After a lifelong struggle with obesity, the three Perrio siblings travel to Houston in a last-chance journey to lose weight.

While the Perrios struggle with weight loss, the revelation of a past tragedy explains their resistance to recovery; the siblings must come together to overcome their fears and forge a path to a healthy future.

Tanisha weighs around 600-lbs, and she's desperate to survive for her kids and avoid her mother's tragic fate of dying at age 50 from super obesity; now at 32, her future looks grim if she doesn't make a drastic change to save her life.

A teen sleeps for 10 days.

A tumor hides another malady; a marathon runner experiences chronic fatigue.

A woman undergoes a risky craniotomy; a man searches for answers.

A teenager is rushed to the hospital after taking aspirin to help alleviate altitude sickness; a woman has pain in her arm that mysteriously spreads.

A woman and her husband decide to start a family after numerous negative pregnancy tests; a man appears to suffer an embolism.

Dr. Schaeffer has to straighten a woman's serpentine foot to reset her life, as Dr. Vincent gets a drummer's foot back on the beat.

Dr. Ebonie's skills are tested as she attempts to diagnose a patient with feet covered in huge, wart-like masses; Dr. Brad is confronted with a mystery case that could be related to the elephant man as well as a patient with paper-thin skin.

Nate sees Dr. Brad for help with the raging calluses on his feet; Savannah has a rare condition that made her big toe grow to an enormous size and hopes Dr. Ebonie can help; Dr. Brad is determined to uncover the mystery behind John's foot growth.

Troy's extra toe causes him pain, and he hopes Dr. Ebonie can provide him with relief; Dr. Brad does his best to untangle a ballet dancer's twisted feet; Ramon turns to Dr. Ebonie for help with the sacks of fluid hanging from his leg and ankle.

Charmaine from Trinidad suffers from one of the most extreme cases of neurofibromatosis ever recorded; tumors cover every inch of her body and obstruct her ability to breathe and swallow; without surgery, these growing tumors threaten her life.

Thirty-year-old Alexandra has a 20-pound, sagging tumor that starts at the back of her neck and now reaches below her waist; as the tumor on Claudia's backside continues to grow, so does the urgency for surgeons to remove it.

Despite his family's pleas, Marlow explores a high-risk surgery to remove a facial tumor; Amy has let the tumor on her back grow for more than 17 years; after finally making the decision to remove it, she learns that now it might be too late.

The bulbous tumor growing from Jennifer's stomach threatens her relationship with her long-time boyfriend; fifteen-year-old Marcelo travels from Angola to Los Angeles to have a massive neck tumor removed, but the operation may be too risky.

Louise's skin condition has taken over her life, now she desperately needs help; the cysts, blackheads and acne on 43-year-old Scott's back are ruining his life.

24-year-old Elise visits Dr. Emma in a last-ditch attempt to fix her excruciatingly painful skin condition. Plus, Gary wants a lump on the back of his head removed.

Rachael's body is covered in hundreds of lumps and bumps and maybe Dr. Emma can help her live a more normal life; John seeks surgery for his nose, which has become big and bulbous.

Gavin visits Dr. Emma about the smelly blisters in his armpits and groin; Abi suffers from severe acne, but has a fear of needles and swallowing tablets.

20-year-old Mariah visits Dr Emma about her severe acne; Jonathan has around 40 fatty lumps under his skin; young mom Holly worries she has two extra nipples.

24-year-old Elise visits Dr. Emma in a last-ditch attempt to fix her excruciatingly painful skin condition. Plus, Gary wants a lump on the back of his head removed.

Rachael's body is covered in hundreds of lumps and bumps and maybe Dr. Emma can help her live a more normal life; John seeks surgery for his nose, which has become big and bulbous.

Gavin visits Dr. Emma about the smelly blisters in his armpits and groin; Abi suffers from severe acne, but has a fear of needles and swallowing tablets.

20-year-old Mariah visits Dr Emma about her severe acne; Jonathan has around 40 fatty lumps under his skin; young mom Holly worries she has two extra nipples.

The bulbous tumor growing from Jennifer's stomach threatens her relationship with her long-time boyfriend; fifteen-year-old Marcelo travels from Angola to Los Angeles to have a massive neck tumor removed, but the operation may be too risky.

