage; Lisa desperately searches for a woman's only child, hoping it will heal her.

Lisa hopes that locating a man's biological mother will finally allow him to overcome his lifelong struggle with abandonment; Chris locates a woman's only child and delivers the difficult details of her daughter's birth story.

Identical twins enlist Lisa's help to unlock the mystery of why they were placed for adoption; Chris hopes to fulfill the wishes of a deceased father by tracking down the first-born son he and his wife had placed for adoption.

Lisa helps a man find answers about his adoption; a breast cancer survivor searches for her birth mother.

Chris unwraps the mystery of a woman's origins, which at a Korean orphanage; Lisa desperately searches for a woman's only child, hoping it will heal her.

Lisa hopes that locating a man's biological mother will finally allow him to overcome his lifelong struggle with abandonment; Chris locates a woman's only child and delivers the difficult details of her daughter's birth story.

Identical twins enlist Lisa's help to unlock the mystery of why they were placed for adoption; Chris hopes to fulfill the wishes of a deceased father by tracking down the first-born son he and his wife had placed for adoption.

A mother's battling with hoarding discovers her own daughters compulsion; a family's unity at risk.

Seymour needs to conquer the roach infestation and clear out the hoard in his house, or the city will condemn the home and leave him homeless.

Diana, a once thin and active woman, is now a prisoner to her body and trades the comfort of her apartment for a weight loss journey under the strict authority of her niece.

Chuck's second year of weight loss and a new relationship; Paula struggles with juggling many responsibilities along with her weight-loss.

Penny returns to Maryland believing she can lose weight; Tara continues to lose weight and is dating for the first time.

Bethany has two daughters who live in fear of losing their mom to her food addiction; once an addiction counselor, Bethany has gotten so big that she can no longer work; now she risks losing her life if Dr Now can't help her curb her own addiction.

JT is almost 900lbs with a 100-lb lymphedema mass on his leg and a food addiction that is bound to kill him if he doesn't change; his girlfriend takes him to Houston, but when his behavior drives her away, JT is left with only Dr. Now to help.

Gina and wife Beth live with Gina's mother, but she and Gina's sister blame Beth for Gina's spiraling weight problem; it will take all Gina's will to leave home for Houston to get Dr Now's help, to save her life and her marriage.

When Travis gets too big to walk down the aisle, he promises to give his wife a proper wedding; he gains more weight, leaving Dr Now as Travis' only hope to lose weight and get the life he and his wife dreamed of having together.

Abi was struggling with his weight before a fluke accident left him mostly paralyzed; bedbound for seven years since then and topping 700 pounds, Abi's only hope for a future with his wife is to get Dr. Now's help to lose weight.

When a regular trip to the grocery store turns into an emergency for the EMTs, Delana must admit how badly she needs Dr. Now's help to lose weight; hopefully her road to recovery will lead her to reconcile with the daughter she's grown apart from.

At age 58, Rose had almost given up and eaten herself to death, but it turned out her family needed her too much for her to go; now she has more than 400 pounds to lose if she wants to get healthy for them, and she's determined to do it.

When a regular trip to the grocery store turns into an emergency for the EMTs, Delana must admit how badly she needs Dr. Now's help to lose weight; hopefully her road to recovery will lead her to reconcile with the daughter she's grown apart from.

At age 58, Rose had almost given up and eaten herself to death, but it turned out her family needed her too much for her to go; now she has more than 400 pounds to lose if she wants to get healthy for them, and she's determined to do it.

Abi was struggling with his weight before a fluke accident left him mostly paralyzed; bedbound for seven years since then and topping 700 pounds, Abi's only hope for a future with his wife is to get Dr. Now's help to lose weight.

James becomes bedridden, unable to stand and can barely move his legs; Holly and Mark prepare for skin removal surgery.

Chuck weighs almost 700 pounds; he has had to downsize his business and his wife feels like a single-parent who is ready to leave him.

