A patient gets drunk to save his life; a patient is stiff after a fall; a patient tasered by the police; a boy impaled by a bottle rocket in the neck.

A wrist fracture turns into a medical mystery; two fishermen get stuck on the same lure; a cheerleader with a sprained finger nearly dies of an unexpected cause; a power outage foils the ER team's effort to get a dying patient to the O.R.

A teen football player suffers a stroke; a doctor remembers his first major trauma in the 1970s; a doctor tries to figure out what causes a patient's abdominal pain.

Ryan moved to Montana to keep himself from going down a dark path of drug addiction but his new path may be no less lethal than the last if he can't find a way to curb his eating habits before they kill him.

An 800-pound man who lost his job and is mostly housebound looks to find the strength to face his past and save his own life.

Joe made a drastic turn from being suicidal and is now ready for marriage, but the reality of more weight loss could stop him from achieving his dream.

After a difficult childhood with an abusive stepfather and drug-addicted mother, Sarah is fighting for her life at only 24 years old.

Maja moves to Houston to undertake a difficult weight-loss journey with the support of her boyfriend, Christian; when Christian decides he's had enough and leaves Maja high and dry, she discovers that the only person she can count on is herself.

Maja cannot be allowed to undergo bariatric surgery unless she quits emotional eating. However, it seems like Justin may end up making Dr. Now proud.

At over 700 pounds, Brianne undertakes a weight-loss journey to save her own life; she faces an unexpected challenge to her fragile progress when her husband suffers a heart attack on a birthday she will never forget.

When Annjeanette was nine, a campaign was established to send her to fat camp; she hated that her weight had become a source of public shame and she has struggled to overcome her food addiction; now, she must change her habits to save her life.

There is much to be gained and lost for Brianne in year two of her journey, in which she both loses weight and gains independence; getting back with Erica becomes the top priority for Annjeanette, who chooses love over even her own health.

Nothing means more to Chris than his relationship with his daughter, Zoey, but now he feels he is failing her as his weight gain begins to limit his mobility.

There is much to be gained and lost for Brianne in year two of her journey, in which she both loses weight and gains independence; getting back with Erica becomes the top priority for Annjeanette, who chooses love over even her own health.

Nothing means more to Chris than his relationship with his daughter, Zoey, but now he feels he is failing her as his weight gain begins to limit his mobility.

When Annjeanette was nine, a campaign was established to send her to fat camp; she hated that her weight had become a source of public shame and she has struggled to overcome her food addiction; now, she must change her habits to save her life.

Gastric surgery freed Brittani from her housebound life, but to achieve her ideal body she'll have to endure two more painful surgeries; Sean's super-obesity nearly killed him.

Randy's food addiction dissolved his marriage and keeps him from seeing his daughter, so he endures a rigorous pre-surgery diet surrounded by fast-food temptations to regain control of his life.

Brittani married a man who loves large women, but at 600-lbs, she can barely contribute to their marriage, and gets surgery to try to have a normal relationship.

Robin and her brother Chris are both obese and already lost a sibling to obesity; they plan to visit Dr. Now together when Chris suffers a stroke and can't go; Chris' son Garrett, already 600 pounds at age 20, is game to join the journey.

Robin and Garrett started their weight-loss journeys together as aunt and nephew; almost four years later, they're like war buddies, striving to reach their target weights through a combination of shedding pounds and skin removal surgeries.

Through tough times, food has always been Tammy's friend; now she has gotten so big that her daughters and mother have moved home to care for her, and unless Dr. Now can get her to confront her grief, food might be her killer.

Mike was born with a talent for sports and an omnivorous appetite to match; after his football dreams were dashed by multiple concussions, Mike packed on over 700 pounds, now he must find a new purpose in life to avoid succumbing to pain and regret.

Devastated by two miscarriages due to her weight, Schenee is desperate to start a family and stop relying on her husband, Freddie, to take care of her; she hopes weight loss surgery will be able to fix her fertility issues as well as her marriage.