Louise's skin condition has taken over her life, now she desperately needs help; the cysts, blackheads and acne on 43-year-old Scott's back are ruining his life.

Most of the extreme weight on Tracey's body resides in her shockingly misshapen legs, which are massive with severe lymphedema, and gastric surgery is her only chance of survival; Brenda and Melissa prepare for skin removal surgery.

Christina has not left her house in two years due to her size; she has eaten herself into a state that will soon kill her if she does not change.

Paula has built a wall around herself to push people away; when she suddenly loses a loved one she can no longer ignore the threat of losing her own life.

Steven Assanti weighs nearly 800 pounds and his brother Justin almost 600 pounds, and although they can't stand each other, their father packs up the family to travel across the country and seek help.

After a year on a weight loss program, Steven remains completely non-compliant and Justin focuses on a new career instead of his diet, but time is quickly running out for surgery.

After meeting and falling in love at a bariatric rehab center, Lee and Rena are battling health and anger issues while taking a desperate, second attempt to save their relationship and their lives.

A woman whose extreme obesity has left her nearly immobile must overcome both her physical and emotional pain if she is ever to live a normal life again.

Alicia, all smiles and laughter on the outside, secretly fears that her food addiction will kill her before she can marry her long-time love or watch her nieces grow up.

Wess gets off to a great start in Dr. Now's program, but when the cravings continue after surgery, Dr. Now sends him to therapy to confront his demons; Wess must ask himself whether he is ready to live his truth as a gay man in small-town Texas.

Syreeta thinks that anyone trying to help has an ulterior motive, but she's gotten so big she desperately needs help; she's learning to let down her guard for her husband, but weight-loss surgery will be tough if she can't learn to trust the surgeon.

Wess gets off to a great start in Dr. Now's program, but when the cravings continue after surgery, Dr. Now sends him to therapy to confront his demons; Wess must ask himself whether he is ready to live his truth as a gay man in small-town Texas.

Syreeta thinks that anyone trying to help has an ulterior motive, but she's gotten so big she desperately needs help; she's learning to let down her guard for her husband, but weight-loss surgery will be tough if she can't learn to trust the surgeon.

Alicia, all smiles and laughter on the outside, secretly fears that her food addiction will kill her before she can marry her long-time love or watch her nieces grow up.

Gabriel has a huge growth on his clavicle but is terrified of surgery; Karen has dealt with painful, scaly feet for 22 years with no diagnosis; Lorne has embarrassing tumors on his face and body and believes this is why he hasn't met the one yet.

Rhonda has bumps all over her head, including a horned growth that has her deeply concerned; Fred has a mysterious condition on his hands and has not been able to get answers from any doctors; Kevin has a huge lump protruding from his hip.

Jen has substantial growths on her ears that cause her depression, pain and vertigo; Juliet is under emotional distress because of the bumps all over her neck and chest; Gerald has a mysterious, kiwi-size lump on his middle finger.

Gerald is back to see Dr. Lee and a hand specialist about a huge, intrusive bump on his middle finger; Vinnie has a large, embarrassing birthmark on his neck; Leta has a lump on the back of her thigh that she has been hiding from her fiancée.

Tony has large growths on his nose that impair his breathing; Kevin has a bump in his jawline that is a lady deterrent; Marie has an unsightly lump on her forehead that makes her a hermit; Tommy's leg bump makes it difficult for him to work.

Gerard has nearly a hundred lumps varying in size all over his body; Gina has bloody lesions all over; Eric has a large bump on his head that he calls his on and off button.

Traci's confidence has been destroyed after years of bullying from the bumps on her face; Ravon has a unique dangling growth on his leg; David has a large lump.

David is back to see Dr. Lee after she spots a suspicious growth under his eye; Nicole is depressed because of the bumps all over her neck; Steve has a noticeable lump on his forehead; Allen has a growth on his biceps but is terrified of doctors.

Tim has a massive growth on his back that affects his ability to work and socialize; Daniel has debilitating psoriasis that covers most of his body; Gloriana and Yolanda are a mother and daughter duo who have bonded over their bumps.

Inoke has a huge, possibly life-threatening bulge on his shoulder; Delano returns with his back lump after Dr. Lee removed a liter of fluid from it; Reed has hundreds of bumps on his chest that burst and leave nasty scars.