Christina has not left her house in two years due to her size; she has eaten herself into a state that will soon kill her if she does not change.

Joyce needs home health care and hasn't left the house in three years; getting to Dr. Now in Houston is just the first step and when he prescribes therapy where Joyce must revisit an unhappy past with her mom; it might be more than she can handle.

Shantel's brother Carlton lives downstairs but she hardly ever sees him because at 600 lbs each, neither can do the stairs safely; to break free from a death spiral of codependent eating they need Dr. Now's help to reforge their sibling relationship.

Seana is 23 and nearly 700 lbs, living at her mom's house, depressed and anxious, her weight-gain threatening to take her last breath; Dr. Now can give her the tools she needs to live, but until she chooses life, no one can save Seana but herself.

At 600 pounds, Ashley has to move home so her mom can help her care for herself and her newborn daughter; Ashley must overcome a lifetime's worth of unfortunate circumstances and get Dr. Now's help in Houston.

William was always mobile and fairly athletic - that is, until he wasn't; it's been years now since a knee injury derailed his sports career, and he's ballooned up over 600 pounds; now, to lose weight he'll have to face up to how bad it's gotten.

Charles replaced one addiction with another when he quit doing hard drugs. Now his BMI is over 100 and he can't stop eating. He needs Dr. Now's help, but with his brother doing everything for him, is he too comfortable to make the trek to Houston?

Shakyia was always chubby, but now she does not leave the house and makes no effort; her older sister rallies her to Houston to meet Dr. Now and lose weight, but she is in for a shock when her mother decides that caring for her is just too much.

Charles replaced one addiction with another when he quit doing hard drugs. Now his BMI is over 100 and he can't stop eating. He needs Dr. Now's help, but with his brother doing everything for him, is he too comfortable to make the trek to Houston?

Shakyia was always chubby, but now she does not leave the house and makes no effort; her older sister rallies her to Houston to meet Dr. Now and lose weight, but she is in for a shock when her mother decides that caring for her is just too much.

William was always mobile and fairly athletic - that is, until he wasn't; it's been years now since a knee injury derailed his sports career, and he's ballooned up over 600 pounds; now, to lose weight he'll have to face up to how bad it's gotten.

When Beverly has weight loss surgery, three cousins are inspired to begin their own weight loss.

Stressed out Naomi struggles with her liquid diet and may reach her breaking point; Drew wants to have the weight loss surgery, but when he steps on a scale he's thrown off entirely; bed-bound Chitoka asks Dr. Procter for a house call.

After struggling with her liquid diet, Naomi learns if she is approved for surgery; Drew's new weigh-in leads him down a slippery path; family tragedy motivates Chitoka to try to become more mobile, starting by trying to leave her bedroom.

Cary's paralyzing obsession with Elvis memorabilia has left his New York City apartment virtually uninhabitable.

Randy is being forced to leave the apartment he has lived in for more than 20 years.

Laura's collection has spiraled into a compulsion; during her clean-up, a house fire ignites.

Milton's compulsion has taken over his life; Louise's unhealthy living conditions are making her cancer prognosis worse.

Getting too hot can be fatal for twins Andrew and Brandon, who meet Josh, a fellow sufferer of Ectodermal Dysplasia.

Tiffany and Yajaira have Jarcho Levin Syndrome, which malformed their ribs and spines during infancy.

Born with Goldenhar Syndrome, Austin and Elena have been bullied for looking different, and feel isolated from other kids.

A couple's long awaited date night leads them to a secluded pasture; a couple with a hidden medical secret; an athletic couple loses their match against the "Kama Sutra.".

A couple's alone time at a pool party gets them busted; a man looking to score medicine; a sticky situation that ends in the emergency room.

Alone time at a spa ends up like a crime scene; a nature lover's odd injury; a realtor and his crush go straight from the bedroom to the ER.

A young couple's trip to the grocery store to spice things up; newlyweds with bad luck; a tryst in the shower sends one pair to the emergency room.