Mark sets out with a goal for weight-loss surgery, but as weight loss gets easier, he turns down medical advice and decides to do it on his own; Mark thinks he can lose 500 pounds by himself, but Dr. Now sees this as another excuse not to change.

Shannon's husband loves her the way she is, but that may not help because she's 700 pounds and bedridden; Dr. Now knows it's not easy to break a toxic cycle of overfeeding and enabling, but that's what needs to happen if Shannon wants to live.

Mark sets out with a goal for weight-loss surgery, but as weight loss gets easier, he turns down medical advice and decides to do it on his own; Mark thinks he can lose 500 pounds by himself, but Dr. Now sees this as another excuse not to change.

Shannon's husband loves her the way she is, but that may not help because she's 700 pounds and bedridden; Dr. Now knows it's not easy to break a toxic cycle of overfeeding and enabling, but that's what needs to happen if Shannon wants to live.

Devastated by two miscarriages due to her weight, Schenee is desperate to start a family and stop relying on her husband, Freddie, to take care of her; she hopes weight loss surgery will be able to fix her fertility issues as well as her marriage.

For Milla Clark, after three years and five surgeries, success would mean beating the odds and becoming one of Dr. Nowzaradan's most impressive weight-loss patients, but failure would mean slipping back to the bedbound life.

A mother of two who is too ashamed of her size to be seen with her children; she is committed to regaining her confidence and being a proud mother.

Milla is bedridden and dependent on her husband and five kids, who can't resist her unending requests for junk food.

Thederick has become housebound from eating and only goes outside to greet the ice cream man; after a recent hospital scare, it's finally clicked that if Dr. Now's program doesn't work for him, then nothing will.

Tanisha weighs around 600-lbs and she's desperate to survive for her kids and avoid her mother's tragic fate of dying at age 50 from super obesity; now at 32, her future looks grim if she doesn't make a drastic change to save her life.

Seana is 23 and nearly 700 lbs, living at her mom's house, depressed and anxious, her weight-gain threatening to take her last breath; Dr. Now can give her the tools she needs to live, but until she chooses life, no one can save Seana but herself.

Mercedes, who has severe lymphedema, must overcome trauma to lose weight.

Lacey ballooned up over 600 lbs on pizza and ice cream and knows Dr. Now is her best hope for success; she must now rally her divorced parents around her for support and find a way to modulate her moods that won't include binge-eating.

Lacey wants skin removal surgery, but Dr. Now begins to wonder if she even wants to lose weight; in Houston, Mercedes and her kids face destitution.

Nothing means more to Chris than his relationship with his daughter, Zoey, but now he feels he is failing her as his weight gain begins to limit his mobility.

Lacey wants skin removal surgery, but Dr. Now begins to wonder if she even wants to lose weight; in Houston, Mercedes and her kids face destitution.

Nothing means more to Chris than his relationship with his daughter, Zoey, but now he feels he is failing her as his weight gain begins to limit his mobility.

Lacey ballooned up over 600 lbs on pizza and ice cream and knows Dr. Now is her best hope for success; she must now rally her divorced parents around her for support and find a way to modulate her moods that won't include binge-eating.

The family anxiously wait while Drew undergoes surgery; Chitoka surprises even the doctor when she pushes herself further than ever before; things take an unexpected turn when Naomi and her boyfriend go on their first dinner date after surgery.

After years of being bedridden, Chitoka's surgery day is finally here, but her size makes the procedure extremely dangerous; Naomi shares a secret with her friends; the cousins reveal their startling transformations at Beverly's birthday party.

A year after the Anderson family started their weight loss journey, they find that the honeymoon period is over as they begin to struggle; their 600-pound cousin Shavonne wants to follow in their footsteps.

Shavonne calls out the family for not losing weight; Naomi gets devastating news that might derail her goals for good; Drew attempts to re-enter the dating world for the first time in a decade; Chitoka tries to get back on track.