With pandemic safety protocols in place, Dr. Lee reopens her office; Monica has a large birthmark growing on the side of her face; Jackie has a melon-sized lump on the back of her shoulder; Reginald has large, rare growths on the back of his head.

Dr. Lee tries to provide the help Reginald needs to remove the large, rare growths on the back of his head; Che're has a prominent bump on her face that has put her in a dark place; Juan has several painful boils on the back of his neck.

Dennis has several giant growths on the back of his head; Juan has a rare condition he hopes Dr. Lee will understand; Natalie searches for answers as to why her body is covered in hundreds of mysterious dark bumps.

Audrey pops the painful bumps that cover her body so she can feel relief; Felicia has a peculiar-looking dark growth on her forehead; Krista's excessive sweating is so severe that on any given day she could fill up an entire milk jug with her sweat.

John fears the large lump on his neck could become so big that it may eventually suffocate him; Shoshana is depressed because of the big growth on her forehead; Ashley hopes Dr. Lee can provide some relief from her three painful skin conditions.

Yaellie, 9, has itchy psoriasis on over 90 percent of her body; former U.S. Marine Matt has a large recurring lump in his armpit; twins Tracie and Stacie have numerous matching bumps on their heads that sometimes leak.

Joanne has been held back from success because of her forehead growth; Shakisha split her left earlobe after stretching it with gauges; Mike is a tough guy with a soft bump on his head; Dania's rhinophyma has kept her from enjoying her life.

James has a large, squishy lump on his forehead; Tanisha has a growth on her arm and itchy scars all over her body; Ed wants his stomach lump removed before his girlfriend gets out of prison; Justin has painful mystery bumps all over his head.

John fears the large lump on his neck could become so big that it may eventually suffocate him; Shoshana is depressed because of the big growth on her forehead; Ashley hopes Dr. Lee can provide some relief from her three painful skin conditions.

Yaellie, 9, has itchy psoriasis on over 90 percent of her body; former U.S. Marine Matt has a large recurring lump in his armpit; twins Tracie and Stacie have numerous matching bumps on their heads that sometimes leak.

Joanne has been held back from success because of her forehead growth; Shakisha split her left earlobe after stretching it with gauges; Mike is a tough guy with a soft bump on his head; Dania's rhinophyma has kept her from enjoying her life.

James has a large, squishy lump on his forehead; Tanisha has a growth on her arm and itchy scars all over her body; Ed wants his stomach lump removed before his girlfriend gets out of prison; Justin has painful mystery bumps all over his head.

Dennis has several giant growths on the back of his head; Juan has a rare condition he hopes Dr. Lee will understand; Natalie searches for answers as to why her body is covered in hundreds of mysterious dark bumps.

Audrey pops the painful bumps that cover her body so she can feel relief; Felicia has a peculiar-looking dark growth on her forehead; Krista's excessive sweating is so severe that on any given day she could fill up an entire milk jug with her sweat.

A woman calls 911 after being locked inside her own vehicle; a man has too much fun in a pool.

A mom calls after a fast food restaurant makes her food wrong; a man needs help getting out of handcuffs.

Lisa helps a man yearning to discover his biological roots, but fearful of rejection from the family he has never met; Chris reveals the truth to a woman who has felt guilty that her birth might have devastated the life of her 14-year-old mom.

A tough Texas lawman seeks Lisa's help to tackle the one investigation he's never been able to solve: the story of his own birth and adoption.

Chris tries to unravel a legal mystery involving a woman's sister who she last saw across a New York courtroom 30 years ago.

A Vietnam vet hopes Lisa can help him make amends for the past by locating the daughter he lost custody of forty years ago; a woman's struggle to fit in takes a surprising turn when Chris reveals a series of stunning coincidences very close to home.

The recent revelation of a 49-year-old man's adoption sends Chris searching for answers to a secret his adoptive parents took to the grave; a biracial woman enlists Lisa's help to find her birth family, revealing some unfortunate tragedies.

Pat and Joe have an extreme collection of infamous kid dolls; Kitty Kay Sera is obsessed with the color pink.

A woman collects Mickey Mouse memorabilia; a collection of more than 2,000 wigs.

Bob and Lizzie love to flaunt their collection of love dolls around town; Everything about Doris is from 1950.

Frances and Bob have transformed their entire home into a feline fantasy land; Ron has built a replica of the Oval Office in his home.

Stanley has been obsessed with being an adult baby for the past 18 years;.

Over 300 mannequins have taken over Chad Michael's house; Zizi is obsessed with carrots, from tattoos to decorating every room in her house with them.

Megan is a 33-year-old alcoholic with social anxiety and a troubled past.

Phil is a 58-year-old meth user whose addiction spans over three decades.

Theresa is a homeless alcoholic whose addiction puts her life at risk.

Phyllis and Patty aren't just identical twins, they are identical hoarders as well.

Lalie and her children suffer from mold, mice and flea infestations due to their upstairs neighbor and landlord, Denise, who is a massive hoarder.

Beverly's clutter has filled up her entire home and her three beloved dogs have helped make the space completely unlivable.

Terry and Bill seem to be the perfect couple; the murder of her daughter has led Nancy to hoard.

Property investors purchase a house that is occupied by a hoarder; rat infestation compromises the building's foundation.

Lalie and her children suffer from mold, mice and flea infestations due to their upstairs neighbor and landlord, Denise, who is a massive hoarder.

Beverly's clutter has filled up her entire home and her three beloved dogs have helped make the space completely unlivable.

Terry and Bill seem to be the perfect couple; the murder of her daughter has led Nancy to hoard.

Property investors purchase a house that is occupied by a hoarder; rat infestation compromises the building's foundation.

Theresa is a homeless alcoholic whose addiction puts her life at risk.

Phyllis and Patty aren't just identical twins, they are identical hoarders as well.

Liz, completely bed-bound, has severe lymphedema that makes it impossible to walk; utterly isolated, Liz has no friends, battles depression and lives with a mother too ill to take care of her.

James comes from a long line of family obesity; he is determined not to die as his sister and father did; he hopes to get gastric bypass and even start dating again.

A mother of two who is too ashamed of her size to be seen with her children; she is committed to regaining her confidence and being a proud mother.

Unable to stand for more than a short period of time, Karina's weight places a burden on her parents and drives a wedge between her and her sister.

Lisa's struggle with her weight begins as a child and significantly worsens after witnessing her brother's murder; now bedridden and unable to care for herself, Lisa must find a way to lose the weight, or she will never see her grandchildren grow up.

After years of a tumultuous relationship with her husband, Tamy's eating addiction has caused her weight to balloon to over 500 pounds; she has become a hermit and hopes to restart her life so she can better care for her son, Zachary.

Fearing he'll suffer the same fate as 700-pound brother David, Benji hopes to be able to support both himself and his brother on their life-or-death weight loss journey.

Former plus-size model and advocate Renee realizes the mortal mistakes she has made as her weight swells to 600 pounds and her health crumbles.

Mark sets out with a goal for weight-loss surgery, but as weight loss gets easier, he turns down medical advice and decides to do it on his own; Mark thinks he can lose 500 pounds by himself, but Dr. Now sees this as another excuse not to change.

With her weight spiraling, Stephanie needs her mom's help to care for her three kids; she's at the point where she'll have to lose weight or risk not having the chance to see her kids grow up.

Mark sets out with a goal for weight-loss surgery, but as weight loss gets easier, he turns down medical advice and decides to do it on his own; Mark thinks he can lose 500 pounds by himself, but Dr. Now sees this as another excuse not to change.

With her weight spiraling, Stephanie needs her mom's help to care for her three kids; she's at the point where she'll have to lose weight or risk not having the chance to see her kids grow up.

Former plus-size model and advocate Renee realizes the mortal mistakes she has made as her weight swells to 600 pounds and her health crumbles.

A knee injury leaves Lindsay addicted to painkillers.

A 22-year-old heroin addict has been a substance abuser since elementary school.

Josh is a 37-year-old meth addict; his addiction began at age 15.

A 20-year meth addict's addiction worsens after the sudden death of his father.

A man has an upside-down head; a girl's face tumor; triplets undergo surgery; a man with misshapen tumors and giant-sized limbs; a man who eats but can't gain any weight.

A man loses his face to cancer; a baby born with a parasitic tumor; a girl's feet won't stop growing; a boy's face melts away.

In Thailand, a woman has the world's largest hands; an Ethiopian girl has a life-threatening neck tumor; 4-year-old conjoined twins risk surgery; a young woman has a body affected by vitiligo; in Spain, a woman's face is blistering away.