The members of the Anderson family work through their issues in group therapy; Chitoka and Shavonne face the painful memories that have kept them from losing more weight.

Shavonne undergoes high-risk bariatric surgery; Chitoka struggles to lose enough weight to be approved for skin tightening surgery; Drew works up the courage to go on another date; the family throws a party for Shavonne to reveal her weight loss.

A boy has infrequent bowel movements; a bodybuilder discovers a painful lump in her jaw.

A baby develops a bulging forehead and eye color changes; a teen suffers hand pain during swim practice.

A young woman experiences fainting spells after a car accident; an 11-year-old suffers a terrible headache.

A woman experiences dizzy spells after a vacation; a woman suffers stomach pain and bizarre swelling.

Student experiences crippling pain in his lower back; an adopted child has a lump on her shoulder.

An infant screams in the pool; a mother is struck by a series of headaches.

Louise and her lavish hoarding could end up on the street.

A woman has been sent to jail four times for her hoarding; people purchase a house.

As the lead singer for a rock bands, Kelly Jay has lived quite a life and he has collected a massive hoard to prove it; with his family ready to call it quits, Kelly must choose between his clutter and the people he loves.

Phyllis and Patty aren't just identical twins, they are identical hoarders as well.

Lalie and her children suffer from mold, mice and flea infestations due to their upstairs neighbor and landlord, Denise, who is a massive hoarder.

Beverly's clutter has filled up her entire home and her three beloved dogs have helped make the space completely unlivable.

As the lead singer for a rock bands, Kelly Jay has lived quite a life and he has collected a massive hoard to prove it; with his family ready to call it quits, Kelly must choose between his clutter and the people he loves.

Phyllis and Patty aren't just identical twins, they are identical hoarders as well.

Lalie and her children suffer from mold, mice and flea infestations due to their upstairs neighbor and landlord, Denise, who is a massive hoarder.

Beverly's clutter has filled up her entire home and her three beloved dogs have helped make the space completely unlivable.

Louise and her lavish hoarding could end up on the street.

A woman has been sent to jail four times for her hoarding; people purchase a house.

A man has an upside-down head; a girl's face tumor; triplets undergo surgery; a man with misshapen tumors and giant-sized limbs; a man who eats but can't gain any weight.

A man with branch like growths covering his hands and feet seeks treatment; a woman's muscles are slowly turning to bone; two brothers with tumors covering their bodies undergo surgery.

A farmer's arm gets stuck in a corn picker; a woman's home project turns into a nightmare as doctors try to save her life; a young man's life changes in an instant on a California beach.

A mom sends a text while driving and wakes up with a guardrail through her car; young woman partying falls off a boat into a spinning propeller;a professional sword swallower nearly makes the ultimate sacrifice.

A boulder falls on a woman rock climbing; a California woman falls on her bag of knitting needles; an adrenaline junkie nearly ends his thrill-seeking life attempting to break a speed record.

Truck mechanic Bruce is crushed by a truck; high school student Hannah joins her friends on top of a car to go "car surfing.".

A patient fights for his life after a four-story fall; a 12-year-old boy is hit by a car and injures his foot.

A heart attack victim is brought back to life; a mother and her newborn survive a horrific crash; a 65-year-old man falls two floors down an elevator shaft.

A newborn with a potentially life-threatening infection; the victim of a gang-related attack; a patient who has survived a bullet passing through all of his vital organs.

A man falls five stories; a shopkeeper is shot in the head at point-blank range; a woman accidentally drinks a bottle of cleaning fluid.

A man wounded in a drive-by shooting; a patient with flesh-eating bacteria; a woman hit by a car.

Two brothers arrive at the ER after being crushed by a falling building; a victim of a gang-related incident; a patient who fell 40 feet.

An infant has an eye problem; a young girl is unusually sweaty.