A Brazilian man with an elephant leg; a man is scared stiff; a Thai man could be the tallest man in the world; a child born with an unknown condition; a toddler is covered in hair.

A woman embraces her facial hair; a man is born with three legs; a woman covered in bubble shaped growths.

A gunman opens fire outside a strip club; a street performer's magic trick goes horribly wrong; BMX superstar T.J. Lavin's routine jump has a shocking outcome.

A maintenance worker falls from an iconic hotel sign; a rat bite has horrifying implications for its trainer and a plane crashes on a residential street.

A shootout leaves a police officer clinging to life; a cowboy and cupid help a she-devil in distress; a zip-line guide falls 80 feet to the canyon floor.

Doctors retrieve a stolen Rolex from a very private spot; a pick-up turns deadly when a cabbie is shot multiple times; a dirt-bike accident in the desert leaves a 52-year-old thrill-seeker clinging to life.

Fall from a ladder; young car-crash victims.

Gunshot victims; homeless children with colds; seizure; stroke victim.

A family of three and the drunk driver who hit them; burn victim; crash victim; baby with sickle-cell anemia.

Car-crash victims; smoker fights for breath; uncooperative patient.

Horseback-riding accident; broken wrist; crash victims.

Gunshot victims; homeless children with colds; seizure; stroke victim.

A family of three and the drunk driver who hit them; burn victim; crash victim; baby with sickle-cell anemia.

Car-crash victims; smoker fights for breath; uncooperative patient.

Horseback-riding accident; broken wrist; crash victims.

Doctors retrieve a stolen Rolex from a very private spot; a pick-up turns deadly when a cabbie is shot multiple times; a dirt-bike accident in the desert leaves a 52-year-old thrill-seeker clinging to life.

Fall from a ladder; young car-crash victims.

Jennifer and her daughter Marissa are stuck in a co-dependent relationship and, with a combined weight of over 900-lbs., both of their lives are in jeopardy; Jennifer must regain control and save both of their lives before it is too late.

Amber is 23, over 600-lbs, and relies on her family and boyfriend for even simple needs; her fear of dying young is so overwhelming that she decides to relocate 2,000 miles in hopes that weight loss surgery will give her life back.

Susan, 37-year-old woman, has never lived on her own because of her weight, is finally seeking help to get out on her own.

Devastated by two miscarriages due to her weight, Schenee is desperate to start a family and stop relying on her husband, Freddie, to take care of her; she hopes weight loss surgery will be able to fix her fertility issues as well as her marriage.

After a difficult childhood with an abusive stepfather and drug-addicted mother, Sarah is fighting for her life at only 24 years old.

With the support of his fiancée, Kathryn, Robert turns to Dr. Nowzaradan in a final, desperate attempt to save his life; he tries to reverse a lifelong food addiction that has left him bed-bound, saddled with grotesque lymphedema, and nearly 900-lbs.

At over 700 pounds, Brianne undertakes a weight-loss journey to save her own life; she faces an unexpected challenge to her fragile progress when her husband suffers a heart attack on a birthday she will never forget.

Octavia has been bedbound for nearly a year when she decides to make the trip to Houston to get help from Dr. Now, but when it turns out that her best friend is also her worst enabler, Octavia will have to choose between old habits and a new life.

Nothing means more to Chris than his relationship with his daughter, Zoey, but now he feels he is failing her as his weight gain begins to limit his mobility.

Patrick's weight has never been a bother, but now he's so big that it's getting in the way of his relationship with his daughter; if he wants to see her graduate high school, he'll have to reverse course.

Nothing means more to Chris than his relationship with his daughter, Zoey, but now he feels he is failing her as his weight gain begins to limit his mobility.

Patrick's weight has never been a bother, but now he's so big that it's getting in the way of his relationship with his daughter; if he wants to see her graduate high school, he'll have to reverse course.

Octavia has been bedbound for nearly a year when she decides to make the trip to Houston to get help from Dr. Now, but when it turns out that her best friend is also her worst enabler, Octavia will have to choose between old habits and a new life.

Dr. Meegan Gruber specializes in performing surgery while patients are completely awake; Derrick orders lunch while getting his "man boobs" removed; Genny has a request to get rid of both of her chins; Megan needs surgery to fix her "ball sack arms."