Parents notice their 7-month-old son has troubling physical impairments; a woman traveling the world starts experiencing unusual back pain and tingling in her feet.

A young child does not respond to pain; a woman experiences unexplained seizures.

A teenager's hair begins to fall out.

Baby Samantha has surgery to remove congenital cataracts that could lead to blindness; as the months pass, Samantha is unable to roll, crawl or talk, and her head is unusually small for her age; her parents seek help.

A baby's gaze is fixed on the ceiling; a woman's bruise will not disappear.

A young child does not respond to pain; a woman experiences unexplained seizures.

A teenager's hair begins to fall out.

Baby Samantha has surgery to remove congenital cataracts that could lead to blindness; as the months pass, Samantha is unable to roll, crawl or talk, and her head is unusually small for her age; her parents seek help.

A baby's gaze is fixed on the ceiling; a woman's bruise will not disappear.

An infant has an eye problem; a young girl is unusually sweaty.

Parents notice their 7-month-old son has troubling physical impairments; a woman traveling the world starts experiencing unusual back pain and tingling in her feet.

Mike's religious beliefs have kept him from seeing a doctor about his huge growth; Kylie has come to love her birthmark and is torn about whether or not to get it removed; Shad's head bump bursts open and smells like death.

Tyler's hands are so dry, cracked and painful that he considers getting them amputated; Ebonee covers the tiny bumps around her eyes with sunglasses; Ralph feels like a cyst factory with painful cysts covering his back.

Kelly has a massive shoulder growth; Erica stabbed her hand with a pencil 45 years ago and believes the lead remains trapped in her palm; Paula's painful and swollen feet ooze a substance that emits the foulest of odors.

Dr. Lee has a surprise for Paula, who has oozing, odoriferous and painful legs; Mike needs to get rid of the bump on his head before two major life events; Amanda feels inadequate for her husband because of the saggy growth on her back.

Alyse has been suffering from a burning rash that feels like it's rubbing away her existence; Terry has become too big for his britches due to a painful butt cheek lipoma; James has demons on his back that are ruining his life.

Krystal, a witch, looks to clear a curse of a cyst from her face; Keven wants to get a butt lipoma removed to get his tush back into a regular shape; Raquel, Dr. Lee's esthetician BFF, almost suffocates Dr. Lee with love and a facial.

J-Fab is the life of the party, but her shoulder bump is seriously cramping her style; Dan is a gentle giant with lumps on his head that add a few inches; Teresa's red face and bumpy nose make her feel like a monster.

Fit guy Alonso wants to show off his progress in the gym, but his 70 lipomas are holding him back; Porscha is a comic book enthusiast with two symmetrical lumps on her face; Jeffrey has a leaky lump named Larry on the back of his head.

Robert carries the weight of providing for his family and the weight of the huge lump on his head; Christina has liquid-filled growths next to her eyes; Felipe, a photographer with a dry skin condition so severe he risks losing his career.

Natasha has ambitions of becoming a model, but her massive ear keloids are keeping her off the runway; eight-year-old Wynter wants her scaly mermaid skin cured; Dr. Lee's bestie, Raquel, needs help with a new product for a private area.

Nhan has an extreme, red birthmark that covers half his face; Debbie worries that her shoulder lump will prematurely age her; Justin is a dude rockin' a man bun, but he's having no fun due to the bumps poking through his scalp.

Jess is a widower looking for love who is stuck with a giant bump on his neck; Cherish developed a leopard-print face during pregnancy; former NFL defensive tackle Marcell Dareus hopes Dr. Lee can tackle his forehead lipoma.

Brent has a tricep bump potentially intertwined in his muscle; Jeb loves the beach but refuses to go because of the massive number of blackheads, pimples, and cysts all over his body; Wanda's mysterious mark that caves in her side.

Don's psoriasis has completely taken over his body; Jeff has a large growth on his spine; Sara has an extra set of breasts and nipples.