Dr. Meegan Gruber faces the most daunting awake surgery of her career: removing a giant hanging stomach; Jason looks for a butt lift to help him scandalize all of Kentucky; a patient calls her psychic mid-surgery.

Mother of eight Rubi stuns Dr. Meegan Gruber when she arrives with a hip condition unlike anything the doctor has ever seen; Ashley asks to have her bat wings clipped; Jim seeks a solution for a giant neck that's swallowing his jawline.

A woman is impaled on an iron spike; a man spears his friend on a fishing trip; an elderly gardener's shears are lodged in his eye.

A man is impaled on a fence post; a farmer has an object lodged in his brain; a woman is skewered on a hooked pole when she feeds the birds.

A woman gets a Christmas tree imbedded in her neck; a boy out fishing almost chokes on a barb; a man is filled with enough air to fill 1000 balloons; learn how they survived.

A circus sword-swallower suffers from a persistent case of hiccups; a mother and daughter mysteriously collapse in the ER; a woman loses control of her legs at her daughter's graduation.

An ER doctor's friend arrives at the hospital combative and out of control; a cyclist's throat is torn open when a driver opens a car door in her path; a nursing student is found passed out on the hospital floor.

A young girl is mysteriously paralyzed from the waist down; a young man complains of a splitting headache; a bride-to-be has appendicitis on her wedding day.

A mother and son suffer with the same rare genetic condition, causing them constant pain; surgery to remove a toe could be the only answer for one of them.

Podiatrist Marion solves the mystery of Jonathan's twisted toes, gets marathon runner Robert's feet fit for his next race and helps a drag queen back into heels.

Marion solves the mystery of the V-shaped gap in Debra's toes; she has a surprising treatment for a psoriasis patient to stop the itch.

Marion and Kenny wage war on beastly bunions; they combat stubborn verrucae, persistent calluses and fungal nails that have outstayed their welcome.

Sharon's smelly feet make her and her husband's lives a misery; however, strange smells, verrucae and hooked toes are all in a day's work for Marion.

When faced with treating a man whose cheek is about to pop due to a 4lb tumor, Dr. Panossian worries it could become a deadly situation; a woman whose lower lip won't stop growing turns to Dr. Rovelo for help.

Dr. Roostaeian wants to help a young woman living with the largest birthmark he's ever seen, however, surgery could be life-threatening; after being hit by a drunk driver, Dr. Rovelo's patient hasn't been able to close his mouth.

Dr. Panossian and Dr. Rovelo join forces to remove a tumor that has wrapped around a man's head; a woman hopes Dr. Rovelo can remove her mouthy birthmark.

Dr. Roostaeian and Dr. Panossian encounter one of the challenging cases of their career when they meet a young man with two faces; Dr. Rovelo treats one of the first monkeypox cases in Los Angeles.

When faced with treating a man whose cheek is about to pop due to a 4lb tumor, Dr. Panossian worries it could become a deadly situation; a woman whose lower lip won't stop growing turns to Dr. Rovelo for help.

Dr. Roostaeian wants to help a young woman living with the largest birthmark he's ever seen, however, surgery could be life-threatening; after being hit by a drunk driver, Dr. Rovelo's patient hasn't been able to close his mouth.

Dr. Panossian and Dr. Rovelo join forces to remove a tumor that has wrapped around a man's head; a woman hopes Dr. Rovelo can remove her mouthy birthmark.

Dr. Roostaeian and Dr. Panossian encounter one of the challenging cases of their career when they meet a young man with two faces; Dr. Rovelo treats one of the first monkeypox cases in Los Angeles.

Marion and Kenny wage war on beastly bunions; they combat stubborn verrucae, persistent calluses and fungal nails that have outstayed their welcome.

Sharon's smelly feet make her and her husband's lives a misery; however, strange smells, verrucae and hooked toes are all in a day's work for Marion.

Pauline must keep her weight loss on track after a medical emergency; Chay admits to being a transgender woman, and the resulting stress may threaten her weight loss journey.

Melissa, mother of four, finds herself feeling overwhelmed due to a rocky marriage and an unexpected pregnancy; when Ashley's weight-loss journey hits a wall, she sets out to find new inspiration to get herself back on track.

Christina's weight loss threatens her life; after losing 300 pounds, Paula must endure more surgery to deal with a body entirely covered in loose and sagging skin.