Angelina has a huge chest lump under her left breast; Delano has a football-sized mass on his back.

Melissa tries to cover a huge lipoma with a sweatshirt for years; Tyler's fear of cancer keep him from having his huge head lumps diagnosed; Tahj is covered in painful boils; Amber has ear keloids that take control of her life.

Ronen's mysterious lump above his knee is one of the largest Dr. Lee has ever seen; Amber suffers from a debilitating skin disease that no one understands; Sandy has a neck lump she calls Tommy; Kristy's eyelid cyst is ruining her life.

Half of Mary's body is a size 18 while the other half is a size 8; Anthony's cyst is in the area called the "Triangle of Death;" Shane wants to get a lump off his back; Brandi is anxious about getting a lump removed from her chest.

Angelina has a huge chest lump under her left breast; Delano has a football-sized mass on his back.

Melissa tries to cover a huge lipoma with a sweatshirt for years; Tyler's fear of cancer keep him from having his huge head lumps diagnosed; Tahj is covered in painful boils; Amber has ear keloids that take control of her life.

Ronen's mysterious lump above his knee is one of the largest Dr. Lee has ever seen; Amber suffers from a debilitating skin disease that no one understands; Sandy has a neck lump she calls Tommy; Kristy's eyelid cyst is ruining her life.

Half of Mary's body is a size 18 while the other half is a size 8; Anthony's cyst is in the area called the "Triangle of Death;" Shane wants to get a lump off his back; Brandi is anxious about getting a lump removed from her chest.

Brent has a tricep bump potentially intertwined in his muscle; Jeb loves the beach but refuses to go because of the massive number of blackheads, pimples, and cysts all over his body; Wanda's mysterious mark that caves in her side.

Don's psoriasis has completely taken over his body; Jeff has a large growth on his spine; Sara has an extra set of breasts and nipples.

Jane discovers a suspicious pattern of babies with extremely low birth weights coming out of the clinic; Chris finds out that Dr. Hicks may have hidden birth records in his mausoleum; Diane hopes to meet her biological father.

Jane and Lisa meet the first Hicks baby, Stephen Dilbeck; Chris and Sallie open the mausoleum in search of birth records rumored to be inside as they work on getting approval of an exhumation.

Stephen Dilbeck gets some shocking information about his birth family from Jane and Lisa; Chris and Sallie work on getting approval of an exhumation that will answer questions for hundreds of Hicks babies.

Jane and Lisa share the news about the exhumation with a group of Hicks babies that have questioned whether Dr. Hicks was in fact their biological father; Sallie and the Hicks babies learn the DNA results.

Wendy and her team encounter unexpected challenges with the exhumation; Sallie struggles emotionally with her decision to exhume; the Hicks babies learn the DNA results; three Hicks babies are connected with biological family.

A teenage girl sleeps for weeks at a time, a boy with a brain-crushing skull defies the odds and a unique couple faces a big challenge.

A boy with an extra arm growing out of his back; a woman whose knees bend backwards; a tumor in a woman's eye could soon threaten her life.

A teenager whose body is aging ten times faster than normal, a girl with a massive tumor in the middle of her face needs emergency care and a woman battling a rare disorder can't stop eating.

Two feet tall woman; real-life Sleeping Beauty; isolated bubble man.

A man loses his face to cancer; a baby born with a parasitic tumor; a girl's feet won't stop growing; a boy's face melts away.

In Thailand, a woman has the world's largest hands; an Ethiopian girl has a life-threatening neck tumor; 4-year-old conjoined twins risk surgery; a young woman has a body affected by vitiligo; in Spain, a woman's face is blistering away.

A Brazilian man with an elephant leg; a man is scared stiff; a Thai man could be the tallest man in the word; a child born with an unknown condition; a toddler is covered in hair.

A doctor with a severe bee allergy is stung while treating a critical patient who's been stabbed in the eye; a man comes into the ER after slitting his own throat; a paramedic becomes a patient when she's struck by a mysterious illness.

A man's mysterious injury; a patient says they've been shot in the head; a woman is brain dead.

A patient's violent outbursts; a man's heart fails; a patient with severe burns prays for a miracle.

Two separate car crash victims are brought to the ER in their underwear; a woman is acting delusional and refuses to allow the ER staff to touch her; a doctor struggles to diagnose a dehydrated and nauseous 10 year old.

A man's itchy rash turns out to be more than just poison oak; a young woman bleeds profusely from the inside of her lip, but there is no obvious cause; a family of three is admitted as car accident victims, but the doctor makes a shocking discovery.

A patient's pet causes pandemonium; a man experiences paralysis that climbs up his legs to his chest until he can no longer breathe; a war veteran suffers from phantom pain in his amputated hand.

A patient's violent outbursts; a man's heart fails; a patient with severe burns prays for a miracle.

Two separate car crash victims are brought to the ER in their underwear; a woman is acting delusional and refuses to allow the ER staff to touch her; a doctor struggles to diagnose a dehydrated and nauseous 10 year old.

Two separate car crash victims are brought to the ER in their underwear; a woman is acting delusional and refuses to allow the ER staff to touch her; a doctor struggles to diagnose a dehydrated and nauseous 10 year old.

A man's itchy rash turns out to be more than just poison oak; a young woman bleeds profusely from the inside of her lip, but there is no obvious cause; a family of three is admitted as car accident victims, but the doctor makes a shocking discovery.

A patient's pet causes pandemonium; a man experiences paralysis that climbs up his legs to his chest until he can no longer breathe; a war veteran suffers from phantom pain in his amputated hand.

A doctor with a severe bee allergy is stung while treating a critical patient who's been stabbed in the eye; a man comes into the ER after slitting his own throat; a paramedic becomes a patient when she's struck by a mysterious illness.

A man's mysterious injury; a patient says they've been shot in the head; a woman is brain dead.

After years of a tumultuous relationship with her husband, Tamy's eating addiction has caused her weight to balloon to over 500 pounds; she has become a hermit and hopes to restart her life so she can better care for her son, Zachary.

A woman struggles to make a positive change to be part of her partner and son's lives and turn her life around.

Bedridden Marla is so heavy she cannot stand up; she must face the hard truth about her condition and understand the toll it takes on her supportive family.

Since the death of his mother, Aaron lives at home to care for his aging father, but due to his food addiction, Aaron has to heavily rely on his father for help instead. Aaron must learn to care for himself to avoid eating himself to death.

Octavia has been bedbound for nearly a year when she decides to make the trip to Houston to get help from Dr. Now, but when it turns out that her best friend is also her worst enabler, Octavia will have to choose between old habits and a new life.

After regaining her mobility, Octavia is determined to never be stuck in the bed again, but difficult life circumstances threaten her ability to eat right and stay on track; Aaron is laid low by the death of his father, but true love saves him.

Despite moving to Houston with the solid support of her boyfriend, Aaron, and her cousin, Jasmine, Tiffany finds it difficult to break the cycle of depressed eating when her two roommates don't join her diet and leave the house every day for work.

Bethany has two daughters who live in fear of losing their mom to her food addiction; once an addiction counselor, Bethany has gotten so big that she can no longer work; now she risks losing her life if Dr Now can't help her curb her own addiction.

Isaac helped raise his siblings after his mom suffered a debilitating stroke when he was 10; while learning to cook for his family, he began comfort-eating; now to avoid eating himself to death, Isaac must learn to take care of himself for a change.

Patrick's weight has never been a bother, but now he's so big that it's getting in the way of his relationship with his daughter; if he wants to see her graduate high school, he'll have to reverse course.

Isaac helped raise his siblings after his mom suffered a debilitating stroke when he was 10; while learning to cook for his family, he began comfort-eating; now to avoid eating himself to death, Isaac must learn to take care of himself for a change.