Once 800lbs, housebound and alone, Joe is now engaged and planning a wedding; after losing over 300lbs, Pauline is on the verge of independence if only she can qualify for the skin surgery she needs so badly.

Surgery enabled Laura's independence, but the complications nearly killed her, and she's terrified about the next skin surgery; Chay revealed to her family she was transgender, but living life as an overweight woman.

A number of challenges seem to have cornered Betti Jo and her husband; Susan encounters a serious problem that can throw everything off track.

Over 11 years, Melissa has lost 500 pounds and saw her weight drop to 137 pounds; now facing marital problems, three pregnancies, and life as a single mom, Melissa is struggling with a 150-pound weight gain and finds herself at a crossroads.

Steven Assanti weighs nearly 800 pounds and his brother Justin almost 600 pounds, and although they can't stand each other, their father packs up the family to travel across the country and seek help.

After successful sleeve gastrectomy procedures, the Dreier twins collectively lose more than 400 pounds and work toward skin surgeries when a major life event disrupts their world and threatens their progress.

Erica must return to California to continue her weight-loss journey, but she fears past emotional trauma will derail her progress.

After successful sleeve gastrectomy procedures, the Dreier twins collectively lose more than 400 pounds and work toward skin surgeries when a major life event disrupts their world and threatens their progress.

Erica must return to California to continue her weight-loss journey, but she fears past emotional trauma will derail her progress.

Steven Assanti weighs nearly 800 pounds and his brother Justin almost 600 pounds, and although they can't stand each other, their father packs up the family to travel across the country and seek help.

JD is a gentle giant with a pear-shaped mass hanging off of his ear; David has two bumps on his neck and one on his finger that give him pain; Julie hopes Dr. Lee can remove her large back growth so she can return to the sea.

Stephen's large, bulbous nose gets him unwanted attention, and he hopes Dr. Lee can help; Veronica wants to be free of secrets, including the bump on her butt; Marty has a large, 30-year-old growth on his shoulder that he is ready to remove.

Brittany has been called a monster due to her genetic condition that causes head-to-toe bumps; Leonardo has a fist-size growth on his head, but he is terrified of doctors; Tamyra has skin so thick that she shaves the bottom of her feet for relief.

Jaclyn has a lump on the back of her head that causes her emotional distress; Shane has a growth between his eyes that could put him in danger at his electrician job; Brittany has seen multiple doctors about the sores on her body with no answers.

Stacey's shoulder growth prevents her from being the playful teacher she once was; Matthew worries that his mysterious shin rash may be dangerous.

Lattyse was born with a mysterious growth above her eyebrow that gives her headaches. Robert has a tomato-sized growth on his butt cheek that causes him pain and discomfort. Sharon has an embarrassing, stinky, squirting cyst under her breast.

Keke is covered in bumps that make her embarrassed to be intimate with her husband; Jim is a widower with two lumps who wants them removed for himself and his late wife; Corey has been labeled a devil worshiper because of his forehead growth.

Monica returns for a second time in hopes that Dr. Lee can remove some more of her face growths; Ken has several large cysts on his head that he has tried to remove on his own; Maranda has a mystery skin sore that causes discomfort.

Corey is a drag queen and has a bump dangling from his booty; Adam has a semicircle of about a dozen cysts on his head that he covers with a hat; Virginia has large growths on both of her upper arms that make it difficult to travel in her RV.

Terry's nose growth has prevented him from meeting his grandkids; Remi has alligator-like skin and is not used to taking care of herself; Austin has an embarrassing birthmark right next to his eyelid; Mary Jo has a throbbing bump on her neck.

Roger has enormous growths on his nose that drip pus, attract flies, and are so large that he can barely breathe; Sandra and Jessie are sisters who bonded over their many undiagnosed face bumps.

With lumpy lipomas and cysts-a-plenty, Dr. Lee and her staff will have their hands full during one of their busiest days of the year.

Roger returns with his gigantic nose growths in the hope that Dr. Lee and her colleagues can help before it's too late; Christine has lost her essence due to a large growth on her shoulder; Tiffany has a recurring cyst on her eyelid.

Ruben is a personal trainer whose head growth has prevented him from seeing clients; Kaitlin has blue marks and scars up and down her arms due to long-term drug use; Adrian was left with a disfiguring bump on her behind after falling down stairs.