Patrick's weight has never been a bother, but now he's so big that it's getting in the way of his relationship with his daughter; if he wants to see her graduate high school, he'll have to reverse course.

Bethany has two daughters who live in fear of losing their mom to her food addiction; once an addiction counselor, Bethany has gotten so big that she can no longer work; now she risks losing her life if Dr Now can't help her curb her own addiction.

Most of the extreme weight on Tracey's body resides in her shockingly misshapen legs, which are massive with severe lymphedema, and gastric surgery is her only chance of survival; Brenda and Melissa prepare for skin removal surgery.

Laura has used food to cope with her emotions; she is confined to a wheelchair and relies on an oxygen tank to breathe and her husband and mother to survive.

With her weight loss, Laura is much less dependent on her husband Joey, who is now having trouble finding his place in their relationship; challenging patient Marla returns and the fireworks begin once again.

Vianey and Allen are locked in a co-dependent relationship based on a shared love of food; as they head to Houston, they will soon find out if their relationship can handle the strain of growing healthy together.

Vianey and Allen have been on a weight-loss journey together; after Allen's surgery is a success and Vianey's is not, the couple struggle to get back on the same page to save their lives.

Lupe has spent the last 10 years in bed and is totally dependent on her husband, prompting a cross-country move that could save her life or end up backfiring.

Dr. Nowzaradan is worried Lupe's emotional issues are blocking her weight loss journey since she's shed over 300-lbs but still can't walk; when Ashley is struck with sudden paralysis, her own emotional stability is thrown into peril.

Brittani has lost over 400 pounds in two years, so she and husband Bill think about expanding their family; Lupe has struggled since surgery, but, having left her husband, may finally start to make the permanent changes she needs.

Krystal S. has finally met the man of her dreams, but she won't let herself marry him until she can be sure that she won't become bedridden and force him into the role of caretaker.

Tommy wants to lose weight so he can marry his fiancee and have the life he always dreamed of with her, but to break the cycle of pathological eating that left him nearly bed-bound, he'll have to face a piece of his past he has always kept secret.

Krystal S. has finally met the man of her dreams, but she won't let herself marry him until she can be sure that she won't become bedridden and force him into the role of caretaker.

Tommy wants to lose weight so he can marry his fiancee and have the life he always dreamed of with her, but to break the cycle of pathological eating that left him nearly bed-bound, he'll have to face a piece of his past he has always kept secret.

Brittani has lost over 400 pounds in two years, so she and husband Bill think about expanding their family; Lupe has struggled since surgery, but, having left her husband, may finally start to make the permanent changes she needs.

Having her daughters help bathe her is not how Chrystal pictured parenting but she is so large that there's no other option; Chrystal wants Dr. Now's help but she didn't know that bringing her childhood trauma to light would be part of the deal.

Ashley confronts medical setbacks and struggles to get past the trauma that ignited her eating disorder.

At 24-years-old, Bettie Jo is on her way to reaching 700 pounds and relies on her husband for her basic needs.

At 600 pounds, Ashley has to move home so her mom can help her care for herself and her newborn daughter; Ashley must overcome a lifetime's worth of unfortunate circumstances and get Dr. Now's help in Houston.

Cillas' food addiction is getting in the way of his ability to be there for his fiancée, Jessica, and her three daughters; if he doesn't lose weight soon, he knows he'll lose either his girls or his life.

Cillas must face difficulties from his childhood to progress to his goal weight and set an example for his children; Tiffany struggles to lose weight when financial hardships place a strain on her relationship with her boyfriend, Aaron.

When Travis gets too big to walk down the aisle, he promises to give his wife a proper wedding; he gains more weight, leaving Dr Now as Travis' only hope to lose weight and get the life he and his wife dreamed of having together.

Cynthia, a single mother focused on raising five kids, comes to realize what her death would mean for their future.